INORGANICA CHIMICA ACTA
·
2024
·
IF 2.7
An-Na Chen,Lei Liu,Chun-Yang Pan
Three copper complex borates, [Cu(en) 2 ]·[B 4 O 5 (OH) 4 ]·2H 3 BO 3 ( 1 , en = ethylenediamine), [Cu(Eten) 2 ]·[B 5 O 6 (OH) 4 ] 2 ( 2 , Eten = N -ethyl ethylenediamine) and [Cu(Dmen) 2 ]·[B 10 O 13 (OH) 6 ] ( 3, Dmen = N,N -dimethyl ethylenediamine) have been successfully synthesized and structurally characterized by single-crystal X-ray diffraction, PXRD, and FTIR. Their oxoboron clusters are [B 4 O 5 (OH) 4 ] 2− , [B 5 O 6 (OH) 4 ] − and [B 10 O 13 (OH) 6 ] 2− , respectively. Copper ion was used as the central atom, ethylenediamine and its derivatives were selected as ligand. The structure of oxoboron clusters in 1 , 2 and 3 can be modulated through varying ethylenediamine derivative ligand, as well as temperature and pressure of reaction system. These copper complex borates exhibited open framework formed by the interconnection of hydrogen bonds of oxoboron clusters. Moreover, the oxygen reduction reaction activity of these borate-based catalysts was investigated. The half-wave potential values of the products after heating 1 – 3 with carbon at 600 °C (1/C-600, 2/C-600 and 3/C-600) were 0.817, 0.80 and 0.73 V, respectively.
研究领域:
材料化学
·
电催化
·
配位化学
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产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF ONCOLOGY
·
2014
·Vol. 45
·期 5
·2092-2100
·
IF 2.773
Yun Fu,Yingli Yang,Sufeng Zhou,Youxun Liu,Yanbin Yuan,Shaoshan Li,Changzheng Li
The Mannich base containing ciprofloxacin and kojic acid structural units was prepared and evaluated in antitumor activity. The enhancement in antitumor activity was observed both from the Mannich base (IC50: 103.3±5.0 µM for HepG2, 87.9±8.0 µM for HCT-116 cell) and its copper complex (IC50: 11.5±1.8 µM for HepG2, 44.4±2.5 µM for HCT-116 cell) compared to the ciprofloxacin and kojic acid. The mechanistic studies via RT-PCR, cell cycle analysis, mitochondrial membrane potential measurement, inhibition of topoisomerase and molecular docking indicated that there is a different molecular mechanism between the Mannich base and its copper complex. The cytotoxicity of the Mannich base was involved in apoptosis, cell cycle arrest, depolarization of mitochondrial membrane and weaker topoisomerase II inhibition, but the copper complex exerted its cytotoxicity mainly through dual topoisomerase inhibition, especially stabilizing the intermediate of cleavage DNA-topoisomerase complex.
研究领域:
药理学
·
肿瘤学
·
分子生物学
✓ 已验证
DOI
PubMed
高影响因子
International Journal of Electrochemical Science
·
2023
·
IF 1.5
Waqar Uddin
A new analytical approach for the kinetic determination of 2,7-dihydroxynapthalene (2,7-DHN) by perturbation effect with its narrow concentration range on Belousov-Zhabotinsky (BZ) oscillator catalyzed by tetra-aza-macrocyclic copper complex catalyst ([CuL](ClO 4 ) 2 was reported in this paper. The Ligand “L” in this complex is 5,7,7,12,14,14-hexemethyl-1,4,8,11-tetraazacyclotetradeca-4,11-diene. Perturbation experiments were performed after optimizing the oscillation parameters which indicates that the change in the oscillation amplitude (ΔA) is directly proportional to the concentration of 2,7-DHN added in the range of 4.50 × 10 -4 mol L -1 to 1.80 × 10 -3 mol L -1 with the correlation coefficient of 0.98. The calculated relative standard deviation (RSD) from the 6 measurements obtained by the injection of 5.00 × 10 -3 mol L -1 is 1.90 %. The lower limit of detection (LOD) is 2.10 × 10 -4 mol L -1 . Factors that influence the oscillation system were studied. A reaction perturbation mechanism was proposed based on a novel FKN model.
