Nanoscale Research Letters
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2013
·Vol. 8
·期 1
·1-7
·
IF 2.524
Hu Hongwei,Ding Jianning,Zhang Shuai,Li Yan,Bai Li,Yuan Ningyi
Ag 2 S quantum dots were deposited on the surface of TiO 2 nanorod arrays by a two-step photodeposition. The prepared TiO 2 nanorod arrays as well as the Ag 2 S deposited electrodes were characterized by X-ray diffraction, scanning electron microscope, and transmission electron microscope, suggesting a large coverage of Ag 2 S quantum dots on the ordered TiO 2 nanorod arrays. UV–vis absorption spectra of Ag 2 S deposited electrodes show a broad absorption range of the visible light. The quantum dot-sensitized solar cells (QDSSCs) based on these electrodes were fabricated, and the photoelectrochemical properties were examined. A high photocurrent density of 10.25 mA/cm 2 with a conversion efficiency of 0.98% at AM 1.5 solar light of 100 mW/cm 2 was obtained with an optimal photodeposition time. The performance of the QDSSC at different incident light intensities was also investigated. The results display a better performance at a lower incident light level with a conversion efficiency of 1.25% at 47 mW/cm 2 .
研究领域:
材料科学
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能源科学
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纳米技术
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DOI
PubMed
高影响因子
ANALYTICAL CHEMISTRY
·
2019
·
IF 6.35
Huan Gao,Junfang Zhang,Ying Liu,Wenwen Tu,Tianxiang Wei,Zhihui Dai
Development of sensitive detection methods for microRNAs has realistic application value for early clinical analysis and accurate diagnosis. In this study, a triple-helix molecular switch electrochemiluminescence resonance energy transfer (ECL-RET) nanoamplifier was designed to construct an electrochemiluminescence (ECL) biosensor for microRNA determination. The newly synthesized S-doped Lu2O3, which shows a 3 times better ECL performance than Lu2O3, was chosen as the donor in this ECL-RET system. Accordingly, Ag2S quantum dots (QDs) were used as the matched acceptor. They exhibited overlapping spectra and efficient energy transfer between each other. Furthermore, using a triple-helix switch structure with an improved quenching effect for signal amplification and a nano-DNA walker transformational system as a powerful method for target amplification, a supernanoamplifier was achieved. As a consequence, the proposed ECL biosensor for microRNA-141 detection exhibited good analytical performance with a low detection limit (16 aM). The sensor not only led to the development of a novel ECL-RET pair but also provided a strong nanoamplifier for biosensing platform construction, which may offer some new considerations regarding material design, signal amplification, and show promising application value in biomedical and clinical diagnosis.
研究领域:
生物传感技术
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纳米材料科学
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临床诊断
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DOI
PubMed
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2023
·
IF 3.3
Qingyuan Cheng,Liman Li,Mingxia Yu
Silver chalcogenide (Ag2X; X = S, Se, Te) quantum dots (QDs) have facilitated the biomedical applications of QDs due to their low toxicity and tunable emission reaching the second near-infrared window (NIR-II window, 1000–1700 nm). The photoluminescence intensity of Ag2S QDs and Ag2Se QDs is considerably enhanced via Pb doping. However, the developed Pb-doped Ag2S QDs lacked in vivo verification, and the toxicity of the Pb-doped Ag2X QDs was only preliminarily assessed. Although QDs containing Pb have been widely introduced into the field of biomedicine, there are still concerns regarding toxicity associated with Pb. In the present study, we prepared polyethylene glycol (PEG)-modified Pb-doped Ag2S QDs with better biocompatibility and tested their in vivo bioimaging and toxicity in comparison with Ag2S QDs modified with the same PEG under identical concentrations. Results indicated that the PEG-modified Pb-doped Ag2S QDs significantly enhanced the brightness of in vivo bioimaging and spatial resolution for vessels inside the tumor without increasing toxicity, assessed based on cell viability post incubation for 96 h, intracellular ROS level, DNA damage, early apoptosis and mitochondrial injury. Our study demonstrated that the PEG-modified Pb-doped Ag2S QDs could serve as an advanced fluorescent probe for various biomedical applications.
