CANADIAN JOURNAL OF CHEMICAL ENGINEERING
·
2021
·Vol. 100
·期 12
·3717-3726
·
IF 2.007
Piao Cao,Lin Zheng,Weizhen Sun,Ling Zhao
Four typical Brønsted acidic ionic liquids (BILs) and concentrated sulphuric acid (H 2 SO 4 ) were used to catalyze the transesterification of fish oil with ethanol to produce fatty acid ethyl ester (FAEE) in this work. The experimental results show that the imidazole BILs lead to fewer side reactions and higher product quality than H 2 SO 4 . Molecular dynamics (MD) simulations indicate that [PSMim][HSO 4 ] molecules can be enriched at the interface and enhance the contact of eicosapentaenoic acid triglyceride (EPATG, a typical component of fish oil) and ethanol. And ester groups of EPATG tend to expose more to ethanol in the BILs system, which facilitates the occurrence of transesterification. However, H 2 SO 4 has no positive effect on the distribution of the two reactants. For the transesterification, the interfacial property affects the catalytic activity a lot, instead of catalyst acidity. Also, the reaction rate is accelerated, obviously, by ultrasound-led liquid–liquid phase emulsification.
研究领域:
生物化学
·
催化化学
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2014
·
IF 4.058
Xiaoli Zou,Tao Zhou,Juan Mao,Xiaohui Wu
In this study, a novel ultrasound-enhanced heterogeneous Fe 0 /persulfate (US/Fe 0 /PS) system was developed and investigated for the degradation of an antibiotic sulfadiazine (SD). It was demonstrated that the US/Fe 0 /PS system could achieve a significant synergy in the degradation efficiency of SD, as compared to its corresponding comparative systems. The SD degradation in the US/Fe 0 /PS system could be applied by the pseudo-first-order kinetic with a k obs (SD) value of 3.4 ± 0.20 h −1 . Affecting factors such as initial pH, dosage ratio of [Fe 0 ]:[PS], US input power and reaction temperature were further studied. SD could be effectively degraded with a relatively low PS dosage at a broad pH range of 3–7. Simultaneous evolution of soluble iron species and PS was evaluated in three comparative systems (US/Fe 0 , Fe 0 /PS and US/Fe 0 /PS) during the reaction. It could be concluded that the promotional role of US would be dual in the US/Fe 0 /PS system, i.e. enhancement in the heterogeneous iron corrosion reactions and acceleration in the bulk radical reactions. Identification of the degradation intermediates indicated that sulfate radical (SO 4 − ) oxidation was the main SD degradation pathway. Attacking of the amine group in the benzene ring would be its first step, followed by cleavage of C–N bonds in the heterocyclic ring. Another degradation pathway, i.e. direct cleavage of the S–N bond should be also present.
研究领域:
环境科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
ULTRASONICS SONOCHEMISTRY
·
2017
·
IF 4.218
Likang Fu,Libo Zhang,Shixing Wang,Wei Cui,Jinhui Peng
A synergistic extraction method for gold from the refractory gold ores via ultrasound and chlorination-oxidation was developed. The effects of solid-liquid ratio, extraction time, ultrasound power, NaClO concentration and NaOH concentration on the extraction rate of gold from the refractory gold ore were investigated . The optimum conditions were as follows: NaClO concentration of 1.5 mol/L, NaOH concentration of 1.5 mol/L, solid-liquid ratio of 5, ultrasound power of 200 W and ultrasound time of 2 h. Under the optimal conditions, 68.55% of gold was extracted. However, only 45.8% of gold was extracted after 6 h without the ultrasound-assisted extraction. XRD and SEM were used to analyze the influence of ultrasound on the mineral properties and strengthening mechanism. The results showed that the interface layer was peeled, new surface was exposed, reaction resistance was reduced, the liquid-solid reaction was promoted and reaction speed was greatly improved under ultrasound. According to the results of range and variance analysis, the optimum leaching experiment with orthogonal design was almost identical with the optimum experiment of single factor. Among them, the ultrasound power was the most significant factors affecting leaching rate of gold. Compared with other extraction method, the synergistic extraction process decomposed completely sulfide and improved significantly the extraction rate of gold.
研究领域:
冶金学
·
化学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ORGANIC PROCESS RESEARCH & DEVELOPMENT
·
2021
·
IF 3.317
Fei Yu,Yafei Mao,Hongtu Zhao,Xiunan Zhang,Ting Wang,Mingpu Yuan,Suping Ding,Na Wang,Xin Huang,Hongxun Hao
Protein drugs have attracted extensive attention from the academic community. However, crystallization of proteins is difficult and the yield of current main technologies is too low, which limits their large-scale industrial production. In this work, enhancement of continuous crystallization of lysozyme under an ultrasonic field was explored. A plug-flow tubular crystallizer, which was separated into a nucleation zone and a growth zone, was applied. The effect of ultrasound on steady-state time, crystal habit, particle size, particle size distribution, and the process yield was evaluated based on univariate analysis experiments. It was found that ultrasound can shorten the time for continuous crystallization to reach a steady state, reduce the degree of aggregation, and promote nucleation. Furthermore, the separation of the growth zone from the nucleation zone in the ultrasonic-assisted continuous crystallization can further increase the size of the lysozyme crystals, which would help in increasing the yield.
