JOURNAL OF APPLIED POLYMER SCIENCE
·
2021
·Vol. 138
·期 29
·50685
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IF 3.125
Ngoc Minh Ho,Thuy Chinh Nguyen,Thi Thanh Van Tran,Tien Dung Nguyen,Hoang Thai
The epoxy/silica nanocomposites containing a wide range of isopropyltri[di(octyl) phosphate] titanate coupling agent (KR-12) modified nanosilica (m-nanosilica) loading (0–7 wt%) cured with tetrabutyl titanate hardener were prepared. Their morphology, thermal stability, thermal expansion, and mechanical properties including hardness, abrasion resistance were investigated. The wetting ability of epoxy-nanosilica systems on glass surface was assessed based on static contact angle. The obtained results showed that the contact angle of the nanocomposites containing m-nanosilica is slightly changed as compared to the contact angle of pure epoxy resin and lower than that of the nanocomposite containing unmodified nanosilica. The data of dynamic mechanical analysis of the nanocomposites using different nanosilica content indicated that the presence of m-nanosilica lowered the recovery energy of the nanocomposites to 41.62% as compared to neat epoxy. The limiting oxygen index (LOI) of the nanocomposites confirmed that the m-nanosilica increased the flame retardance of epoxy matrix. When using 7 wt% of m-nanosilca, the LOI value of the nanocomposite was 27.4 while this index of neat epoxy was 21.6. The scanning electron microscopic images of residual char combustion of the nanocompsites indicated a formation of nanosilica layer contributed to restrain combustion of the material.
研究领域:
材料科学
·
化学工程
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DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2022
·
IF 9.965
Jieding Wei,Renqiang Zhao,Dian Luo,Xiangyu Lu,Wenxiu Dong,Yucheng Huang,Xiaomei Cheng,Yonghong Ni
Much effort has been devoted to improving the photocatalytic capacity of graphitic carbon nitride (g-C 3 N 4 ). In this paper, we reported the successful synthesis of a hybrid photocatalyst with superb photocatalytic hydrogen production activity through decorating atomically precise Ni 6 (SC 2 H 4 Ph) 12 nanoclusters on g-C 3 N 4 nanosheets (labeled as Ni 6 /g-C 3 N 4 ) at room temperature. Zeta potential experiments demonstrated that the electrostatic interaction between Ni 6 and g-C 3 N 4 led to the formation of Ni 6 /g-C 3 N 4 . The photocatalytic measurements revealed that the 5 %-Ni 6 /g-C 3 N 4 prepared with the original mass ratio of m(Ni 6 )/m(g-C 3 N 4 ) = 1/20 exhibited the strongest hydrogen production activity. In the system with triethanolamine (TEOA) as the sacrifice agent, the visible-light hydrogen production rate reached up to 5.87 mmol h −1 g −1 , approximately 290 times higher than that of pure g-C 3 N 4 (0.02 mmol h −1 g −1 ). Density functional theory (DFT) calculations testified that the above significant enhancement of photocatalytic hydrogen evolution of the hybrid photocatalyst arose from the photogenerated electrons transfer from Ni 6 to g-C 3 N 4 .
研究领域:
材料科学
·
催化化学
·
理论计算
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DOI
PubMed
高影响因子
CHEMOSPHERE
·
2019
·
IF 5.108
Nannan He,Shihai Cao,Lihao Zhang,Zhidan Tian,Huan Chen,Fang Jiang
The porous graphitic carbon nitride nanosheets (PCNSs) with high yields were synthesized by using one–step chemical exfoliation method. PCNSs accelerated separation efficiency of photo-generated electron−hole pairs in comparison to bulk graphitic carbon nitride. The PCNS5 (exfoliation for 5 h) exhibited optimal photocatalytic disinfection capability towards Escherichia coli K-12 under simulated solar light irradiation with complete disinfection of 6.5 log 10 cfu/mL of E. coil K-12 within 2 h. The enhanced photocatalytic activity of PCNS5 originated from mesoporous nanosheet structure. The possible mechanism of photocatalytic disinfection has proposed that intracellular reactive oxygen species levels and the activities of antioxidant enzymes (e.g., catalase and superoxide dismutase) were enhanced. Transmission electron microscope images observed during photocatalytic disinfection process suggested that the cell membrane was regarded as the first target for oxidation, resulting in a faster leakage of cytoplasmic content and finally degradation of DNA leading to bacterial death. Furthermore, the trapping experiment showed that superoxide radical (•O 2 − ) and holes (h + ) were responsible for E. coli K-12 disinfection by PCNS5.
