Scientific Reports
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2014
·Vol. 4
·期 1
·1-8
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IF 5.078
Gong Hao,He Zihao,Peng Anlin,Zhang Xin,Cheng Biao,Sun Yue,Zheng Ling,Huang Kun
Protein misfolding and aggregation are associated with more than twenty diseases, such as neurodegenerative diseases and metabolic diseases. The amyloid oligomers and fibrils may induce cell membrane disruption and lead to cell apoptosis. A great number of studies have focused on discovery of amyloid inhibitors which may prevent or treat amyloidosis diseases. Polyphenols have been extensively studied as a class of amyloid inhibitors, with several polyphenols under clinical trials as anti-neurodegenerative drugs. As oxidative intermediates of natural polyphenols, quinones widely exist in medicinal plants or food. In this study, we used insulin as an amyloid model to test the anti-amyloid effects of four simple quinones and four natural anthraquinone derivatives from rhubarb , a traditional herbal medicine used for treating Alzheimer's disease. Our results demonstrated that all eight quinones show inhibitory effects to different extent on insulin oligomerization, especially for 1,4-benzoquinone and 1,4-naphthoquinone. Significantly attenuated oligomerization, reduced amount of amyloid fibrils and reduced hemolysis levels were found after quinones treatments, indicating quinones may inhibit insulin from forming toxic oligomeric species. The results suggest a potential action of native anthraquinone derivatives in preventing protein misfolding diseases, the quinone skeleton may thus be further explored for designing effective anti-amyloidosis compounds.
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JOURNAL OF MATERIALS RESEARCH
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2017
·Vol. 32
·期 7
·1248-1257
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IF 1.673
Jufeng Huang,Wei Xing,Fazle Subhan,Xiuli Gao,Peng Bai,Zhen Liu,Youhe Wang,Qingzhong Xue,Zifeng Yan
With increasing output of petroleum coke, the value-added exploitation of petroleum coke has become a tough problem. Preparing porous carbons is a traditional way to the value-added exploitation of petroleum coke. Here, we used a facile and efficient hard-templating strategy to synthesize mesoporous carbon with high surface area from petroleum coke. N2 adsorption analyses show that the BET specific area and pore volume of the carbons can reach up to 864 m2/g and 1.37 cm3/g, respectively. To utilize the abundant mesopores of the carbons, anthraquinone-modified mesoporous carbon was tested as an electrode material for supercapacitor applications. Electrochemical measurements demonstrated that the specific capacitance reached up to 366 F/g at the current density of 1 A/g, indicating a promising prospect of using this carbon in electrochemical energy-storage field. More importantly, the strategy used in this work can be easily modified to prepare other nano-carbon materials from petroleum coke.
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
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2024
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IF 3.8
Zhengkai Li,Heng Wang,Hanwen Yan,Hao Wang,Zhencai Zhang,Yiwen Zhang,Junyu Chu,Feng Huo,Fei Xu
Biobased poly(isosorbide carbonate) (PIC) has the advantages of renewable sources, nontoxic environmental resistance, and high transparency. However, the optical properties of PIC are limited by the rigid alicyclic skeleton within polymer chains, resulting in a low refractive index and high birefringence. In this work, a novel diether anthraquinone (DAQ) monomer containing an aromatic cardo-ring and carbonyl-modified side group was designed and synthesized, which successfully improved the refractive index and inhibited the birefringence by reducing optical anisotropy combined with increasing the molar refractive index of repeating units. To overcome the potential steric effect of DAQ and low activity of endo-OH groups on isosorbide (ISB), highly active choline tartaric acid (ChTa) ionic liquid catalysts were designed and evaluated systematically, resulting in a series of copolymers with sufficient Mw (up to 140,800 g/mol). Notably, poly(ISB-co-DAQ carbonate) with 30/70 mol % of ISB/DAQ (PI30D70C) exhibited excellent optical properties with ignorable birefringence (Δn = 0.0005) and high transmittance (89%), and especially higher refractive index (nd = 1.6207) than PIC (nd = 1.4966) at 589 nm. Additionally, the copolycarbonates had excellent thermal, mechanical, and hydrophobicity properties, indicating their potential for optical applications and providing a strategy for designing optical polycarbonates.
