ACS Applied Polymer Materials
·
2022
·
IF 4.855
Yingjun Yang,Xiaoqiang Hou,Shufang Ma,Siyuan Huang,Jingyi Chen,Zejian Fang,Guanjian Nie,Bingshe Xu,Christophe A. Serra,Shukai Ding
AIEgens have attracted intensive interest because of the unusual fluorescence feature. Although AIEgen-based materials have been developed for responding to the diverse ex-stimuli, such as mechano-, electro-, and thermal-stimuli, the practical application of AIEgen-based thermoluminescence is hampered for the following reasons: (1) high cost attributed to the complicated chemical modification, (2) low contrast and responsiveness resulting from the chromophoric property of the thermal functional group. In this contribution, a facile encapsulation technology-based strategy without any chemical modifications is developed to form the encapsulated TPE nanogels for the preparation of the AIEgen-based thermoluminescence. Thanks to the coexistence of the liquid and solid phases, the nanogel-based AIEgens can not only attain the transparent feature but also a reversible transformation between the single-molecule and aggregated state by ex-thermal stimuli. In the nanogel, the two aggregated states of TPE molecules are observed that result from being tangled by poly-TPGDA and from being self-assembled, respectively. Furthermore, the nanogels prepared at different temperatures demonstrate the controllable fluorescence intensity. The higher preparation temperature results in more aggregated TPE and higher fluorescence intensity. Finally, the nanogels are easily formed into the transparent film thermometers because of their flowability, which shows a switchable and stable fluorescence by ex-thermal stimuli. The transparent film thermometer demonstrates high potential in anticounterfeiting technology and biological imaging.
✓ 已验证
产品关联
DOI
高影响因子
Cell Reports Physical Science
·
2022
·
IF 7.832
Lei Lu,Mengyao Yang,Youngseo Kim,Tingting Zhang,Nahyun Kwon,Haidong Li,Sungnam Park,Juyoung Yoon
Biocompatible aggregation-induced emission (AIE) materials from natural resources are of great interest for a variety of potential applications. Here, we report the unconventional AIE nature of the green tea polyphenol epigallocatechin gallate (EGCG), which is investigated by observing the disappearance and reoccurrence of fluorescence when EGCG is dissolved and recrystallized in aqueous solutions. The intermolecular through-space conjugation and structural rigidification induced by multiple intermolecular H-bonds play critical roles in the AIE phenomenon. This inspires the development of a multicolored, monodisperse, photostable, and non-toxic nano-AIE luminogen (nano-AIEgen), which is simply prepared by polyphenol-amine-based crosslinking in aqueous solutions, demonstrating great potential for living cell bioimaging. Our strategy to develop nano-AIEgens using AIE-active hydrophilic natural products—e.g., plant polyphenols, such as tannic acid, that exhibit similar AIE characteristics—can help push the boundary of the exploration of various novel, large-scale, biocompatible, water-soluble, and degradable AIE materials from natural resources.
研究领域:
材料科学
·
生物化学
·
纳米技术
·
生物医学工程
✓ 已验证
DOI
高影响因子
BIOMATERIALS
·
2021
·
IF 12.479
Meng Li,Haifei Wen,Haoxuan Li,Zhi-Chao Yan,Ying Li,Lei Wang,Dong Wang,Ben Zhong Tang
The outbreak of infectious diseases such as COVID-19 causes an urgent need for abundant personal protective equipment (PPE) which leads to a huge shortage of raw materials. Additionally, the inappropriate disposal and sterilization of PPE may result in a high risk of cross-contamination. Therefore, the exploration of antimicrobial materials possessing both microbe interception and self-decontamination effects to develop reusable and easy-to-sterilize PPE is of great importance. Herein, an aggregation-induced emission (AIE)-active luminogen-loaded nanofibrous membrane ( [email protected] ) sharing sunlight-triggered photodynamic/photothermal anti-pathogen functions are prepared using the electrospinning technique. Thanks to its porous nanostructure, [email protected] shows excellent interception effects toward ultrafine particles and pathogenic aerosols. Benefiting from the superior photophysical properties of the AIE-active dopants, [email protected] exhibits integrated properties of wide absorption in visible light range, efficient ROS generation, and moderate photothermal conversion performance. A series of antimicrobial evaluations reveal that [email protected] could effectively inactivate pathogenic aerosols containing bacteria (inhibition rate: >99%), fungi (~88%), and viruses (>99%) within only 10 min sunlight irradiation. This study represents a new strategy to construct reusable and easy-to-sterilize hybrid materials for potential bioprotective applications.