研究领域:
生物化学
·
制药工程
✓ 已验证
产品关联
DOI
高影响因子
MOLECULAR PHARMACEUTICS
·
2019
·
IF 4.396
Huanling Guo,Ming Xu,Zhong Cao,Wei Li,Lida Chen,Xiaoyan Xie,Wei Wang,Jie Liu
Ultrasound-induced microbubble sonoporation has been shown to effectively improve drug/gene delivery efficiency by enhancing tissue and cell permeability. However, the microscale size and short duration of ultrasound contrast agents limit their accumulation in target areas. Here, a kind of ultrasound-triggered phase-transitioning and size-changing cationic nanodroplet, perfluoropentane/C9F17-PAsp(DET)/miR-122/poly(glutamic acid)-g-MeO-poly(ethylene glycol) (PGA-g-mPEG) ternary nanodroplets (PFP-TNDs/miR-122), was developed to deliver microRNA-122 (miR-122) for hepatocellular carcinoma (HCC) treatment. PFP served as an ultrasound-sensitive core for ultrasound-triggered phase transition and size change from the nanoscale to the microscale. Positively charged C9F17-PAsp(DET) ensured adequate miRNA loading. PGA-g-mPEG, which served as the shell of the nanodroplet, modified the nanodroplets, enhanced their stability in serum, and protected miR-122 from degradation in vivo. The results exhibited that PFP-TNDs/miR-122 has a nanosize diameter (362 ± 15 nm) and remained stable for 24 h. After treatment with PFP-TNDs/miR-122 combined with ultrasound irradiation, the miR-122 expression level was significantly increased by approximately 600-fold in HepG2 cells, 500-fold in SMMC-7721 cells, and 30-fold in human HCC xenografts. Moreover, PFP-TNDs/miR-122 combined with ultrasound radiation effectively suppressed the growth, migration, and invasion of HCC cells, and inhibited tumor proliferation in mice. This study revealed that the biodegradable PFP-TNDs is a promising therapeutic gene carrier with functions of gene protection and effective gene delivery for clinical applications. Furthermore, PFP-TNDs/miR-122 associated with ultrasound irradiation may pave a new way to improve the prognosis of patients with HCC.
研究领域:
医学
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生物技术
·
肿瘤学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
·
2022
·Vol. 102
·期 11
·4685-4696
·
IF 4.125
Lihui Zhang,Min Zhang,Arun S. Mujumdar,Kun Liu
BACKGROUND In order to prolong the storage and inhibit microorganisms of pakchoi, the antibacterial activity and mechanism of ultrasound combined with sodium hypochlorite (NaClO-US), the efficiency of NaClO-US in reducing Escherichia coli , Staphylococcus aureus and Pseudomonas aeruginosa as well as preserving quality of pakchoi were investigated. RESULTS Ultrasound treatment could significantly reduce the usage of NaClO solution from 800 ppm to 500 ppm. NaClO-US decreased the counts of E. coli , S. aureus and P. aeruginosa , which disrupted the bacterial cell membrane with cytoplasmic leakage. In addition, NaClO-US significantly increased cell membrane permeability, while cell membrane integrity decreased, the secondary structure of bacterial proteins showed several obvious changes, such as the increase of random coil content, as well as the decrease of α -helix content. The bacterial counts, E. coli , S. aureus and P. aeruginosa population in pakchoi treated with NaClO-US reduced by 1.89, 1.40, 1.60, 1.72 log CFU g −1 , respectively compared to control sample after storage for 15 days. NaClO-US resulted in minimum chlorophyll depletion, flavor and sensory deterioration. CONCLUSION NaClO-US solution treatment inhibited microorganisms and prolonged storage of pakchoi. © 2022 Society of Chemical Industry.