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ACS Applied Polymer Materials
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2024
·
IF 4.4
Zhen Chen,Yan Wang,Zebing Ning,Qi Huang,Jia Zhou,Faquan Yu
Conjugated microporous polymers (CMPs) rank among the most promising materials for sustainable lithium-ion batteries (LIBs) in terms of their tunable chemical structures and designable electrochemical performance. Herein, a CMP of poly(anthraquinone-co-hexaazatriphenylene) (PAQ-HATN) was synthesized by combining anthraquinone (AQ) with a highly active hexaazatriphenylene (HATN) group, which is endowed with abundant redox-active groups, high specific surface area, and insolubility in an electrolyte. Further, to address the existing problems of PAQ-HATN, including poor rate performance, low conductivity, and structural instability, the strategy through the integration of an organic polymer (PAQ-HATN) with inorganic material (TiS2) was used. The prepared composite as a cathode material (PAQ-HATN@TiS2) achieves improved conductivity and effective utilization of the redox activity sites. As expected, PAQ-HATN@TiS2 exhibits high initial capacity (347.6 mA h g–1 at 25 mA g–1), good rate performance (114.8 mA h g–1 at 1000 mA g–1), and long cycle stability (157.4 mA h g–1 at 800 mA g–1 and 1000th cycle), indicating the PAQ-HATN@TiS2 compound is a potential cathode for energy storage.
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JOURNAL OF HAZARDOUS MATERIALS
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2024
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IF 12.2
Liang Zhou,Jie Zhou,Yicen Dong,Yangjie Wu,Zhangying Xi,Zixuan Lu,Juying Lei,Jinlong Zhang,Yongdi Liu
Collaborative treatment of pollutants is a promising approach for wastewater treatment . In this work, a covalent organic framework material (COFs) with an imine structure was synthesised by the Schiff base reaction, and photochemical tests showed good photochemical effects. It was used to explore the photocatalytic treatment of co-existing pollutants (heavy metal ions and antibiotics) and the performance of treating co-existing wastewater was investigated. The degradation performance of levofloxacin (LVX) and Cr(VI) was improved in the coexisting pollutants system, with the LVX degradation being 4.2 times more effective than that of the LVX solitary system. Moreover, this phenomenon was also observed in LVX/Ag(I), LVX/Fe(III), sulfadiazine/Cr(VI), norfloxacin/Cr(VI) and tetracycline/Cr(VI) systems. The analysis of active species suggesting that the synergistic promotion of photocatalytic oxidation-reduction systems was not only promoting from the improvement of simple charge separation, but it was also found that high-valent metal species can act directly in the oxidative decomposition of antibiotics. The interaction of pollutants and intermediates were rationally exploited and confirmed by control experiments and theoretical calculation. This conclusion helps us to re-examine the underlying mechanisms of photocatalytic synchronous oxidation and reduction reactions, simultaneously beneficial for the development of mixed pollutant control processes.
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ChemPhotoChem
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2024
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IF 3
Zhenyan Zhou,Lei Wang,ShouCai Yan,Ziang Liu,Rensong Sun,Yuan Qiao,Engin Umut Akkaya
Cancer cells change their glucose metabolism towards lactic acid production for various defensive and proliferative advantages. Dichloroacetate (DCA) is an inhibitor of a key enzyme and thus, changes back the OX-PHOS to glycolysis ratio. We designed and synthesized a singlet oxygen triggered source of dichloroacetate which releases this inhibitor during photodynamic singlet oxygen generation. Synergistic action of DCA and singlet oxygen results in significant enhancement of photocytotoxicity. The results suggest that this approach could offer significant improvement in the therapeutic outcome of PDT.
