Biomaterials Science
·
2020
·Vol. 8
·期 6
·1658-1668
·
IF 6.183
Zhengjie Zhou,Yang Yan,Qiang Zhang,Yiyun Cheng
An abnormal tumor growth induces solid stress in tumors, thus reducing blood perfusion. As a result, the impaired blood perfusion, with dense interstitial matrix in tumors significantly reduces the penetration and efficacy of nanotherapeutics. In this study, we have developed a losartan-loaded polydopamine nanoparticle (PLST) for the enhanced delivery of nanoparticles to tumors and improved photothermal cancer therapy. Losartan, an angiotensin inhibitor, is also able to alleviate the solid stress in tumors. It was laden on polydopamine nanoparticles via π–π stacking and was released upon tumor extracellular acidity. PLST reduced collagen production in vitro along with the lowered expression of profibrotic factors of TGF-β1, CCN2, and TIMP-1. The in vivo studies reveal that PLST reduced solid stress in tumors, and the amount of PLST accumulated in tumors was enhanced. The efficiency of the photothermal ablation of tumors was significantly enhanced by using PLST.
研究领域:
癌症治疗
·
纳米技术
·
药学科学
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry C
·
2021
·Vol. 9
·期 14
·4888-4894
·
IF 7.393
Xiaoping Guo,Shijie Zhen,Tianchang Ouyang,Shangxiong Zhou,Qiwen Pan,Dandan Yang,Jianhao Chen,Guoping Dong,Zujin Zhao,Jianrong Qiu,Ben Zhong Tang
With the wide use of micro–nano photonic devices in on-chip optical communication, physical and chemical sensing, organic microlasers have gained increasing attention owing to their special advantages including high integration, easy preparation and excellent optical properties. However, traditional microlasers suffer from the “aggregation-caused quenching” (ACQ) effect of gain molecules and high lasing thresholds. In this contribution, we meticulously designed organic microlaser assemblies based on an “aggregation-induced emission” (AIE) fluorophore for its unique characteristics. An innovative AIE fluorophore, namely triphenylamine-benzo[1,2-b:4,5-b′]-dithiophene 1,1,5,5-tetraoxide (TPA-BDTO), with highly efficient emission at the aggregated state is employed to hybridize with the PMMA matrix, obtaining microbottles with an ultra-smooth surface via the self-assembled strategy. Benefiting from the spatially well-separated intensity based on the prolate shape of the TPA-BDTO–PMMA microbottle, we realize a single-mode microlaser in a microbottle with an appropriate pump power via precise manipulation. Moreover, the TPA-BDTO–PMMA microlaser is demonstrated as an axial tensile strain sensor with high sensitivity (0.34 pm με−1), high resolution, real-time response and simple structure, which create new opportunities for organic microlasers and even lay a foundation for the research of lab-on-chips.
研究领域:
光学
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材料科学
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传感器技术
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产品关联
DOI
高影响因子
Journal of Materials Chemistry A
·
2017
·Vol. 5
·期 21
·10669-10677
·
IF 8.867
Lian-Kui Wu,Wei-Yao Wu,Jie Xia,Hua-Zhen Cao,Guang-Ya Hou,Yi-Ping Tang,Guo-Qu Zheng
A nanostructured nickel–cobalt alloy with an oxide layer was fabricated and its superior catalytic activity towards the electrochemical oxygen evolution reaction in alkaline media was investigated. Firstly, a NiCo–SiO2 composite film was prepared via a potentiostatic electro-codeposition method. Then the SiO2 template was etched and the NiCo component was activated leading to the generation of a NiCoOx layer during consecutive CV scans in concentrated alkaline solution. The results show that this nanostructured NiCo alloy with the oxide layer can provide a current density of 100 mA cm−2 in 1.0 M KOH at a low overpotential of 326 mV and exhibits good stability towards water oxidation. The excellent OER performance is enabled with the unique metal-oxide structure, which allows high electrical conductivity in the metal and high catalytic activity on the oxide.
