Food Bioscience
·
2024
·
IF 4.8
Yueyao Gui,Bing Zheng,Hairong Huang,Jianhua Xie,Yi Chen,Jialuo Shan,Xingxing Chang,Xiaobo Hu,Qiang Yu
Alcoholic liver disease (ALD) is characterized by inflammation and oxidative stress induced by excessive alcohol consumption. It is necessary to find a way to use natural active substances to alleviate the liver damage caused by alcohol. The object of this study was to investigate the beneficial effects of pure Polygomatum cyrtonema polysaccharide (PCP-80%) on ALD, and to explore its possible mechanism from the aspect of oxidative stress, inflammation and intestinal microbiota. The results demonstrated that PCP-80% effectively reduced serum biochemical index level and improved liver disease induced by acute alcohol exposure. Furthermore, PCP-80% showed promising outcomes in mitigating oxidative stress and liver inflammation associated with ALD. This might relate to the inhibition of NF-κB pathway and the activation of Keap1/HO-1 pathway. Additionally,PCP-80% enhanced the intestinal barrier and elevated the levels of propionic acid in the colon contents. It also partially reversed the alcohol-induced disturbances in the intestinal microbiome. Overall, PCP-80% exhibited significant therapeutic potential in alleviating acute alcoholic liver injury by reducing oxidative stress, inflammation, and relieving disturbances in the intestinal microbiome. These findings presented a novel approach for the treatment of acute alcoholic liver injury, offering prospects for improving disease prognosis.
研究领域:
药理学
·
肝病学
·
胃肠病学
·
免疫学
·
微生物学
✓ 已验证
产品关联
DOI
高影响因子
Hepatology International
·
2024
·
IF 5.9
Li Lin,Kong Lina,Xu Shuai,Wang Changyuan,Gu Jiangning,Luo Haifeng,Meng Qiang
Background and purpose Alcoholic liver disease (ALD), a metabolic liver disease caused by excessive alcohol consumption, has attracted increasing attention due to its high prevalence and mortality. Up to date, there is no effective and feasible treatment method for ALD. This study was to investigate whether Farnesoid X receptor (FXR, NR1H4) can alleviate ALD and whether this effect is mediated by inhibiting absent in melanoma 2 (AIM2) inflammasome activation. Methods The difference in FXR expression between normal subjects and ALD patients was analyzed using the Gene Expression Omnibus (GEO) database. Lieber–DeCarli liquid diet with 5% ethanol (v/v) (EtOH) was adopted to establish the mouse ALD model. Liver histopathological changes and the accumulation of lipid droplets were assessed by H&E and Oil Red O staining. Quantitative real-time PCR, Western blotting analysis and immunofluorescence staining were utilized to evaluate the expression levels of related genes and proteins. DCFH–DA staining was adopted to visualize reactive oxidative species (ROS). Results FXR was distinctly downregulated in liver tissues of patients with steatosis compared to normal livers using the GEO database, and in ethanol-induced AML-12 cellular steatosis model. FXR overexpression ameliorated hepatic lipid metabolism disorder and steatosis induced by ethanol by inhibiting the expression of genes involved in lipid synthesis and inducing the expression of genes responsible for lipid metabolism. Besides, FXR overexpression inhibited ethanol-induced AIM2 inflammasome activation and alleviated oxidative stress and ROS production during ethanol-induced hepatic steatosis. However, when FXR was knocked down, the results were completely opposite. Conclusions FXR attenuated lipid metabolism disorders and lipid degeneration in alcohol-caused liver injury and alleviated oxidative stress and inflammation by inhibiting AIM2 inflammasome activation. Graphical abstract
研究领域:
肝病学
·
分子生物学
·
炎症
·
代谢紊乱
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nanoscale Advances
·
2023
·Vol. 5
·期 3
·830-839
·
IF 4.7
Yazhou Huang,Yunfei Zhang,Junyan Lv,Yinfeng Shao,Dongfang Yang,Yuan Cong
The sensitive detection of cardiac troponin I (cTnI) is of great significance for the early diagnosis of acute myocardial infarction (AMI). Herein, in order to fabricate an electrochemical biosensor for ultrasensitive cTnI detection, atomic layer deposition (ALD) was employed to directly deposit NbS2 nanoflakes (NFs) on carbon fiber paper (CFP). Due to the self-limiting reaction of ALD, NbS2NFs were deposited uniformly and accurately on the surface of carbon fibers by controlling the number of ALD cycles, which ensured ultrasensitive detection. Precise regulation of the nanoscale morphology and electrochemical performance of NbS2 nanoflakes via ALD cycles was observed in depth. Owing to the high surface area and conductivity, an anodic/cathodic current of ∼3.01 mA of NbS2NFs/CFP can be obtained. Subsequently, an electrochemical biosensor based on the excellent performance of NbS2NFs/CFP was fabricated. The ultrasensitive detection of cTnI in a linear range of 1 fM to 0.1 nM with a detection limit of 0.32 fM was achieved.
