JOURNAL OF APPLIED POLYMER SCIENCE
·
2019
·Vol. 136
·期 45
·48186
·
IF 2.188
Xiaoguang Ying,Anshun Kang,Xiaomei Zhu,Xiao Li
Electrospinning is an important tool for generating continuous fibers with large surface area and high pore ratio. The combination of nanofiber membrane and molecular imprinting can effectively measure specific adsorption of putrescine with coloring procedure. In this work, molecularly imprinted electrospun chromogenic membrane was synthesized with 1,4-butanediol (BDO) as imitate template. Poly(vinyl alcohol) (PVA) is used as spinning solution and ninhydrin as chromogenic agent for visualizing detection of target molecular putrescine. The adsorption concentration on molecularly imprinted polymer is illustrated by blue-purple colored stains and recorded by interactive three-dimensional surface plot of ImageJ. The results indicated that a uniform and bead-free PVA nanofiber was obtained using 10% (w/w) PVA solution, 15 kV voltage, 15 cm spinning distance, and 600 rpm roller speed. Also, the adsorption performance of molecular imprinting chromogenic membrane was investigated in detail, showing a higher adsorption capacity of 33.16 μg cm −2 and maximum imprinting efficiency of 2.30 under the best recognition conditions of 315 μL ninhydrin, 0.25% (w/w) BDO, and 0.4 cm sensing distance, as well as a short adsorption equilibrium time of 40 min. In addition, three amine competitors were discussed to reveal the better selectivity and higher specific recognition ability in the imprinted membrane. HIGHLIGHTS The molecular imprinting and coloring structure is constructed in nanofiber membrane with an enhanced specific surface area. The adsorption on imprinted membrane is visualized by chromogenic reaction between putrescine and ninhydrin to form a three-dimensional interactive surface proceeded using the ImageJ software. The imprinted nanofiber membrane with large area and high pore ratio is applied in detecting target in trace concentration within shortened time. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019 , 136 , 48186.
研究领域:
材料科学
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分析化学
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纳米技术
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高分子科学
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产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 15.1
Liupeng Yang,Huiya Chen,Qun Zheng,Peiru Luo,Wenjuan Yan,Suqing Huang,Dongmei Cheng,Han Hong Xu,Zhixiang Zhang
The invasion area of red imported fire ants (RIFAs) in China continues to expand due to factors such as ecological changes and human activities, and the resulting damage is becoming increasingly severe. The development of smart nanopesticides that respond to environmental stimuli response with precisely controlled release has great potential in improving insecticidal effects. In this work, a smart pH and α-amylase dual stimuli-responsive pesticide delivery system was constructed by combining mono-(6-amino-6-deoxy)-β-cyclodextrin (β-CD-NH 2 ) with zeolitic imidazole skeleton-90 (ZIF-90) nanoparticles ( [email protected] ) loaded with indoxacarb. The average particle size of the prepared [email protected] was 249 nm, and the loading efficiency was 18.43%. The β-CD-NH 2 coating on the surface of nanoparticles reduced the photodegradation of indoxacarb and prevented the premature release of the active ingredient. In vitro release kinetics showed that [email protected] rapidly released IDC under acidic and amylase conditions, consistent with the oral and intestinal environment of RIFAs. The results of bioactivity tests showed that [email protected] enhanced the toxicity of IDC toward RIFAs by increasing feeding and damaging intestinal cells. The mortality rate of the [email protected] group was significantly higher than that of the IDC EC-treated group at 72 h. The nontargeted metabolomic results showed that [email protected] affected the metabolism of RIFAs by interfering with the metabolic pathways of six amino acids and one amino acid transport carrier, whereas IDC EC interfered with only two of these amino acid metabolic pathways. Overall, this work provides insight into the effective control of RIFA damage for sustainable pest management.
