ACS ES&T Engineering
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2024
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IF 7.4
Wenting Zhou,Yuanmiaoliang Chen,Dejun Feng,Lu Xiao,Xianhui Li,Zhangxin Wang
Membrane wetting induced by liquid absorbents severely hinders the practical applications of a gas–liquid membrane contactor (GLMC) for carbon dioxide (CO2) capture. To overcome this challenge, membranes with enhanced wetting resistance have been developed, but their CO2 absorption rates have often been overlooked. Herein, we unveil the interplay between membrane wetting resistance and the CO2 absorption rate for different GLMC membranes and elucidate the underlying mechanisms. Specifically, two representative membranes were used in this study: a polyvinylidene fluoride (PVDF) membrane with interconnected pores and an anodic aluminum oxide (AAO) membrane with disconnected pores. For each membrane, we modify it using fluoroalkyl silane agents with different chain lengths to obtain a range of membranes with different wetting resistances. Through GLMC tests, we identify a trade-off between membrane wetting resistance and the CO2 absorption rate for the PVDF membranes, i.e., an enhanced wetting resistance leads to a lowered initial CO2 flux. In contrast, for the AAO membranes, the CO2 absorption rate is independent of the membrane wetting resistance. Using electrochemical impedance and ultrasonic time-domain reflectometry analysis, the interplay between membrane wetting resistance and the CO2 absorption rate can be explained by the change of the gas–liquid interfaces in the GLMC membranes. This study reveals the critical role of the gas–liquid interface in GLMC for CO2 capture, providing valuable insights into membrane development for environmental applications of GLMC.
研究领域:
环境工程
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化学工程
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材料科学
✓ 已验证
产品关联
DOI
高影响因子
International Journal of Extreme Manufacturing
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2024
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IF 16.1
Youdi Hu,Yanlei Hu,Zhenyu Wang,Jiale Yong,Wei Xiong,Dong Wu,Shixiang Xu
Surface enhanced Raman scattering (SERS) enabled trace molecules detection has important application prospects. By structuring/modifying the surface of SERS substrate, molecules in highly-diluted solution can be concentrated into localized active area for highly sensitive detection. However, subject to the difficulty of fabrication process, it remains challenging to balance hot-spots construction and concentration capacity to molecules simultaneously. Therefore, preparing SERS substrate with dense ordered hot-spots and efficient concentration capacity is of great significance for highly sensitive detection. Herein, we propose the Ag and fluoroalkyl modified hierarchical armour substrate (Ag/F-HA), which has a double-layer stacking design to combine analyte concentration with hotspot construction. The micro armour structure fabricated by femtosecond-laser processing to serve as a superhydrophobic and low-adhesive surface to concentrate molecules, while anodic aluminum oxide (AAO) template creates nanopillars array serving as dense and ordered hot spots. Under the synergy action of hot-spots and molecule concentration, Ag/F-HA achieves the detection limit down to 10−7 M of Doxorubicin (DOX) molecules with a relative standard deviation (RSD) of 7.69%. Additionally, Ag/F-HA exhibits the excellent robustness to resist external disturbance such as liquid splash or abrasion. Based on our strategy, the SERS substrates with directional analyte concentration are further explored by patterning microcone array with a defect. This work opens a way to the realistic implementation of SERS in diverse scenarios.
研究领域:
分析化学
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材料科学
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纳米技术
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生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
ADVANCED MATERIALS
·
2024
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IF 27.4
Haobo Wang,Qing You,Bei Kang,Huaqing Jing,Zhiyuan Shi,Sona Krizkova,Zbynek Heger,Vojtech Adam,Xiaoyuan Chen,Nan Li
Hepatic fibrosis progresses concomitantly with a variety of biomechanical alternations, especially increased liver stiffness. These biomechanical alterations have long been considered as pathological consequences. Recently, growing evidence proposes that these alternations result in the fibrotic biomechanical microenvironment, which drives the activation of hepatic stellate cells (HSCs). Here, an inorganic ascorbic acid-oxidase (AAO) mimicking nanozyme loaded with liquiritigenin (LQ) is developed to trigger remodeling of the fibrotic biomechanical microenvironment. The AAO mimicking nanozyme is able to consume intracellular ascorbic acid, thereby impeding collagen I deposition by reducing its availability. Simultaneously, LQ inhibits the transcription of lysyl oxidase like 2 (LOXL2), thus impeding collagen I crosslinking. Through its synergistic activities, the prepared nanosystem efficiently restores the fibrotic biomechanical microenvironment to a near-normal physiological condition, promoting the quiescence of HSCs and regression of fibrosis. This strategy of remodeling the fibrotic biomechanical microenvironment, akin to “pulling the rug out from under”, effectively treats hepatic fibrosis in mice, thereby highlighting the importance of tissue biomechanics and providing a potential approach to improve hepatic fibrosis treatment.