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ACS Applied Materials & Interfaces
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2024
·
IF 8.3
Xiaofei Miao,Jingye Chen,Chenyang Zhong,Jing Tong,Huayan Yang,Xifeng Yang,Xuebin Qiao,Zhongxin Song,Lei Zhang
In carbon-based supercapacitors, redox couples can effectively improve the energy density of supercapacitors; however, most redox couples still suffer from serious shuttle diffusion. Currently, there is no universal strategy to effectively constrain their shuttle diffusion. Therefore, developing a simple, effective, and universal method to suppress shuttle diffusion remains a great challenge. Herein, we designed and prepared a hierarchical structure electrode composed of three functional layers (inner conductive layer, intermediate storage layer, and outer confinement layer) for redox-enhanced supercapacitors. The hierarchical electrode can be fabricated on a large scale in three simple steps based on commercial carbon felt. The rationally designed three functional layers endow the hierarchical structure electrode with excellent conductivity, adsorption capacity, and confinement ability. Long-term charge–discharge cycle results prove that the hierarchical structure electrode exhibits an outstanding restriction effectiveness on three redox media with different molecular sizes (anthraquinone (AQ), naphthoquinone (NQ), and p-benzoquinone (PQ)). Specifically, for AQ, NQ, and PQ, the hierarchical structure electrodes showed CV peak current attenuation rates of only 5.64%, 3.54%, and 10.34% after 5,000 cycles of charge–discharge, while common electrodes exhibited attenuation rates of 10.44%, 15.02%, and 20.20%, respectively. Moreover, the soft-pack supercapacitors composed of hierarchical electrodes still had a capacitance retention of 86.6% after 5,000 cycles of charge–discharge. All the results demonstrate that the structure design is reasonable and the hierarchical structure electrode has a great potential to be the universal electrode for suppressing the shuttle diffusion of redox media in supercapacitors and other energy storage devices.
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CHINESE JOURNAL OF CATALYSIS
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2025
·
IF 17.7
Lixia Li,Xiuqi Li,Feiyue Li,Xiang Zhen,Mingdong Dong,Jinxing Long,Xiaobing Wang,Zhiyong Jiang
Harnessing photocatalyzed hydrogen atom transfer (HAT) for the precise activation of C–H/O–H bonds is a pivotal yet challenging strategy to selectively drive oxidative C–C bond scission in renewable lignin, yielding value-added chemicals with exceptional selectivity. Herein, we present a metal-free photochemical strategy that enables selective C–C bond scission in lignin via a unique synergistic HAT pathway driven by triplet-excited 2-ethylanthraquinone (EAQ*) and hydroxyl radicals ( • OH) generated in situ from EAQH 2 and O 2 . Under simulated natural conditions, this process achieves a benzaldehyde yield of 146.6 mol% from a lignin-derived phenolic dimer. Mechanistic investigations reveal that preferential activation of the C α -OH in lignin facilitates a tandem HAT process, forming alkoxy radical intermediates that undergo β –scission to produce benzaldehyde, as corroborated by extensive control reactions and density functional theory calculations. Furthermore, this straightforward protocol efficiently cleaves the C–C bonds of technical kraft lignins, providing a rapid, scalable, and metal-free protocol for lignin valorization under mild conditions.
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MICROCHEMICAL JOURNAL
·
2025
·
IF 5.1
Rong Fang,Jiao Ma,Meiling Wang,Kunpeng Guo
Generally, it is essential to externally introduce redox probes for cortisol detection through molecularly imprinted electrochemical sensor. However, this approach complicates the detection process, hinders real-time monitoring and may cause significant interference during body fluid analysis. To address the issue, we innovatively proposed a self-signal sensor based on humic acid (HA)-mediated conductive redox nanoprobe. Amphiphilic HA can effectively coat multi-walled carbon nanotubes (MWCNT) through π-π interactions, providing exceptional dispersibility while retained conductivity. Additionally, due to its colloidal characteristics, the HA coated MWCNT exhibited remarkable adsorption capacity towards various types of redox molecules, particularly cationic redox species, thus acquiring a kind of conductive redox nanoprobe in a facile way. The nanoprobe could serve as a bottom layer to prepare an electrochemical sensor in combination with cortisol-imprinted polydopamine as the upper layer. Finally, a self-signal electrochemical sensor for cortisol was successfully fabricated, achieving a detection limit of 0.72 × 10 −9 M, a wide detection range from 1 nM to 1 mM and good recovery. Overall, we believe the HA-mediated strategy proposed in this study could inspire more innovation in the field of self-signal sensing.
