CHEMICAL RESEARCH IN TOXICOLOGY
·
2016
·
IF 3.025
Xiufang Song,Qiong Shi,Zixuan Liu,Yawen Wang,Yuxin Wang,Erqun Song,Yang Song
We previously demonstrated that halogenated quinone induces DNA double strand breaks (DSBs) in a ROS-dependent manner, which coordinates with downstream repair cascade including nonhomologous end joining, base excision repair, and nucleotide excision repair. However, these error-prone processes may cause the potential risk of genome instability, and current has no information on how faithful repair route, such as homologous recombination (HR), was affected. RAD51 is a key protein in the HR pathway of DSBs repair. Here, we found that tetrachlorobenzoquinone (TCBQ) causes a time-dependent reverse U-shape biphasic trend of RAD51 expression. An increase in the early stage and a following decrease of RAD51 expression were found in both 12.5 and 25 μM TCBQ groups, wherein higher concentration faced a faster response. The upregulated RAD51 in the early phase suggested the attempting to repair TCBQ-induced DNA damage; however, the downregulation of RAD51 in the late phase implicated that the rescue probably be abandoned with severe DNA damage. This phenomenon is a general toxic manner of TCBQ regardless of cell type. Surprisingly, TCBQ showed minimum effect on RAD51 mRNA (or protein) synthesis as well as RAD51 degradation. Specific inhibition of RAD51 by siRNA amplified TCBQ-induced DNA damage and cytotoxicity, while cells with enhanced RAD51 expression resisted TCBQ-induced toxicity. The modulation of RAD51 is correlated with p53 level, which suggests p53 has a role in TCBQ-induced RAD51 clearance. Together, our data suggested that TCBQ increases genome instability and cell death through a unique mechanism of inducing DNA damage and inhibiting DNA repair.
研究领域:
毒理学
·
分子生物学
·
遗传学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Energy Storage
·
2024
·
IF 8.9
Yuxiao Chu,Yuxin Yang,Haihui Lin,Zilong Zhang,Shilong Chang,Cuihong Zhang,Peng Zhang,Lei Dong,Fu-Gang Zhao,Xiao-Jin Wu,Jian Chen,Yongmiao Shen
Polyaniline and benzoquinone with powerful electrochemical activity and reversibility were widely used to boost specific capacitance of graphene electrode material and energy density of the corresponding supercapacitor devices. Inspired by these previous reports, herein, a novel heterogeneous polymer (polyAHQDME) containing both aniline units and benzoquinone ones were designed and synthesized, and finally grafted on reduced graphene oxide (rGO) framework. As expected, redox-active polyAHQDME modifier enabled rGO with an ultrahigh specific capacitance of 685.4 F g −1 , five folds bare rGO counterpart. When assembled into symmetric two-electrode devices in quasi-solid-state aqueous and organic electrolytes, respectively, the key energy density parameter could reach as high as 21.6 and 100.6 Wh kg −1 , outperforming most recently-reported modified carbon electrode materials.
研究领域:
材料科学
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电化学
✓ 已验证
产品关联
DOI
高影响因子
ACS Nano
·
2025
·
IF 16
Shuo Meng,Shanshan Yang,Ting He,Jian Guo,Mingze Xu,Lu Chen,Kexuan Liao,Lianhai Zu,Chen Zhou,Chi Zhang,Jinhu Yang
Benzoquinone (BQ) is considered a promising cathode material for aqueous zinc-ion batteries due to its simplest molecular structure and highest theoretical specific capacity among quinones. However, intrinsic problems derived from BQ including severe dissolution, narrow crystal interplanar d-spacings accessible by desolved Zn2+ only, and poor conductivity cause inferior battery performance. Herein, a strategy based on a “nanopore-confined dual-site synergy mechanism” is proposed to stabilize the BQ cathode and boost Zn2+ desolvation/coordination reactions for stable and fast Zn storage, which is realized by the construction of CoS2 nanodot-embedded MOF-derived porous carbon (MPC) as an efficient host for BQ molecules. The MPC provides enough pore space to accommodate a substantial amount of BQ molecules with good electric conductivity, whereas CoS2 in pores offering abundant Co and S sites exerts strong chemical binding over BQ species and facilitates Zn2+ desolvation/coordination, respectively, synergistically suppressing the dissolution of cathodes and imparting the rapid reaction kinetics of batteries. Consequently, the developed BQ@CoS2-MPC cathode delivers a high reversible capacity of 458 mA h g–1 at 0.5 C, excellent rate capability, and pronounced cycling stability with a low decay of 0.003% per cycle for over 10,000 cycles at 20 C. The work proposes an effective strategy toward high-performance organic electrode materials.
