MICROCHEMICAL JOURNAL
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2025
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IF 5.1
Pengge Wei,Jianxiang Liu,Jing Zhao,Longshan Zhao
Traditional maceration extraction methods for dioscin typically involve substantial consumption of organic solvents and long extraction times. The present study aimed to develop a green and sustainable extraction procedure for the extraction of Dioscin from Dioscorea nipponica Makino (DNM). A series of switchable natural deep eutectic solvent (SNADES) based on medium chain fatty acids were prepared to achieve high extraction efficiency of Dioscin from DNM. As a result, hexanoic acid and heptanoic acid were selected as the optimal solvents. The optimal extraction conditions were as follows: a molar ratio of 1:1, a liquid-solid ratio of 50 mL·g −1 , an ultrasonic duration of 50 min, and a polarity switch phosphoric acid dosage of 800 μL without additional salt. The SNADES-UALLME method established in this study minimizes the use of organic reagents and provides a new insight for development of green extraction methods for active ingredients from traditional Chinese medicine.
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高影响因子
ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Weijie Zhang,Lintao Wang,Wei Pei,Jie Dang,Yewen Zhang,Xiang Liu,Abdullah Maqsood,QinQin He,Min Li
Introducing defects into Metal–organic frameworks (MOFs) is an effective measure to increase adsorption sites, which is of great significance for improving phosphorus (P) adsorption performance. In this study, various defect-containing cerium (Ce)-based MOFs (Ce-MOFs) were prepared by introducing different types and equivalents of monocarboxylates. Among them, butyric acid (BA)-regulated Ce-MOF (Ce-MOF(40BA)) exhibited excellent adsorption performance with a maximum phosphate adsorption capacity of 117.28 mg P/g. When the initial phosphate concentration was 3 mg P/L, the adsorption equilibrium could be reached within 10 min with a phosphate removal rate of 96.6%. Thermogravimetry analysis (TGA) showed that the average coordination number of Ce-MOF (40BA) was only 4.33 compared to six of the pristine Ce-MOF, indicating an abundant defect content. By increasing defects, mesopores were introduced, enriching the material’s pore structure and achieving a mesopore proportion up to 58.81%. X-ray photoelectron spectroscopy (XPS) analysis revealed that the introduction of defects created numerous unsaturated metal centers, leading to a significant increase in Ce(III) contents. Further density functional theory (DFT) calculations indicated that the defective Ce-MOF had a lower binding energy compared to the pristine Ce-MOF, making it more favorable for phosphate adsorption. This study provides a strategy for preparing efficient defect-containing MOF adsorbents. The excellent adsorption performance of Ce-MOF(40BA) in practical wastewater bodies makes it a promising material for solving water eutrophication.
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PubMed
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JOURNAL OF FOOD COMPOSITION AND ANALYSIS
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2025
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IF 4.6
Yawen Zhang,Hongli Zhang,Jiangong Ma,Jing Zhao,Huajuan Yin,Xu Jing,Xiaowen Wang
With the advent of new-generation green extraction solvents, deep eutectic solvents (DESs) present significant prospects for the extraction of bioactive substances. In this study, saponins were extracted from oats using an ultrasonic-assisted method with green DESs, replacing conventional toxic organic solvents. Adding sodium chloride markedly reduced solubility, resulting in the separation of two phases from the extract: DES and water. The saponins were separated into the water phase, while the DES was reused in subsequent extractions, supporting extractant recycling and promoting sustainable development. Adding salt offers a more gentle, convenient, and cost-effective alternative to current phase separation methods, such as pH adjustment, temperature variation, and carbon dioxide or nitrogen gas application. Optimizing the extraction and recovery parameters yielded the highest oat saponin extraction efficiency at 18.73 mg g –1 , and the recovery was 86.4 %. When compared with ethanol extracts, DES extracts exhibited superior antioxidant activity. Lastly, the greenness of this extraction method was confirmed through three greenness evaluation programs of greenness. The extraction method based on emerging responsive solvents can be extended to other hydrophilic bioactive substances.