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CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Renzhi Xiong,Yiting Sun,Jiahao Huang,Fangde Liu,Yanhe Xiao,Baochang Cheng,Shuijin Lei
Photocatalytic production of H 2 O 2 faces challenges such as low charge separation efficiency, narrow light absorption, and sluggish reaction kinetics. This study developed a WO 3− x @Zn 3 In 2 S 6− x S-scheme heterojunction and designed atomic-level W S interface chemical bonds through a defect-induced strategy to address these challenges. Oxygen/sulfur vacancies not only promote the formation of chemical bonds but also trigger a local surface plasmon resonance effect (LSPR) in WO 3− x , enabling full-spectrum light harvesting and photothermal heating. The S-scheme charge transfer retains the high-energy electrons in Zn 3 In 2 S 6− x and holes in WO 3− x to realize dual H 2 O 2 generation pathways. Coupled with LSPR-induced thermal activation, this multidimensional strategy achieved an unprecedented H 2 O 2 yield (3891.2 μmol g −1 h −1 ) under simulated sunlight, which is 9.2 times and 161.5 times higher than that of the non-thermally activated pristine Zn 3 In 2 S 6− x and WO 3− x , respectively. In situ X-ray photoelectron spectroscopy and a series of photoelectrochemical measurements confirmed the S-scheme charge dynamics, and electron spin resonance verified the thermally enhanced reactive oxygen species generation. This work establishes defect-mediated heterointerfacial engineering as a universal paradigm for solar-to-chemical energy conversion and provides feasible insights for designing photothermal-assisted photocatalytic systems.
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FOOD CHEMISTRY
·
2025
·
IF 9.8
Qidong Yu,Yiding Li,Wenmin Zhang,Xueting Cui,Shiye Xie,Lan Zhang
Monitoring trace oxygenated polycyclic aromatic hydrocarbons (O-PAHs) in tea infusions is crucial, as long-term consumption of O-PAHs-contaminated tea can harm health. In this work, covalent organic framework (COF) TpBD-(OH) 2 coating was fabricated for solid-phase microextraction (SPME) of O-PAHs. The coating contains abundant benzene rings and hydrogen bonding sites (oxygen and nitrogen groups). Density functional theory calculations, electrostatic potential distribution and X-ray photoelectron spectroscopy analysis indicated the COF efficiently adsorbs O-PAHs via van der Waals force, hydrogen bonding, electrostatic force, size matching, and π-π interaction. Under the best SPME conditions, a method for detecting O-PAHs in tea infusions was developed using gas chromatography-tandem mass spectrometry (GC–MS/MS). The method possessed low limit of detection (0.5–1.0 ng L −1 ), wide linearity (2.0–1000.0 ng L −1 ) and satisfactory recoveries (82.5 %–117.5 %). Furthermore, the method was used to study the impacts of different roasting methods on O-PAHs contamination, and results showed carbon roasting posed a higher risk.
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ACS Sustainable Chemistry & Engineering
·
2025
·
IF 7.3
Ya Chu,Weiqiang Zhang,Baoye Hu,Jinghong Wen,Mengmei Qin,Guangjiu Zhao
Regulation of surface ligands in hybrid organic–inorganic perovskite quantum dots (HOIP QDs) is key to enhancing their optoelectronic properties. However, achieving both high photoluminescence (PL) and long-term stability in chiral HOIP QDs remains challenging. Here, we report the use of chiral anthraquinone derivatives (AQ) as surface ligands, replacing conventional long-chain alkyl ligands, to construct two potassium-doped chiral QDs, (R)AQ-QDs and (S)AQ-QDs. These QDs exhibit high photoluminescence quantum yields (PLQYs) of 98.74 and 97.68%, respectively, along with notable stability. Optical characterization indicates an efficient chirality transfer from the organic ligands to the K0.23MA0.77PbBr3 lattice. Furthermore, density functional theory (DFT) calculations and femtosecond transient absorption (fs-TA) spectroscopy reveal reduced surface trap states, as evidenced by stronger ligand binding and prolonged carrier lifetimes. A white-light-emitting diode (LED) fabricated using the AQ-QDs shows a color rendering index (CRI) of 65.1 and a correlated color temperature (CCT) of 6169 K. The reported work highlights the potential of chiral ligand engineering in improving PL efficiency and stability in perovskite QDs.
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