研究领域:
微生物学
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环境科学
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材料科学
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DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2024
·
IF 8.1
Suwan Cui,Bingqian Bi,Bohao Qi,Nuo Wang,Hao Liu,Yuan Cheng,Xiaojun Sun,Haoshuai Li,Yiming Li,Jinren Lu,Mutai Bao
During frequent transportation, the marine environment is continuously exposed to significant threats from crude oil and organic solvent leakage. Non-covalent self-assembly of organogelator on the adsorbent matrix to fix non-polar solvents is an efficient and sustainable remediation method. This contribution proposes an organogelator-adsorbent composite by blending aluminum 12-hydroxystearate (Al HSA) and expanded graphite (EG) during lignin-based polyurethane foaming. Al HSA molecule synergizes with EG to modulate the shape (hexagonal), oil retention, mechanical property, and hydrophobicity (water contact angle = 151.3°) of the lignin-based polyurethane foam (LPUF) skeleton. Al HSA-LPUF (OTS-LPUF/EAH) superhydrophobic foam exhibits sorption capacity up to 13.2–53.0 g g −1 in various oils and organic solvents. From the microscopic morphology, the Al HSA on the skeleton self-assembles into spherical nanoclusters driven by hydrogen bonding, realizing the capturing of oils and organic solvents. Even after 20 cycles, the foam still has a high oil/water separation capacity and mechanical performance. OTS-LPUF/EAH also shows improved flame retardancy and a 61 % reduction in total smoke release (TSR) compared to pristine LPUF.
研究领域:
材料科学
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环境科学
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产品关联
DOI
高影响因子
MOLECULES
·
2022
·Vol. 27
·期 22
·7804
·
IF 4.927
Danyang Zhang,Xia Li,Xiaoshi He,Yan Xing,Bo Jiang,Zhilong Xiu,Yongming Bao,Yuesheng Dong
Methylglyoxal-induced oxidative stress and cytotoxicity are the main factors causing neuronal death-related, diabetically induced memory impairment. Antioxidant and anti-apoptotic therapy are potential intervention strategies. In this study, 25 flavonoids with different substructures were assayed for protecting PC-12 cells from methylglyoxal-induced damage. A structure–activity relationship (SAR) analysis indicated that the absence of the double bond at C-2 and C-3, substitutions of the gallate group at the 3 position, the pyrogallol group at the B-ring, and theRconfiguration of the 3 position enhanced the protection of flavan-3-ols, and a hydroxyl substitution at the 4′ and meta-positions were important for the protection of flavonol. These SARs were further confirmed by molecular docking using the active site of the Keap1–Nrf2 complex as the receptor. The mechanistic study demonstrated that EGCG with the lowest EC50protected the PC-12 cells from methylglyoxal-induced damage by reducing oxidative stress via the Nrf2/Keap1/HO-1 and Bcl-2/Bax signaling pathways. These results suggested that flavan-3-ols might be a potential dietary supplement for protection against diabetic encephalopathy.Keywords:flavonoids;methylglyoxal;PC-12 cells;structure–activity relationship;oxidative stress;molecular docking
研究领域:
药理学
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神经科学
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生物化学
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分子生物学
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产品关联
DOI
PubMed
高影响因子
Journal of Extracellular Vesicles
·
2025
·Vol. 14
·期 4
·e70068
·
IF 14.5
Jiangbin Chen,Qi Tan,Zimo Yang,Wenjuan Chen,E. Zhou,Minglei Li,Jingjing Deng,Yali Wu,Jiatong Liu,Juanjuan Xu,Mengfei Guo,Yang Jin
