Journal of Cleaner Production
·
2022
·
IF 11.072
Jianyong Che,Wenjuan Zhang,Baozhong Ma,Chengyan Wang
A succinct process for recovering Cu from acidic waste etchant (AWE) was developed in this work, which included recycling Cu via oxalate precipitation, preparing CuO nanoparticles by thermal decomposing the precipitate, and recovering NaCl via evaporation crystallization. A comparison of copper precipitation by H 2 C 2 O 4 and Na 2 C 2 O 4 suggested that an efficient recovery efficiency of Cu was obtained by Na 2 C 2 O 4 (∼99%), which was higher than that by H 2 C 2 O 4 (80.31%). Through thermodynamic analysis, a H + -release mechanism was proposed to explain the significant difference in copper precipitation between Na 2 C 2 O 4 and H 2 C 2 O 4 . By parameter optimization, 99.8% of Cu was recovered without adjusting pH value under optimal conditions, such as temperature of 40 °C, sodium oxalate of 1.2 mol/mol, and reaction time of 2 h. Furthermore, CuO nanoparticles with a purity of 99.92% and particle size of 30 nm were prepared, and the phase transformation of Cu was investigated in-depth using X-ray diffraction (XRD), Scanning electron microscope (SEM), X-ray photoelectron spectroscopy (XPS), and Fourier transform infrared spectrum (FT-IR). Finally, the chloride ions were recovered as NaCl at 99.51% purity. This study provides a potential route to deal with strongly acidic waste etchant and achieve its high-value utilization.
研究领域:
环境科学
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材料科学
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产品关联
DOI
高影响因子
HYDROMETALLURGY
·
2021
·
IF 4.156
Linquan Sun,Hongdong Yu,Fancheng Meng,Tao Qi,Shili Zheng,Yihe Peng,Lina Wang
Niobium consumption has burgeoned owing to the increasing application of niobium in critical industries, including the aerospace and oil and gas industries. Conventional metallurgical technologies and separation methods for niobium extraction use highly concentrated HF, which is hazardous to both humans and the environment. A solvent extraction system comprising trioctyl tertiary amine (N235) and 4-methyl-2-pentanone (MIBK) that can extract and separate niobium from an oxalate-containing H 2 SO 4 solution is proposed in this paper. Niobium solutions tend to contain titanium and iron impurities; therefore, the effects of various conditions on the separation of the three elements were investigated. The extraction mechanism and thermodynamics of the process were also examined. Over 82% niobium was extracted at an organic-to-aqueous phase ratio of 1:1 and the H + concentration of 8.29 mol/L using an organic phase with 50 vol% N235 and 50 vol% MIBK as the extractants at 20 °C. Only 18.4% titanium and 3.35% iron were co-extracted. Two stripping processes, both of which further separated niobium and titanium, are also proposed herein. The possible composition of the niobium-containing extraction complex was [(R 3 NH)·NbO(C 2 O 4 ) 2 (H 2 O) 2 ], as supported by a Fourier transform infrared spectroscopy (FT-IR) analysis and ultraviolet–visible (UV–vis) spectrophotometry . The extraction mechanism was inferred to be the association of R 3 NH + in N235 with the [NbO(C 2 O 4 ) 2 (H 2 O) 2 ] − from the acidic niobium-containing solution, and the stripping mechanism was concluded to be anion exchange. The enthalpy change (∆H o ) of the extraction system was −11.0 kJ/mol at 288.15–313.15 K, which indicated that niobium extraction from the H 2 SO 4 solution with oxalate using N235 and MIBK was an irreversible exothermic process.