研究领域:
分析化学
·
电化学
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产品关联
DOI
PubMed
高影响因子
Small
·
2024
·Vol. 20
·期 35
·2401756
·
IF 13
Meng Yuan,Ke Han,Hong Yang,Li Mi,Chaofeng Huang,Xun Hu,Fei He
Fabrication of nanozyme with catecholase-like catalytic activity faces the great challenge of merging outstanding activity with low cost as well as simple, rapid, and low-energy-consumed production, restricting its industrial applications. Herein, an inexpensive yet robust nanozyme (i.e., DT-Cu) via simple one-step coordination between diaminotriazole (DT) and CuSO 4 within 1 h in water at room temperature is constructed. The asymmetric dicopper site with CuN 3 O configuration for each copper as well as Cu─O bond length of ≈1.83 Å and Cu···Cu distance of ≈3.5 Å in DT-Cu resemble those in catechol oxidase (CO), which ensure its prominent intrinsic activity, outperforming most CO-mimicking nanozymes and artificial homogeneous catalysts. The use of inexpensive DT/CuSO 4 in this one-pot strategy endows DT-Cu with only ≈20% cost of natural CO per activity unit. During catalysis, O 2 experienced a 4e-dominated reduction process accompanied by the formation of 1 O 2 and H 2 O 2 intermediates and the product of H 2 O. Benefiting from the low cost as well as the distinctive structure and superior intrinsic activity, DT-Cu presents potential applications ranging from biocatalysis to analytical detection of biomolecules such as epinephrine and beyond.
研究领域:
生物化学
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材料科学
·
催化反应
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产品关联
DOI
PubMed
高影响因子
CRYSTENGCOMM
·
2017
·Vol. 19
·期 17
·2349-2358
·
IF 3.474
Yu-Peng Zhou,Zhang-Wen Wei,Zhuo-Jia Lin,Hui-Tao Ling,Zhengang Guo,Mei Zhang,Chi-Keung Lam,Bao-Hui Ye,Hsiu-Yi Chao
With the idea of supramolecular hosts encircling monoanions, a series of urea-containing trinuclear cationic copper complexes were designed, prepared and structurally analyzed. Copper(I) acetylides [Cu3(μ-dppm)3(μ3-η1-CCC6H4-4-NHC(O)NHC6H4-4-R)2]+ (dppm = bis(diphenylphosphino)methane; R = NO2 (1), CF3 (2), Cl (3), H (4), tBu (5), and OCH3 (6)) were prepared with F−, BF4−, or NO3− present as the anion. Eight 1-D anion coordination polymers (ACPs), 1·F, 2·F, 3·BF4, 4·F, 5·F, 5·BF4, 5·NO3 and 6·0.5F·0.5BF4, were clearly determined by X-ray diffraction. Diversity in the polymeric architecture is generated by both the choice of R-group used and anion present. 2·F, 3·BF4, 4·F, and 5·F show linear 1-D structures; 5·BF4 and 5·NO3 feature single-stranded helical structures; 1·F and 6·0.5F·0.5BF4 exhibit meso-helical structures. Solid state UV-vis absorption and luminescence properties are also discussed.
研究领域:
化学
·
材料科学
✓ 已验证
DOI
高影响因子
ELECTROPHORESIS
·
2012
·Vol. 33
·期 11
·1589-1594
·
IF 3.303
Lin Wang,Ying Liu,Haoyue Xie,Zhifeng Fu
A transition metal chelate unstable at a high oxidation state, diperiodatocuprate (III) (K 5 [Cu(HIO 6 ) 2 ], DPC), was synthesized and applied in the luminol-based chemiluminescence (CL) system for highly sensitive CE end-column detection of dopamine (DA). This method was based on the fact that DA enhanced the CL emission resulting from the reaction between luminol and DPC in alkaline medium. The DPC-luminol-DA CL system showed very intensive emission and very fast kinetic characteristics, thus resulting in a high sensitivity in flow-through detection mode for CE. Under optimal conditions, the linear range was 1.0 × 10 −8 –5.0 × 10 −5 g/mL ( R 2 = 0.9984) with a limit of detection of 6.0 × 10 −9 g/mL (S/N = 3). The RSDs of the peak height and the migration time were about 4.2 and 2.4% for a standard sample at 3.0 × 10 −6 g/mL ( n = 5), respectively. The presented method has been successfully used for the determination of DA in commercial preparation and human urine samples after clean-up using SPE.