Dendritic cell (DC)-derived extracellular vesicles (DEVs) are promising candidates for cancer vaccines, but their therapeutic effects still need further optimization. In this study, we utilized neoantigens, lipopolysaccharide and IFN-γ to induce the maturation of DCs, and then isolated DEVs derived from these mature DCs. We showed that the immune checkpoint inhibitor (anti-CTLA-4 antibody, aCTLA-4) can improve the immunostimulatory function of DEVs by directly activating T cells through immune checkpoint signal blockade. The cytokine interleukin-12 (IL-12), as one of the third signals for T cell activation, can also enhance the capability of DEVs to activate T cells directly. Based on these findings, we designed the engineered DEVs conjugated with IL-12 and aCTLA-4 (DEV@IL-12-aCTLA-4) to improve the therapeutic potential of DEVs by providing sufficient immune regulatory signals. Moreover, the carrier property of DEVs also contributes to the delivery of IL-12 and aCTLA-4 to lymph nodes. This indicates that the conjugation of DEVs with IL-12 and aCTLA-4 constitutes a complementary approach, where IL-12 and aCTLA-4 help to enhance the T cell activation effect of DEVs, and DEVs facilitate the delivery of IL-12 and aCTLA-4. Our results showed that DEV@IL-12-aCTLA-4 can enhance the Th1 immune response and reverse exhausted CD8 + T cells in the tumour microenvironment, effectively inducing robust T cell immune responses and inhibiting tumour growth in tumour-bearing mice. Overall, this study expands the theoretical foundation of DEVs and provides a universal strategy for optimizing cancer combination immunotherapy by reprogramming DEVs.
研究领域:
免疫学
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肿瘤学
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2022
·
IF 16.744
Tianrui Cui,Yancong Qiao,Ding Li,Xiaorui Huang,Le Yang,Anzhi Yan,Zhikang Chen,Jiandong Xu,Xichao Tan,Jinming Jian,Zhen Li,Shourui Ji,Houfang Liu,Yi Yang,Xuegong Zhang,Tian-Ling Ren
With the advent of an aging society and increasing concern for cardiovascular health, comfortable long-term electrocardiographic (ECG) monitoring systems in daily life are much in demand. If the system can give real-time feedback on cardiovascular status and offer timely personalized advice like doctors, it will be beneficial to promote cardiovascular health and alleviate the imbalance of medical resources. Herein, we report a multifunctional, conformal, and air-permeable electronic skin (e-skin) based on MXene-Polyurethane mesh (MPM). When used as ECG electrodes, the e-skin shows ultra-low electrode–skin contact impedance (4.68 kΩ at 1 kHz), high signal-to-noise ratio (16.5 dB), and high breathability (2.1838 kg/m 2 /day), and can be continuously worn for at least 7 days. As a strain sensor, the e-skin exhibits a large measurement range (>40 %) and unique segmental sensitivity (GF = 172.54 in 0 ∼ 18.64 % and 79.38 in 18.64 ∼ 50 %), which is suitable for detecting both subtle and large physiological signals. More significantly, by combining the MPM e-skin with a flexible printed circuit board (FPCB) and a merged convolutional neural network & long-short-term memory (CNN & LSTM) intelligent algorithm, the acquired wearable intelligent e-skin system can realize daily 12-hour 12-lead ECG monitoring with diagnostic accuracy over 99 % for four arrhythmias. These results show that the MPM e-skin has huge potential in multifunctional intelligent healthcare systems. In particular, an intelligent ECG system similar to a “daily doctor” is proposed for daily long-term cardiovascular health monitoring.