研究领域:
冶金学
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化学工程
✓ 已验证
DOI
高影响因子
JOURNAL OF MOLECULAR STRUCTURE
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2021
·
IF 3.196
Yajie Wang,Xianhe Gong,Xin Dong,Yunjie Wu
In this work, arsenite (As(III)) removal in a goethite/oxalate suspension under UVA-irradiation (λ max = 365 nm) was explored under different conditions (initial pH, oxalate concentration, goethite dosage, and phosphate). SEM, EDS, FTIR, XRD and XPS were used to investigate the morphology, composition, functional groups, structure, and surface properites of goethite. The greatest efficiency of As(III) removal was 95.52% at pH 3.0, 100.0 µg·L –1 As(III), 0.05 g·L –1 goethite, and 0.5 mmol·L –1 oxalate. The removal of As(III) in the goethite/oxalate system was strongly pH-dependent. An increase in pH was accompanied by a reduction in photo-oxidation efficiency and an increase in adsorption efficiency. Addition of appropriate amounts of oxalate can enhance As(III) removal at pH 3.0 by promoting the photo-dissolution of iron oxide. However, the addition of oxalate was detrimental to As(III) removal at pH 7.0 due to its competition for photo-generated hole ( h vb + ) as well as adsorption sites. Increasing dosage from 0.0 to 0.5 g·L –1 accelerated As(III) removal at both pH 3.0 and pH 7.0. ESR, radical-scavenging, and N 2 -purging experiments showed that As(III) removal was mainly achieved by photo-oxidation at pH 3.0 and HO · appeared to be the primary oxidant for the As(III) oxidation, which was strongly dependent on HO 2 · /O 2 ·– . However, adsorption served as a major pathway and photo-oxidation played a minor role at pH 7.0. As(III) photo-oxidation was predominantly attributed to the direct reaction between As(III) and h vb + under neutral conditions. In addition, O 2 played an important role in As(III) photo-oxidation under acidic and neutral conditions. Moreover, goethite remained morphologically intact and demonstrated good reusability up to five regeneration cycles. These findings show that As(III) can be effectively removed from water containing iron oxides and carboxylic acid, which is important for the remediation of arsenic-contaminated waterbodies and wastewaters.
研究领域:
环境科学
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化学
✓ 已验证
产品关联
DOI
高影响因子
Cells
·
2023
·Vol. 12
·期 5
·771
·
IF 6
Kui Kang,Mengyi Zhang,Lei Yue,Weiwen Chen,Yangshuo Dai,Kai Lin,Kai Liu,Jun Lv,Zhanwen Guan,Shi Xiao,Wenqing Zhang
Plants produce diverse secondary compounds as natural protection against microbial and insect attack. Most of these compounds, including bitters and acids, are sensed by insect gustatory receptors (Grs). Although some organic acids are attractive at low or moderate levels, most acidic compounds are potentially toxic to insects and repress food consumption at high concentrations. At present, the majority of the reported sour receptors function in appetitive behaviors rather than aversive taste responses. Here, using two different heterologous expression systems, the insectSf9cell line and the mammalian HEK293T cell line, we started from crude extracts of rice (Oryza sativa) and successfully identified oxalic acid (OA) as a ligand ofNlGr23a, a Gr in the brown planthopperNilaparvata lugensthat feeds solely on rice. The antifeedant effect of OA on the brown planthopper was dose dependent, andNlGr23amediated the repulsive responses to OA in both rice plants and artificial diets. To our knowledge, OA is the first identified ligand of Grs starting from plant crude extracts. These findings on rice–planthopper interactions will be of broad interest for pest control in agriculture and also for better understanding of how insects select host plants.Keywords:ligand identification;gustatory receptor;Nilaparvata lugens;oxalic acid;antifeedant
研究领域:
昆虫学
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植物科学
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农业科学
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产品关联
DOI
PubMed
高影响因子
HOLZFORSCHUNG
·
2022
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IF 2.493
Li Yan,Xiaodi Ji,Feiyang Zeng,Zhangjing Chen,Yafang Lei
As a renewable biomass material, wood is often deteriorated by decay fungi. Quercetin was here grafted onto poplar ( Populus nigra ) using oxalic acid as a linker through vacuum-pressure treatment and esterification with various molar ratios of quercetin to oxalic acid (Q/O) to enhance the wood decay resistance. Decay resistance, flexural strength, graft mechanism, and microscopic structure of the quercetin-grafted wood were analyzed. Results indicated that the decay resistance of quercetin-grafted wood to white-rot fungi ( Trametes versicolor ) and brown-rot fungi ( Gloephyllum trabeum ) was significantly improved. The modulus of rupture (MOR) of the quercetin-grafted wood was reduced while the modulus of elasticity (MOE) was improved. Quercetin was grafted onto wood through formation of ester groups among oxalic acid, wood, and quercetin. The highest amount of ester groups in the grafted wood was achieved when Q/O was 1:2 and Q/O lower than 1:2 would severely degrade the wood. The thickness of cell walls of the quercetin-grafted wood increased and reached a maximum of 2.2 μm with Q/O of 1:2. Quercetin can be grafted on wood cell wall by oxalic acid as an environment-friendly preservative to enhance the decay resistance of wood.