研究领域:
材料科学
·
纳米技术
·
生物医学工程
·
光疗
·
抗菌技术
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF MOLECULAR STRUCTURE
·
2025
·
IF 4.7
Huaqin Jiang,Lingling Shi,Wenxiang Wang,Yang Yang,Min Fang,Weiju Zhu,Cun Li
The peroxynitrite anion (ONOO - ) and viscosity play crucial roles in both physiological and pathological processes. In this study, we developed a bifunctional fluorescent probe MAR with an aggregation-induced emission (AIE) feature for detecting viscosity and ONOO - across different channels. MAR exhibited significant fluorescence enhancement to viscosity with a red emission at 600 nm and a good linear relationship in the range of 11.6 to 956 cP. Additionally, MAR could rapidly recognize and quantitatively respond to ONOO - with high selectivity, good sensitivity, a low detection limit (LOD = 6.97 nM), and a wide range of pH value (4.0 - 10.0), accompanied by visible blue fluorescence emission at 408 nm. The considerable wavelength separation (Δλ = 192 nm) between the maximum emission peaks of MAR for viscosity and ONOO - ensured minimal signal crosstalk in bioimaging. Cell imaging experiments indicated that MAR could target intracellular lipid droplets and respond to the changes of viscosity and ONOO - through independent red and blue channels. These results indicated that the AIEgen fluorescence sensor MAR was a promising candidate for detecting ONOO - levels and viscosity changes in live cells.
研究领域:
生物化学
·
医学检测
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
Science China-Materials
·
2022
·Vol. 66
·期 3
·1180-1188
·
IF 8.64
Luo Weihua,Xu Xingtang,Tang Yiyuan,Wu Zhen,Wang Guojie
Stimuli-responsive aggregation-induced emission (AIE) materials with regulated color and fluorescence have shown promising applications in smart optical systems, while most of them are only regulated by a single stimulus. Herein, a cyanostilbene-based fluorophore ( Z -BDPA) with AIE enhancement properties is elaborately designed, which exhibits multiple regulable color and fluorescence owing to its various photochemical reactions and reversible pH response. After exposure to 420 nm light, the green emission of Z -BDPA in tetrahydrofuran (THF) becomes brighter owing to the Z→E isomerization, which can be recovered under 365 nm irradiation; the yellow fluorescence of Z -BDPA in THF/H 2 O mixtures with 90% water fraction ( f w ) becomes stronger yellow-green fluorescence due to the photodimerization. At acidic conditions, Z -BDPA powder with yellow fluorescence can become another AIEgen Z - p -BDPA with blue fluorescence via protonation, which would be recovered through deprotonation under basic conditions. Under ultraviolet light irradiation, the blue fluorescence of Z - p -BDPA is blue-shifted and increased due to the photo-isomerization and subsequent photocyclodehydrogenation reactions. Based on the regulable color and fluorescence upon the photochemical and pH responses, Z -BDPA has been successfully applied in photo-patterning and anti-counterfeiting.
✓ 已验证
产品关联
DOI
高影响因子
BIOMATERIALS
·
2022
·
IF 15.304
Xiaoxue Ge,Meng Gao,Bairong He,Nannan Cao,Kerun Li,Yong Liu,Sanmei Tang,Kai Liu,Jing Zhang,Fang Hu,Lei Zheng,Bo Situ
The increasing resistance among fungi to antimicrobials are posing global threats to health. Early treatment with appropriate antifungal drugs guided by the antifungal susceptibility testing (AFST) can dramatically reduce the mortality of severe fungal infections. However, the long test time (24–48 h) of the standard AFSTs cannot provide timely results due to the slow growth of the pathogen. Herein, we report a new AFST that is independent of growth rate analysis using a luminogen with aggregation-induced emission characteristics (AIEgen) named DMASP. DMASP is a water-soluble small-molecule probe that can readily penetrate the dense fungal cell wall . Based on its mitochondria-targeting ability and AIE characteristics, fungal activity can be dynamically indicated via real-time fluorescence monitoring. This allows fungal susceptibility to various antimicrobials to be assessed within 12 h in a wash-free, one-step manner. This method may serve as a promising tool to rapidly detect possible drug-resistant fungal strain and guide the precise use of antimicrobial against fungal diseases.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Polymers
·
2020
·Vol. 12
·期 3
·551
·
