CHEMICAL ENGINEERING JOURNAL
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2023
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IF 15.1
Min Li,Ying Wang,Xin Zhou,Qi Zhang,Mingyang Chen,Dandan Han,Junbo Gong,Hongzhen Li
In this work, the micro/nano spherulitic hierarchical 2,2′,4,4′,6,6′-hexanitrostilbene (HNS) with the excellent specific surface area was prepared for the first time, which was expected to overcome the agglomeration problems of nanoscale HNS. In detail, poly( N -isopropyl acrylamide) (PNIPAM), polysuccinimide (PSI), and polyvinylpyrrolidone (PVP) were selected as additives to induce forming spherulitic HNS. Leaflike crystals were obtained in the presence of PNIPAM, while spherulitic HNS could be fabricated in the presence of PSI or PVP. And the prepared spherulitic HNS owned nearly 6 times the specific surface area of the raw HNS, with decreased impact sensitivity and advanced melting and decomposition temperatures, demonstrating a good desensitization effect, and a favorable energy release of the hierarchical structure. Moreover, morphological changes under the effect of the molecular weight and concentration of PVP were explored. The approximated morphological evolution of spherulitic HNS was consistent with the classical spherulitic growth by noncrystallographic branching. Furthermore, it was verified that preferential adsorption of PVP and PSI on the HNS inhibits the growth steps of the (200) face and introduces stress to generate crystal defects, which triggers noncrystallographic branching and further spherulitic growth. Overall, the strategy of fabricating micro/nano spherulitic hierarchical energetic materials via polymer-additive induced noncrystallographic branching is promising to solve the problems of nanoscale energetic materials in agglomeration and microscale bulk crystals in low activity.
研究领域:
材料科学
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高能材料
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聚合物科学
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纳米技术
✓ 已验证
DOI
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2023
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IF 6.1
Zhengming Xu,Shuang Liu,Huining Lai,Lijun You,Zhengang Zhao
Arbutin, salidroside, polydatin, and phlorizin are typically natural bioactive phenolic glycosides. To improve the liposolubility and bioavailability, highly liposoluble derivatives including 6′-O-lauryl arbutin, 6′-O-lauryl salidroside, 6″-O-lauryl polydatin, and 6″-O-lauryl phlorizin were efficiently synthesized by enzymatic acylation in a green solvent 2-MeTHF. Their reaction conversions reached 84.4, 99.5, 99.8, and 89.1%, respectively, when catalyzed by Lipozyme 435 at 20 mg/mL at 50 °C. As expected, the derivatives had high log P (1.66–2.37) and retained good antioxidant activity, making them potential alternatives to butylated hydroxytoluene (BHT) and tert-butyl-hydroquinone (TBHQ) in lipid systems. Then, the intestinal permeability characteristics and metabolism of phenolic glycosides and their derivatives were investigated based on Caco-2 monolayers. The permeability of polydatin and phlorizin was mainly through active transport, but that of arbutin and salidroside involved both passive diffusion and active uptake. The acylated derivatives suffered from severe CES-mediated hydrolysis but exhibited a larger transported amount than phenolic glycosides.
研究领域:
药学
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有机化学
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生物化学
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药理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2024
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IF 5.7
Lin-Lin Tian,Yan-Xue Bi,Hua Zhang
Fifteen stilbenoid derivatives, including five previously undescribed ones (albaphenols A–E, 1–5) with diverse scaffolds, were obtained from the well-known agricultural economic tree Morus alba. Their structures, including absolute stereochemistries, were fully characterized by detailed interpretation of spectroscopic data and quantum chemical computational analyses of nuclear magnetic resonance (NMR) and electric circular dichroism (ECD). Albaphenol A (1) features an unprecedented rearranged carbon skeleton incorporating a novel 2-oxaspiro[bicyclo[3.2.1]octane-6,3′-furan] motif; albaphenol C (3) is likely derived from a cometabolite through an interesting intramolecular transesterification reaction; and albaphenol E (5) bears a cleavage-reconnection scaffold via a dioxane ring. All of the compounds exhibited significant inhibition against the diabetic target α-glucosidase, with low to submicromole IC50 values (0.70–8.27 μM), and the binding modes of selected molecules with the enzyme were further investigated by fluorescence quenching, kinetics, and molecular docking experiments. The antidiabetic effect of the most active and abundant mulberrofuran G (6) was further assessed in vivo in diabetic mice, revealing potent antihyperglycemic activity and comparable antidiabetic efficacy to the clinical drug acarbose.
研究领域:
药理学
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有机化学
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生物化学
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药物化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）