JOURNAL OF APPLIED POLYMER SCIENCE
·
2025
·
IF 2.8
Jiayao Wang,Jingguo Li,Shaokui Cao,Yingliang Liu,Jun Shi
In recent years, the remotely multi-responsive chitosan (CS) hydrogel has been garnering extensive attention owing to its remarkable potential in biomedical applications. Meanwhile, it presents a wide range of uses in the realm of controlled drug delivery and photothermal chemical combination therapy. In this paper, the CS/β-glycerophosphate disodium salt (β-GP) physical crosslinked network was employed as the framework to encapsulate near-infrared (NIR) responsive hollow copper sulfide (CuS)/polydopamine (PDA) nanoparticles, and the NIR/pH synergistic responsive CS/CuS/PDA hydrogel was fabricated. The negatively charged β-GP, along with the hollow CuS/PDA nanoparticles, played a key role in promoting the creation of abundant electronegative cavities. As a result, the hybrid hydrogel achieved an impressively high DOX loading rate, reaching up to 95.5%. The CS/CuS/PDA hydrogel exhibits excellent pH responsiveness, which could be attributed to the disintegration of the CS/β-GP network under acidic buffer solution. In addition, hollow CuS/PDA nanoparticles embedded in the hydrogel endow the hydrogel with excellent NIR photothermal responsiveness, which significantly promotes the release of DOX. Consequently, the CS/CuS/PDA hydrogel reveals excellent synergistically enhanced NIR, pH, and thermal triple-responsiveness, indicating its tremendous promise in the field of controlled drug release.
研究领域:
生物医学工程
·
材料科学
·
药学
✓ 已验证
产品关联
DOI
高影响因子
Materials Science & Engineering C-Materials for Biological Applications
·
2021
·
IF 7.328
Na Guo,Feng Cang,Zhen Wang,Ting-Ting Zhao,Xin-Rui Song,Stefano Farris,Yan-Yan Li,Yu-Jie Fu
Microbial contamination of water represents a great threat to the public health that has attracted worldwide attention. In this work, polypyrrole magnetic nanoparticles (Fe 3 O 4 @PPy NPs) with sterilization properties were fabricated. More specifically, the Fe 3 O 4 @PPy NPs obtained via aqueous dispersion polymerization and an in situ chemical oxidative polymerization exhibited a cationic surface and high photothermal conversion efficiency. More than 50% of bacteria adsorption can be achieved at a dosage of 100 μg/mL Fe 3 O 4 @PPy NPs under magnetic field, and high photothermal sterilization efficacy (~100%) can be obtained upon NIR exposure at the same dosage for 10 min. Noteworthy, the Fe 3 O 4 @PPy NPs can be recycled by magnetism and reused without affecting their photothermal sterilization capability. This study clearly provides experimental evidence of the great potential of Fe 3 O 4 @PPy NPs as stable and reusable nanocomposite materials for bacteria adsorption and photothermal sterilization performance. The application of Fe 3 O 4 @PPy NPs can realize enviromental-friendly bacterial contaminated water treatment as well as provide stratgies for synergistical antibacterial materials design.
研究领域:
环境科学
·
材料科学
·
微生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2017
·Vol. 53
·期 3
·1810-1823
·
IF 2.599
Zhang Zheng,Shi Jun,Song Zhixuan,Zhu Xiaoyi,Zhu Yaping,Cao Shaokui
In this work, near-infrared (NIR)-responsive core–shell gold nanorods/mesoporous silica/reduced graphene oxide (Au/SiO 2 /rGO) nanoparticles with synergistically enhanced photothermal stability and transition effect had been prepared via electrostatic interaction. Gold nanorods (AuNRs) and rGO were employed as the NIR-responsive components. UV–Vis–NIR extinction spectra revealed that the surface plasmon resonance peak of AuNRs from Au/SiO 2 /rGO nanohybrids remained unchanged after 9 h NIR exposure. UV–Vis–NIR extinction results also showed that thin silica shell was superior to the thick ones in the photothermal stability improvement of Au/SiO 2 /rGO nanoparticles. Moreover, the doxorubicin release of Au/SiO 2 /rGO was more rapid than that of Au/SiO 2 upon NIR irradiation, indicating that synergistically enhanced photothermal effect between rGO and AuNRs endowed Au/SiO 2 /rGO nanoparticles with excellent photothermal transition efficiency. Such novel NIR-responsive core–shell hybrid nanoparticles with enhanced photothermal stability and transition effect are well suited for further biological applications, such as photothermal therapy, bioimaging and drug delivery.