IF 3.426
Jie Zhao,Xiangqiang Pan,Jian Zhu,Xiulin Zhu
Stimuli-responsive functional gels have shown significant potential for application in biosensing and drug release systems. In this study, aggregation-induced emission luminogen (AIEgen)-functionalized, diselenide-crosslinked polymer gels were synthesized via free radical copolymerization. A series of polymer gels with different crosslink densities or tetraphenylethylene (TPE) contents were synthesized. The diselenide crosslinker in the gels could be fragmented in the presence of H2O2or dithiothreitol (DTT) due to its redox-responsive property. Thus, the TPE-containing polymer chains were released into the aqueous solution. As a result, the aqueous solution exhibited enhanced fluorescence emission due to the strong hydrophobicity of TPE. The degradation of polymer gels and fluorescence enhancement in an aqueous solution under different H2O2or DTT concentrations were studied. Furthermore, the polymer gels could be used as drug carriers, suggesting a visual drug release process under the action of external redox agents. The AIEgen-functionalized, diselenide-crosslinked polymer gels hold great potential in the biomedical area for biosensing and controlled drug delivery.Keywords:polymer gels;redox response;aggregation-induced emission (AIE);fluorescent probes;drug release carriers
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2022
·
IF 10.383
Yanhong Duo,Meng Suo,Daoming Zhu,Zihuang Li,Zheng Zheng,Ben Zhong Tang
Relative to traditional photosensitizer (PS) agents, those that exhibit aggregation-induced emission (AIE) properties offer key advantages in the context of photodynamic therapy (PDT). At present, PDT efficacy is markedly constrained by the hypoxic microenvironment within tumors and the limited depth to which lasers can penetrate in a therapeutic context. Herein, we developed platelet-mimicking MnO2 nanozyme/AIEgen composites (PMD) for use in the interventional PDT treatment of hypoxic tumors. The resultant biomimetic nanoparticles (NPs) exhibited excellent stability and were able to efficiently target tumors. Moreover, they were able to generate O2 within the tumor microenvironment owing to their catalase-like activity. Notably, through an interventional approach in which an optical fiber was introduced into the abdominal cavity of mice harboring orthotopic colon tumors, good PDT efficacy was achieved. We thus propose that a novel strategy consisting of a combination of an AIEgen-based bionic nanozyme and a biomimetic cell membrane coating represents an ideal therapeutic platform for targeted antitumor PDT. This study is the first to have combined interventional therapy and AIEgen-based PDT, thereby overcoming the limited light penetration that typically constrains the therapeutic efficacy of this technique, highlighting a promising new AIEgen-based PDT treatment strategy.
研究领域:
生物医学工程
·
癌症研究
·
纳米技术
·
治疗学
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF MEDICINAL CHEMISTRY
·
2025
·
IF 6.8
Shicheng Pei,Zhaohan Liu,Qishu Jiao,Qiling Jin,Xuan Luo,Yuanyuan Liu,Shuyao Zhou,Shuqin Pang,Xiaoxing Wu,Keming Xu,Wenying Zhong
Efficacious chemotherapy and real-time therapeutic monitoring remain major challenges in cancer treatment. Traditional systems often lack tumor specificity, limiting efficacy, and hindering therapy optimization. Moreover, the absence of real-time monitoring can lead to missed opportunities and increased risks of side effects. Herein, we designed a self-reporting ratiometric AIEgen-peptide nanoprobe (TPE-1(Hyd-DOX)-DEVD) for activatable chemotherapy and noninvasive imaging of therapeutic outcomes. When doxorubicin (DOX) in the nanoprobe is selectively activated in the acidic tumor microenvironment, the ensuing caspase-3 cascade triggers a morphological transformation of the nanoprobe that amplifies the TPE fluorescence. This enhancement allows the TPE/DOX fluorescence ratio to serve as an indicator for monitoring DOX activation and for providing therapeutic feedback. Both in vitro and in vivo studies demonstrated that TPE-1(Hyd-DOX)-DEVD exhibited an impressive tumor suppression efficacy and excellent biocompatibility. This study highlights the strong potential of this nanoprobe as a valuable tool for cancer theranostics, offering hope for more effective and personalized treatment strategies.