研究领域:
林学
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材料科学
✓ 已验证
DOI
高影响因子
Pharmaceuticals
·
2025
·Vol. 18
·期 4
·448
·
IF 4.8
Xueli Guo,Zhongyan Liu,Lina Wu,Pan Guo
Background : Liver cancer, especially hepatocellular carcinoma, a prevalent malignant tumor of the digestive system, poses significant therapeutic challenges. While traditional chemotherapy can inhibit tumor progression, its clinical application is limited by insufficient efficacy. Hydrophobic therapeutic agents further encounter challenges including low tumor specificity, poor bioavailability, and severe systemic toxicity. This study aimed to develop a liver-targeted, glutathione (GSH)-responsive micellar system to synergistically enhance drug delivery and antitumor efficacy. Methods : A GSH-responsive disulfide bond was chemically synthesized to conjugate glycyrrhetinic acid (GA) with curcumin (Cur) at a molar ratio of 1:1, forming a prodrug Cur-GA (CGA). This prodrug was co-assembled with glycyrrhizic acid (GL) at a 300% w / w loading ratio into micelles. The system was characterized for physicochemical properties, in vitro drug release in PBS (7.4) without GSH and in PBS (5.0) with 0, 5, or 10 mM GSH, cellular uptake in HepG2 cells, and in vivo efficacy in H22 hepatoma-bearing BALB/c mice. Results : The optimized micelles exhibited a hydrodynamic diameter of 157.67 ± 2.14 nm (PDI: 0.20 ± 0.02) and spherical morphology under TEM. The concentration of CUR in micelles can reach 1.04 mg/mL. In vitro release profiles confirmed GSH-dependent drug release, with 67.5% vs. <40% cumulative Cur release observed at 24 h with/without 10 mM GSH. Flow cytometry and high-content imaging revealed 1.8-fold higher cellular uptake of CGA-GL micelles compared to free drug ( p < 0.001). In vivo, CGA-GL micelles achieving 3.6-fold higher tumor accumulation than non-targeted controls ( p < 0.001), leading to 58.7% tumor volume reduction ( p < 0.001). Conclusions : The GA/GL-based micellar system synergistically enhanced efficacy through active targeting and stimuli-responsive release, providing a promising approach to overcome current limitations in hydrophobic drug delivery for hepatocellular carcinoma therapy.
研究领域:
药剂学
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肿瘤学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
·
2021
·Vol. 56
·期 10
·5220-5229
·
IF 3.713
Ying-Xing Huang,Jun-Ru Qi,Jin-song Liao,Wen-Xin Jiang,Yong Cao,Jie Xiao,Xiao-Quan Yang
Summary The objective of this work was to extract high methoxyl (HM) pectin with oxalic acid, characterise its physicochemical properties and evaluate its dispersion stability in acidified milk drink (AMD). HPSEC–MALLS analysis revealed that the obtained HM pectin was high in molecular weight (522.4 kDa). The ζ-potential of the obtained HM pectin in aqueous solution at pH 4.0 was −31.5 mV. The AFM images proved that the obtained HM pectin contained several long linear molecules. The apparent diameter of AMD stabilised by the obtained HM pectin was 636 nm at the concentration of 3.0‰. The stability analysis of AMD and the microscopic observation with confocal laser scanning microscopy (CLSM) proved that the obtained HM pectin was a prominent stabiliser in AMD.