研究领域:
材料科学
·
生物医学工程
·
纳米医学
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2021
·
IF 9.229
Fan Hao,Liangyu Wang,Binling Chen,Lin Qiu,Jun Nie,Guiping Ma
Smart response hydrogel has a broad application prospect in human health real-time monitoring due to its responses to a variety of stimuli. In this study, we developed a novel smart hydrogel dressing based on conductive MXene nanosheets and a temperature-sensitive PNIPAm polymer. γ-Methacryloxypropyltrimethoxysilane (KH570) was selected to functionalize the surface of MXene further to improve the interface compatibility between MXene and PNIPAm. Our prepared K-M/PNIPAm hydrogel was found to have a strain-sensitive property, as well as a respond to NIR phase change and volume change. When applied as a strain flexible sensor, this K-M/PNIPAm hydrogel exhibited a high strain sensitivity with a gauge factor (GF) of 4.491, a broad working strain range of ≈250%, a fast response of ∼160 ms, and good cycle stability (i.e., 3000 s at 20% strain). Besides, this K-M/PNIPAm hydrogel can be used as an efficient NIR light-controlled drug release carrier to achieve on-demand drug release. This work paved the way for the application of smart response hydrogel in human health real-time monitoring and NIR-controlled drug release functions.
研究领域:
材料科学
·
生物医学工程
·
纳米技术
·
健康监测
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Yachao Yu,Hua Zhao,Jingmei Liu,Chenghao Li,Pengyuan Liu,Pei Cheng,Yongli Liu,Wenna Guo,Fangxia Guan,Minghao Yao
The treatment of diabetic wounds with bacterial infection is a major challenge in the medical field. Microenvironment-responsive hydrogel dressings have shown great advantages, and photothermal antibacterial therapy is a potential antimicrobial strategy to avoid the generation of resistant bacteria. In this work, a glucose-triggered near-infrared (NIR)-responsive photothermal antibacterial hydrogel was designed and named GOGD based on a cascade reaction of glucose oxidation and polyphenol polymerization. The GOGD hydrogel was composed of gelatin and oxidized dextran (Odex), and loaded with a natural plant polyphenol gallic acid (GA) and the dual-biological enzymes (glucose oxidase GOx and horseradish peroxidase HRP). In response to the high glucose environment, GOx in the hydrogel decomposed glucose to produce hydrogen peroxide, which further catalyzed GA polymerization with HRP to produce poly-GA possessing NIR photothermal capability, thus endow GOGD hydrogel with glucose-triggered NIR responsive photothermal antibacterial property simultaneously targeting the high glucose and infection microenvironment in diabetic wounds. Furthermore, the GOGD hydrogel demonstrated good biocompatibility and a strong ability to scavenge reactive oxygen species (ROS), thereby protecting cells from oxidative damage. In a mouse model, this hydrogel not only displayed excellent hemostatic properties but also significantly enhanced the healing of Staphylococcus aureus -infected diabetic wounds by regulating inflammation and promoting angiogenesis. Therefore, the proposed GOGD hydrogel provides a novel approach to diabetic wound treatment by utilizing its unique glucose-responsive mechanism combined with integrated NIR-photothermal bacterial inhibition. This well-designed material holds great promise for significantly improving the healing of infected diabetic wounds and offers new prospects for future advancements in wound therapy.
研究领域:
生物医学工程
·
材料科学
·
药剂学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Materials Science & Engineering C-Materials for Biological Applications
·
2017
·
IF 4.164
Zhixuan Song,Yang Liu,Jun Shi,Teng Ma,Zheng Zhang,He Ma,Shaokui Cao
In this study, gold nanorods/mesoporous silica/hydroxyapatite (Au/SiO 2 /HAP) hybrid nanoparticles with AuNR core and SiO 2 /HAP hybrid inorganic shell for multi-responsive drug delivery had been prepared. The morphology and structure of the nanoparticles were characterized by TEM, XPS, XRD, FT-IR and N 2 adsorption-desorption isotherms. The degradation of the hybrid nanoparticles could be significantly improved by the dissolution of HAP from the hybrid skeleton in acid environment. In vitro drug release results indicated that Au/SiO 2 /HAP nanoparticles exhibited high drug loading efficiency, excellent near-infrared (NIR)- and pH-responsive drug release properties. Compared to the drug release of Au/SiO 2 nanoparticles over 12 h (about 6.35%), Au/SiO 2 /HAP nanoparticles displayed a higher drug release of 37.62% upon NIR irradiation at pH 4.5 due to the NIR-responsiveness of AuNRs and the pH-responsiveness of HAP in acid media. The cell viability results also indicated that the Au/SiO 2 /HAP nanoparticles exhibited the excellent biocompatibility. The present paper provides a facile route to fabricate a hybrid drug carrier with high drug loading efficiency, excellent pH sensitivity, NIR-sensitivity, biodegradability and biocompatibility.