研究领域:
生物医学工程
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柔性电子学
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心血管监测
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智能医疗系统
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转化医学
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DOI
高影响因子
MICROCHEMICAL JOURNAL
·
2023
·
IF 4.8
Qian Wei,Yan Yan,Qingmei Ge,Mao Liu,Nan Jiang,Hang Cong,Jiang-Lin Zhao
A novel photoelectrochemical sensor was constructed by ternary layer-by-layer composites of reduced graphene oxide (rGO), graphitic carbon nitride quantum dots (g-C 3 N 4 QDs), and hemicucurbit[12]uril (HemiQ[12]), on the Indium-Tin Oxide (ITO) piece in sequence. Electrochemical Impedance Spectroscopy (EIS) was employed to confirm the successful assembly of the sandwich electrode, and the functionalization of each layer was explored by comparing of the currents with stepwise coating of the materials to achieve the synergistic enhancement of photoelectrochemical intensity. The application of proposed electrode was achieved by ultrasensitive sensing for chloramphenicol (CAP), which provided a limit of detection low to 0.089 nM, with high selectivity, good reproducibility and stability. The acceptable recoveries for the determination of CAP in real samples of honey and milk illustrated the feasibility of the established analytical method.
研究领域:
分析化学
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材料科学
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环境科学
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产品关联
DOI
高影响因子
TOXICOLOGY
·
2024
·
IF 4.8
Linjing Xu,Huan Liu,Yifeng Rang,Lizi Zhou,Xukai wang,Yinhuan Li,Chunhong Liu
Nonylphenol (NP) and octylphenol (OP) are environmental contaminants with potential endocrine disrupting effects. However, there is limited research on the mechanisms and intervention of combined NP and OP exposure-induced neurotoxicity. This study aims to explore the cytotoxicity of combined NP and OP exposure and evaluate the potential of Lycium barbarum polysaccharides (LBP) in mitigating the aforementioned toxicity. In present study, LBP (62.5, 125 and 250 µg/mL) were applied to intervene rat adrenal pheochromocytoma (PC-12) cells treated with combined NP and OP (NP: OP = 4:1, w/w; 1, 2, 4 and 8 µg/mL). The results showed that NP and OP induced oxidative stress, disrupted the 5-hydroxytryptamine (5-HT) and cholinergic systems in PC-12 cells. Additionally, they activated the p38 protein kinase (p38) and suppressed the expression of silent information regulation type 1 (SIRT1), monoamine oxidase A (MAOA), phosphorylated cyclic-AMP response binding protein (p-CREB), brain-derived neurotrophic factor (BDNF) and phosphorylated tropomyosin-related kinase receptor type B (p-TrkB). However, N-acetyl-L-cysteine (NAC) treatment counteracted the changes of signalling molecule p38, SIRT1/MAOA and CREB/BDNF/TrkB pathways-related proteins induced by NP and OP. LBP pretreatment ameliorated combined NP and OP exposure-induced oxidative stress and neurotransmitter imbalances. Furthermore, the application of LBP and administration of a p38 inhibitor both reversed the alterations in the signaling molecule p38, as well as the proteins associated to the SIRT1/MAOA and CREB/BDNF/TrkB pathways. These results implied that LBP may have neuroprotective effects via p38-mediated SIRT1/MAOA and CREB/BDNF/TrkB pathways.
研究领域:
毒理学
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神经科学
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药理学
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环境科学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF CONTROLLED RELEASE
·
2025
·
IF 11.5
Juan Qin,Liang-Wei Si,Yi-Ming Liu,Xin-Xin Huang,Rui-Jie Du,Fei Xiong,Duo Wang,Hai-Dong Zhu
Internal radiation (IR), utilizing iodine-125 ( 125 I) seeds as a radiation source, is a clinically established modality for targeted treatment of malignant tumors. In addition to inducing DNA damage in tumor cells, IR therapy can trigger systemic antitumor immune responses, known as the abscopal effect, through immunogenic cell death (ICD). However, the gradual decline in radioactive output and the inherently limited immunogenicity of IR therapy compromise its overall efficacy, with the abscopal effect rarely observed in clinical settings. To overcome these challenges, we developed a bilayer nanofiber-coated stent integrating 125 I seed-based brachytherapy with sustained, spatiotemporally controlled delivery of interleukin-12 (IL-12). Utilizing FDA-approved PLGA and PEO polymers, the inner layer was engineered for IL-12 loading, while the outer layer acted as a regulatory barrier, achieving a biphasic release profile with sustained cytokine delivery for up to 14 days. In vivo studies demonstrated that the IL-12@IRS (IL-12-loaded 125 I internal radiation stent) effectively enhanced antigen presentation and elicited a tumor in situ vaccination effect, thereby promoting durable local and systemic antitumor immunity. This immuno-radiotherapeutic platform not only improves local tumor control but also offers a promising strategy for overcoming immune resistance and inducing robust systemic antitumor effects.