研究领域:
材料科学
·
电化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
WATER RESEARCH
·
2021
·
IF 11.236
Jinxiu Lou,Huijie Lu,Wei Wang,Lizhong Zhu
Halobenzoquinones (HBQs) are emerging disinfection byproducts generated during the reaction of chlorine disinfectant with natural organic matter (NOM) in source water. In this study, the correlations between molecular weight and HBQs generation of river NOM was evaluated. The compositional and functional characteristics of primary HBQs precursors were revealed by using Orbitrap mass spectrometry combined with molecular tagging. The NOM fraction larger than 50 kDa resulted in approximately 9 times more HBQs (50.9 ± 2.7 ng/mgC) than low molecular weight fractions. Significant correlations were found between the yields of HBQs and lignin-like and highly oxygen compounds in NOM, suggesting their critical roles in HBQs formation. Derivatizating the aldehydes, ketones, hydroxyl and carboxyl groups in NOM could reduce HBQs yields by 90.7%–100%. Unraveling the molecular characteristics of HBQs precursors in NOM would greatly benefit the prediction of HBQs yields of different source water, and develop more efficient disinfection byproduct control strategies.
研究领域:
环境科学
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分析化学
✓ 已验证
DOI
PubMed
高影响因子
Nanomaterials
·
2018
·Vol. 8
·期 2
·103
·
IF 3.504
Ying Wu,Jixiao Wang,Bin Ou,Song Zhao,Zhi Wang,Shichang Wang
Electrochemical polymerization of aniline is one of the most promising methods to prepare polyaniline (PANI) materials. However, during this process, the electrolyte solution must be replaced after electropolymerization of a certain time because of the generation and the accumulation of the by-products, which have significant effects on the morphology, purity and properties of PANI products. Treatment and recycling of the used electrolyte solution are worthwhile to study to reduce the high treatment cost of the used electrolyte solution containing aniline and its polymerization by-products. Here, the composition of the used electrolyte solution was separated and determined by high performance liquid chromatography coupled with diode array detection (HPLC-DAD) in the range of ultraviolet and visible (UV-Vis) light. The analysis results revealed that the used electrolyte solution consisted of aniline, p-hydroquinone (HQ), p-benzoquinone (BQ), co-oligomers of aniline and p-benzoquinone (CAB) and acid. Then, n-octanol and 2-octanone were selected as extracts to remove HQ, BQ and CAB from the used electrolyte solution. Following that, the recycled electrolyte solution was prepared by adjusting the concentration of aniline and acid of the aqueous phase, and the electrochemical polymerization process was conducted. Finally, the obtained PANI was characterized by scanning electron microscope (SEM) and electrochemical methods. The experimental results clearly demonstrate that the morphology and specific capacitance of PANI produced from the recycled electrolyte solution can be recovered completely. This research paves the way for reusing the used electrolyte solution for aniline electrochemical polymerization.Keywords:polyaniline nanowires;electrochemical polymerization;p-benzoquinone;supercapacitor;extraction
研究领域:
材料科学
·
电化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FOOD CONTROL
·
2021
·
IF 5.548
Zeyi Wu,Qin Ye,Jinshuang Wang,Ningxiang Yu,Xiaohua Nie,Chaosheng Xia,Xianghe Meng
Chicken breast, a food rich in protein, was deep-fried in soybean oil (SBO) at 140, 175 and 190 °C for 20 continuous batches, and the profiles of acid value (AV), peroxide value (PV), 2-tert-Butyl-1,4-dihydrobenzoquinone (TBHQ), and 2-tert-Butyl-1,4-benzoquinone (TBBQ) in SBO and fried chicken breast were determined. The results suggested that frying at 140 °C produced increased conversion of TBHQ to TBBQ and oxidation of the frying oil than at 175 °C, which was close to that found at 190 °C. The highest TBBQ peak concentration of 2.89 ± 0.12 and 13.88 ± 0.27 mg/kg for fried chicken breast and frying oil corresponded to the 7th and 6th frying batch at 140 °C, respectively. The experimental results on determination of the AV, PV, moisture and the content of oxygen in frying oil suggested that more moisture and oxygen were retained in oil when frying at 140 °C than that at 175 °C, which may explain the over-conversion of TBHQ to TBBQ when frying at low temperature. The results on aeration frying and water injection frying experiments indicated that moisture and oxygen had a great impact on the oxidation of TBHQ in frying oil.
