International Journal of Nanomedicine
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2023
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IF 8
Wei Xu,Honglan Wang,Lihui Dong,Pan Zhang,Yan Mu,Xueyan Cui,Jianping Zhou,Meirong Huo,Tingjie Yin
Introduction: Herein, a hyaluronic acid (HA)-coated redox-sensitive chitosan-based nanoparticle, HA(HECS-ss-OA)/GA, was successfully developed for tumor-specific intracellular rapid delivery of gambogic acid (GA).Materials and methods: The redox-sensitive polymer, HECS-ss-OA, was prepared through a well-controlled synthesis procedure with a satisfactory reproducibility and stable resulted surface properties of the assembled cationic micelles. GA was solubilized into the inner core of HECS-ss-OA micelles, while HA was employed to coat outside HECS-ss-OA/GA for CD44-mediated active targeting along with protection from cation-associated in vivo defects. The desirable redox-sensitivity of HA(HECS-ss-OA)/GA was demonstrated by morphology and particle size changes alongside in vitro drug release of nanoparticles in different simulated reducing environments.Results: The results of flow cytometry and confocal microscopy confirmed the HA-receptor mediated cellular uptake and burst drug release in highly reducing cytosol of HA(HECS-ss-OA)/GA. Consequently, HA(HECS-ss-OA)/GA showed the highest apoptosis induction and cytotoxicity over the non-sensitive (HA(HECS-cc-OA)/GA) and HA un-coated (HECS-ss-OA/GA) controls against A549 NSCLC model both in vitro and in vivo. Furthermore, a diminished systemic cytotoxicity was observed in HA(HECS-ss-OA)/GA treated mice compared with those treated by HA un-coated cationic ones and GA solution.
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NEW JOURNAL OF CHEMISTRY
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2023
·Vol. 47
·期 12
·5773-5779
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IF 3.3
Jinxu Cao,Feng Shi,Long Chen,Xuemei Xu,Zhen Chen,Zhanjun Yang,Xingmao Jiang
Bio-activity conservation of biomolecules after immobilizing in nanomaterials has been a tough challenge, especially in biomedical applications. Herein, we developed a novel freezing-assisted reverse microemulsion method to encapsulate water-soluble enzymes in hollow mesoporous silica nanospheres (HMSNs) for maximumly maintaining enzyme bio-activity. Firstly, a low-temperature and ethanol-free synthesis was carried out, and glucose oxidase (GOx) as a model enzyme was encapsulated into HMSNs to obtain GOx@HMSNs. The TEM and SEM images showed a uniform sphere morphology of GOx@HMSNs with a large hollow cavity for GOx loading. The element mapping, FTIR spectrum and TGA curve further confirmed the effective physical encapsulation of GOx in HMSNs, which can maintain stable bio-activity as verified by the enzyme activity assay. In addition to the facile synthesis for avoiding enzyme-denaturation, the N2 adsorption–desorption curves further demonstrated that small mesopores on HMSNs for blocking enzyme leakage may be another important factor for conserving GOx activity. Finally, GOx@HMSNs as a biosensor significantly possessed a wider linear range of 0.06 mM to 2.61 mM with a low detection limit of 0.01 mM, indicating high sensitivity. Therefore, our synthesis method provides a promising approach for biomolecule immobilization with potent bio-activity and biosensor applications with superior sensitivity.
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JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY
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2023
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IF 2.2
Wenxi Zhu,Xiuhua Zheng
The development of high-temperature and salt-resistant foaming agents is critical to the successful drilling of complex and low-pressure reservoirs. In this study, a novel alkyl glycine surfactant (AGS-8) was synthesized by the one-step method. The foam quality of AGS-8 at high temperatures (140–180 °C) and the salt solutions (5–36%wt) was evaluated by the Waring-Blender method to explore its applicability in harsh reservoirs. Results show that: (1) The successful synthesis and chemical structure of AGS-8 was determined by FTIR and 1H-NMR. (2) AGS-8 shows good thermal stability within 330 °C and has high surface activity. (3) AGS-8 generated stable foams after aging at 180 °C for 16 h. The outstanding high-temperature foam stability of AGS-8 is an important feature different from the conventional commercial foaming agents. (4) AGS-8 generated stable foams in saturated salt solution (36%wt NaCl) after 150 °C aged. A synergistic foam stabilization effect was found between high concentrations of NaCl (≥25%wt) and AGS-8. (5) The foam stabilization mechanism of AGS-8 was discussed and can be summarized as the electrostatic attraction effect of head groups and the enhancement of inter-molecular repulsive force. In conclusion, AGS-8 was found to be a promising foaming agent in the drilling of high-temperature salt-gypsum formations.