研究领域:
生物医学工程
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材料科学
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纳米技术
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毒理学
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产品关联
DOI
高影响因子
Biomaterials Science
·
2024
·
IF 5.8
Jia-Hua Zou,Li-Li Chen,Yong-Guo Hu,Dong Zhou,Yong Li,Bin Zhang,Xin-Yue Xu,Bo Liu,Jin-Xuan Fan,Yuan-Di Zhao
Accurate tumor detection is crucial for the early discovery and subsequent treatment of small neoplastic foci. Molecular imaging, which combines non-invasiveness, high specificity, and strong sensitivity, excels in diagnosing early tumors and stands out among tumor diagnosis methods. Here, we introduced a dual-modal imaging probe capable of actively targeting tumor cells, suitable for both near-infrared (NIR) fluorescence and magnetic resonance imaging (MRI). Dendritic mesoporous silica was used as a carrier for the probe, encapsulating Ag2S quantum dots (QDs) for NIR fluorescence imaging. Additionally, the probe conjugated the MRI contrast agent Gd-DOTA and cetuximab, which targeted EGFR on the tumor cell membrane surface, to achieve dual-modal imaging in the tumor area. This strategy provided a methodology for the accurate diagnosis of early-stage tumor lesions and guides precise lesion resection during surgery, offering significant potential for clinical application.
研究领域:
生物医学工程
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分子成像
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癌症诊断
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纳米技术
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产品关联
DOI
PubMed
高影响因子
CHEMISTRY-A EUROPEAN JOURNAL
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2019
·Vol. 25
·期 31
·7553-7560
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IF 5.16
Kai Cheng,Xiao-Shuai Zhang,Jie An,Cheng Li,Ruo-Yun Zhang,Run Ye,Bang-Jiao Ye,Bo Liu,Yuan-Di Zhao
Graphical Ag 2 S quantum dots are shown to be capable of killing tumor cells by photodynamic therapy with near-infrared light irradiation, and after modification with polydopamine, they can induce more reactive oxygen species as a result of the regulation of polydopamine, which is demonstrated by experiments. Given their superior penetration depths, photosensitizers with longer absorption wavelengths present broader application prospects in photodynamic therapy (PDT). Herein, Ag 2 S quantum dots were discovered, for the first time, to be capable of killing tumor cells through the photodynamic route by near-infrared light irradiation, which means relatively less excitation of the probe compared with traditional photosensitizers absorbing short wavelengths. On modification with polydopamine (PDA), PDA-Ag 2 S was obtained, which showed outstanding capacity for inducing reactive oxygen species (increased by 1.69 times). With the addition of PDA, Ag 2 S had more opportunities to react with surrounding O 2 , which was demonstrated by typical triplet electron spin resonance (ESR) analysis. Furthermore, the PDT effects of Ag 2 S and PDA-Ag 2 S achieved at longer wavelengths were almost identical to the effects produced at 660 nm, which was proved by studies in vitro. PDA-Ag 2 S showed distinctly better therapeutic effects than Ag 2 S in experiments in vivo, which further validated the enhanced regulatory effect of PDA. Altogether, a new photosensitizer with longer absorption wavelength was developed by using the hitherto-unexplored photodynamic function of Ag 2 S quantum dots, which extended and enhanced the regulatory effect originating from PDA.
研究领域:
纳米技术
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癌症治疗
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材料科学
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
ADVANCED POWDER TECHNOLOGY
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2021
·
IF 4.833
Minjie Gao,Haodong Zhao,Zhihua Wang,Yanbao Zhao,Xueyan Zou,Lei Sun
Although Ag 2 S quantum dots (QDs) have attracted extensive attention in the fields of diagnosis and therapy, it is still a challenge to prepare Ag 2 S QDs with well-controlled size distribution. Herein, size-tunable Ag 2 S QDs with glutathione (GSH) as ligands were prepared via a facile aqueous precipitation method. The QDs are precisely prepared through carefully controlled growth of Ag2S QDs by varying the heating time. Morphology and structure characterization verify that Ag 2 S QDs with 2.0–5.8 nm in diameter are coordinated with GSH through thiol group. The as-prepared Ag 2 S QDs exhibit broad absorption spectra and narrow fluorescence emission spectra in the near-infrared region. Meanwhile, the QDs perform excellent and stable photothermal effect with a photothermal conversion efficiency up to 58.6%. More importantly, it is found that the size of Ag 2 S QDs has a significant influence on the fluorescence intensity and photothermal effect. The cell viability evaluation in vitro demonstrates that Ag 2 S QDs have low cytotoxicity to 293 T cells and Hela cells by methyl thiazolyl tetrazolium test. This paper proposes a convenient route to prepare unique Ag 2 S QDs, which are capable to act as ideal theranostics probes for photothermal therapy and simultaneously monitoring the therapeutic effect for effective cancer treatment.