研究领域:
材料科学
·
电化学
✓ 已验证
DOI
高影响因子
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
·
2025
·
IF 3.3
Zhao Bingshan,Micklefield Jason,Wang Yonghua,Wang Fanghua
N-trans -feruloyltyramine (FLA) is one kind of phenylpropanoid compound found in various plants. Numerous studies have confirmed that it exhibits a wide range of physiological functions, such as antioxidant, ɑ-glucosidase inhibition, and anti-inflammatory activity. However, the low content of FLA in plants greatly limits its potential use in food and pharmaceutical industries. It is, therefore, very important to establish an effective synthesis of FLA. In this study, a green and efficient method to synthesize FLA was sought using an amide bond synthetase (ABS) biocatalyst. Ten kinds of ABS enzymes, including AlCfaL from Azospirillum lipoferum , were screened as the potential biocatalysts for the production of FLA. To obtain optimum reaction conditions, the effects of various parameters on conversion of FLA were firstly evaluated. Under the optimum conditions using 1 mM N-trans -ferulic acid, 50 mM tyramine (substrate ratio of 1:50), 10 mM MgCl₂, 8 mM ATP, and 35 µM AlCfaL enzyme at 30 °C with a shaking speed of 500 r/min for 48 h, maximum conversion rate of 74% was reached. Given that the amidation reaction is mediated by relative expensive ATP, we further optimized reaction systems to incorporate an ATP recycling system consisting of a polyphosphate kinase enzyme (CHU) and an inexpensive polyphosphate (PolyP) as the phosphate donor. Response surface methodology (RSM) based on five-level, five-variable central composite design (CCD) was used to evaluate the optimal parameters for the production of FLA. The effects of AMP, PolyP, AlCfaL, CHU concentrations, and reaction time on the conversion rate of FLA were analyzed. The optimum conditions derived via RSM were 7.12 mM AMP, 5.96 mg/mL PolyP, 39.72 μM AlCfaL, 27.68 μM CHU, and a reaction time of 36 h. Validation experiments conducted under these optimized conditions yielded an actual conversion rate of 63.5%, which compared well to the maximum predicted value of 64.2%.
研究领域:
生物化学
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酶工程
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食品科学
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药学
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DOI
PubMed
高影响因子
Small
·
2010
·Vol. 7
·期 1
·87-94
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IF 6.171
Yi-Lun Ying,Hai-Yan Wang,Todd C. Sutherland,Yi-Tao Long
An aptamer is a specific oligonucleotide sequence that spontaneously forms a secondary structure capable of selectively binding an analyte. An aptamer’s conformation is the key to specific binding of a target molecule, even in the case of very closely related targets. Nanopores are a sensitive tool for the single-molecule analysis of DNA, peptides, and proteins transporting through the pore. Herein, a single α -hemolysin natural nanopore is utilized to sense the conformational changes of an adenosine 5’-triphosphate (ATP)-binding aptamer (ABA). The known DNA sequence of the ABA is used as a model to develop real-time monitoring of molecular conformational changes that occur by binding targets. The native, folded ABA structure has a nanopore unfolding time of 4.17 ms, compared with 0.29 ms for the ABA:ATP complex. A complementary 14-mer strand, which binds the ABA sequence in the key nucleic acids responsible for folding, forms linear duplex DNA, resulting in a nanopore transit time of 0.50 ms and a higher capture probability than that of the folded ABA oligomer. Competition assays between the ABA:ATP and ABA:reporter complexes are carried out, and the results suggest that the ABA:ATP complex is formed preferentially. The nanopore allows for the detection of an ABA in its folded, ATP-bound, and linear conformations.
研究领域:
分子生物学
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生物传感器
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核酸化学
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单分子检测
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转化医学
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DOI
高影响因子
RSC Advances
·
2016
·Vol. 6
·期 7
·5636-5640
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IF 3.289
Liqiang Yan,Zhineng Kong,Wei Shen,Wenqi Du,Yan Zhou,Zhengjian Qi
In this work, we developed a novel colorimetric and ratiometric fluorescence probe for the selective and sensitive monitoring of cysteine based on a coumarin Schiff-base platform. This probe exhibited remarkable AIE characteristics with an exceptionally large blue shift (125 nm), which showed low emission in DMSO but strong aggregation-induced emission in water solution. An excellent linear relationship of fluorescence intensity ratio (F450/F575) (R2 = 0.9922) versus Cys concentration in the range of 1–13 μM was obtained.