研究领域:
纳米技术
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害虫管理
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昆虫毒理学
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代谢组学
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产品关联
DOI
高影响因子
Journal of Environmental Chemical Engineering
·
2023
·
IF 7.7
Yongpan Shan,Yajie Ma,Changcai Wu,Xiangliang Ren,Xianpeng Song,Dan Wang,Hongyan Hu,Xiaoyan Ma,Yan Ma
Control release of pesticides based on target plant characteristics is highly desirable for improving the effective utilization rate and reducing non-target organism risks. Here, the controlled release formulations (Cu-CS@IN@MIL-100 (Fe)) were successfully prepared by employing MIL-100 (Fe) as the carrier material, indoxacarb (IN) as the model pesticide, and chitosan (CS) as a coating to chelate copper ions by chemical crosslinking. The prepared Cu-CS@IN@MIL-100 (Fe) had an acceptable loading content (36.25 %). The introduction of CS and copper ions endowed it with sustained release properties under weak acidity conditions like cotton leaves. The laboratory bioassay experiments showed that Cu-CS@IN@MIL-100 (Fe) had practical good insecticidal activity (LC 50 = 4.936 mg/L) in controlling Helicoverpa armigera larvae. For long-term control efficacy experiments, after 14 days of application, the Cu-CS@IN@MIL-100 (Fe) treatment (73 %) mortality of Helicoverpa armigera larvae was significantly higher than the 15 % indoxacarb suspension concentrates (SC) treatment (27 %). Moreover, Cu-CS@IN@MIL-100 (Fe) had no adverse effect on cottonseed germination and the acute toxicity to Chrysopa pallens larvae was significantly lower than IN SC. Therefore, MIL-100 (Fe) could be used as an ecological safety carrier for pesticide delivery to improve IN effective utilization and reduce non-target organism risks.
研究领域:
农业科学
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农药科学
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环境科学
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材料科学
✓ 已验证
产品关联
DOI
高影响因子
TALANTA
·
2013
·
IF 3.498
Jiao Li,Yuanyuan Li,Tong Chen,Luan Xu,Xiaoyan Liu,Xiaoli Zhang,Haixia Zhang
In this paper, linear and cyclic tetrapeptide bonded stationary phases, were synthesized by the solid-phase synthesis method. Each amino acid coupling step was monitored by the ninhydrin test using UV/visible spectrophotometry. The proposed materials were characterized by UV spectroscopy , Fourier transform infrared spectroscopy, elemental analysis and thermogravimetric analysis , which proved the successful immobilization of tetrapeptide on the silica support. The cyclopeptide stationary phase displayed mixed-mode behavior and had the size selectivity for polycyclic aromatic hydrocarbon such as anthracene , while the linear peptide stationary phase only exhibited typical hydrophilic interaction chromatography (HILIC) characteristics and was more hydrophilic under the same mobile phase condition. Retention behaviors of polar compounds on the two stationary phases were studied through varying column temperature, the water content, pH and ionic strength in mobile phase. Applications in the separation of the mixture of nucleosides , sulfa compounds, organic acids and isomers of substituted benzoic acid compounds were demonstrated.
研究领域:
化学
·
生物学
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材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
npj Science of Food
·
2025
·Vol. 9
·期 1
·1-8
·
IF 7.8
Pan Hui,Zhang Wei,Jin Meng,Zhang Fang,Chen Xuelei,Meng Xiao,Shao Hua,Song Liqun,Zhang Zhihu,Wang Cuijuan
Concerns over health risks associated with mixed pesticide residues have led to a demand for rapid analytical methods. We present a portable surface-enhanced Raman spectroscopy (SERS) device specifically designed for real-time monitoring of indoxacarb (INDX) and chlorfenapyr (CFP) in vegetable juice. This point-of-use sensor integrates silver nanoparticles with a metal-organic framework (Ag/MOF-808(Zr)) and employs a 19-well quartz plate alongside a portable Raman spectroscopy instrument, facilitating simultaneous adsorption, separation, and detection. Detection limits for INDX and CFP in ginger and spinach juices were 0.26–0.76 ppb. Notably, results closely matched those from liquid chromatography, and in-situ detection was achieved within 2 min without pre-treatment, significantly enhancing efficiency over conventional chromatographic methods. This innovative approach demonstrates substantial potential for detecting pesticide mixtures in non-laboratory settings, presenting a valuable option for point-of-use applications.
研究领域:
分析化学
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食品安全
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环境监测
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纳米技术
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光谱学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
DYES AND PIGMENTS
·
2025
·
IF 4.2
Guoqiang Kuang,Yabing Wang,Mengxiong Zhu,Hongbin Yin,Yijie Tao,Yafei Guo,Shiguo Zhang
The synthesis of high-performance electrochromic polymers remains a key research highlight in the field of electrochromism. Herein, a series of donor-acceptor type conjugated polymers are synthesized based on 4,9-Dihydro-s-indaceno[1,2-b:5,6-b]dithiophene (IDT), 3,4-ethylenedioxythiophene (EDOT), benzo[c][1,2,5]thiadiazole (BTD) and benzothiadiazo-[3,4-g]-quinoxaline (TQX) units by Stille coupling polymerization. By fine-tuning the ratios between the monomers, the synthesized copolymers exhibited diverse color options and tunable properties, by applying an extra potential, polymer films transit from yellow, pink, green, and dark brown to highly transmissive state, along with outstanding electrochromic properties in both the NIR region and the visible region, such as high optical contrast, rapid switching response, and excellent stability. As a result, the derived electrochromic devices demonstrate an optical contrast exceeding 40 % and retained over 74 % of their optical contrast after 1000 switching cycles. These findings collectively demonstrate that these copolymers hold significant potential for applications in smart windows and adaptive camouflage as a versatile color palette.
