DYES AND PIGMENTS
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2022
·
IF 5.122
Yurong Guo,Yue Liang,Yanan Wang,Jingran Zhang,Chao Wang,Yan Sun,Xia Feng,Guangjiu Zhao
The BODIPY-Fluorene derivatives with an orthogonal conformation were prepared for the emission of efficient phosphorescence. The derivatives show visible light absorption (497–513 nm), high phosphorescence quantum efficiency (36.2%) and realize control of luminescence color from green to orange-red. Typical orthogonal conformation and smaller excited state (S 1 and T 4 ) energy gap (0.05 eV) are favorable for intersystem crossing (ISC) process. The calculation are carried out for rationalization between the photophysical properties and conformation of the BODIPY-Fluorene derivatives. We demonstrate that the conformational substitution positions and the distance between D-A are promising strategy to regulate the emission lifetime and quantum efficiency for BODIPY derivatives. Moreover, the ability to generate singlet oxygen was measured by photooxidation of 1,3-diphenylisobenzofuran (DPBF) by singlet oxygen ( 1 O 2 ) photosensitization . At the same time, the LED device displays bright orange-red emission. This work paves the way for further research into the design and application of such materials in advanced optics.
研究领域:
材料科学
·
光学
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DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2024
·Vol. 59
·期 41
·19628-19641
·
IF 3.5
Song Shuang,Yang Na,Nawaz Muhammad Azhar Hayat,He Di,Han Wenzhao,Sun Baosheng,Steinmann Casper,Qi Hong,Li Ying,Shen Xiande,Yu Cong
Drug-resistant bacterial wound infections have become a major threat to human health worldwide, and there is an urgent need to develop a new generation of antibacterial agents to replace conventional antibiotics. In this work, we proposed an efficient nanoplatform that combines photothermal therapy (PTT) and light-triggered release of nitric oxide (NO) to combat bacteria. A multifunctional nanoplatform (BBDH NPs) based on a BODIPY probe, NO thermal responsive donor [ N , N ′-di-sec-butyl- N , N ′-diniroso-1,4-phenylenediamine (BNN6)], and a PEGylated polymer was prepared with a nanoprecipitation method. BBDH NPs represent a one-two punch against bacterial infections, combining potent photothermal therapy and the controlled release of NO, enabling rapid and efficient eradication of gram-negative and gram-positive bacteria. Histological analysis on a mouse model demonstrates that wounds treated with BBDH NPs and 685 nm laser irradiation have completed re-epithelialization, significant collagen deposition, and a number of hair follicle formation. BBDH NPs also exhibit a remarkable therapeutic effect on wounds infected with methicillin-resistant Staphylococcus aureus (MRSA). These results highlight that the proposed synergistic antibacterial strategy can be used as a potential therapeutic tool in drug-resistant, bacterial-infected wounds. Graphical
研究领域:
生物医学工程
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纳米医学
·
感染性疾病
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DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2017
·
IF 5.401
Kai Liu,Ye Zhang,Ti Zhou,Xiaohe Liu,Bo Chen,Xin Wang,Xiaojun Zhao,Jianzhong Huo,Yajing Wang,Bolin Zhu
A novel multifunctional sensor based on the ‘privileged ligand’ salen scaffold conjugated with BODIPY was designed and synthesized. This conjugate displays a sequential recognition of Hg 2+ and I − with high selectivity and sensitivity via formation of three-component ensembles.These new approaches have been successfully applied for the detection of their corresponding targets in Haihe River with acceptable recovery.
