POLYHEDRON
·
2024
·
IF 2.4
Zhengwei Wu,Jiawen Bao,Hongyang Zhang,Yingying Luo,Zhonglu You
Molecular nanoclusters comprising heterometallic Ni-Zn cores are an interesting class of compounds. In this paper, five novel Ni II -Zn II complexes [Ni 2 Zn 2 ClL 3 (HL) 3 ]·0·.25H 2 O ( 1 ), [Ni 2 Zn 2 BrL 3 (HL) 3 ]·0·.25H 2 O ( 2 ), [Ni 2 Zn 2 Br 2 L 2 (N 3 ) 2 (MeOH) 2 ]·2MeOH ( 3 ), [Ni 2 Zn 2 I 2 L 2 (N 3 ) 2 (MeOH) 2 ]·2MeOH ( 4 ), and [Ni 2 Zn 2 I 2 L 2 (N 3 ) 2 (DMF) 2 ] ( 5 ), were prepared from the Schiff base 2-(3-ethoxy-2-hydroxybenzylideneamino)-4-methylphenol (H 2 L). The complexes have been characterized by elemental analysis, IR, UV–Vis spectra. Molecular structures of the complexes have been determined by single crystal X-ray determination. In complexes 1 and 2 , three of the Schiff bases coordinate to the metal atoms via ether oxygen, imino nitrogen and two phenolate oxygen atoms, while the fourth one coordinates through ether oxygen, imino nitrogen and one phenolate oxygen atoms. In complexes 3 , 4 and 5 , all the donor atoms in the Schiff base ligands participate in coordination. The Ni and Zn atoms in the complexes are in octahedral and trigonal bipyramidal coordination, respectively. The anions of the metal salts and the azide anion, as well as methanol and DMF molecules furnish the coordination sphere. The compounds were evaluated for their antibacterial activities on Bacillus subtilis , Staphylococcus aureus , Escherichia coli and Pseudomonas fluorescens , and antifungal activities on Candida albicans and Aspergillus niger . Interestingly, the complexes have effective activities against Bacillus subtilis and Staphylococcus aureus .
研究领域:
无机化学
·
生物化学
·
药物化学
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DOI
高影响因子
NATURAL PRODUCT RESEARCH
·
2022
·
IF 2.488
Ruolan Chen,Ziyang Li,Chan Qin,Peijun Lu,Jiaru Lin,Wenxu Zheng,Yahong Xiong,Chunyuan Li
A novel tyroscherin derivative named pseudallecin A (1) with a natural unprecedented morpholine-2, 3-dione structural unit, and a new biogenic synthesis related organic acid named pseudallecin B (2) were purified from a symbiotic fungus Pseudallescheria boydii derived from Pomacea canaliculata. Their structures were elucidated via spectroscopic analyses and ECD calculation. Pseudallecin A exhibited strong inhibitory activities against both Gram-positive Escherichia coli and Gram-negative Staphylococcus aureus.
研究领域:
微生物学
·
有机化学
·
药理学
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DOI
高影响因子
International Journal of Minerals Metallurgy and Materials
·
2026
·Vol. 33
·期 6
·1886-1899
·
IF 8.8
Zeng Yong,Che Xiyuan,Zhang Lei,Chen Peng,Song Shaoxian,Wang Deshou,Jia Feifei
Thiosulfate gold extraction technology has gained considerable interest owing to its environmental compatibility and broad applicability to diverse ore types. However, the lack of efficient methods to recover Au(S 2 O 3 )
3− 2
from leaching solutions has hindered its industrial implementation. To address this challenge, this study used a thiosulfate leaching solution from quartz-type gold ores to design an activated carbon-coated titanium electrode (Ti@AC) with a porous surface structure. This electrode facilitated the direct reduction of low-concentration Au(S 2 O 3 )
3− 2
to metallic gold (Au 0 ) in solution, achieving a gold recovery of 99.58%, surpassing other recovery methods from the leaching solution by 30%–80%. After ten consecutive 200 L pilot-scale tests, the Ti@AC electrode demonstrated remarkable stability, consistently maintaining a recovery >98% and yielding 20.23 g of gold. The porous architecture of the activated carbon (AC) promoted the adsorption of low-concentration Au(S 2 O 3 )
3− 2
, while its low charge transfer resistance facilitated the efficient conversion of Au(S 2 O 3 )
3− 2
to Au 0 . Moreover, the reduction reaction generated a concentration gradient near the cathode, promoting the diffusion of Au(S 2 O 3 )
3− 2
toward the electrode and ensuring an efficient recovery process. This study provides a feasible strategy for the direct reduction of low-concentration precious metal ions to monomers with high recovery and low costs, which is promising for industrial applications.