研究领域:
食品科学
·
化学
✓ 已验证
DOI
高影响因子
FOOD CHEMISTRY
·
2019
·
IF 5.399
Yuting Li,Qiaoling Huang,Xiangying Yu,Yujia Liu,Lin Li,Bing Li,Xia Zhang,Sui Chen,Zhan Liu,Xianglong Zhao,Jingjing Ma
The reaction of N ε -(carboxymethyl) lysine (CML) with eight kinds of non-flavonoid o -benzoquinones and five kinds of flavonoid o -benzoquinones were investigated by cyclic voltammetry at pH 5.0, 7.0 and 8.0 and scan rate of 10, 50 and 100 mV/s. The reactivity of o -benzoquinones towards CML is weakened by the electron-donating substituent and strengthened by the electron-withdrawing substituent on the o -benzoquinone rings. The steric hindrance of the substituents on o -benzoquinone rings also weakens the quinone reactivity. Reaction of 4-methylbenzoquinone with CML (38.0 ± 1.3%) was found to be faster than that with l -lysine (31.3 ± 1.5%) and Nα-acetyl- l -lysine (14.5 ± 0.1%) but slower than that with l -cysteine (≥100.0%) and Nα-acetyl- l -cysteine (≥100.0%) at pH 7.0 and scan rate of 10 mV/s. Products obtained by the reaction of CML with o -benzoquinones were found to include a CML-quinone adduct according to the cyclic voltammetry and UPLC-QTOF-MS/MS analysis.
研究领域:
生物化学
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电化学
·
药物化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MICROPOROUS AND MESOPOROUS MATERIALS
·
2016
·
IF 3.349
Tong-Mou Geng,Deng-Kun Li,Zong-Ming Zhu,Ye-Bin Guan,Yu Wang
The benzoquinone-based conjugated microporous/mesoporous polymers were synthesized through Sonogashira–Hagihara cross-coupling with tetrabromo-1,4-benzoquinone (TBrBQ) and 1,4-diethynylbenzene (DEB) by both solution polymerization (DBQP) and miniemulsion polymerization (DBQN). The Brunauer–Emmett–Teller (BET) surface areas of these polymers were 356 and 25 m 2 g −1 and pore average diameter were concentrated at around 2.12 and 3.84 nm for DBQP and DBQN, respectively. The two dimensional π-conjugated polymer frameworks could be combined with permanent microporous/mesoporous, luminescent properties and abundant oxygen atoms in the skeleton. Fluorescence studies found that both DBQP and DPQN could be utilized as fluorescent chemosensors for picronitric acid (PA) in acetone suspension.
研究领域:
材料科学
·
化学
✓ 已验证
产品关联
DOI
高影响因子
Journal of Breath Research
·
2015
·Vol. 9
·期 1
·016003
·
IF 4.631
Liying Peng,Lei Hua,Enyou Li,Weiguo Wang,Qinghua Zhou,Xin Wang,Changsong Wang,Jinghua Li,Haiyang Li
Ion mobility spectrometry (IMS) is a promising non-invasive tool for the analysis of exhaled gas and exhaled nitric oxide (NO), a biomarker for diagnosis of respiratory diseases. However, the high moisture in exhaled gas always brings about extra overlapping ion peaks and results in poor identification ability. In this paper, p-benzoquinone (PBQ) was introduced into IMS to eliminate the interference of overlapping ion peaks and realize the selective identification of NO. The overlapping ions caused by moisture were titrated by PBQ and then converted to hydrated PBQ anions (C6H4\text{O}_{2}^{-}(H2O)n). The NO concentration could be determined by quantifying gas phase hydrated nitrite anions (N\text{O}_{2}^{-}(H2O)n), product ions of NO. Under optimized conditions, a limit of detection (LOD) of about 1.4 ppbv and a linear range of 10–200 ppbv were obtained for NO even in 100% relative humidity (RH) purified air. Furthermore, this established method was applied to measure hourly the exhaled NO of eight healthy volunteers, and real-time monitoring the exhaled NO of an esophageal carcinoma patient during radical surgery. These results revealed the potential of the current dopant titrating IMS method in the measurement of exhaled NO for medical disease diagnosis.