研究领域:
分析化学
·
环境监测
·
分子探针
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生物传感
·
无机离子检测
✓ 已验证
DOI
高影响因子
INORGANIC CHEMISTRY
·
2015
·
IF 4.762
Fangfang Zhong,Ahmet Karatay,Liang Zhao,Jianzhang Zhao,Cheng He,Caishun Zhang,Halime Gul Yaglioglu,Ayhan Elmali,Betül Küçüköz,Mustafa Hayvali
Pt(II) dbbpy bisacetylide (dbbpy = 4,4′-di(tert-butyl)-2,2′-bipyridine) complex (Pt-1) with two different Bodipy ligands was prepared with the goal to attain broad-band visible light absorbing, efficient funneling of the photoexcitation energy (via resonance energy transfer, RET) to the energy acceptor and high triplet formation quantum yields. Construction of the above-mentioned molecular structural motif is challenging because two different arylacetylide ligands are incorporated in the complex; normally two homoleptic acetylide ligands were used for this kind of N∧N Pt(II) complexes. A reference complex with trans bis(tributylphosphine) Pt(II) bisacetylide protocol (Pt-4) was prepared for comparison of the photophysical properties. The two different Bodipy ligands in Pt-1 and Pt-4 constitute singlet/triplet energy donor/acceptor, as a result the harvested photoexcitation energy can be funneled to the triplet state confined on one of the two Bodipy ligands. The photophysical properties of the complexes were studied with steady state UV–vis absorption and luminescence spectroscopies, femto- and nanosecond transient absorption spectroscopies, cyclic voltammetry, as well as DFT/TDDFT calculations. Fluorescence/phosphorescence dual emission were observed for the complex. The ultrafast intramolecular singlet/triplet energy transfer in Pt-1 was confirmed by the transient absorption spectroscopy (kFRET = 2.6 × 1011 s–1, ΦFRET = 87.1%) followed by an intersystem crossing (kISC = 1.9 × 1010 s–1), and the triplet state lifetime (τT) is 54.1 μs. The reference complex Pt-4 shows drastically different kinetics with kFRET = 6.9 × 1010 s–1, ΦFRET = 81.0%, kISC = 5.83 × 109 s–1, and τT = 147.9 μs. Different singlet oxygen (1O2) quantum yields (ΦΔ = 75% and 70%) and triplet state quantum yields (ΦT = 91% and 69%, respectively) were observed for complexes Pt-1 and Pt-4.
研究领域:
化学
·
光物理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Analytical Methods
·
2013
·Vol. 5
·期 20
·5589-5596
·
IF 1.855
Guangfei Wu,Fang Zeng,Shuizhu Wu
Hypochlorite is one of the biologically important reactive oxygen species (ROS). Herein, a BODIPY-based fluorescent probe (BOD-OXIME) has been designed and synthesized for fluorescence detection of hypochlorite in aqueous media and imaging in live cells. Incorporating hydrophilic carboxyl and hydroxyl moieties makes the probe BOD-OXIME highly water soluble, thus making it operable in totally aqueous media. Besides, the probe can respond quickly toward hypochlorite in aqueous media. This new probe exhibits high selectivity and sensitivity towards ClO− over other reactive oxygen species (ROS) and reactive nitrogen species (RNS). Furthermore, the probe BOD-OXIME can be successfully applied to image both exogenous and endogenous ClO− in living cells.
研究领域:
分析化学
·
生物化学
·
细胞生物学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2022
·Vol. 57
·期 45
·21206-21218
·
IF 4.682
Song Shuang,Xu Guochao,Yang Na,Shahzad Sohail Anjum,Lv Junying,Shen Xiande,Yu Cong
Wound healing is a complicated process that can be susceptible toward infection caused by bacteria. The surging drug resistance has become one of the biggest challenges to the treatment of these infections in public health. Herein, a new asymmetrical aza-boron-dipyrromethene (ABDP) probe is prepared and encapsulated with cholesterol-modified polyethylene glycol polymer (Chol-PEG 2000 -NH 2 ) to construct a PTT/PDT dual-modality antibacterial agent (the ABDP NPs) and provide a new material for the treatment of MRSA-based infections. The ABDP NPs show remarkable wide UV–Vis absorption at 300–850 nm and superior bactericidal effects against Staphylococcus aureus ( S. aureus ), Escherichia coli ( E. coli ), and Methicillin-resistant S. aureus (MRSA), which can be controlled by a phototheranostic antibacterial switch (808 nm laser). Histological analysis indicates that wounds treated by the ABDP NPs plus NIR laser irradiation exhibit more complete re-epithelialization, abundant collagen fibers, and higher hair follicle numbers than the vancomycin-treated group. This study provides a promising perspective using aza-BODIPY dye for the treatment of multidrug-resistant bacteria-based infections and clinical applications in the future.
研究领域:
生物医学工程
·
药学
·
微生物学
✓ 已验证
DOI
高影响因子
DYES AND PIGMENTS
·
2021
·
IF 4.889
Youliang Tian,Quan Cheng,Huiping Dang,Hongyun Qian,Changchang Teng,Kai Xie,Lifeng Yan
In PDT, high doses of photosensitizers can lead to prolonged patient photosensitivity and undesired side effects. As a classic fluorescent dye, BODIPY has attracted much attention in optical diagnosis and therapy due to its excellent stability, effective singlet oxygen production, and flexible modification. Herein, we synthesized successfully two organic near-infrared BODIPY derivatives with active groups. NO 2 -BDPI could be transformed into NH 2 -BDPI after responding to hydrogen sulfide in solution and brought an apparent color change. And both dyes possessed excellent single oxygen production capacity ( Φ Δ = 0.629 for NO 2 -BDPI and Φ Δ = 0.688 for NH 2 -BDPI). After being encapsulated with an amphiphilic polypeptide , NH 2 -BDPI could be assembled into nano–NH 2 –BDPI particles that own good water solubility and passively tumor-targeting via the enhanced permeability and retention (EPR) effect. Benefiting from the admirable cellular uptake and excellent intracellular ROS generation in vitro , the nano–NH 2 –BDPI shows splendid PDT effect towards 4T1 and HeLa cells under very low doses (0.24 μM) and NIR power density (660 nm 10 mW/cm 2 ). In vivo experiment, the nano-photosensitizer exhibited highly effective tumor suppression and ablation under a 40 mW/cm 2 NIR irradiation. The exploration demonstrated the commendable PDT effect of NH 2 -BDPI and made it be a potential candidate for further NIR imaging-guided PDT research in clinical application.