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高影响因子
Sensors and Actuators Reports
·
2025
·
IF 7.6
Yuhuai Qin,Wenxue Sun,Joseph Brake,Sulin Gao,Qianqian Li,Xinrong Zhu,Jiang Bian,Xiaobin Wu
Lead ions are an environmental pollutant and a threat to human health. Traditional methods for detecting lead ions suffer disadvantages such as being time-consuming and expensive, therefore there is a need to develop simpler and faster methods. We developed an optimized spectroscopic method to detect lead ions by first identifying a lead-specific chelator 2,3-dimercaptosuccinic acid (DMSA) which was screened using a novel biological screening system and verified by metal chromophore assays. Synthetic gold nanostars (GNSs) were explored for use as probes and we found that DMSA-Pb chelates catalyzed the etching of GNSs in solution resulting in a color change. We observed a change in the longitudinal local surface plasmon resonance (LSPR) peak of GNSs in the presence of DMSA-Pb which could be measured in subsequent experiments. The optimized etching reaction displayed strong sensitivity and selectivity for Pb 2+ and achieved a detection limit of 2 nM less than 2 minutes, which is well below the safety threshold of Pb 2+ in environmental water and food. The Pb 2+ contents of rice, beans, milk, grapes, peaches, and cabbage were detected by the DMSA-Pb GNSs method and were consistent with those of inductively coupled plasma mass spectrometry (ICP-MS). Our study provides a novel and practical approach for rapid, safe, and cost-effective detection of lead ions.
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DOI
高影响因子
FOOD CHEMISTRY
·
2025
·
IF 9.8
Chunjuan Wang,Qin Guo,Ao Gao,Jingmei Zhang,Hailong Wan,Qianchen Liu,Junli Song
A smartphone-assisted fluorescent and colorimetric detection method for nitrite based on 2,3-diaminonaphthalene (DAN) and gold nanoclusters (AuNCs) paper strip was developed. DAN reacts with NO 2 - via a coupling reaction under acidic conditions to generate naphthotriazole (NAT), emitting strong blue fluorescence at 435 nm. The red fluorescence of AuNCs at 650 nm is quenched by the reduction of nitrite. The ratio of fluorescent intensity (I 435 /I 650 ) exhibits a good linear relationship with NO 2 - concentration (0.01–9.0 μg/mL), with LOD and LOQ of 2.3 μg/L and 8.7 μg/L, respectively. The fluorescent detection mode was successfully applied to the determination of nitrite in water and food samples, with recoveries ranging from 80.0 % to 103.0 %. Furthermore, a smartphone-integrated paper strip platform was designed for on-site colorimetric analysis. It was noteworthy that the strip's fluorescence color transitions dynamically from red to blue under ultraviolet light, thereby enabling visual semi-quantification.
研究领域:
分析化学
·
生物传感
·
环境监测
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产品关联
DOI
PubMed
高影响因子
OPTICS AND LASER TECHNOLOGY
·
2025
·
IF 5
Lingjun Zhou,Panyi Wang,Tenglong Sun,Yanan Chen,Muzhi Cai,Wenyan Zheng,Feifei Huang,Ying Tian,Liaolin Zhang,Junjie Zhang
Tellurite glasses with the composition 67TeO 2 -3Al 2 O 3 -xZnO-(30-x)Na 2 O (x = 0–20 mol%) were synthesized via melt-quenching. Raman analysis revealed Al/Zn synergistically strengthened the network via Al-O-Te/Zn-O-Te bonds below 15 mol% ZnO, whereas excess ZnO triggered Zn 2+ /Al 3+ site competition, reducing crystallization resistance. The glass with 15 mol% ZnO (TANZ) shows optimal thermal stability ( T g = 311 °C, ΔT = 139 °C) and serves as the host for obtaining mid-infrared emission. The Ho 3+ /Yb 3+ co-doped TANZ glass shows high absorption and emission cross-sections of 7.36 × 10 –21 cm 2 and 5.86 × 10 –21 cm 2 , respectively, along with a long lifetime of 1.33 ms at 2 μm. These results highlight the potential of TANZ glasses as robust gain materials for mid-infrared fiber lasers.