研究领域:
肿瘤学
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免疫学
·
生物材料
·
转化医学
·
放射治疗
·
药物递送系统
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产品关联
DOI
PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2024
·
IF 8.1
Yi-Hong Wu,Wei Guo,Yu-Zhu Sun,Shu-Ying Sun
Coal-based solid waste, as a secondary resource, contains significant quantities of aluminum, silicon, and lithium resources. The desilication solution is a waste solution with low concentrations of lithium ions, which is produced during the resource utilization process of coal-based solid waste. Developing adsorbents with high lithium selectivity and alkaline stability is important for the recovery of lithium in coal-solid waste alkaline leachate. In this study, resin functionalized with 2-hydroxymethyl-12-crown-4 (2H12C4) is prepared by esterification. The reaction conditions, including resin type, reaction temperature, time, and catalyst dosage, are optimized. The selective adsorption of 2H12C4-D113 is evaluated in a simulated desilication solution. The results show that 2H12C4-D113 with high selectivity for Li + adsorption is successfully synthesized at 1 g of 2H12C4 per g of resin, 110 ℃ reaction temperature, 6 h reaction time, 0.5 g of catalyst per g of resin and 1 mol of anhydrous lithium chloride per mol of 2H12C4. The adsorption rate of the 2H12C4-D113 resin is relatively rapid, and its adsorption kinetics satisfy the proposed second-order kinetic curve, and its Li + adsorption capacity is greatly influenced by Li + concentration. The peaking adsorption capacity of this resin is 58.71 mg/g in pure lithium solution (Li + =200 mg/L) with high alkalinity, and the peaking adsorptive capacity is 9 mg/g in the pre-desilication solution (Li + =274 mg/L, Na + =101 g/L). Furthermore, density functional theory (DFT) is utilized to study the selective adsorption mechanisms, geometrical characteristics, and thermodynamic parameters of the complexes between crown ether and different ions. DFT simulation reveals that 2H12C4-D113 has high selectivity for Li + adsorption with a Li + -O bond length of 1.86–1.88 Å, and an adsorption energy of 2H12C4-Li + (−369 KJ/mol) being the highest among the mental ions.
研究领域:
材料科学
·
环境科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF POWER SOURCES
·
2019
·
IF 7.467
Ting Feng,Haining Wang,Yiyang Liu,Jin Zhang,Yan Xiang,Shanfu Lu
An electrolyte solution that includes redox couples is an essential component of a redox flow battery (RFB), and it directly affects the efficiency, power density, and cycle stability of the device. In this work, 12-phosphotungstic acid (PTA), a keggin type heteropolyacid, is evaluated as a redox active material in negative electrolyte. PTA has high redox reversibility and electrochemical activity with a kinetic constant of 0.015 cm s −1 and a low permeability of 6.17 × 10 −10 cm 2 min −1 through a Nafion ® 211 membrane. A single RFB is assembled with PTA and HI as the negative and positive redox active materials, respectively. The cell has a specific capacity of 12.8 Ah·L −1 at 100 mA cm −2 ; however, it exhibits poor cycle stability because of the osmotic pressure imbalance between the electrolyte solutions, the permeation of I − , and the serious hydrogen evolution side reaction. Using a mixed solution of PTA and HI as electrolytes on both sides of the cell and by adjusting the charge cutoff voltage, the cycle stability improved significantly. During 700 charge/discharge cycles at 100 mA cm −2 , the battery has high coulombic efficiency of 99.6%, energy efficiency around 80.1%, and capacity retention of 99.99% per hour.
研究领域:
能源存储
·
电化学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）