研究领域:
分析化学
·
生物医学
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DOI
PubMed
高影响因子
JOURNAL OF HETEROCYCLIC CHEMISTRY
·
2019
·Vol. 56
·期 12
·3354-3362
·
IF 1.241
Zi-Bo Yang,Dong-Dong Li,Xiu-Mei Zhao,Lu-Yao Wang,Lin-Lin Dai
Five innovative ternary copper (II) complexes [Cu (OH-PIP)(Phe)Cl]( 1 ), [Cu (OH-PIP)(Gly)(H 2 O)]NO 3 ·2H 2 O ( 2 ), [Cu (OH-PIP)(Ala)(Cl)]·H 2 O ( 3 ), [Cu (OH-PIP)(Met)]PF 6 ·2H 2 O ( 4 ), and [Cu (OH-PIP)(Gln)(H 2 O)]Cl·3H 2 O ( 5 ) have been synthesized and characterized by infrared spectroscopy, elemental analysis, and single crystal X-ray diffraction analysis. X-ray crystallography showed that all Cu atoms were five-coordinated in a square-pyramidal configuration. They are screened for in vitro cytotoxicity against a panel of human cancer cell lines CAL-51, MDA-MB-231, HeLa, MCF-7, SGC-7901, A549, K562, and SMMC-7721. The most promising results were achieved for complexes 1 to 5 , with the IC 50 values in the range of 0.082μM to 0.69μM (against CAL-51 cell lines). The anticancer activities against CAL-51, MDA-MB-231, and MCF-7 were higher than that of Carboplatin. The mechanism studies showed that complexes 1 to 5 could inhibit proteasome activity, induce apoptosis, and inhibit cell proliferation, indicating their great potential as proteasome inhibitors for triple-negative breast cancer therapy.
研究领域:
生物化学
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药物化学
·
肿瘤学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MOLECULAR STRUCTURE
·
2018
·
IF 2.011
Yi-Chun Chu,Tian-Tian Wang,Xiang-Yu Ge,Peng-Hao Yang,Wei Li,Jing Zhao,Hai-Liang Zhu
Two Cu(II) complexes of the non-steroidal anti-inflammatory drug Naproxen were synthesized, characterized and evaluated for anti-inflammatory, analgesic, ulcerogenic and urease inhibition activities. The complex 1 [Cu(nap) 2 (H 2 O) 3 ]·H 2 O was reported previously, and the crystal structure of complex 2 [Cu(nap) 2 (dap)(H 2 O)] (nap = Naproxen, dap = 1,3-diaminopropane) was confirmed by X-ray diffraction crystallography . The anti-inflammatory and ulcerogenic study showed that the compounds 1 and 2 were the promising anti-inflammatory agents and demonstrated significant gastric tolerance when compared with Naproxen, especially for complex 1 with the edema inhibition of 93.6% after 3 h, and ulcer index of 15 ± 2. Analgesic and urease inhibition assay showed that complex 2 was a potent urease inhibitor with the IC 50 value of 1.69 ± 0.08 μ M and pain inhibition value of 65%. As effective urease inhibitors, molecular docking study was performed to investigate the binding mode of the complexes with urease.
研究领域:
药物化学
·
生物无机化学
·
药理学
✓ 已验证
DOI
高影响因子
JOURNAL OF COORDINATION CHEMISTRY
·
2014
·
IF 2.212
Yu Jin,Chun-Hua Yu,Wen Zhang
Protonated benzylamine and its N-methylated derivatives, [C6H5CH2NH3−n(CH3)n]+ (n = 0−3), have been adopted as cations in chlorocadmate(II) and chlorocuprate(II) complexes, showing inorganic–organic hybrid architectures. For the Cd(II) compounds, the anionic structures vary from perovskite-type layers (n = 0) to chains (n = 1–3). For Cu(II) compounds, the anionic structures range from perovskite-type layers (n = 0), chains (n = 1) to mononuclear species (n = 2–3). Coordination geometries of the metal ions and intermolecular interactions have been analyzed. Their dielectric properties have been measured.