研究领域:
医学
·
药学
·
生物材料
✓ 已验证
DOI
高影响因子
LIQUID CRYSTALS
·
2018
·
IF 2.636
Huiyi Feng,Xiaotong Geng,Jianrong Lin,Hongyu Guo,Fafu Yang
The novel triphenylene-Bodipy derivatives 6 and 7 based on 1,3,5-triazine core were designed and synthesised by introducing BODIPY unit and triphenylene units sequentially onto cyanuric chloride. The Bodipy derivative 6 with one triphenylene unit was a nematic liquid crystal but the derivative 7 with two triphenylene units was a hexagonal columnar liquid crystal. The investigation on photophysical properties suggested that both of them exhibited excellent fluorescence with high fluorescence quantum yields and the Stokes shifts were larger than their Bodipy precursors. This research presented a good example of design and synthesis of columnar Bodipy liquid crystal with high fluorescence and large Stokes shift.
研究领域:
材料化学
·
光学材料
·
有机合成
✓ 已验证
DOI
高影响因子
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
·
2022
·Vol. 23
·期 22
·14473
·
IF 6.208
Guojing Li,Mengqian Yang,Qilong Sha,Li Li,Xiaogang Luo,Fengshou Wu
Organic nanomaterials have attracted considerable attention in the area of photodynamic and photothermal therapy, owing to their outstanding biocompatibility, potential biodegradability, well-defined chemical structure, and easy functionalization. However, it is still a challenge to develop a single organic molecule that obtains both photothermal and photodynamic effects. In this contribution, we synthesized a new boron-dipyrromethene (BODIPY)-based derivative (DPBDP) with an acceptor–donor–acceptor (A-D-A) structure by coupling 3,6-di(2-thienyl)-2,5-dihydropyrrolo [3,4-c] pyrrole-1,4-dione (DPP) and BODIPY. To enhance the hydrophilicity of the BODIPY derivative, the polyethylene glycol (PEG) chains were introduced to themeso- position of BODIPY core. The amphiphilic DPBDP was then self-assembled into related nanoparticles (DPBDP NPs) with improved hydrophilicity and enhanced absorbance in the NIR region. DPBDP NPs could simultaneously generate the singlet oxygen (1O2) and heat under the irradiation of a single laser (690 nm). The1O2quantum yield and photothermal conversion efficiency (PCE) of DPBDP NPs were calculated to be 14.2% and 26.1%, respectively. The biocompatibility and phototherapeutic effect of DPBDP NPs were evaluated through cell counting kit-8 (CCK-8) assay. Under irradiation of 690 nm laser (1.0 W/cm2), the half maximal inhibitory concentration (IC50) of DPBDP NPs was calculated to be 16.47 µg/mL. Thus, the as-prepared DPBDP NPs could be acted as excellent candidates for synergistic photodynamic/photothermal therapy.Keywords:BODIPY;nanoparticles;self-assembly;photodynamic therapy;photothermal therapy
研究领域:
生物医学工程
·
材料科学
·
肿瘤学
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DOI
PubMed
高影响因子
ORGANIC ELECTRONICS
·
2023
·
IF 3.2
Bao Xie,Lunxiang Yin,Chang Liu,Junmei Fan,Xu Wang,Yanqin Li
Boron dipyrromethene (BODIPY) dyes have attracted great interests in organoboron chemistry because of their excellent photophysical and electrochemical properties . However, the power conversion efficiency (PCE) of BODIPY-based photovoltaic devices is still relatively low in organic small-molecule solar cells, so the design and development of new photovoltaic materials based on BODIPY have become particularly important by adjusting molecular energy level and bandgap. Recently, symmetrical “BODIPY-TPA” conjugated material gave a desirable electrochemical bandgap as low as 1.36 eV, which prompts us to systematically regulate molecular energy level and bandgap by finely optimizing the structure of reference material SM1 . Therefore, two series of BODIPY dyes were synthesized successfully by one-step Stille reaction . The first type is symmetric D-π-A-π-D-type molecules SM1 and SM3 , where electron-rich triphenylamine and carbazole groups (D) are located on two sides of electron-deficient BODIPY part (A) via thiophene π-spacer, respectively. The second type is unsymmetric D-π-A-type molecules SM2 and SM4 , constructed by removing one “π-D” segment from the symmetric structure. A synergetic effect of regulating terminal group and molecular skeleton length simultaneously