研究领域:
材料科学
·
生物化学
·
电化学
·
医学诊断
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Science China-Materials
·
2016
·Vol. 59
·期 10
·833-841
·
IF 0
Shen Ting,Tian Jianjun,Li Bo,Cao Guozhong
TiO 2 nanocrystals are widely used in photoanodes for quantum dot solar cells (QDSCs) owing to their chemical stability and suitable energy band structure. However, surface defects and grain boundaries of TiO 2 nanocrystals photoanodes allow high surface charge recombination, which limits the performance of QDSCs. In this work, an ultrathin TiO 2 layer is introduced to the surface of TiO 2 photoanodes by atomic layer deposition (ALD). The ultrathin layer not only reduces the surface defects of TiO 2 nanoparticles and strengthens the connection between adjacent nanoparticles to suppress the charge recombination for improving the electron collection efficiency (η cc ), but also increases the surface energy of photoanodes to load more quantum dots (QDs) for enhancing the light harvesting efficiency (LHE). As a result, the solar cell based on CdS/CdSe QDs with ALD treatment exhibits an efficiency of 5.07% that is much higher than that of the cells without modification (4.03%).
研究领域:
材料科学
·
纳米科技
·
能源化学
·
光伏技术
·
表面工程
·
半导体物理
·
光电转换
✓ 已验证
DOI
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2021
·
IF 8.128
Ben Chen,Jin Zhang,Jing Yu,Rui wang,Beibei He,Jun Jin,Huanwen Wang,Yansheng Gong
Poor visible light utilization and charge separation efficiency of TiO 2 restrict its extensive application in the photocatalytic field. Herein, a specific Z-scheme TiO 2-x /Cu/ZnO heterojunction was successfully constructed by atomic layer deposition (ALD) technique and spray pyrolysis technology. Benefited from the surface plasmon resonance (SPR) effect of Cu and Z-scheme heterojunction, the visible light absorption capacity was greatly enhanced. Meanwhile, ZnO nanolayer coating, prepared by ALD technique, protects Cu element to hinder its oxidation, thus enhancing the separation efficiency of photogenerated carriers. Therefore, the photocatalytic hydrogen production performance was significant improved, exhibiting a maximum value of 342.0 µmol·g −1 ·h −1 for the optimal B-T-0.1C-10Z (black TiO 2 /0.1Cu/10 nm ZnO) sample without any noble-metal cocatalyst, which is higher than pure TiO 2 (310.7 µmol·g −1 ·h −1 , with 3 wt% Pt) synthesized by spray pyrolysis method under equal conditions. In addition, a possible mechanism for the enhanced performance was briefly discussed based on the experimental results.