研究领域:
肝病学
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生物医学工程
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药理学
✓ 已验证
DOI
PubMed
高影响因子
Journal of Physical Chemistry Letters
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2023
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IF 5.7
Yirong Su,Peng Ran,Juan Hui,Wenbo Ma,Zeng Chen,Haiming Zhu,Yang “Michael” Yang
Traditional indirect flat-panel X-ray imaging (FPXI) uses inorganic scintillators with high-Z elements, which lack spectral information about X-ray photons and reflect only integrated X-ray intensity. To address this issue, we developed a stacked scintillator structure that combines organic and inorganic materials. This structure allows X-ray energies to be distinguished in a single shot by using a color or multispectral visible camera. However, the resolution of the resulting dual-energy image is primarily limited by the top scintillator layer. We inserted a layer of anodized aluminum oxide (AAO) between the double scintillators. This layer limits the lateral propagation of scintillation light, improves imaging resolution, and acts as a filter for X-rays. Our research demonstrates the advantages of stacked organic–inorganic scintillator structures for dual-energy X-ray imaging and provides novel and practical applications for relatively low-Z organic scintillators with high internal X-ray-to-light conversion efficiency.
研究领域:
医学成像
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材料科学
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辐射探测
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光学材料
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X射线光谱学
✓ 已验证
DOI
高影响因子
ANALYTICA CHIMICA ACTA
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2022
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IF 6.911
Wenrui Ma,Lulu Liu,Xu Zhang,Xingfei Liu,Yi Xu,Shunbo Li,Muling Zeng
Developing sensitive and miniaturized biosensors for the detection of microRNAs (miRNAs) is highly desirable due to their association with early cancer diagnosis and prognosis. Here, a new microfluidic-based biosensor, combined with multifunctional nanosurface and DSN-assisted target recycle amplification strategy, is designed for the detection of miRNA-21. The design of nanosurface includes gold nanoparticles on porous anodic aluminum oxide (AAO) for surface enhanced Raman scattering (SERS) substrate, Au MBA @Ag core-shell nanoparticles for SERS nanotags and single-stranded DNA (ssDNA) in between for miRNA capture and nanotags immobilization. When the target miRNA is present near the nanosurface, it will be captured by ssDNA via hybridization reaction. Then, triggered by the DSN-assisted target recycle process, the freshly formed DNA/miRNA heteroduplexes are cleaved by DSN enzyme into DNA fragments and single-strand miRNA. The SERS nanotags are also dissociated from the nanosurface, leading to decrease of SERS signal. The cleaved target miRNA can be captured and SERS nanotags are released again in the next cycle, resulting in amplification of detection signal. To improve the accuracy of this biosensor, the functionalized AAO membrane is subdivided into two groups - AAO/Au array linked with encoded core-shell SERS nanotags acting as a reactor and primary detector and AAO/ [email protected] array serving as a collector and secondary detector for the dissociative SERS nanotags from the reactor. The decrease of SERS signal in primary detector and increase of signal in secondary detector ensures the accuracy and it is called dual-SERS detection strategy. The detection of miRNA-21 can be achieved with only 30 μL sample and 10 μL enzyme and a wide linear range of 10 fM∼10 nM is obtained. In addition, the microfluidic dual-SERS detection strategy can greatly reduce the possibility of false positive or false negative in single detection mode and it can be applied to the simultaneous detection of multiple miRNAs via integrating different probes.
研究领域:
生物传感器
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微流控技术
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表面增强拉曼散射（SERS）
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纳米技术
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癌症诊断
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分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）