研究领域:
材料科学
·
高分子化学
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电致变色
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有机电子学
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智能材料
✓ 已验证
DOI
高影响因子
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
·
2025
·
IF 3
Yilin Huang,Xingli Huo,Huijun Liu,Danni Li,Zongning Yin
Lysine succinylation is a major post-translational modification affecting diverse proteins, and its excessive occurrence can lead to protein misfolding and aggregation—hallmarks of various proteinopathies, such as amyloid-β and Tau tangle formation in Alzheimer's disease and islet amyloid polypeptide aggregation in type 2 diabetes. Here, we investigated the inhibitory effects of bile acid metabolites (deoxycholic acid, glycocholic acid, and taurocholic acid sodium) and natural polyphenols (anthocyanin and salidroside) on succinylation and succinylation-induced amyloid aggregation. Succinylation levels were evaluated using the ninhydrin assay before and after treatment, and aggregation behavior and structural alterations were characterized by SDS-PAGE, inverted fluorescence microscopy, and intrinsic fluorescence spectroscopy. Additionally, fluorescence quenching and molecular docking were used to explore the underlying mechanisms. All five small molecules significantly reduced succinylation in a concentration-dependent manner (p < 0.05). Among bile acids, taurocholic acid sodium exhibited the strongest suppression of aggregation (40.99 %), followed by glycocholic acid (28.32 %) and deoxycholic acid (27.94 %). Anthocyanin showed greater inhibition (33.81 %) than salidroside (26.54 %) (all p < 0.05). The results suggest that these small molecules inhibit succinylation-induced aggregation potentially by interacting with proteins and altering their conformations, thereby preventing excessive succinylation at lysine residues. This study provides new insight into the interplay between bile acid metabolism and protein homeostasis and highlights the therapeutic potential of natural compounds in preventing protein aggregation-related diseases.
研究领域:
生物化学
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分子生物学
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神经退行性疾病
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代谢
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药理学
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结构生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CARBOHYDRATE POLYMERS
·
2019
·
IF 6.044
Liru Zhang,Jie Liu,Xuejing Zheng,Ali Zhang,Xianliang Zhang,Keyong Tang
Herein the construction of a strong gelatin hydrogel is presented by using pullulan dialdehyde (PDA) as a macromolecular crosslinker. The resultant PDA crosslinked gelatin hydrogels (G-PDA) exhibit extremely high mechanical strength, manifested in the achieved optimal compressive stress of 5.80 MPa at 80% strain, which is up to 152 times higher than pure gelatin hydrogel. The G-PDA were characterized by Fourier transform infrared (FTIR) spectroscopy and scanning electron microscopy (SEM). The extent of crosslinking was determined by ninhydrin assay. The results suggested that the synergistic effect of dual-crosslinking, which is composed of short- and long-range covalent crosslinking and thermoreversible physical crosslinking, may played a key role in enhancing the load-bearing capacity of ensuing hydrogels. The swelling and enzymatic degradation of G-PDA are gradually limited with increasing PDA concentration. The result from MTT assay demonstrated that G-PDA is non-cytotoxic against MC3T3 cells, regardless of the concentrations of PDA.
研究领域:
材料科学
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生物医学工程
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生物材料
✓ 已验证
产品关联
DOI
PubMed
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2022
·Vol. 46
·期 40
·19442-19454
·
IF 3.925
Zhi-Gang Yin,Xiong-Wei Liu,Lin Chen,Xiong-Li Liu,Bo-Wen Pan,Ying Zhou
A substrate-dependent, highly β-regioselective one-pot multicomponent 1,3-dipolar cycloaddition reaction of 3-methyl-4-nitro-5-isatylidenyl-isoxazoles with azomethine ylides (thermally generated in situ from ninhydrin and sarcosine) is reported for the first time, furnishing a library of biologically useful bispiro[oxindole-isoxazole-indandione] hybrids. Target novel and structurally complex compounds have been obtained in good yields and diastereoselectivities (up to 91% yield and 20 : 1 dr) with two adjacent spiro quaternary centres. Furthermore, the described method, which is different from our previous work of α-regioselective cycloaddition of 3-methyl-4-nitro-5-isatylidenyl-isoxazoles, is a highly β-regioselective cycloaddition. The newly synthesized compounds potently inhibited the proliferation of various cancer cell lines. The most potent compound 4ah could induce the apoptosis of K562 cells through a caspase-dependent and -independent pathway.