研究领域:
材料科学
·
光催化技术
·
表面化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Small
·
2023
·Vol. 20
·期 7
·2306513
·
IF 13.3
Renbo Lei,Yupu Tang,Shihan Yan,Weitao Qiu,Zheng Guo,Xu Tian,Qian Wang,Kai Zhang,Shanshan Ju,Shihe Yang,Xinwei Wang
With the rapid development of performance and long-term stability, bismuth vanadate (BiVO 4 ) has emerged as the preferred photoanode in photoelectrochemical tandem devices. Although state-of-the-art BiVO 4 photoanodes realize a saturated photocurrent density approaching the theoretical maximum, the fill factor (FF) is still inferior, pulling down the half-cell applied bias photon-to-current efficiency (HC-ABPE). Among the major fundamental limitations are the Fermi level pinning and sluggish surface kinetics at the low applied potentials. This work demonstrates that the plasma-assisted atomic layer deposition technique is capable of addressing these issues by seamlessly installing an angstrom-scale FeNi-layer between BiVO 4 and electrolyte. Not only this ultrathin FeNi layer serves as an efficient OER cocatalyst, more importantly, it also effectively passivates the surface states of BiVO 4 , de-pins the surface Fermi level, and enlarges the built-in voltage, allowing the photoanode to make optimal use of the photogenerated holes for achieving high FF up to 44% and HC-ABPE to 2.2%. This study offers a new approach for enhancing the FF of photoanodes and provides guidelines for designing efficient unassisted solar fuel devices.
研究领域:
材料科学
·
光电化学
✓ 已验证
DOI
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2023
·Vol. 34
·期 4
·2306399
·
IF 19
Haoyang Jiang,Junqing Liu,Bin Tang,Zhendong Yang,Xinghui Liang,Xinyu Yu,Yirong Gao,Jinping Wei,Zhen Zhou
The practical implementation of garnet-type solid electrolytes, such as Li 6.4 La 3 Zr 1.4 Ta 0.6 O 12 (LLZTO), faces the significant challenge of Li dendrites. Though artificial interfacial strategies are effective in dendrite suppression, further investigation is needed to understand the mechanism of homogeneous Li deposition and its practicability under real-world conditions. Herein, a bilayer interface is constructed to address these issues. Such a bilayer interface consists of one conformal Li 2 O-rich layer, generated by rubbing LLZTO pellets inside molten Li with low-dose In 2 O 3 , and another Li 2 O layer deposited through atomic layer deposition (ALD). The regulatory effect of the initial Li 2 O-rich layer on achieving uniform Li deposition is explored, and the critical current density is enhanced to 2.4 mA cm −2 . However, simple interfacial strategy is insufficient to prevent anodic degradation for cycling at room temperature without stack pressure, leading to increased current leakage and directly reducing Li + within the electrolyte. After insulating it with a second ALD-Li 2 O layer that minimally hampers ionic conduction, the Li/Li symmetric cells achieve long cycling life exceeding 1000 h at 0.5 mA cm −2 and maintain stable operation even at 2 mA cm −2 . This work provides valuable insights for interfacial strategies towards practical solid-state batteries.
研究领域:
材料科学
·
电化学
·
电池技术
✓ 已验证
DOI
高影响因子
Advanced Sustainable Systems
·
2023
·
IF 7.1
Xincan Cai,Wenda Bao,Lianqi Zhao,Yuqing Zuo,Haojie Zhao,Longxing Su,Yue Zhang,Hui Zhang,Jin Xie
In lithium batteries, the interface between electrolytes and electrodes with optimized structural stability and fast charge transfer kinetics plays a pivotal role in achieving overall cycle and rate performance. Introducing a uniform interfacial layer that conducts Li + ions while insulating electrons, through atomic layer deposition (ALD) of lithium compounds, has shown promise in facilitating lithium ion transport and enhancing interface stability. However, synthesizing lithium compounds with both robust chemical stability and a broad electrochemical window using ALD poses challenges due to the difficulty of obtaining desired products under specific ALD reaction conditions. In this study, this challenge by investigating Li 3 PO 4 is addressed, a compound grown by ALD that exhibits a noteworthy property: the in situ formation of a more stable LiPO 3 phase under high applied voltage. The LiPO 3 phase possesses an extended theoretical stability window (LiPO 3 : 2.48-5.00 V versus Li 3 PO 4 : 0.69-4.21 V), and its emergence substantially enhances the electrochemical performance of all-solid-state lithium batteries based on polyethylene oxide (PEO). This work not only presents experimental evidence of the in situ transformation of the interfacial layer but also offers a pragmatic approach to realizing all-solid-state lithium batteries with elevated energy density, emphasizing safety and stability considerations.