研究领域:
纳米医学
·
生物材料
·
药物递送系统
✓ 已验证
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2018
·
IF 6.735
Wanting Dai,Huilong Guo,Bo Gao,Miaoliang Ruan,Lanqin Xu,Jianping Wu,Thomas Brett Kirk,Jiake Xu,Dong Ma,Wei Xue
In this work, near-infrared (NIR)-responsive double network shape memory hydrogels were formed by chemically cross-linking Pluronic F127 diacrylate macromer (F127DA) and physical blending of poly(lactide-co-glycolide) (PLGA) with graphene oxide (GO, an energy convertor to convert NIR irradiation to thermal energy). The hydrogels were manufactured with 3D-printing technology using ultraviolet light polymerization. The morphologies and crystalline structure of the hydrogels were determined by scanning electron microscopy (SEM) and X-ray diffraction (XRD). The NIR and thermal activated shape memory properties, mechanical toughness, and cytotoxicity were investigated. The shape memory properties were improved by incorporating GO into the hydrogels and the mechanical properties were enhanced by the addition of PLGA, which served as a second network. The cytotoxicity was assessed by the CCK-8 assay, which revealed no cytotoxicity. The nontoxicity, high mechanical toughness (3.45 MPa in the swollen state), and biosafety at the shape recovery temperature (36 ± 1 °C), which was achieved by NIR stimuli, indicates that shape memory hydrogels can be used in biomedical materials safely. The practical potential of the F127DA/PLGA/GO hydrogels was further revealed by their 3D-printing performance, their shape fixity ratio greater than 85%, and their shape recovery time under 300 s. Our results propose that F127DA/PLGA/GO hydrogels will be a promising material in biomedical applications as a drug carrier and an antibacterial scaffold.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
ACS Biomaterials Science & Engineering
·
2022
·
IF 5.395
Jinwei Luo,Zewei Ma,Fengjuan Yang,Tianhua Wu,Shengwu Wen,Jingxian Zhang,Langhuan Huang,Suiping Deng,Shaozao Tan
Natural polymer gels with sensitivity to near-infrared (NIR) light have attracted the attention of scientists working on intelligent drug delivery systems. Compared to ultraviolet or visible light, NIR light has the advantages of strong trigger levels, deep penetration through affected tissues, and fewer side effects. Herein, we present a topical photothermal hydrogel for NIR-controlled drug delivery. The proposed DexIEM-GM-Laponite hydrogel was prepared through free radical polymerization of vinyl-functionalized dextran (DexIEM), vinyl-modified graphene oxide (GM), and Laponite; thereafter, the hydrogel was loaded with ciprofloxacin (CIP, an antibacterial drug) as a model drug. With the Laponite content increased, the density of crosslinking in the hydrogel increased, and its mechanical properties improved noticeably. Under NIR irradiation, the DexIEM-GM-Laponite hydrogel exhibited a photothermal property, where the surface temperature increased from 26.8 to 55.5 °C. The simulation of subcutaneous drug delivery experiments ex vivo showed that under the specified pork tissue thickness (2, 4, and 6 mm), the CIP release remained NIR-controllable. Additionally, the results of the antibacterial performance tests indicated the excellent antibacterial effect of the hydrogel, and the blood hemolysis ratio of the hydrogel was less than 5%, signifying good blood compatibility. This work will provide an avenue for the application of NIR light-responsive materials in antimicrobial therapy.
研究领域:
材料科学
·
生物医学工程
·
药剂学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2023
·
IF 8.6
Shengnan Huang,Fengxi Chen,Deyu Zhu,Jun Li,Yunling Liu,Rong Chen
Chlorophenols (CPs) are universal and toxic pollutants in nature, as they have been widely detected in surface water, groundwater, sediment, ambient air, soil, and the human body. In this work, novel FeOOH/BiO 2-x binary heterostructure composites with UV-Vis-NIR full-spectrum response were successfully constructed by anchoring highly dispersed amorphous FeOOH on BiO 2-x nanosheets. A series characterization indicated the binary components were successfully obtained. The FeOOH/BiO 2-x photocatalysts exhibited highly enhanced photocatalytic activity for the degradation of chlorophenols under UV-Vis-NIR full-spectrum irradiation. The amorphous FeOOH could effectively broaden the light response range, modulate the energy band structure and promote the separation and transfer of photogenerated electron-holes pairs, thus boosting the activation of molecular oxygen to generate •O 2 – . Furthermore, FeOOH/BiO 2-x maintained excellent photocatalytic performance upon real solar light of varied irradiance for consecutive 7 days, indicative of great potential towards phenolic pollutants degradation in water. The redox couples of Fe 3+ /Fe 2+ and Bi (3+x)+ /Bi 3+ also accelerate the efficient generation of reactive oxygen species over FeOOH/BiO 2-x with improved durability. This work not only contributes to the design of full-spectrum responsive photocatalysts, but also provides a rational strategy for molecular oxygen activation towards the elimination of emerging contaminants.