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INORGANIC CHEMISTRY
·
2023
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IF 4.6
Lan Ding,Yongping Ding,Fenghua Bai,Gonglai Chen,Shuwei Zhang,Xiaoxue Yang,Huiqin Li,Xiaojing Wang
Given the global warming caused by excess CO2 accumulation in the atmosphere, it is essential to reduce CO2 by capturing and converting it to chemical feedstock using solar energy. Herein, a novel Cs3Bi2Br9/bismuth-based metal–organic framework (Bi-MOF) composite was prepared via an in situ growth strategy of Cs3Bi2Br9 quantum dots (QDs) on the surface of Bi-MOF nanosheets through coshared bismuth atoms. The prepared Cs3Bi2Br9/Bi-MOF exhibits bifunctional merits for both the high capture and effective conversion of CO2, among which the optimized 3Cs3Bi2Br9/Bi-MOF sample shows a CO2–CO conversion yield as high as 572.24 μmol g–1 h–1 under the irradiation of a 300 W Xe lamp. In addition, the composite shows good stability after five recycles in humid air, and the CO2 photoreduction efficiency does not decrease significantly. The mechanistic investigation uncovers that the intimate atomic-level contact between Cs3Bi2Br9 and Bi-MOF via the coshared atoms not only improves the dispersion of Cs3Bi2Br9 QDs over Bi-MOF nanosheets but also accelerates interfacial charge transfer by forming a strong bonding linkage, which endows it with the best performance of CO2 photoreduction. Our new finding of bismuth-based metal–organic framework/lead-free halide perovskite by cosharing atoms opens a new avenue for a novel preparation strategy of the heterojunction with atomic-level contact and potential applications in capture and photocatalytic conversion of CO2.
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Analytical Methods
·
2023
·Vol. 15
·期 8
·1037-1046
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IF 3.1
Zhaoyan Yang,Shenfei Zong,Guohua Jiang,Kai Zhu,Ziting Qian,Kuo Yang,Zhuyuan Wang,Yiping Cui
All-inorganic perovskite nanocrystals (CsPbX3 NCs, X = Cl, Br, I) are promising fluorescence materials for biological detection due to their excellent optical properties. However, there is still a challenge to obtain stable CsPbX3 NCs with more biofunctions. Here, we proposed a distinct strategy by absorbing the functionalized metal nanoprobes onto the phospholipid encapsulated CsPbX3 NCs to achieve CsPbX3-metal hybrids as probes for the detection of tumor-derived exosomes. Here, the metal nanoprobes have two functions: first, it endows phospholipid encapsulated CsPbX3 NCs with recognition ability; second, it avoids the fluorescence quenching of CsPbX3 NCs during the biological modification process by using metal nanoparticles as a bridge to connect with CsPbX3 NCs and various biomolecules. The obtained CPXD–AD exhibited a bright fluorescence signal, narrow full width at half-maximum (FWHM), and high specificity. Under optimal conditions, the CPXD–AD-based fluorescence-linked immunosorbent assay (FLISA) was successfully established and used for both qualitative and quantitative detection of tumor-derived exosomes.