研究领域:
材料科学
·
电化学
·
电池技术
·
固态电解质
✓ 已验证
DOI
高影响因子
ELECTROCHIMICA ACTA
·
2018
·
IF 5.116
Huilin Hou,Huabing Liu,Fengmei Gao,Minghui Shang,Lin Wang,Linli Xu,Wai-Yeung Wong,Weiyou Yang
Constructing semiconductor heterojunction with optimal structure and composition is highly desired to maximize the solar light utilization for photoelectrochemical (PEC) water splitting. Here, we reported the fabrication of BiVO 4 @ZnO heterojunction with a novel nanostructure for PEC water splitting via foaming-assisted electrospinning and subsequent atomic layer deposition (ALD) techniques. In such BiVO 4 @ZnO heterojunction , the isolated BiVO 4 nanoparticles were packaged within the ZnO microbelt matrix. During PEC water splitting, the BiVO 4 acts as the primary light absorber for wider solar spectral harvesting, and the ZnO prompts the transfer of the photo-excited high-energy electrons, which would render them with prolonged lifetime and enhanced separation of the photogenerated charge carriers. In addition, the microbelts architecture with a hollow channel can also effectively improve the interfacial charge separation and transportation. Accordingly, the PEC performances of BiVO 4 @ZnO hybrid microbelts were significantly enhanced with a photocurrent density up to ∼0.46 mA cm −2 (at 1.23 V vs. reversible hydrogen electrode (RHE) under simulated sunlight illumination), which is 15.3 times to that of pure BiVO 4 counterpart (∼0.03 mA cm −2 ). The photocurrent density of the BiVO 4 @ZnO electrode can be further increased to 1.07 mA cm −2 at 1.2 V vs. RHE by adding hole scavenger (NaSO 3 ) in the electrolyte solution under AM 1.5 G irradiation.
研究领域:
材料科学
·
纳米技术
·
可再生能源
·
电化学
·
半导体物理
✓ 已验证
DOI
高影响因子
ENVIRONMENTAL ENTOMOLOGY
·
2025
·
IF 1.5
Meng Wei,Zhang Wanming,Zhang Dan,Zheng Jingjun,Huang Dechao,Guo Qianshuang,Du Yongjun
The sex pheromone of the oriental armyworm, Mythimna separata (Walker), in China has always been confusing. It was initially considered as cis-11-hexadecenal (Z11-16:Ald) or cis-11-hexadecenyl acetate (Z11-16:Ac) and cis-11-hexadecenol (Z11-16:OH), as well as a mixture of these compounds. However, inconsistent results have frequently occurred using these compounds or mixtures in field trapping. Through gland analysis from individual females and nationwide field experiments, we identified two distinct types: Z11-16:Ald (aldehyde type or A type) and a mixture of Z11-16:Ac and Z11-16:OH (ester type or E type). Electroantennography (EAG) results indicated that both strains of males co-existed in the field. A strain of males had a strong EAG response to Z11-16:Ald but weak responses to Z11-16:Ac and Z11-16:OH, whereas E strain males had strong responses to Z11-16:Ac and Z11-16:OH but a weak response to Z11-16:Ald. Z11-16:OH identified in female E strain inhibited the attraction of A strain males to A type pheromones. Both A and E types of sex pheromone were respectively formulated and field evaluation (2014-2021) across > 20 provinces from southern to northern China showed geographic and generational variations. During overwintering, E strain males were predominantly caught in Hainan, Fujian, and Guangdong provinces, while A strain males were mainly trapped in Guangxi, Anhui, Sichuan, Jiangsu, and Jiangxi provinces. Subsequent generations exhibited mixed populations in most regions. These findings suggest regional adaptation and migration-driven hybridization. The study highlights the necessity of strain-specific pheromone blends for effective monitoring and control. This work resolves long-standing ambiguities in M. separata sex pheromone ecology.