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JOURNAL OF MOLECULAR LIQUIDS
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2025
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IF 5.2
Sen Li
The design of effective phenol adsorbents remains an important issue in industrial wastewater treatment. This study develops amide-containing gemini surfactants to modify vermiculite (G8-NE-VT, G8-OL-VT and G12-NE-VT) for phenol adsorption. Guided by “functional connector” strategy, longer alkyl chains in G12-NE-VT contribute to looser surfactant packing and greater hydrophobicity, while functional groups in the spacer of G8-OL-VT improve interaction density and adsorption performance. The adsorption of phenol follow the order of: G8-OL-VT (160.78 mg/g) > G12-NE-VT (111.06 mg/g) > G8-NE-VT (80.82 mg/g). The highest adsorption amounts are obtained on G8-OL-VT (274.23 mg/g). All the adsorption processes are fitted well by pseudo-second-order kinetic model and Redlich-Peterson isotherm. Exothermic adsorption character involves hydrophobic interactions, hydrogen bonding, π-π stacking, and electrostatic interactions between phenol and organo-VT. Shorter alkyl chains enhance the role of additional interactions for phenol retention. Moreover, the applicability of G8-OL-VT is demonstrated by reliable regeneration and high selectivity. Results in this work focus on achieving high adsorption capacity and advancing material design for pollutant treatment, as well as overcome the challenges associated with phenol’s intrinsic polarity and hydrophilia, resulting in superior adsorption performance compared to conventional adsorbents.
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SEPARATION AND PURIFICATION TECHNOLOGY
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2025
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IF 9
Song Xue,Yu Xu,Sihui Ding,Haoxiang Meng,Xiaodong Sun,Qi Zhang
Two hydrophobic (deep) eutectic solvents (H(D)ESs), menthol:octanoic acid (Men:OctA) and menthol:trioctylphosphine oxide (Men:TOPO), were prepared, characterized, and then employed for the first time in combination with sulfobutylether-β-cyclodextrin (SBE-β-CD) for chiral separations in capillary electrokinetic chromatography (EKC). The “H(D)ES + SBE-β-CD” dual pseudo-stationary phase (PSP) systems yielded not only enhanced enantioselectivities, but also accelerated migrations of primaquine and chlorpheniramine, two drugs that cannot be resolved using the single SBE-β-CD system. The enhancement originated from the combined effects of stereoselective complexation and hydrophobic partitioning involving the H(D)ES phase, which moved faster than the anionic CD phase under the separation conditions. The best results in terms of enantioresolution and migration time were obtained using a 20 mM phosphate buffer (pH 7.0) containing 2.0 % SBE-β-CD and 0.2 % Men:OctA at an applied voltage of 15 kV. We further compared the chiral EKC performance of the H(D)ESs with a series of conventional PSPs, including three micelles (Tween-20, Brij-35, SDS) and three ionic liquids (ILs). The results showed that none of these modifiers could achieve comparable EKC performance, suggesting that in certain cases, H(D)ESs could be a superior alternative to traditional modifiers for chiral EKC separations.
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JOURNAL OF CEREAL SCIENCE
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2026
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IF 4.3
Baoqing Bai,Shijie Niu,Junnan Li,Bin Feng,Tao Bo,Jinhua Zhang,Ying Zhang,Yukun Yang
Huangjiu, an ancient Chinese alcoholic beverage, is primarily brewed through the fermentation of steamed grains using Jiuqu as starter. This study systematically investigated the effects of five nutritionally rich coarse cereals (oats, quinoa, sorghum, buckwheat and black rice) on the physicochemical, antioxidant and flavor profiles of Huangjiu (CCHJ: MQHM, MQLM, MQYM, MQGL, and MQKQ) fermented with Maiqu . The results demonstrated that five types of CCHJ samples exhibited strong antioxidant capacity, with MQLM and MQHM showing particularly high α-glucosidase inhibition rates, exceeding 95%. Functional component analysis revealed that MQHM contained the highest levels of amino acids, total flavonoids and polyphenols, while MQKQ exhibited the highest organic acid content. A total of 203 volatile flavor compounds (VFCs) were identified, with MQGL having the highest concentration, followed by MQHM. Furthermore, 12 common compounds, including ethanol, isopropanol, acetoin, 4-ethyl-2-methoxyphenol, ethyl palmitate, 3-methyl-1-butanol, 2-methoxy-4-vinylphenol, (S)-2-heptanol, phenethyl alcohol, 3,4-dimethylbenzaldehyde, methanol, and octanoic acid, were identified as key aroma compounds in CCHJ samples based on their odor activity value (OAV). The distinctive sweet profile of MQHM was strongly correlated with these compounds. These findings provide valuable insights into how to optimize the use of traditional coarse cereals and advancing the development of novel functional Huangjiu products.
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SEPARATION AND PURIFICATION TECHNOLOGY
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2026
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IF 9.1
Xingxing Li,Jianing Qi,Mingjing Shi,Yuan Yao,Yingying Cao,Xue Wang,Hui Wang
Artemisinin is primarily derived from Artemisia annua L. However, due to the complex composition of its leaf extract, the purification and separation of artemisinin remain a significant challenge. In this work, various poly(ionic liquid)s (PILs) containing polar ester groups and non-polar long-chain alkyl groups were synthesized through radical polymerization. Subsequently, these PILs were made into coatings with controllable pore sizes and adjustable hydrophobicity. The ethyl octadecanoate based PIL coating showed excellent capability to intensify this purification process. The product purity could reach 96.8% after one crystallization step under the optimal conditions, approximately 30.8% higher than the traditional method. And the product purity could reach 99.9% after three sequential separation processes. In addition, the adsorption kinetics of wax oil on the PIL coating were studied, and the results indicated that it followed a pseudo-first-order kinetic model with a maximum adsorption capacity of 226.33 mg/g. Mechanism analysis demonstrated that hydrogen bonding and van der Waals forces between the wax oil and PIL facilitated the adsorption of the wax oil, thereby increasing the purity of artemisinin.