研究领域:
分析化学
·
材料科学
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生物成像
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传感器与探针
✓ 已验证
DOI
高影响因子
Sustainable Energy & Fuels
·
2020
·Vol. 5
·期 1
·261-266
·
IF 5.503
Jiancong Wu,Wenya Guo,Zhengxin Ding,Jinshui Zhang,Yidong Hou
Iron vanadate (FeVO4) is a promising photoanode for photoelectrochemical (PEC) water splitting because of its unique electronic band structure, in particular the bandgap of 2.1 eV. However, its PEC performance is limited by the charge recombination at transparent conducting substrate/photoanode interface. Herein, we demonstrate that the introduction of an ultrathin (1.1 nm) TiO2 layer between FTO and an FeVO4 photoanode by atomic layer deposition (ALD) technology can well address the issue of interfacial charge recombination, this is because the large valence band offset between TiO2 and FeVO4 can effectively suppress back hole transfer and subsequently improve charge separation. As expected, the modified photoanode exhibited an enhanced PEC water splitting performance. We believe that the strategy of fabricating an ultrathin TiO2 interfacial layer as a hole blocking barrier can also benefit other photoanodes.
研究领域:
材料科学
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能源科学
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产品关联
DOI
高影响因子
Polymer Chemistry
·
2013
·Vol. 5
·期 3
·792-798
·
IF 5.231
Yinyin Bao,Taisheng Wang,Qianbiao Li,Fanfan Du,Ruke Bai,Mario Smet,Wim Dehaen
We designed and synthesized an amphiphilic conjugated polymer P1 based on the 2,2′-biimidazole unit, and then investigated its sensing properties as an aggregation-based platform. P1 shows multicolor emission in organic solvents at different water contents, and is demonstrated to be the first multicolor fluorescent sensor for water. And it exhibits visually noticeable multicolor fluorescence response to Ag+ in aqueous dioxane and to Hg2+ ions in aqueous ethanol. In addition, the polymer–Hg2+ complex system can be used as an efficient cysteine fluorescent sensor based on the aggregation–disaggregation strategy. These results validate P1 as an efficient multifunctional platform with multicolor fluorescence response.
研究领域:
材料科学
·
分析化学
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产品关联
DOI
高影响因子
MECHANICS OF MATERIALS
·
2021
·
IF 3.266
Yin Tao,Guanqing Sun,Yu Wei,Ren Liu,Junhua Zhao
The application of ultraviolet (UV)-curing coatings in precision devices is restricted because of their high shrinkage performance. In this study, hollow polyurethane acrylate (PUA) microspheres are filled into a mixed tripropylene glycol diacrylate (TPGDA) coating with different volume fractions to regulate shrinkage ratios of the coating, where hollow PUA microspheres with different diameters and thicknesses are synthesized using the microfluidics technology . The thickness-dependent mechanical properties of PUA thin films (the same thickness with the shell of each microsphere) are obtained by combining in-situ tensile and nanoindentation experiments with finite element (FE) method. The empirical formula between geometrical parameters (diameter, shell thickness, volume fraction) of hollow PUA microspheres and shrinkage ratios of the TPGDA coating filled with these PUA microspheres are derived using the present representative volume element (RVE) method. Checking against the results of UV-curing shrinkage experiments shows the current empirical formula has high accuracy. This study provides a physical insight into modulating their shrinkage ratios of different UV-curing materials.