研究领域:
纳米技术
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材料科学
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生物医学工程
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癌症研究
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产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
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2016
·
IF 7.145
Jing Zhang,Guangyu Hao,Chenfei Yao,Jiani Yu,Jun Wang,Weitao Yang,Chunhong Hu,Bingbo Zhang
Bimodal imaging has captured increasing interests due to its complementary characteristics of two kinds of imaging modalities. Among the various dual-modal imaging techniques, MR/fluorescence imaging has been widely studied owing to its high 3D resolution and sensitivity. There is, however, still a strong demand to construct biocompatible MR/fluorescence contrast agents with near-infrared (NIR) fluorescent emissions and high relaxivities. In this study, BSA-DTPAGd derived from bovine serum albumin (BSA) as a novel kind of biotemplate is employed for biomineralization of paramagnetic NIR Ag2S quantum dots (denoted as Ag2S@BSA-DTPAGd pQDs). This synthetic strategy is found to be bioinspired, environmentally benign, and straightforward. The obtained Ag2S@BSA-DTPAGd pQDs have fine sizes (ca. 6 nm) and good colloidal stability. They exhibit unabated NIR fluorescent emission (ca. 790 nm) as well as high longitudinal relaxivity (r1 = 12.6 mM–1 s–1) compared to that of commercial Magnevist (r1 = 3.13 mM–1 s–1). In vivo tumor-bearing MR and fluorescence imaging both demonstrate that Ag2S@BSA-DTPAGd pQDs have pronounced tiny tumor targeting capability. In vitro and in vivo toxicity study show Ag2S@BSA-DTPAGd pQDs are biocompatible. Also, biodistribution analysis indicates they can be cleared from body mainly via liver metabolism. This protein-mediated biomineralized Ag2S@BSA-DTPAGd pQDs presents great potential as a novel bimodal imaging contrast agent for tiny tumor diagnosis.
研究领域:
生物医学工程
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材料科学
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纳米技术
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医学成像
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产品关联
DOI
PubMed
高影响因子
MICROCHEMICAL JOURNAL
·
2025
·
IF 5.1
Meixin Li,Pengfei Yu,Shanshan Li,Mati Ullah Khan,Shun Wang,Jiaqi Tian,Shuang Liu,Ling Kong,Zhiwei Chen
Aflatoxin B 1 (AFB 1 ) and ochratoxin A (OTA) are highly toxic mycotoxins prevalent in food and feed, posing severe threats to human and animal health. This work presents an innovative photoelectrochemical aptamer sensor for the detection of AFB 1 and OTA, leveraging a ternary BiOBr/Bi/BiOI heterojunction and Ag 2 S quantum dot-mediated signal amplification. The BiOBr/Bi/BiOI composite was synthesized via a one-step hydrothermal reduction using l -ascorbic acid (AA), exhibiting a high specific surface area to enhance biorecognition efficiency. In situ-assembled Ag 2 S quantum dots amplified photocurrent responses, while a single aptamer probe enabled specific dual-target recognition. Under optimized conditions, the sensor achieved exceptional sensitivity: linear ranges of 0.001–100 ng·mL −1 for both mycotoxins, with detection limits of 4.34 fg·mL −1 (AFB 1 ) and 13.54 fg·mL −1 (OTA). Validation in complex food matrices confirmed high accuracy and robustness. This platform not only provides a reliable method for mycotoxin monitoring but also establishes a versatile design paradigm for multiplexed detection of food contaminants.
研究领域:
分析化学
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食品科学
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生物传感器
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纳米技术
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环境监测
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产品关联
DOI
高影响因子
TALANTA
·
2025
·
IF 6.1
Meixin Li,Zongbo Song,Shanshan Li,Mati Ullah Khan,Yongzhi Wang,Yunsi Xu,Shun Wang,Ling Kong,Zhiwei Chen,Feng Sang
Patulin (PAT), a potent mycotoxin commonly found in fruit and vegetable products, represents a critical threat to food safety and public health. Its cytotoxicity arises from the disruption of intracellular signaling pathways and oxidative balance, leading to gastrointestinal impairment, immune suppression, and systemic toxicity. To mitigate these risks, we present a label-free photoelectrochemical (PEC) aptasensor for ultrasensitive PAT detection, employing an in situ-synthesized Ag 2 S quantum dot (QD)-sensitized BiOI/Bi 2 O 3 heterojunction. The BiOI/Bi 2 O 3 heterostructure enhanced charge carrier separation, while the in situ-anchored Ag 2 S QDs functioned as effective photosensitizers, significantly amplifying the PEC response. Integrated with a PAT-specific aptamer, the sensor demonstrated selective target recognition, achieving a linear detection range from 0.001 to 100 ng/mL and a remarkably low detection limit of 0.56 pg/mL. The aptasensor exhibited high selectivity against structurally similar mycotoxins, excellent stability (94.2% signal retention through 15 on/off light irradiation cycles). Successful PAT quantification in spiked apple juice samples confirmed its practicality for real-world applications. This study establishes a sensitive, cost-effective, and reliable analytical tool for monitoring mycotoxins in food safety protocols.