研究领域:
材料科学
·
光学
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产品关联
DOI
高影响因子
Probiotics and Antimicrobial Proteins
·
2025
·
IF 4.4
Zhang Shuo,Gao Peichao,Wang Qunxin,Liu Shuhui,Okoth Sheila,Zhang Meihua,Ji Helong,Yan Liping,Fan Wentao,Song Suquan
Fatty liver hemorrhagic syndrome (FLHS) has become a common and serious disease in intensive laying hen farming, seriously endangering the productivity and health of laying hens. Although probiotics have been recognized as an emerging candidate therapeutic strategy for liver disease, their effective substances and mechanisms for alleviating FLHS remain to be elucidated. In this study, corticosterone (Cort) was applied to induce FLHS in laying hens, and Lactobacillus plantarum ( L. plantarum 1–2-3) was used for the intervention. The results showed that L. plantarum 1–2-3 treatment significantly ameliorated Cort-induced hepatic steatosis and liver damage in laying hens, as evidenced by decreased levels of triglyceride (TG), total cholesterol (TC), aspartate aminotransferase, and alanine aminotransferase. Importantly, we found that L. plantarum 1–2-3 could biosynthesize gamma-aminobutyric acid (GABA) by expressing glutamic acid decarboxylase. Surprisingly, feeding GABA to laying hens replicated the effect of L. plantarum 1–2-3 in alleviating Cort-induced FLHS. GABA significantly down-regulated the mRNA expression of Acc , Fasn , Cd36 , and Gpam while upregulating the levels of Ppara and Cpt1a . An in vitro verification study showed that GABA decreased TG and TC content in Leghorn male hepatoma cells. Moreover, GABA significantly enhanced antioxidant enzyme activity, inhibited oxidative stress in hepatocytes, regulated the AMPK/NLRP3 signaling pathway, and reduced the protein expression of NF-κB, TNFα, and IL-1β. In conclusion, our study demonstrated that L. plantarum 1–2-3 could effectively alleviate FLHS in laying hens, while GABA was an important postbiotic for L. plantarum 1–2-3 to exert lipid-lowering and anti-inflammatory effects.
研究领域:
微生物学
·
兽医学
·
肝脏病学
·
营养生物化学
·
分子生物学
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产品关联
DOI
PubMed
高影响因子
BIOMATERIALS
·
2021
·
IF 12.479
Jiankun Guan,Yuxin Wu,Xin Liu,Huimin Wang,Ningbing Ye,Zheng Li,Chen Xiao,Zhijie Zhang,Zifu Li,Xiangliang Yang
Cancer stem cells (CSCs) present grand challenges for triple-negative breast cancer (TNBC). Conventional chemotherapy drugs, including Camptothecin (CPT), not only cannot eradicate CSCs but also foster a suppressive immune microenvironment for the initiation and proliferation of CSCs. Herein, we report a novel prodrug CPT–SS–NLG919 (CN) and its nanoformulation [email protected] ( [email protected] ), which potently suppress CSCs by regulating CSCs niche in murine TNBC 4T1 tumors. Via inducing immunogenic cell death (ICD) and simultaneous inhibiting indoleamine 2, 3-dioxygenase (IDO), CN and [email protected] promote DC maturation, decrease Treg cells, mitigate tryptophan consumption, and reduce the amount of IL-6, IL-13, and TGF-β, converting CSCs niche to a hostile condition for CSCs to live in and eliminating CSCs efficiently, thereby inducing efficient tumor inhibition in 4T1 tumor models. Our work represents a new paradigm of eliminating CSCs by regulating tumor immune microenvironment and suggests that CN and its nanoformulation [email protected] are promising candidates for the treatment of intractable TNBC.
研究领域:
肿瘤学
·
药理学
·
免疫学
·
纳米技术
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DOI
PubMed
高影响因子
MOLECULAR BIOLOGY REPORTS
·
2022
·Vol. 49
·期 8
·7665-7676
·
IF 2.742
Jiang Haoran,Wen Xianxin,Zhang Xue,Zhong Xianhua,Li Zhangyong,Zhang Bingyu
Background Hepatocellular carcinoma (HCC) is the main types of primary liver cancer, which shows some abnormal glycosylation, such as the increase of fucose. Lens culinaris agglutinin (LCA), a natural plant lectin that can bind to mannose and fucose, has been reported to be antiproliferative to may tumors. However, the effect of LCA on the vitality and migration ability of human hepatoma cells is not demonstrated. Therefore, the aim of this study is to investigate the effects of LCA on vitality and migration in human hepatoma cells and its potential mechanisms. Methods and results LCA had no significant effect on viability of human hepatoma cells (HCCLM3, MHCC97L and HepG2) and hepatocytes (L02) by CCK-8 kit, but it could inhibit human hepatoma cells migration significantly without affecting hepatocytes by Transwell method. Sugar inhibition assay was used to verify the possible binding site between LCA and human hepatoma cells. The result showed that Mannose- and fucose- related sites were associated with LCA inhibiting human hepatoma cells migration. Moreover, LCA could affect HCCLM3 migration by activating ERK1/2 and JNK1/2/3 signalling pathways. LCA did not affect MMP-2 and MMP-9 of HCCLM3 through gelatinase zymography. However, the results of immunofluorescence standing showed that LCA could reduce the F-actin formation in HCCLM3 via ERK1/2 and JNK1/2/3 signalling pathways. Conclusions LCA might inhibit human hepatoma cell migration by reducing the F-actin formation via the mannose and fucose-mediated ERK1/2 and JNK1/2/3 signalling pathway. This result will deepen people’s understanding on plant lectin as a drug in tumor glycobiology.