研究领域:
食品科学
·
微生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INDUSTRIAL CROPS AND PRODUCTS
·
2020
·
IF 4.244
Xinsheng Wang,Yanfang Wu,Jie Li,Aoxiang Wang,Guangyao Li,Xueli Ren,Weiping Yin
In this work, deep eutectic solvents (DESs) were synthesized using ultrasound-assisted and stirring heating methods. DES combined with ultrasonic-assisted extraction (UAE) was proposed for the efficient extraction of glycosides from Syringa pubescens Turcz. A series of DES systems were used to evaluate the extraction efficiency of glycosides in S. pubescens . The DES composed of choline chloride/glycerol extracted higher than those of conventional solvents and other DESs. The extraction procedure of DES-UAE was optimized using response surface methodology. The extraction solvent was choline chloride-glycerol formed a DES with the mole ratio of 1:2 with 20 % of water content. The optimum conditions for echinacoside (ECH) and oleuropein (OLE) were ultrasound power of 200 W, extraction temperature of 68 °C, solvent to solid ratio of 20:1 mL/g and the extraction time of 45 min. Furthermore, the DES with 30 % water content can be used as dilution solvent before HPLC analysis of DES extract. In addition, the enrichment of ECH and OLE from DES extract was achieved using HPD-450 macroporous resin, with the recoveries of 80.04 % and 86.21 %, respectively.
研究领域:
植物化学
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分析化学
✓ 已验证
产品关联
DOI
高影响因子
Sustainability
·
2023
·Vol. 15
·期 11
·9060
·
IF 3.9
Tingting Zhang,Yanling Yang,Xing Li,Zhiwei Zhou,Bigui Wei
This study investigated the ultrasonic–thermal regeneration of powdered activated carbon (PAC) spent using 4-chlorophenol (4-CP). Similarly, a thermal regeneration process was also studied and the reaction conditions (i.e., regeneration temperature, heating rate, regeneration time) were tested. Fourier transform infrared spectroscopy (FT-IR), thermogravimetric analysis (TGA), scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS) and X-ray diffraction (XRD) analysis were applied to characterize the regenerated PACs under different treatments (thermal, ultrasonic and ultrasonic–thermal) and also compare them with the fresh and exhausted PACs. According to our regeneration observations, the ideal regeneration parameters were determined to be a 40 kHz frequency, 0.18 W/mL sonication power, 0.1 M NaOH and 50% (v/v) ethyl alcohol as the regeneration solution, and 1 g/L of saturated PAC mass with thermal regeneration as the second stage at 500 °C, desorbed for 30 min with a heating rate of 20 °C min−1. Under these conditions, the RE value achieved 90.99% and the η value reached 5.6%. The results of FTIR, XPS and XRD revealed that the oxygen functional group content of ultrasonic–thermal regenerated PAC significantly increased. These oxygenous groups exerted a positive effect on the adsorption process of the regenerated PAC and the subsequent adsorption–regeneration process.Keywords:ultrasonic;thermal;regeneration;powdered activated carbon;characteristic
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2023
·
IF 8.6
Yongjia Lei,Lirong Zhao,Cheng Fang,Ravi Naidu,Dong Tian,Li Zhao,Mei Huang,Jinsong He,Zhang Cheng,Zhenxing Zeng,Jianmei Zou,Xiaohong Zhang,Shihuai Deng,Fei Shen
A novel enhanced defluorination of perfluorooctanoic acids (PFOA) by surfactant-assisted ultrasound (US) coupling persulfate (PS) was proposed in this study. Instead of adding the surfactant into the PFOA solution directly, the promoted defluorination was obtained by adding the surfactant to the US bath outside of the PFOA reactor. In this situation, the effects of the critical micelle concentration (CMC), concentration and type of the surfactant, the US frequency and the pH of the US bath liquid on the PFOA defluorination were investigated. The results demonstrated that the PFOA defluorination at low-frequency levels (25 kHz-59 kHz) was facilitated by raising US frequency. Besides, the addition of three surfactants (Triton X-100, sodium dodecyl sulfate (SDS) and cetyltrimethylammonium bromide (CTAB)) all increased the PFOA defluorination by Triton X-100 > CTAB > SDS , which is opposed to their CMC (Triton X-100: 0.28 mM＜CTAB: 1.07 mM＜SDS: 7.69 mM). Rising the surfactant concentration would not enhance the defluorination, the best one was obtained at its CMC. Moreover, changing the pH of the US bath liquid by adding acid or alkaline solution inhibited the defluorination, which might be attributed to acid or base causing damage to the chemical properties or physical structure of surfactant (certified by the SEM tests). Additionally, the mechanism of enhanced PFOA defluorination was examined by electron paramagnetic resonance analysis, which proved that adding surfactant facilitated the generation of the radicals (·OH and S O 4 ∙ - ), as well as the radicals’ amount increased over time during 60 min. Finally, the inhibited defluorination of adding surfactant directly to the PFOA solution was studied by the SEM analysis, the results demonstrated that adsorption and wrapping between surfactant micelles and PFOA reduced the contact between PFOA and radicals and affected the surfactant effect on the surface tension.
