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PHYSICAL CHEMISTRY CHEMICAL PHYSICS · 2014 ·Vol. 16 ·期 23 ·11584-11589 · IF 4.198

Thermoresponsive fluorescence of a graphene–polymer composite based on a local surface plasmon resonance effect

Yunyun Huang,Wensheng Lin,Kan Chen,Wenkai Zhang,Xudong Chen,Ming Qiu Zhang

A water-processable blue fluorescent silver nanoparticle@graphene–polymer composite (Ag@G–pNIPAM) consisting of graphene coated with a thermally responsive poly-(N-isopropylacrylamide) (pNIPAM) shell is prepared. The pNIPAM shell swells or collapses as a function of temperature, serving as a means to trap silver nanoparticles in solution and get them sufficiently close to the graphene core to provide fluorescence enhancement based on the local surface plasmon resonance (LSPR) effect. The unique thermoresponsive properties and high enhancement ratio of the material should find application in solution fluorescence enhancers and a variety of biomedical applications, such as cellular uptake, sensing and imaging.

研究领域: 纳米医学 · 生物材料 · 分子影像学 · 生物传感 · 药物递送系统

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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS · 2018 · IF 2.559

Combination of 3-methyladenine therapy and Asn-Gly-Arg (NGR)-modified mesoporous silica nanoparticles loaded with temozolomide for glioma therapy in vitro

Peng Zhang,Menghuan Tang,Qin Huang,Guanjian Zhao,Ning Huang,Xiang Zhang,Ying Tan,Yuan Cheng

Mesoporous silica nanoparticles (MSNPs) of a small diameter were loaded with the anticancer drug temozolomide (TMZ), coated with polydopamine (PDA), and conjugated with Asn-Gly-Arg (NGR) for use in the treatment of glioma. The accumulation of NGR-MSNPs in C6 cells was shown to be higher than that of unmodified MSNPs. Anticancer drugs can cause autophagy in tumor cells, whereas autophagy inhibitors can block this reaction and enhance the therapeutic effect of the drugs. In this study, we demonstrated that MSNP-TMZ-PDA-NGR had stronger autophagy- and apoptosis-inducing effects in C6 cells than TMZ alone, and its anticancer effect was further enhanced when combined with autophagy inhibition. These results demonstrate that the combination of targeting vehicles and autophagy inhibitors may have research value in the treatment of gliomas.

CAS / MDL: 62-31-7 989-38-8

研究领域: 纳米技术 · 药学 · 肿瘤学 · 细胞生物学

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Thermoresponsive fluorescence of a graphene–polymer composite based on a local surface plasmon resonance effect

Combination of 3-methyladenine therapy and Asn-Gly-Arg (NGR)-modified mesoporous silica nanoparticles loaded with temozolomide for glioma therapy in vitro