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Food Bioscience
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2026
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IF 5.9
Dancai Fan,Zijia Song,Yaya Wang,Binying Fu,Shijie Li,Shuo Wang
Accurate differentiation between dairy processing technologies such as pasteurization and ultra-high temperature sterilization is crucial for ensuring product quality, protecting consumer rights, and maintaining market order. This study identified antigen structure-sensitive antibodies and developed a high-performance sELISA detection method. By detecting antigenic changes in lactoferrin (LF) during processing, it enables the identification of milk thermal processing conditions. This antibody pair not only exhibits excellent binding affinity for native LF but also possesses processing-dependent recognition ability for heat-treated LF. While mild denaturation at 75°C reduces its recognition efficiency, it promotes the formation of stable lactose-LF complexes, thereby preserving conformation-dependent antigenicity. In contrast, combined high-temperature and pressure processing overrides the protective effect of lactose, rendering sELISA detection ineffective. Based on experimental and molecular docking results, the positive effect of lactose on LF antigenicity during thermal processing provides key support for distinguishing between pasteurization and ultra-high temperature (UHT) processing. Furthermore, validation with real samples confirms that this method can effectively differentiate pasteurized milk from UHT milk/reconstituted milk, offering technical support for industrial quality control and product authenticity verification.
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Food Science & Nutrition
·
2026
·Vol. 14
·期 1
·e71465
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IF 3.8
Chenxi Zhou,Xiaohua Li,Chungen Xing,Chun Cao
Radiation‐induced intestinal injury (RIII) is a common complication in patients under radiotherapy for abdominopelvic and retroperitoneal malignancies, significantly impairing quality of life and overall survival. However, the therapeutic effect of standard enteral nutrition (EN) is limited. This study aimed to investigate the protective role and potential mechanisms of octanoic acid (OA)‐rich EN in RIII. C3H/HeN mice were randomly assigned to four groups: Sham, Radiation (RI), RI + EN and RI + OA‐rich EN to investigate the impacts of OA‐rich EN. Then mice were randomly assigned to five groups: Sham, RI, RI + OA‐rich EN, RI + OA‐rich EN + Luzindole, RI + OA‐rich EN + EX527 to examine whether OA‐rich EN alleviated RIII through the melatonin‐silent information regulator 1 (SIRT1) pathway. We evaluated the intestinal histopathology, apoptosis, tight junction protein expression and permeability. Moreover, melatonin and inflammatory cytokine levels were measured in the intestine and serum. SIRT1/Peroxisome Proliferator‐Activated Receptor Gamma Coactivator 1‐Alpha (PGC‐1α)/Peroxisome Proliferator‐Activated Receptor Gamma (PPARγ) pathway was also assessed. OA‐rich EN promoted melatonin secretion in the intestine and serum, activated the SIRT1/PGC‐1α/PPARγ pathway, markedly improved intestinal histopathology, and significantly reduced levels of inflammatory factors in intestine and serum. These beneficial effects were greater than EN alone. Furthermore, these beneficial effects were abolished when OA‐rich EN was co‐administered with either a melatonin antagonist or a SIRT1 inhibitor. This is the first confirmation that OA‐rich EN alleviated RIII by promoting melatonin secretion, which in turn activated the SIRT1/PGC‐1α/PPARγ pathway. Our findings highlight OA‐rich EN as a promising nutritional strategy to improve intestinal health and reduce treatment‐related complications in patients receiving abdominal radiotherapy. OA‐rich EN conferred superior intestinal protection compared with standard EN, achieving this through nutrient‐hormone interaction: by upregulating endogenous melatonin levels, activating the SIRT1/PGC‐1α/PPARγ pathway, thereby suppressing intestinal inflammation, enhancing the intestinal mucosal barrier function, and reducing epithelial cell apoptosis.