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InfoMat
·
2023
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IF 22.7
Peilin Liu,Shuaicheng Lu,Jing Liu,Bing Xia,Gaoyuan Yang,Mo Ke,Xuezhi Zhao,Junrui Yang,Yuxuan Liu,Ciyu Ge,Guijie Liang,Wei Chen,Xinzheng Lan,Jianbing Zhang,Liang Gao,Jiang Tang
Lead sulfide (PbS) colloidal quantum dot (CQD) photodiodes integrated with silicon-based readout integrated circuits (ROICs) offer a promising solution for the next-generation short-wave infrared (SWIR) imaging technology. Despite their potential, large-size CQD photodiodes pose a challenge due to high dark currents resulting from surface states on non-passivated (100) facets and trap states generated by CQD fusion. In this work, we present a novel approach to address this issue by introducing double-ended ligands that supplementally passivate (100) facets of halide-capped large-size CQDs, leading to suppressed bandtail states and reduced defect concentration. Our results demonstrate that the dark current density is highly suppressed by about an order of magnitude to 9.6 nA cm −2 at −10 mV, which is among the lowest reported for PbS CQD photodiodes. Furthermore, the performance of the photodiodes is exemplary, yielding an external quantum efficiency of 50.8% (which corresponds to a responsivity of 0.532 A W −1 ) and a specific detectivity of 2.5 × 10 12 Jones at 1300 nm. By integrating CQD photodiodes with CMOS ROICs, the CQD imager provides high-resolution (640 × 512) SWIR imaging for infrared penetration and material discrimination.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2023
·
IF 8.2
Zhaowen Liu,Hongcai Wang,Yanan Bu,Ting Wu,Xiuqiong Chen,Huiqiong Yan,Qiang Lin
The application of hydrophobic β-carotene in the food industry are limited due to its susceptibility to light, high temperature, pH value, and other factors, leading to poor stability and low bioavailability. To address this problem, we adopt a more green and environmentally friendly reducing agent, 2-methylpyridine borane complex (pic-BH 3 ), instead of traditional sodium borohydride, to achieve the simple green and efficient synthesis of amphiphilic oxidized sodium alginate grafted oleoamine derivatives (OSAOLA) through the reduction amination reaction of Schiff base. The resultant OSAOLA with the degree of substitution (DS) of 7.2 %, 23.6 %, and 38.8 % were synthesized, and their CMC values ranged from 0.0095 to 0.062 mg/mL, indicating excellent self-assembly capability in aqueous solution. Meanwhile, OSAOLA showed no obvious cytotoxicity to RAW 264.7 cells, thus revealing good biocompatibility. Furthermore, β-carotene, as the hydrophobic active ingredients in foods was successfully encapsulated in the OSAOLA micelles by ultrasonic-dialysis method. The prepared drug-loaded OSAOLA micelles could maintain good stability when stored at room temperature for 7 d. Additionally, they were able to continuously release β-carotene and exert long-term effects in pH 7.4 PBS at 37 °C, effectively improving the bioavailability of β-carotene, which exhibited tremendous application potential in functional food and biomedical fields.
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ACS Applied Materials & Interfaces
·
2023
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IF 9.5
Ya Wang,Huicheng Hu,Mohan Yuan,Hang Xia,Xingchen Zhang,Jing Liu,Ji Yang,Shaoqiu Xu,Zhaorong Shi,Jungang He,Jianbing Zhang,Liang Gao,Jiang Tang,Xinzheng Lan
Lead sulfide (PbS) colloidal quantum dots (CQDs) for photodetectors (PDs) have garnered great attention due to their potential use as low-cost, high-performance, and large-area infrared focal plane arrays. The prevailing device architecture employed for PbS CQD PDs is the p–i–n structure, where PbS CQD films treated with thiol molecules, such as 1,2-ethanedithiol (EDT), are widely used as p-type layers due to their favorable band alignment. However, PbS-EDT films face a critical challenge associated with low film quality, resulting in many defects that curtail the device performance. Herein, a controlled oxidization process is developed for better surface passivation of the PbS-EDT transport layer. The dark current density (Jd) of PbS CQD PDs based on optimized PbS-EDT layer shows a dramatic decrease by nearly 2 orders of magnitude. The increase of carrier lifetime and suppression of carrier recombination via controlled oxidation in PbS-EDT CQDs were confirmed by transient absorption spectra and electrochemical impedance spectra. The device based on the optimized PbS-EDT hole transport layer (HTL) exhibits a specific detectivity (D*) that is 3.4 times higher compared to the control device. Finally, the CQD PD employing oxidization PbS-EDT CQDs is integrated with a thin film transistor (TFT) readout circuit, which successfully accomplishes material discrimination imaging, material occlusion imaging, and smoke penetration imaging. The controlled oxidization strategy verifies the significance of surface management of CQD solids and is expected to help advance infrared optoelectronic applications based on CQDs.