研究领域:
医学诊断
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分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ANALYST
·
2015
·Vol. 140
·期 23
·7939-7947
·
IF 4.107
Yi Hong Huang,Jian Hua Chen,Li Jing Ling,Zhen Bo Su,Xue Sun,Shi Rong Hu,Wen Weng,Yang Huang,Wen Bing Wu,Ya San He
In the present study, carbon nanocages (CNCs) decorated with gold nanoparticles (AuNPs) with diameters of 2–5 nm were synthesized by simply mixing their solutions. The sizes of the AuNPs are small enough to diffuse into the inside of the CNCs by electrostatic incorporation and their morphologies were characterized by transmission electron microscopy, X-ray diffraction, energy dispersive spectrometry, Raman spectrometry and ultraviolet visible absorption spectra. The AuNPs@CNCs modified electrode was prepared for simultaneous highly sensitive determination of catechol (CC) and hydroquinone (HQ). This modified electrode demonstrated fantastic eletrochemical catalytic activities towards CC and HQ by cyclic voltammetry and differential pulse voltammetry. The calibration curves showed a linear response between the peak currents and the concentrations of CC and HQ. A wide dynamic detection range of 1.0–250.0 μM and 0.1–200.0 μM with a low detection limits (S/N = 3) of 0.0986 μM and 0.0254 μM can be obtained for CC and HQ respectively. The present method was successfully employed for determination of CC and HQ in a practical sample.
研究领域:
材料科学
·
分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
WATER RESEARCH
·
2022
·
IF 13.4
Xiwen Liu,Penghui Shao,Shanshan Gao,Zhaoyu Bai,Jiayu Tian
Benzoquinone (BQ) is of great significance for enhancement of contaminants degradation in the homogeneous oxidation system of peroxymonosulfate (PMS). However, the role of BQ in the heterogeneous activation of PMS for contaminants oxidation is still not clear. Herein, this work reported that the addition of BQ into the Fe 3 S 4 /PMS system could effectively enhance the degradation and mineralization of bisphenol A (BPA). Mechanistic study uncovered that the BQ and PMS would form active complexes (BQ-PMS*) on the surface of Fe 3 S 4 and the excited BQ-PMS* can oxidize the BPA. To be specific, the electron of BPA was extracted by BQ-PMS* and then transfer to the surface of Fe 3 S 4 . The surface electron can induce the change of valence state of S and Fe elements, which can trigger the degradation of BPA and inhibit the decomposition of BQ itself. To the best of our knowledge, it is the first time to unveil the positive role of BQ in the heterogeneous activation of PMS, which may shed new light on the establishment of high-efficient PMS-based oxidation technology for remediation of organic pollutant.
研究领域:
环境科学
·
化学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SCIENCE OF THE TOTAL ENVIRONMENT
·
2024
·
IF 8.2
Zhourui Xu,Jianjian Wei,Aroob Abid,Zirui Liu,Yasen Wu,Jia Gu,Dehua Ma,Min Zheng
Halobenzoquinones (HBQs) are a class of disinfection byproducts with high cytotoxicity and potential carcinogenicity , which have been widely detected in chlorination of drinking water and swimming pool water. However, to date, the formation of HBQs upon ozonation and the HBQ precursors have been overlooked. This study investigated the formation of chlorinated and dechlorinated HBQs from six dichlorophenol (DCP) isomers. The monomeric and dimeric HBQs were identified in all the ozonation effluents, exhibiting 1–100 times higher toxicity levels than their precursors. The sum of detected HBQs intensity had a satisfactory linear relation with the maximum toxic unit ( R 2 = 0.9657), indicating the primary toxicity contribution to the increased overall toxicity of effluents. Based on density functional theory calculations, when ozone attacks the para carbon to the hydroxyl group of 2,3-DCP, the probability of producing chlorinated HBQs is 80.41 %, indicating that the para carbon attack mainly resulted in the formation of monomeric HBQs. 2,3-dichlorophenoxy radicals were successfully detected in ozonated 2,3-DCP effluent through electron paramagnetic resonance and further validated using theoretical calculation, revealing the formation pathway of dimeric HBQs. The results indicate that chlorinated phenols, regardless of the positions of chlorine substitution, can potentially serve as precursors for both chlorinated and dechlorinated HBQs formation during ozonation.
研究领域:
环境科学
·
毒理学
·
水处理工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）