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PubMed
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JOURNAL OF MEMBRANE SCIENCE
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2026
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IF 9
Dai Shi,Shan Luo,Jiamei Sun,Shunwen Xiao,Xianyu Sun,Yanyue Qu,Ruiyuan Zeng,Meijie Wang,Ran Chen,Youqing Tian,Yumeng Zhao,Beili Lu,Lirong Tang,Biao Huang,Hanyang Liu,Xinda You
Ionic covalent organic framework (iCOF) membranes are promising for nanofiltration, yet combining high charge density with confined pore size remains challenging because strong electrostatic repulsion disrupts ordered stacking and generates structural defects. Here, we propose a “moderately charged–highly charged–moderately charged” strategy to construct sandwich-like COF membranes (SCOFMs). By layer-by-layer assembly of TpPa-SO 3 H and TpPa-2SO 3 H nanosheets, SCOFMs with enhanced chargeability and narrowed nanopores are obtained. Increasing the outer-to-inner layer ratio from 10:0 to 7:3 raises the membrane surface charge density from −1.51 to −1.84 mC m −2 and reduces the pore diameter from 0.95 to 0.68 nm. This improvement originates from the higher chargeability and smaller pore size of TpPa-2SO 3 H, while the sandwich structure mitigates interlayer repulsion and promotes dense stacking. The synergistic Donnan exclusion and size-sieving endow SCOFM (7:3) with high rejection of 96.4 % for Na 2 SO 4 , 97.2 % for MgSO 4 , 84.4 % for NaCl, and >99 % for various antibiotics. Benefiting from this architecture, it also maintains Na 2 SO 4 rejection larger than 91 % and stable water permeance for over 50 days. This approach simultaneously narrows nanopores and enhances the membrane surface charge density, offering a promising route for high-performance nanofiltration membranes.
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Sustainable Chemistry and Pharmacy
·
2026
·
IF 5.8
Jin-Yue Dong,Rong-Jie Wang,Qing Ran,Xiao-Bei Yang,Wen-Chao Han,Feng-Qi Dong,Di Chen
A novel microextraction method based on switchable natural deep eutectic solvents (SNADES) was developed for the determination of illicitly added non-steroidal anti-inflammatory drugs (NSAIDs) in herbal extracts, enabling one-step phase separation and magnetic retrieval of the extractant. The addition of ammonia solution induces the reversible transition of the hydrophobic SNADES (menthol:decanoic acid = 1:1) to a hydrophilic state, thereby significantly enhancing the extraction efficiency of the target analytes. Citric acid-modified Fe 3 O 4 composites (Fe 3 O 4 @CA) were employed to achieve rapid phase separation and efficient magnetic retrieval of the SNADES phase. After systematic optimization, the optimal conditions were established as 30 μL of SNADES, 70 mg of citric acid, 4 mg of Fe 3 O 4 , an extraction time of 4 min, and 100 μL of acetonitrile for desorption. Under the optimal conditions, four NSAIDs (flurbiprofen, diclofenac sodium, ibuprofen, and ketoprofen) exhibited good linearity over the concentration range of 0.1–20 μg/mL, with correlation coefficients (R 2 ) ≥ 0.993. The method provided relative recoveries of 93.7–109.2 % for the target analytes, with relative standard deviations (RSDs) ≤ 9.7 %. The limits of detection were in the range of 0.016–0.036 μg/mL. Spiked recovery experiments in real herbal extracts confirmed the method's accuracy (96.0–112.3 %), demonstrating that the proposed approach provides a rapid, efficient, and green sample preparation strategy for the screening of illicit synthetic drugs in herbal products.
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TRIBOLOGY LETTERS
·
2026
·Vol. 74
·期 2
·34
·
IF 3.5
Yang Jing,Liu Xiao,Chen Qiang,Guo Pingxia,Feng Kai,Cai Meirong
As global environmental standards grow increasingly strict, developing eco-friendly, high-efficiency water-based lubrication additives has become a pivotal focus in tribology. In this work, three novel heterocycle-, phosphorus-, and sulfur-free protic ionic liquids (PILs), namely EDG-HA, EDG-OA, and EDG-LA, were successfully synthesized and employed as additives in aqueous lubricant systems with the objective of alleviating the environmental contamination and biological toxicity problems related to conventional lubricant additives. A systematic evaluation of the PILs revealed that lubricants blended with the additives demonstrate significantly superior corrosion protection and lubricating performance when compared to pure water. Specifically, the 1% EDG-LA lubricating solution reduced the friction coefficient (COF) and wear volume (WV) by approximately 69.3% and 94.5%, respectively. By combining quartz crystal microbalance (QCM) adsorption tests and X-ray photoelectron spectroscopy (XPS) analysis, the lubrication mechanisms were clarified: PILs form robust physical adsorption and tribo-chemical reaction film on metal friction pairs, effectively preventing direct metal-to-metal contact. The current research promotes the development of water-soluble additives with potential eco-friendly and high-efficiency through a novel perspective. Graphical
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危险品化学品经营许可证（带存储）