研究领域:
食品科学
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化学工程
✓ 已验证
产品关联
DOI
高影响因子
ACS Catalysis
·
2023
·
IF 12.9
Yingying Cheng,Wenjing Xu,Jing Hou,Peng Kang
The electrosynthesis of multi-carbon chemicals such as glyoxylic acid (GX) and glycolic acid (GC) from oxalic acid (OA) offers a feasible pathway to achieve sustainable chemical production, especially when coupled with the electroreduction of CO2 to form OA. Here, we demonstrate a series of gallium tin oxide catalysts for selective, controlled OA electroreduction to GX and GC in acidic media. The product distribution can be tuned by changing the reaction temperatures. At room temperature using the GaSnOx/C catalyst, GX can be obtained with a GX Faradaic efficiency (FEGX) of 92.7% at −0.7 V vs RHE and a GX current density (jGX) of −100.2 mA cm–2. At a raised temperature of 80 °C using the GaSnOx/C catalyst, a GC Faradaic efficiency (FEGC) of 91.7% at −0.8 V vs RHE can be obtained. The accelerated OA electroreduction results from the Ga/Sn synergy in the catalysts. A proper Ga/Sn ratio not only enriches OA adsorption and enhances surface binding of intermediates, but also ensures catalyst stability in acidic media.
研究领域:
化学工程
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材料科学
·
可持续化学
✓ 已验证
产品关联
DOI
高影响因子
BIOSENSORS & BIOELECTRONICS
·
2019
·
IF 9.518
Ying Gan,Ning Hu,Chuanjiang He,Shuqi Zhou,Jiawei Tu,Tao Liang,Yuxiang Pan,Dmitry Kirsanov,Andrey Legin,Hao Wan,Ping Wang
Urolithiasis commonly occurs in kidney and ureteral, and may cause local organ/tissue damage, even kidney failure. The incidence of this disease is increasing worldwide, in which calcium oxalate is the major composition forming the urinary calculus. Therefore, to monitor this disease for the prevention and treatment, measuring the oxalate in the urine is of great significance. Here, a rapid and sensitive colorimetric method was developed based on 3,3',5,5'-tetramethylbenzidine-manganese dioxide (TMB-MnO 2 ) nanosheets for oxalate detection. MnO 2 nanosheets acted as an efficient biomimetic oxidase to catalyze the reaction with TMB and oxalate. Pale yellow TMB can be oxidized to blue oxide TMB catalyzed by BSA-stabilized MnO 2 nanosheets, and oxalate can selectively inhibit this reaction by consuming and reacting with MnO 2 nanosheets, thus achieving the quantitative detection of oxalate. Moreover, a home-made bionic electronic-eye (E-eye) system was developed as a portable in-situ detection platform to efficiently measure the oxalate concentrations in 10 s by direct photographing. By optimizing experimental conditions, this method shows a wide linear range (7.8 μM to 250 μM) and a low detection limit (0.91 μM) for oxalate detection. Besides, this method exhibits high selectivity even with 80-fold interfering chemicals. Furthermore, the performance of the method was validated by testing the artificial urine samples, indicating its great potential for monitoring and diagnosis of urolithiasis in point-of-care applications.