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Yupei Sun,Qin Lu,Die Dong,Rimei Chen,Zhiping Chen,Zhen Xie,Hongxiang Zhu,Qing Bu,Hui He,Shuangfei Wang
Monitoring-guided therapy is currently the most ideal strategy for closed-loop therapy for skin tumors. Here, a bionic cellulosic in situ hydrogel was engineered by integrating the near-infrared-Ⅱ(NIR-Ⅱ) responsive upconversion nanoprobe into the near-infrared-Ⅰ(NIR-Ⅰ) responsive cellulose nanocrystal (CNC)-based in situ hydrogel for tumor imaging and ablation, dynamic detection and healing of infection wounds. Interestingly, the CNC-integrated nanointerface is noteworthy as it reduces the mutual interference of organic functional components and inorganic nanoparticles in the hydrogel. Moreover, the biocompatible hydrogel can be injected into the body to determine tumor size and location with the assistance of photoacoustic and magnetic resonance imaging, which facilitates precise photothermal ablation of tumors triggered by NIR-Ⅰ laser. The hydrogel with shape adaptability can enable it to cover irregular infection wounds, visualize its bacterial infection status by NIR-Ⅱ irradiation, eliminate drug-resistant bacteria and biofilms, and promote rapid healing of infection wounds through photothermal therapy. Such a cellulose-integrated nanointerface inspires the assembly of nanocomposites materials in hydrogels for closed-loop monitoring-therapy of skin tumors.
研究领域:
生物医学工程
·
肿瘤学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
Materials Advances
·
2022
·Vol. 3
·期 5
·2568-2582
·
IF 0
Qing Zhong,Gen Li,Hui Long,Jingxian Zhang,Suiping Deng,Langhuan Huang,Shaozao Tan
Temperature-sensitive hydrogels are always hotspot and have shown great potential in the field of biomedicine. Herein, we report N,N-diethylacrylamide (DEA) temperature-sensitive nanocomposite hydrogels with improved mechanical properties composed of carbon nanotubes (CNT) and glycidyl methacrylate functionalized quaternized chitosan (QCGM), followed by deciphering the synergy between CNT and QCGM for the influence on the properties of the hydrogels. The prepared hydrogels not only present a temperature-stimulus response but also feature in NIR-stimulus response performance due to the addition of CNT. In particular, the DQ0.5C1 hydrogel exhibits the optimal performance, including high mechanical strength and thermal behavior, and was subjected to examine the photothermal conversion ability, as well as loading the model drug ciprofloxacin hydrochloride (CIP) to investigate the drug release and antibacterial ability under different conditions. Moreover, the biocompatibility experiments and the in vivo full-thickness skin defect model results signify that the hydrogels have excellent biocompatibility and also can promote wound closure with accelerated wound contraction and improve the wound-healing process. All in all, the prepared temperature-sensitive nanocomposite hydrogels with improved mechanical properties, high biological safety, and accelerated wound healing have considerable practicability in the fields of drug delivery and wound dressing.
研究领域:
生物材料学
·
生物医药工程
✓ 已验证
DOI
ACS Applied Bio Materials
·
2018
·
IF 0
Yeye Zhang,Guangzhao Lu,Yuan Yu,He Zhang,Jie Gao,Zhiguo Sun,Ying Lu,Hao Zou
Light has several advantages as the stimulus for a triggered drug release. Currently, the applications of phototriggered drug-release devices (PDDs) are largely limited by two factors: the limited tissue penetration and detrimental effects caused by excitation light (ultraviolet or visible light). To address this disadvantage, this study developed nanocomposites based on upconversion nanoparticles (UC), which could convert near-infrared light to ultraviolet–visible light and trigger drug release. By loading UC and doxorubicin (DOX) into photoresponsive copolymer PEG-NMAB-PLA (PNP), near-infrared responsive copolymer upconversion nanocomposites (PNP-DOX-UC) were constructed. We proved that PNP-DOX-UC showed the fast release and strong cytotoxicity under near-infrared irradiation in vitro. The therapeutic efficacy study indicated that PNP-DOX-UC+hv had the enhanced antitumor efficiency. In the study, UC becoming an internal ultraviolet–visible light source for near-infrared excitation develops an applicable and efficient approach to meet the requirements for UV/vis excitation, which is a major disadvantage in photosensitive materials developed for pharmaceutical and biomedical applications.
研究领域:
生物医学工程
·
药学
✓ 已验证
产品关联
DOI
PubMed
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