研究领域:
肿瘤学
·
生物医学工程
·
分子影像学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Biosensors-Basel
·
2022
·Vol. 12
·期 9
·745
·
IF 5.743
Li Gao,Yixi Deng,Haolu Liu,King Solomon,Bianjiang Zhang,Huimei Cai
Tea is an important economic crop and health beverage in China. The presence of heavy metal ions in tea poses a significant threat to public health. Here, we prepared an aptamer biosensor labelled with AIEgen nanospheres to detect Pb2+in tea. The dsDNA modified by amino and phosphoric acid was combined with the carboxylated AIEgen NPs to form AIEgen-DNA with a fluorescence group, which was then fixed to the surface of Zr-MOFs to quench the fluorescence of AIEgen NPs. At the same time, PEG was added to remove nonspecific adsorption. Then Pb2+was added to cut the DNA sequences containing the cutting sites, and AIEgen NPs and part of the DNA sequences were separated from the Zr-MOFs surface to recover the fluorescence. By comparing the fluorescence changes before and after adding Pb2+, the detection limit of Pb2+can reach 1.70 nM. The fluorescence sensor was applied to detect Pb2+in tea, and the detection results showed that the tea purchased on the market did not contain the concentration of Pb2+within the detection range. This study provides new insights into monitoring food and agriculture-related pollutants based on fluorescent biosensors.Keywords:lead ions;fluorescent biosensors;metal-organic frames;tea
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Science China-Chemistry
·
2021
·Vol. 64
·期 10
·1770-1777
·
IF 9.445
Xu Mengdi,Hua Luqin,Gong Lihao,Lu Jianlei,Wang Jinhui,Zhao Chuanzhuang
The interaction between the aggregation-induced emissive (AIE) luminogens (AIEgen) and the polymer is the key scientific question in the design of functional AIE hydrogels. In this study, we report the AIE behavior of a poly(acrylic acid) (PAAc) and poly(acrylamide) (PAAm) interpenetrating network (IPN) hydrogel doped with tetra-cationic tetraphenylethene (TCTPE). The cationic AIEgen can bind with PAAc through ionic interaction, while PAAc and PAAm chains can associate with each other through hydrogen-bonds (H-bonds). These two interactions can restrict the intramolecular rotation and thus activate the luminescence of the AIEgen. The PAAc-PAAm H-bonds can be broken by increasing temperature or pH, restoring the intramolecular rotation of the AIEgen and quenching the fluorescence of the hydrogel. Therefore, the TCTPE-doped IPN hydrogel is designed as temperature- and pH-sensitive displayers which can record information imprinted by photo-printing or iono-printing with good switchability and reversibility. Another application of this TCTPE-doped hydrogel is demonstrated as a luminescent soft actuator, which has fast shape deformation and editable fluorescence pattern. The above results reveal a pathway to tune the emission behavior through tuning polymer-polymer and polymer-AIEgen interactions, which may inspire new design strategies of aggregation-induced emissive polymers and broaden their applications.
✓ 已验证
产品关联
DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2024
·Vol. 48
·期 11
·5025-5031
·
IF 2.7
Shang Zhang,Qiuhong Li,Hao Liu,Xueshu Li,Xuemei Wang,Xueqin Du,Cuiling Lv,Zhaodong Wang,Aixiang Li,Lin Niu
Redox stimulation at the molecular level has been the focus of many fields, especially in electrofluorochromic (EFC) devices with individually addressable pixels and switching function. In this study, the fluorescent molecule ((1E)-1-((4-(1,2,2-triphenylvinyl)benzylidene)-hydrazineylidene)ethyl)ferrocene (FcMe-TPE) with aggregation-induced emission (AIE) properties was synthesized and mixed with PVA to prepare an EFC hydrogel material (PVA/FcMe-TPE) with high conductivity. The obtained hydrogel exhibited reversible fluorescent switching behavior, which could be achieved by adding a redox agent alternately based on the redox properties of the FcMe-TPE molecule. The fluorescence intensity of the hydrogel increased by 700 times after adding oxidant and could almost return to the initial value by adding reductant. Interestingly, the effect of the oxidant could be replaced by applying a voltage and the hydrogel exhibited good EFC behaviors. When the voltage increased from 0 V to 1 V, the fluorescence intensity of the hydrogel gradually increased and reached the maximum value at 1 V. The obtained fluorescent hydrogels could be customized to different appearance according to needs, and the EFC devices with individually addressable pixels and switching function were fabricated successfully. Finally, by introducing phytic acid (PA), the mechanical strength of the PVA/FcMe-TPE hydrogel was greatly improved without affecting its EFC performance. This study provides a new idea and solution for the intelligent display field, such as advanced anti-counterfeiting and information encryption.
研究领域:
材料科学
·
化学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）