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REACTIVE & FUNCTIONAL POLYMERS
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2023
·
IF 5.1
Liyang Zhao,Hongli Zhang,Gang Zou
Nonconventional luminogens, represented by clustering-triggered emission (CTE) materials, have attracted increasing attention owing to their unique intrinsic emission and promising applications. However, the influencing factors of clustering-triggered emission and gelation behavior remain poorly understood. Herein, a series of poly(thioether)s with different pendant groups were synthesized and their unique properties were studied. Owing to the similar molecular structure, all five poly(thioether)s exhibited visible photoluminescence , but the intensity varied when the pendant group or solvent changed, which could be attributed to different clustering degree between polymer chains. Moreover, poly(thioether)s with different pendant groups showed the diverse gelation behavior during polymerization process. The impact of pendant group on the clustering-triggered emission property and gelation behavior of poly(thioether) derivatives were investigated in detail, which might be of great fundamental value for the rational design of functional nonconventional luminogens for biological and medical applications.
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International Journal of Electrochemical Science
·
2023
·
IF 1.5
Rujing Ban,Zhengyan Xu,Yang Yang,Dayong Fan,Huidan Lu,Yongping Liu
This work synthesized ultrathin 2D CdSe nanosheets by a facile solvothermal method. The morphology, structure, composition, and thermal stability of the samples were studied and analyzed using transmission electron microscopy (TEM), atomic force microscopy (AFM), X-ray diffraction (XRD), infrared spectra (IR), and thermogravimetric (TG) methods. Results demonstrated that stable wurtzite-structured CdSe nanosheets with 2-3 nm thickness were successfully fabricated. UV-Vis absorption spectroscopy (UV-Vis) and fluorescence spectroscopy analysis exhibited the characteristic absorption peaks and fluorescence emission peaks of CdSe nanosheets with narrow full-width half-maximums (fwhm) and slight Stokes shift, implying ultrathin structure. Photoelectrochemical (PEC) measurement declared a fast and stable photo-response for the as-prepared CdSe ultrathin nanosheets. With the reaction temperature increasing, the PEC activity enhanced due to the decreased nanosheets thickness. This paper provides a new route for the synthesis of CdSe ultrathin nanosheets and their application in the field of photoelectrochemical catalysis.
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Arabian Journal of Chemistry
·
2023
·
IF 6
Ruifeng Liao,Liangliang Shi.,Yi Zhou,Chenyue Jia,Jiangtao Feng,Weinong Zhang,Junbo He
Four novel nonionic 1-alkylaminoglycerol Gemini surfactants, represented by m-s-m ( m = C 8 and C 12 , s = 3 and 4), were synthesized through a two-step reaction in high yields, and confirmed by 1 H NMR, 13 C NMR, and HRMS. The synthesized Gemini surfactants exhibited low CMC (1.41–5.25 mmol/L), excellent surface-tension-reducing ability (25.45–26.83 mN/m), and wetting ability on hydrophobic interface. Gemini surfactants in aqueous solutions were in stable nanoscale dispersion, and exhibited strong and long-lasting foaming ability and emulsifying abilities for benzene/water and triacylglyceride/water systems. Especially, 12 – 4-12 solution displayed excellent tolerance to wide pH range and high salinity. Biological evaluation demonstrated that these Gemini surfactants, except for 8 – 4-8 , showed significant antibacterial activities against Staphylococcus aureus and Escherichia coli at 25 and 50 µg/mL. Hence, these Gemini surfactants have the potential to be used in a varieties of fields as highly efficient agents.
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CHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 15.1
Deqi Fan,Yi Lu,Xueling Xu,Yicheng Tang,Hao Zhang,Yan Mi,Xiaofei Yang
Elaborately designing multifunctional energy conversion materials is vital to promoting renewable energy conversion. Herein, we report a novel approach in which photocatalytic materials and photothermal components are embedded simultaneously into porous delignified wood to construct wood-based hybrid hydrogels for water decontamination, hydrogen generation and freshwater production. Well-designed all-in-one system elaborately interfaces hydrogen-evolving semiconductor CdS with MoSe 2 that functions as co-catalyst and also possesses photothermal effect to simultaneously drive the removal of pollutants, hydrogen production and solar steam generation with high efficiency. The multifunctional system demonstrates a hydrogen evolution rate of 9.7 mmol g –1 h −1 and a high solar evaporation rate of 1.92 kg m −2 h −1 with an energy conversion efficiency up to 90.7% under one sun illumination. The encapsulation of photothermal-assisted photocatalytic systems with hydrogels effectively prevents toxic volatile organic compounds (VOCs) from being evaporated without deteriorating the solar steam generation performance. This study provides new insights into the rational design of novel multifunctional materials for environmental remediation and energy sustainability.
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