研究领域:
有机化学
·
药物化学
·
癌症研究
✓ 已验证
产品关联
DOI
高影响因子
Catalysts
·
2025
·Vol. 15
·期 9
·826
·
IF 4
Anran Zhu,Zhufan Zou,Yu Cong,Yinghua Yin,Ning Li
A novel two-step strategy was developed for the efficient synthesis of decalin and octahydroindene from lignocellulose-derived platform compounds. In the first step, bicyclic intermediates were directly generated via a cascade dehydration/Robinson annulation of 4-hydroxy-2-butanone with cyclohexanone (or cyclopentanone). Among the evaluated catalysts, CaO demonstrated the highest activity and selectivity. Based on CO2-TPD results, the excellent performance of CaO can be rationalized by its proper basicity. In the second step, these intermediates were selectively hydrodeoxygenated to decalin (or octahydroindene) over Ni/H-ZSM-5 catalyst. Under the investigated reaction conditions, ~90% overall yields of decalin and octahydroindene were achieved. This work provides a viable strategy for the selective conversion of lignocellulose-derived platform compounds to the additives for improving the thermal stability of aviation fuel.
研究领域:
催化化学
·
可再生能源
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绿色化学
·
生物质转化
·
燃料添加剂合成
✓ 已验证
产品关联
DOI
高影响因子
Journal of Materials Chemistry A
·
2023
·
IF 11.9
Yanan Duan,Thumawadee Wongwirat,tianxiong Ju,Shihai Zhang,Junji Wei,Lei Zhu
Intrinsic polymer dielectrics with high discharged energy density and discharge efficiency at elevated temperatures have unique advantages for the film capacitors in power electronics in severe environment (e.g., electric vehicles). In this work, a novel polyetherimide with hydroxy groups and a twisted spirane structure was synthesized based on 3,3,3′,3′-tetramethyl-1,1′-spirobisindane-5,5′-diamino-6,6′-diol (SPDD). Owing to the polar hydroxyls and twisted spirane structure, desirable physical properties are obtained: high glass transition temperatures (281–302 °C), relatively high dielectric constant (4.2–5.1), and very low dielectric loss (dissipation factor < 0.002). As a result, this kind of PEIs possessed excellent high temperature dielectric properties. Among them, the PEI with 50% of spirane units exhibited a high discharged energy density of 2.24 J cm−3 at 200 °C and 350 MV m−1 and with a high discharged efficiency of 90%. This is attributed to the twisted spirane structures that break the π-π stacking of the aromatic rings of PEI polymers, thus decreasing both AC and DC electronic conductions at high fields and high temperatures. Based on these performance, spirane-based PEIs are suitable for high temperature capacitive energy storage.
研究领域:
材料科学
·
电气工程
·
聚合物化学
✓ 已验证
产品关联
DOI
高影响因子
Science China-Chemistry
·
2024
·
IF 10.4
Li Jiangao,Niu Niu,Wang Deliang,Liu Xue,Qin Yi,Wang Lei,Tang Ben Zhong,Wang Dong
Exploration of single molecular species synchronously featured by long excitation/emission wavelength, accurate diagnosis, and effective therapy, remains supremely appealing to implement high-performance cancer phototheranostics. However, those previously established phototheranostic agents are undiversified and stereotyped in terms of structural skeleton, and generally exhibit insufficient phototheranostic outcomes. Herein, we innovatively utilized indanone-condensed thiadiazolo[3,4-g]quinoxaline (ITQ) as electron acceptor to construct novel photosensitizer with second near-infrared (NIR-II) emission. Experimental study and theoretical calculation demonstrated that comparing with the counterparts constituting by widely employed NIR-II building block benzobisthiadiazole (BBTD) and 6,7-diphenylthiadiazoloquinoxaline (DPTQ), ITQ-based photosensitizer (TITQ) showed superior aggregation-induced emission (AIE) characteristics, much stronger type-I reactive oxygen species (ROS) production, and prominent photothermal conversion capacity. Furthermore, TITQ nanoparticles with excellent biocompatibility were capable of effectively accumulating in the tumor site and visualizing tumor through fluorescence-photoacoustic-photothermal trimodal imaging with highly spatiotemporal resolution, and completely eliminating tumor by type-I photodynamic-photothermal therapy.
研究领域:
癌症研究
·
光疗
·
纳米医学
·
生物医学工程
·
分子成像
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）