研究领域:
材料科学
·
化学工程
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产品关联
DOI
高影响因子
Food & Function
·
2020
·Vol. 11
·期 5
·3811-3822
·
IF 4.171
Xiaolin Yao,Xiaoxue Yao,Kai Xu,Kao Wu,Fatang Jiang,Katsuyoshi Nishinari,Glyn O. Phillips
Iron-deficiency anemia is an important health problem in global public issues, and development of iron fortifiers in diets is essential for the decrease of iron deficiency. However, there are problems for iron fortification in food because the common bioavailable iron compounds would contribute to iron-promoted lipid oxidation and unpleasant iron odor, presenting an adverse food quality. Ferrous fumarate loaded microstructured gel beads were prepared by an emulsification–gelation method using an alginate-caseinate matrix, and the gel network was formed by crosslinking of Ca2+ or Fe2+. Internal gelated beads showed relatively symmetrical and homogeneous spheres with no adhesion due to the simultaneous release of Fe2+ to initiate gelation in situ. External gelated beads displayed an irregular and adhesive structure, probably because the random contact between Na-ALG and Ca2+ occurred on the droplet surface, and the immediately gelated hardening layer provided a delay for further Ca2+ diffusion. The gel beads exhibited a lag phase in the promotion of lipid oxidation of the emulsion and restrained the iron odor release from ferrous fumarate. Ferrous ion release from microstructured gel beads in the simulated gastric juice was obviously delayed before a more progressive high release in the simulated intestinal juice, beneficial for iron absorption in the duodenum. The iron encapsulated microstructured gel beads might be developed as a promising safe iron fortifier by relieving lipid oxidation and iron odor.
研究领域:
食品科学
·
营养学
·
生物材料学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Polymer Materials
·
2023
·
IF 5
Jianmeng Wu,Hui Yang,Cuihong Hou,Hongling Guan,Shouyu Gu,Yuting Yin,Hongquan Jing,Yanyu Wang,Menglai Wang
Conventional fertilizers suffer from uncontrollable nutrient release rates and low utilization efficiency, which lead to environmental issues. An environmentally responsive fertilizer that can regulate nutrient release in response to environmental fluctuation is considered an essential component of sustainable agriculture. In this study, composite hydrogels with temperature/pH responsiveness were prepared by using modified attapulgite (ATP) as the inorganic filler and N-isopropylacrylamide (NIPAm) and sodium alginate (SA) as the temperature/pH-responsive monomer, and it was used as a carrier of urea to construct the hydrogel fertilizer. The results show that the addition of ATP modified by humic acid and hydrochloric acid to the hydrogel can significantly improve the hydrogel performance, and the hydrogel fertilizers prepared by using these two hydrogels as carriers have excellent environmental responsiveness and slow-release performances. The nutrient release behavior study showed that the hydrogel structure was more easily disrupted, and urea was released more rapidly under acidic and alkaline conditions. The network of the hydrogel collapses and shrinks at 30 °C, while urea was easily released from the hydrogel network. Compared to ordinary urea, the hydrogel fertilizer has an excellent slow-release performance. The environmentally responsive fertilizer would improve nutrient availability and avoid plant root damage and environmental pollution.
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产品关联
DOI
高影响因子
MACROMOLECULES
·
2023
·
IF 5.5
Shunfeng Yu,Kang Liu,Yueyi Tian,Xiaoxiao Chen,Jie Zhang,Mei Gao,Jinhui Wang,Mingming Zhang,Chuanzhuang Zhao
The design of thermoresponsive luminescent polymers with both a tunable upper critical solution temperature (UCST) and a tunable color is of great challenge. Herein, a series of thermoresponsive copolymers with UCST and aggregation-induced emission (AIE) behaviors are prepared, and a color-shifting fluorescent system based on the energy conversion between the AIE polymers and fluorescent dyes is constructed. The copolymers are prepared from acrylamide and 6-(4-vinylphenyl)-2,4-diamino-1,3,5-triazine (VPhDT). Benefitting from VPhDT, an AIE-active monomer that can provide multiple hydrogen bonds and enhance association of the polymer chains, the obtained copolymers exhibit both UCST and AIE behaviors in aqueous solutions. Utilizing the AIE copolymers as the donor and fluorescent dyes as the acceptors, color-shifting fluorescent systems that can emit blue, green, and red lights are established. The color-shifting fluorescent systems also exhibit tunable luminescent intensities and colors with the stimuli of temperature and pH. Such a color-shifting fluorescent system may have promising applications in the fields of temperature sensors and information displays.
研究领域:
聚合物化学
·
材料科学
·
光学材料
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）