研究领域:
生物化学
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分析化学
·
医学诊断
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Cleaner Production
·
2022
·
IF 11.072
Yizhuang Wang,Bingbing Liu,Hu Sun,Yanfang Huang,Guihong Han
Zinc-leaching residue (ZLR) with 0.46% Sn and 54% Pb brings potential threats to environment but is worthy to recover valuable metals. Reduction of Sn(IV) to Sn(II) is critical for tin extraction. In this work, selective extraction and recovery of tin from ZLR via oxalic acid/sulfuric acid leaching and hydrolytic precipitation was proposed. Various reductants were attempted, and the oxalic acid shows superior tin leaching efficiency. The effects of reduction leaching and hydrolysis parameters on the separation of Sn and Pb were systematically investigated. After leaching by 24 g/L oxalic acid in 0.50 mol/L H 2 SO 4 at 60 °C for 30 min with L/S ratio of 10 mL/g and stirring speed of 400 r/min, 90.5% Sn is leached into the solution, and 99.8% Pb is simultaneously concentrated in the leaching residue. In the hydrolysis process , tin sediment with recovery of 93.8% and content of 46.4% was obtained. The as-prepared tin and lead products can directly act as concentrates for the tin and lead smelting . The oxalic acid reduction leaching mechanism of tin was also discussed. Based on the reduction leaching behaviors of tin from ZLR, the possible Sn leaching enhancement via oxalic acid addition in the existing industrial zinc-leaching process was proposed in this work.
研究领域:
冶金学
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环境科学
✓ 已验证
DOI
高影响因子
FOOD RESEARCH INTERNATIONAL
·
2025
·
IF 8
Mengyao Zhang,Jiali Tang,Jiaying Wang,Chenchen Qi,Guohui Chen,Wei Chen,Chengtao Wang
This study explores the grafting of syringic acid onto fucoidan and assesses the resultant graft's (F S) enhanced functional properties and therapeutic potential in a histamine-induced liver injury model. Utilizing a redox system of ascorbic acid and hydrogen peroxide, the grafting process achieved a grafting rate of 290.45 mg CAE/g, confirmed through UV–Vis spectroscopy, FT-IR spectroscopy, scanning electron microscopy, and thermogravimetric analysis. In vivo investigations using histamine-sensitive mice demonstrated that F S significantly mitigated histamine-induced damage, evidenced by improvements in body weight, organ index, and colon length. F S exhibited superior efficacy in restoring liver function indices (ALT, AST, ALP, GGT), enhancing antioxidant defenses (GSH, SOD), and reducing oxidative stress markers (MDA). Anti-inflammatory effects included reduced levels of pro-inflammatory cytokines (TNF- α , IL-6, IL-1 β ) and modulation of apoptosis-related proteins (BCl 2 , BAX). Additionally, F S upregulated key antioxidant genes in the Nrf2/KEAP1 pathway and downregulated inflammatory genes in the NF- κ B pathway. Restoration of colonic tight junction proteins (ZO-1, Occludin, Claudin-1) and normalization of gut microbiota composition further underscored the therapeutic potential of F S. The study highlights the significant enhancement in functional properties of fucoidan through SA grafting, presenting F S as a promising candidate for developing functional foods and nutraceuticals aimed at preventing and mitigating liver damage and related disorders.
研究领域:
生物化学
·
药理学
·
营养学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY
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2015
·
IF 3.082
Rui Cai,Yahong Yuan,Zhouli Wang,Chunfeng Guo,Bin Liu,Laping Liu,Yutang Wang,Tianli Yue
Alicyclobacillus acidoterrestris has recently received much attention due to its implication in the spoilage of pasteurized fruit juices, which was manifested by the production of guaiacol. Vanillic acid and vanillin have been accepted as the biochemical precursors of guaiacol in fruit juices. The purpose of this study was to try to find other precursors and elucidate details about the conversion of vanillic acid and vanillin to guaiacol by A . acidoterrestris . Four potential substrates including ferulic acid, catechol, phenylalanine and tyrosine were analyzed, but they could not be metabolized to guaiacol by all the thirty A . acidoterrestris strains tested. Resting cell studies and enzyme assays demonstrated that vanillin was reduced to vanillyl alcohol by NADPH-dependent vanillin reductase and oxidized to vanillic acid by NAD(P) + -dependent vanillin dehydrogenases in A . acidoterrestris DSM 3923. Vanillic acid underwent a nonoxidative decarboxylation to guaiacol. The reversible vanillic acid decarboxylase involved was oxygen insensitive and pyridine nucleotide-independent.
研究领域:
微生物学
·
食品科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）