on the optoelectronic properties of series of BODIPY dyes, are systematically investigated. As expected, all BODIPY dyes exhibit preferable electrochemical bandgaps of only 1.36–1.56 eV, suitable highest occupied molecular orbital (HOMO) energy levels (<-5.16 eV) and excellent thermal stability ( T d > 340 °C). On the one hand, unsymmetric molecules possess deeper HOMO energy level, whereas symmetric counterparts show enhanced and red-shifted absorption characteristics, ascribed to tunable molecular conjugation length. On the other hand, TPA-containing materials exhibit smaller electrochemical bandgaps, whereas CZ analogues possess lower HOMO energy levels, due to variable electron-rich character of D group. These BODIPY dyes with [6,6]-phenyl-C 61 -butyric acid methyl ester (PC 61 BM) acceptor material , are primarily fabricated to evaluate their photovoltaic properties. The devices based on SM2 and SM4 gave better PCEs of 4.33% and 3.27%, respectively, also yielding higher open-circuit voltages ( V oc s) of 0.87–0.89 V, relative to symmetric ones. In addition, CZ-based devices performed higher V oc than the corresponding TPA-based devices, mainly attributed to deeper HOMO energy level. This work emphasizes a synergetic design strategy of altering end-group structure and molecular main chain length, especially the design of unsymmetric organoboron coordination compounds, which provides important suggestions for enriching novel BODIPY optoelectronic materials.
研究领域:
有机化学
·
材料科学
·
光电子学
✓ 已验证
产品关联
DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2019
·Vol. 43
·期 38
·15057-15065
·
IF 3.069
Jie Hao,Zhi Song Lu,Chang Ming Li,Li Qun Xu
Due to the occurrence of bacterial resistance, there is a significant need to develop alternative antimicrobials to conventional antibiotics. Antibacterial photodynamic therapy (PDT) has been recognized as a promising antibacterial strategy with a low likelihood of generating bacterial resistance. In this work, a maltoheptaose-decorated boron-dipyrromethene (BODIPY) photosensitizer (BODIPY-Mal-I) was synthesized via a copper(I)-catalyzed azide alkyne cycloaddition (CuAAC) reaction, followed by diiodo substitution at the 2,6-positions of the BODIPY core. The as-obtained BODIPY-Mal-I, consisting of a hydrophobic 2,6-diiodo-tetramethyl BODIPY unit and a hydrophilic maltoheptaose segment, can self-assemble and form microaggregates in aqueous medium. Under light illumination, BODIPY-Mal-I in water could generate singlet oxygen rapidly. The generated singlet oxygen could kill the planktonic cells of Gram-positive bacteria efficiently. BODIPY-Mal-I could also eradicate early-stage biofilms of Gram-positive bacteria in the presence of light illumination. In addition, BODIPY-Mal-I exhibits low cytotoxicity to zebrafish embryo without light illumination.
研究领域:
微生物学
·
药理学
·
生物化学
✓ 已验证
产品关联
DOI
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2023
·
IF 4.4
Shengling Li,Xiliang Chang,Xiangpeng Kong,Qi Wang,Feng Zhao,Jia Han,Yu Liu,Tianyuan Wang
In this study, a novel, highly sensitive fluorescent sensor (E)-2-((2-(benzo[d] thiazol-2-yl) quinolin-8-yl) oxy)-N’-(4-(5, 5-difluoro-1, 3, 7, 9-tetramethyl-5H-4λ 4 , 5λ 4 -dipyrrolo [1, 2- c :2’, 1’- f ] [1, 3, 2] diazaborinin-10-yl) benzylidene) acetohydrazide ( TQB ) was developed for dual mode of Ag + detection (colorimetric/fluorescence), and its structural and spectral properties were characterized by 1 H NMR, ESI-MS, X-ray, ultraviolet and fluorescence photometry. It is found that TQB could specifically and efficiently identify Ag + among many other metal ions in CH 3 OH/H 2 O (7:3 v/v, pH = 7.23) buffer. The maximum absorption wavelength of TQB is red-shifted while its fluorescence is quenched with a quenching rate of 88.7%. The energy difference between TQB and TQB -Ag + complex was calculated by DFT, and the applicability of TQB was verified by paper strip test. In addition, TQB has been successfully applied to the determination of Ag + in real water samples with good reversibility and recoveries.
研究领域:
分析化学
·
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
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