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产品关联
DOI
PubMed
高影响因子
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
·
2014
·
IF 3.432
Jing Wu,Linxi Yu,Feifei Yang,Jingjie Li,Peng Wang,Wenbo Zhou,Liwen Qin,Yunqi Li,Jian Luo,Zhengfang Yi,Mingyao Liu,Yihua Chen
A series of 2,3-diaryl-4-thiazolidinone derivatives were synthesized and evaluated for their antiproliferative properties against two well-known cancer cell lines (A549 as human lung cancer and MDA-MB-231 as human breast cancer). Structure activity relationship (SAR) analysis resulted in the discovery of 2-(3-(arylalkyl amino carbonyl)phenyl)-3-(2-methoxy-phenyl)-4-thiazolidinone derivatives with high potent inhibitory effects on the proliferation of both cancer cell lines. Furthermore, several compounds with potent antiproliferative activities displayed excellent inhibitory activities on migration with an IC 50 of about 0.05 μM on MDA-MB-231 cells in two different migration assays. In particular, compound 39 was indicated to suppress tumor growth and metastasis as well as promote survival rate. Intriguingly, this series of analogs have been indicated to inhibit tumor cell proliferation through inducing cell cycle arrest . These results suggested that the new series of 2-(3-(arylalkyl amino carbonyl)phenyl)-3-(2-methoxyphenyl)-4-thiazolidinone derivatives could be regarded and developed as novel highly potential anticancer agents in the future.
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DOI
PubMed
高影响因子
LIQUID CRYSTALS
·
2010
·
IF 1.451
Yan Li,Xinbing Chen,Pei Chen,Zhongwei An,Juan Li
A new series of fused polyheterocyclic aromatic compounds, 7-alkoxybezopyrano[2,3-c]pyrazol-3-one (C-
n
BPP), were synthesised and characterised by infrared, 1H-nuclear magnetic resonance (NMR), 13C-NMR and two-dimensional 1H-13C cosy spectra. Their phase transition behaviour was investigated by differential scanning calorimetry and polarising optical microscopy. All of these compounds showed enantiotropic mesophases with temperature domains of 12–60°C and 22–69°C on heating and cooling processes for a carbon number of the alkoxy chain from 2 to 10. The effect of the length of the alkoxy chain on the mesomorphic properties was discussed. Comparison of C-
n
BPP and several kinds of coumarin derivatives indicated that the intermolecular hydrogen bonding acted as the driving force of the mesophase formation.
研究领域:
有机化学
·
材料科学
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DOI
高影响因子
MATERIALS SCIENCE-POLAND
·
2024
·Vol. 42
·期 2
·70-80
·
IF 1.3
Yanling Yu,Biwu Huang,Yafen Qu,Junshan Qiu,Yong Lai
[2-(3,4-epoxycyclohexyl) ethyl] triphenylsilane was synthesized, using triphenylsilane and 1,2-epoxy-4-vinylcyclohexane as the main raw materials. When the molar ratio of triphenylsilane to 1,2-epoxy-4-vinylcyclohexane was 1.0:1.2, the content of Wilkinson catalyst was 0.4%, the reaction temperature was 90°C, and the reaction time was 6 hours, the yield of [2-(3,4-epoxycyclohexyl) ethyl] triphenylsilane could reach 95.21%. The structure of the synthesized product was analyzed and characterized using FT-IR and 1H-NMR. The synthesized product was added to a bisphenol A-type epoxy resin (E-51) and a modified amine (593 amine) to prepare an adhesive. Then, the adhesive was poured into the mold and cured at 35°C for 8 hours. The cured sample exhibited the best performance when the ECETPS: E-51:593 amine molar ratio was 0.8:7.2:2. Thermal gravimetric analysis (TG) showed that the thermal stability of the cured samples increased relative to pure E-51 amine-cured samples with the synthesized product added. The mechanical properties of the samples were tested using a universal material testing machine, and the results showed a tensile strength of 37.95 MPa and a bending strength of 39.10 MPa.
研究领域:
有机化学
·
材料科学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）