研究领域:
昆虫学
·
化学生态学
·
信息素研究
·
种群遗传学
·
农业害虫治理
✓ 已验证
产品关联
DOI
PubMed
高影响因子
RARE METALS
·
2019
·Vol. 38
·期 6
·588-600
·
IF 1.785
Huang Lei,Su Kun,Zheng Yu-Feng,Yeung Kelvin Wai-Kwok,Liu Xiang-Mei
A TiO 2 nanofilm was prepared on the surface of AZ31 magnesium alloy with controllable thickness through atomic layer deposition (ALD) technique, which can adjust the corrosion behaviors of AZ31 Mg alloy. Compared with the untreated Mg alloys, corrosion current densities ( i corr ) can decline by 58% in the 200-cycles TiO 2 -covered Mg alloy and further decline by up to 74% with the thickness of nanofilm up to 63 nm (400 cycles). The subsequent modification with a cross-linked conversion layer of 3-amino-propyltriethoxysilane (APTES) by a dipping method can produce a compact silane coating on TiO 2 nanofilm, which can seal pinholes of TiO 2 nanofilm and serve as a barrier to further adjust the corrosion behavior of the substrate. The i corr can decline about two orders of magnitude in the TiO 2 /silane composite coating. Making the adjustable corrosion rate come true, which can be attributed to the precise control on the thickness of metal oxide nanofilm and additional protection from the compact silane coating. In vitro study discloses that the TiO 2 /silane hybrid coating shows higher expression of alkaline phosphatase (ALP) and can promote cellular adhesion and proliferation with better cytocompatibility than untreated Mg alloy.
研究领域:
材料科学
·
生物医学工程
·
腐蚀科学
·
表面工程
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2023
·
IF 9.5
Wenda Bao,Yue Zhang,Rongliang Shang,Fufei Cong,Haojie Zhao,Yuqing Zuo,Beili Yi,Jin Xie
Vapor phase infiltration (VPI) derived from atomic layer deposition (ALD) enables inorganic materials to nucleate and grow within the free volume of polymers, which has shown promising prospects in the field of composite solid polymer electrolytes (CSPEs). However, there are only a few types of metal oxides that can be incorporated into the polymer matrix by VPI, let alone binary metal oxides, due to the limited knowledge of the VPI synthesis process. To combine the merits of different metal oxides, we investigate the VPI method to prepare ZnO-Al2O3 composites in poly(ethylene oxide) (PEO). When the introducing order is Al2O3/ZnO (AZO), due to the extremely high reactivity of trimethyl aluminum (TMA) with PEO, VPI-Al2O3 will accumulate near the surface of PEO. The surface Al2O3 layer inhibits the further diffusion of the diethyl zinc (DEZ) into the PEO matrix, leading to weak polymer–filler interactions and limited improvement of the Li+ conduction. In the incorporation order of ZnO/Al2O3 (ZAO), the moderate reactivity of DEZ renders the uniform distribution of VPI-ZnO within PEO, and the following TMA can both react with PEO and VPI-ZnO particles near the surface of PEO, which not only preserves the interactions between VPI-ZnO and PEO but also better inhibits the growth of lithium dendrites. The incorporation order plays a crucial role in the morphology and composition of binary metal oxides synthesized by VPI.
研究领域:
材料科学
·
电化学
·
能源存储
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）