研究领域:
无机化学
·
材料科学
✓ 已验证
DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2018
·
IF 5.667
Datong Wu,Jiapei Yang,Yonggang Peng,Yin Yu,Jie Zhang,Lili Guo,Yong Kong,Jinlong Jiang
It is desirable to develop an approach for highly enantioselective recognition by using electrochemical analysis. Here, a novel chiral poly(ionic liquid)-metal complex ( S , S )-PCIL-5-Cu(II), derived from (1 S ,2 S )-1,2-diphenyl-1,2-ethanediamine, is synthesized through the multi-step route. Combined with the polymer bearing the electroactive unit, an electrochemical chiral sensor is constructed by using ( S , S )-PCIL-5-Cu(II) as modification on the electrode surface for the first time. It is observed that the electrochemical sensor is successfully applied to chiral recognition of various acids by comparing signals including the peak current ( I P ) and the oxidation peak potential ( E P ). Specifically, L or ( S ) forms exhibit higher I P compared to D or ( R ) forms. For example, the peak current ratio ( I L / I D ) for malic acid is 24.8. Meanwhile, E P of D -malic acid is located negatively versus L -malic acid with the separation difference of 88 mV. Additionally, a good linear relationship between the ee value and I P is achieved. In brief, our results highlight the feasibility of the proposed approach for electrochemical chiral recognition and ee determination, which can further advance the feasibility of the functional poly(ionic liquid).
研究领域:
分析化学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
DALTON TRANSACTIONS
·
2021
·Vol. 50
·期 42
·15198-15209
·
IF 4.39
Ying Lu,Tong Zhang,Yue-Xian Zhang,Xiao-Jing Sang,Fang Su,Zai-Ming Zhu,Lan-Cui Zhang
A new polyoxometalate (POM)-based organic–inorganic hybrid Cu-coordination polymer, namely {((Cu(bipy))2(μ-PhPO3)2Cu(bipy))2H(PCuW11O39)·3H2O}n (denoted as compound 1, bipy = 2,2′-bipyridine, PhPO3 = phenylphosphonate), was self-assembled hydrothermally. Single-crystal X-ray diffraction (SC-XRD) analysis shows that two unique types of 1D chains are present in compound 1, i.e. Cu(II)-organophosphine and organonitrogen complex cation ([((Cu(bipy))2(μ-PhPO3)2Cu(bipy))2]4+) chains and Cu-monosubstituted Keggin-type polyoxoanion ([PCuW11O39]5−) chains, forming a hetero-POM. Crystalline compound 1 as a new enzyme immobilization support exhibited a high horseradish peroxidase (HRP) loading capacity (268 mg g−1). The powder X-ray diffraction (PXRD), FTIR, zeta potential, confocal laser scanning microscopy (CLSM) and circular dichroism (CD) results show that HRP is only immobilized on the surface of compound 1 through simple physical adsorption without a secondary structure change. This POM-immobilized enzyme (HRP/1) was first used for degradation of pollutants in wastewater, and it showed a high degradation efficiency and TOC removal efficiency for phenol, 4-chlorophenol (4-CP) and 2,4-dichlorophenol (2,4-DCP) within 30 min reaction time. Moreover, HRP/1 exhibited better operational and storage stabilities and reusability compared with free HRP. This work suggests that POMs can be used as new supports for enzyme immobilization and POM-immobilized enzymes may be used as a new kind of biocatalyst for degradation of phenolic pollutants.
研究领域:
材料科学
·
环境科学
·
生物化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Green Processing and Synthesis
·
2022
·Vol. 11
·期 1
·445-457
·
IF 3.97
Ziqian Wu,Zhihuan Fu,Yunbo Tian,Murtaza Hasan,Liting Huang,Yuanting Yang,Cuijing Li,Ayesha Zafar,Xugang Shu
The emergence of drug-resistant bacteria and the lack of effective antimicrobial agents have posed a threat to public safety, so a new efficient strategy is needed to deal with the increasing severity of bacteria. Herein, a substitute antibacterial agent with high stability and biocompatibility was synthesized by incorporating lysine hydrochloride and copper sulfate pentahydrate following the liquid-phase synthesis method. The composition and structure of the Cu( ii ) complex (Lys–Cu) were characterized by performing ultraviolet-visible spectrophotometry, Fourier-transform infrared spectroscopy, X-ray diffractometry (XRD), thermogravimetric analysis-differential scanning calorimetry, and single-crystal XRD. The crystal structure of Lys–Cu belongs to a monoclinic system, space group P 2 1 , with cell parameters of a = 5.14350(10), b = 16.8308(2), c = 11.4915(2) Å, Z = 2, and D = 1.548 g·cm −3 . Bacteriostatic tests were carried out on Escherichia coli and Staphylococcus aureus . The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values of Lys–Cu against S. aureus were 0.3125 and 0.9250 mg·mL −1 , respectively. The MIC and MBC values of Lys–Cu against bacterial strain E. coli were 0.4685 and 0.9250 mg·mL −1 , respectively.
研究领域:
化学
·
微生物学
·
材料科学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）