研究领域:
环境科学
·
化学工程
·
分析化学
✓ 已验证
产品关联
DOI
高影响因子
ENZYME AND MICROBIAL TECHNOLOGY
·
2016
·
IF 2.624
Lei Zhou,Wei Liu,Zhiqiang Xiong,Liqiang Zou,Junping Liu,Junzhen Zhong,Jun Chen
Polyphenoloxidase (PPO) plays an important role in the browning of vegetables, fruits and edible fungi. The effects of ultrasound, malic acid, and their combination on the activity and conformation of mushroom ( Agaricus bisporus ) PPO were studied. The activity of PPO decreased gradually with the increasing of malic acid concentrations (5–60 mM). Neither medium concentrations (10, 20, 30 mM) malic acid nor individual ultrasound (25 kHz, 55.48 W/cm 2 ) treatment could remarkably inactivate PPO. However, the inactivation during their combination was more significant than the sum of ultrasound inactivation and malic acid inactivation. The inactivation kinetics of PPO followed a first-order kinetics under the combination of ultrasound and malic acid. The conformation of combination treated PPO was changed, which was reflected in the decrease of α-helix, increase of β-sheet contents and disruption of the tertiary structure. Results of molecular microstructure showed that ultrasound broke large molecular groups of PPO into small ones. Moreover, combined treatment disrupted the microstructure of PPO and molecules were connected together.
研究领域:
食品科学
·
生物化学
✓ 已验证
DOI
高影响因子
Journal of Biomedical Nanotechnology
·
2016
·Vol. 12
·期 3
·516-524
·
IF 3.929
Wang Jiayu,Li Pan,Tian Rui,Hu Wenjing,Zhang Yuxia,Yuan Pei,Tang Yalan,Jia Yuntao,Zhang Liangke
Drug-loaded microbubbles have shown attractive potential in disease treatment applications. The present work presents a unique ultrasound (US)-triggered system in which drug-loaded nanoparticles and perfluorocarbon gas are encapsulated within the internal space of microbubbles. The
prepared curcumin-loaded albumin nanoparticle payload microbubbles (CcmANP-MB) exhibited a mean diameter of 4895.1 nm ± 421.2 nm and a drug-loading efficiency of 2.23% ± 0.08% (297% increase compared with the drug loading of common drug-loaded microbubbles). US allowed the release
of the internal payload. In vitro US-triggered drug release experiments showed that the drug release of CcmANP-MB was delayed by lipid membranes and significantly increased after sonication. In vitro and in vivo US imaging experiments demonstrated that CcmANP-MB evidently
enhances US imaging, which indicates that the microbubbles possess good acoustic properties even after encapsulation of nanoparticles. Tumor bearing mice were administered with CcmANP-MB through the tail vein and were then exposed to ultrasound, which resulted in an enhanced drug accumulation
in tumor tissues and a significant increase in tumor growth inhibition rate (57.1%) compared with CcmANP-MB alone (28.8%) as well as curcumin-loaded albumin nanoparticle (26.2%). Therefore, the combination of lecithin microbubbles and albumin nanoparticles provides a platform for targeted
drug delivery in clinical therapy and disease diagnosis.
研究领域:
医学影像
·
药剂学
·
肿瘤学
✓ 已验证
DOI
PubMed
高影响因子
Environmental Science-Water Research & Technology
·
2022
·Vol. 8
·期 12
·3007-3018
·
IF 5.819
Yanning Lv,Minghao Sui,Xinyuan Lv,Jingni Xie
Antibiotics, as emerging trace organic pollutants in water sources, pose a potential threat to drinking water safety. Piezoelectric catalysis is an innovative and green advanced oxidation technology in which mechanical energy can be converted into electrical energy or chemical energy, even without the addition of chemical reagents. Thus, piezoelectric catalysis can be used to degrade trace organic pollutants in water. However, such studies have seldom been reported. In this work, the performance of a typical piezoelectric catalyst, i.e., BaTiO3 (BTO), with mechanical energy from ultrasound (US) for the piezoelectric degradation of sulfamethoxazole (SMX) in water was studied systematically. The results showed that the BTO/US piezoelectric catalytic system exhibited the efficient degradation of SMX. The operating parameters in the BTO/US system were optimized for the effective degradation of SMX, and the influencing factors (initial concentration of SMX, pH, and the coexisting constituents in water) affecting the degradation of SMX by BTO/US were investigated. In addition, the reaction mechanism of the piezoelectric system was investigated via identifying the active species generated in BTO/US through quenching tests and electron paramagnetic resonance analysis. It was found that US could activate BTO to generate hydroxyl radicals (˙OH), superoxide radicals (˙O2−), and singlet oxygen (1O2), thus greatly enhancing the SMX degradation efficiency. Overall, the present study demonstrates that the BTO/US system is a promising form of technology for the green degradation of trace organic pollutants in water.
研究领域:
环境科学
·
催化化学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）