研究领域:
食品安全
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分析化学
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纳米技术
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生物传感器
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毒理学
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光电化学
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产品关联
DOI
PubMed
高影响因子
Science Bulletin
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2022
·
IF 20.577
Shaohua Qu,Qian Jia,Zheng Li,Zhongliang Wang,Li Shang
Near-infrared II (NIR-II) fluorescent nanoprobes hold great potential for biomedical applications. Elucidating the relationship between surface properties of NIR-II nanoprobes and their biological behaviors is particularly important for future probe design and their performance optimization. Despite the rapid development of NIR-II nanoprobes, the distinct role of surface chirality on their biological fates has rarely been exploited. Herein, chiral NIR-II fluorescent Ag 2 S quantum dots (QDs) are synthesized to investigate the relationship between their chirality and biological functions at both in vitro and in vivo levels. D- / L -Ag 2 S QDs exhibit significant differences on their interactions with serum proteins, which further affect the cellular uptake. As a result, D -Ag 2 S QDs can be internalized with higher efficiency (over 2-fold) than that of L -Ag 2 S QDs. Moreover, in vivo studies reveal that the chirality determines the primary localization of these chiral QDs, where a more efficient renal elimination of D -Ag 2 S QDs was observed than that of L -Ag 2 S QDs. Importantly, D -Ag 2 S QDs show preferential accumulation in tumor region than that of L -Ag 2 S QDs in orthotopic kidney tumor model, which points out a new avenue of enhancing targeting capabilities of nanoprobes by engineering their surface chirality.
研究领域:
生物医学工程
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纳米技术
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分子生物学
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癌症研究
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产品关联
DOI
PubMed
高影响因子
TALANTA
·
2021
·
IF 6.057
Huan Gao,Junfang Zhang,Xuan Wei,Qinshu Zhu,Tianxiang Wei
Developing efficient and sensitive cytosensing method has great significance for the detection of low abundant circulating tumor cells (CTCs). Electrochemiluminescence (ECL) biosensor, as an attractive analytical tool, has shown a great potential in sensitive cell counting. Its detection efficiency is strongly dependent on the electrochemiluminescent materials, whose property is related to its morphology and surface vacancies. Herein, the ultrathin Lu 2 O 3 –S nanosheets contain abundant oxygen vacancies were newly synthesized. Its special two-dimensional (2D) structure morphology and surface vacancy endowed it intensified and stable ECL emission. The possible mechanism was deduced from experiments and discussed. Then, through integrating with a DNA device cycle-amplification system plus signal conversion pretreatment, we constructed a crossed enhanced ECL cytosensing platform. In this system, the target cells were transformed into programmable sequences, which could be next coupled with DNA device cycle-amplification on the modified electrode surface. Using Ag 2 S quantum dots as the energy acceptor toward Lu 2 O 3 –S donor, and CCRF-CEM cells (CEM) as the model CTCs, an enhanced ECL cytosensing platform was proposed, displaying good analytical performance for acute lymphoblastic leukemia cancer cell detection. The ECL signal responded proportionately on the CEM cells concentration in a wide range of 5 × 10 to 1 × 10 6 cells/mL, and a low detection limit of 10 cells/mL was obtained. This work provided an alternative way to design high-performance ECL luminophores, and also would be an effective solution for CTCs counting.
研究领域:
生物传感器
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纳米技术
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癌症诊断
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分析化学
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生物化学
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DOI
PubMed
高影响因子
BIOMATERIALS
·
2013
·
IF 7.604
Yan Zhang,Yejun Zhang,Guosong Hong,Wei He,Kun Zhou,Kai Yang,Feng Li,Guangcun Chen,Zhuang Liu,Hongjie Dai,Qiangbin Wang
Ag 2 S quantum dots (QDs) have been demonstrated as a promising near-infrared II (NIR-II, 1.0–1.4 μm) emitting nanoprobe for in vivo imaging and detection. In this work, we carefully study the long-term in vivo biodistribution of Ag 2 S QDs functionalized with polyethylene glycol (PEG) and systematically examine the potential toxicity of Ag 2 S QDs over time. Our results show that PEGylated-Ag 2 S QDs are mainly accumulated in the reticuloendothelial system (RES) including liver and spleen after intravenous administration and can be gradually cleared, mostly by fecal excretion. PEGylated-Ag 2 S QDs do not cause appreciable toxicity at our tested doses (15 and 30 mg/kg) to the treated mice over a period of 2 months as evidenced by blood biochemistry , hematological analysis and histological examinations. Our work lays a solid foundation for further biomedical applications of Ag 2 S QDs as an important in vivo imaging agent in the NIR-II region.
研究领域:
生物医学工程
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药理学
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毒理学
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纳米技术
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成像科学
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）