ACS Applied Nano Materials
·
2021
·
IF 5.097
Chuanhong Wang,Jun Zhang,Zhonggang Wang
Four nonfluorinated and fluorinated nanoporous polymers [PAN-5H, PAN-5F, PAN-2F, and PAN-2(CF3)] were synthesized from a triazine-based tetramine with benzaldehyde, pentafluorobenzaldehyde, 3,5-difluorobenzaldehyde, and 3,5-bis(trifluoromethyl)benzaldehyde, respectively. It is interestingly found that the porosity parameters and selective adsorptions of CO2 and light hydrocarbons strongly depend not only on the number and kind of fluorine atoms and fluorinated groups, but also on the substituted position on the phenyl rings in the fluorinated porous polymers. Relative to PAN-5H and PAN-5F, PAN-2F, and PAN-2(CF3) with phenyls meta-substituted by two fluorinated groups exhibit considerably increased BET surface areas from 502 to 1269 m2/g. At 298 K and 1 bar, the uptakes of C3H8, C2H6, and C2H4 in PAN-2F reach 4.62, 3.64, and 3.20 mmol/g, respectively, whereas PAN-5F exhibits the highest adsorption selectivities of C3H8/CH4 (372.3), C3H8/CO2 (33.2), C2H6/CH4 (21.8), C3H8/C2H6 (9.4), and CO2/CH4 (7.1) among the four polymers. The dynamic breakthrough experiments demonstrate that the mixed gases of C2H6/C2H4, C3H8/CH4, C2H6/CH4, and CO2/CH4 can be separated by the fluorinated polymers under ambient condition. The achieved results are significant for understanding the effects of fluorine-functionalization on the separation of ethylene and CO2 from light hydrocarbons in nanoporous polymers.
研究领域:
材料科学
·
化学工程
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高影响因子
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
·
2022
·Vol. 23
·期 24
·15586
·
IF 6.208
Hao Bai,Liangliang Mu,Li Qiu,Nuo Chen,Jiadong Li,Qingliang Zeng,Xiaoxue Yin,Jianmin Ye
The complement system is composed of a complex protein network and is pivotal to innate immunity. Complement 3 (C3) is a critical protein in the complement cascade and participates in complement activation and immune defense. In this study, C3 from Nile tilapia (Oreochromis niloticus) was cloned and its function in resisting pathogen infection was characterized. The full length of OnC3 open reading frame is 4974 bp, encoding 1657 aa, and the predicted protein mass weight is 185.93 kDa. The OnC3 amino acid sequence contains macroglobulin domains. The expression pattern of OnC3 mRNA in the tissues of healthy fish was detected, with the highest in the liver and the lowest in the muscle. After challenged withStreptococcus agalactiaeandAeromonas hydrophila, the expression of OnC3 mRNA was significantly up-regulated in the liver, spleen, and head kidney. Further, the recombinant OnC3 protein alleviated the inflammatory response and pathological damage of tissues after infected withS. agalactiae. Moreover, the OnC3 promoted the phagocytosis of monocytes/macrophages toS. agalactiae. The data obtained in this study provide a theoretical reference for in-depth understanding of C3 in host defense against bacterial infection and the immunomodulatory roles in teleost fish.Keywords:Oreochromis niloticus;complement 3 (C3);Streptococcus agalactiae;inflammatory response;phagocytosis
研究领域:
免疫学
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水产养殖
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分子生物学
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高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2023
·
IF 4.2
Shao-Qi Zhi,Jun-Yuan Zhang,Song-Hai Wu,Wen-Shuang Zhu,Yu-Dong Shan,Yong Liu,Xu Han
Turning aromatic sulfur impurities to value-added polymers is a promising technology for fuel desulfurization. In this study, Cu(I,II)@g-C3N4 plates prepared via facile calcination show high reactivity in catalytic oxidation of benzothiophene (BT) by persulfate in a mixture of MeCN/H2O (v/v = 50/50). Quenching experiments rule out the primary contributions of SO4•–, •OH, and O2•– to BT oxidation and confirm the presence of carbon-centered radicals during the desulfurization process. XPS and Raman analyses reveal that Cu(I) and graphitic-N are reactive sites for persulfate activation, accompanied with moderate activation of the peroxo group in persulfate via the nonradical pathway. Solid characterizations indicate the formation of polybenzothiophene S,S-dioxide during the oxidation process, which further reveals that the moderately activated persulfate abstracts H from BT to form a BT radical cation, followed by subsequent polymerization of BT radical cations to a BT tetramer, and then the BT tetramer is further oxidized to a BT S,S-dioxide tetramer. The high electrochemical stability and pseudo-capacitive properties of the obtained polymers also imply their high potential to be used for capacitors. This work provides new insight on turning aromatic sulfur impurities in fuels to “treasures”.
研究领域:
化学工程
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环境科学
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高影响因子
Chinese Journal of Natural Medicines
·
2026
·Vol. 24
·期 1
·100-111
·
IF 4.9
Shanshan Li,Peiling Liu,Tiantian Zhang,Shujun Jiang,Faren Xie,Yanliang Zhang
Insects represent emerging sources of bioactive peptides and functional materials. Mantidis Oötheca (Sang-Piao-Xiao in Chinese, SPX) serves as an insect-derived medicine for treating kidney disease. This study demonstrated that supernatant (SPX) improved kidney function in adriamycin (ADR)-induced nephropathy mice model. Transcriptomic analysis revealed that SPX inhibited complement activation by targeting the MASP1-C3/C3a receptor (C3aR) pathway. Peptidomic analysis identified 304 peptides from SPX, with 49 peptides selected for evaluation using prediction tools and molecular docking with complement core protein C3. Three peptides (PMGFPFDR, FNDPK, AAQFFNR) exhibiting docking scores below −8.0 were synthesized to verify complement inhibition and anti-fibrotic activities. The synthetic peptide AAQFFNR demonstrated complement inhibitory activity, with an inhibitory complement hemolytic 50% (ICH 50 ) value of 24.54 μmol·L −1 , and exhibited superior protective effects in ADR-induced HK-2 cells. Surface plasmon resonance (SPR) assay revealed direct interaction between AAQFFNR and complement C3 with K d value of 16.8 μmol·L −1 . The reno-protective effect of AAQFFNR was subsequently verified in ADR-induced mice. This research provides initial evidence that complement C3-inhibiting peptides from insects demonstrate potential in preventing nephropathy through in silico and in vivo validation approaches.
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高影响因子
ACS Nano
·
2026
·Vol. 20
·期 34
·23716-23728
·
IF 17.3
Zeng Qing,Tamtaji Mohsen,Zhou Rui,Zhou Tao,Guo Zhengxiao,Chen GuanHua,Tse Edmund C. M.
Electrocatalytic oxidation of glycerol toward high-value
C3 products
on Pd-based catalysts presents a promising strategy for upgrading
and converting glycerol. However, C3 intermediates often adsorb too
tightly on Pd-based catalyst surfaces during glycerol oxidation, leading
to C–C bond cleavage. Herein, cubic-shaped PdBi nanoparticles
with tunable Ni doping levels are successfully synthesized through
a one-step solvothermal method. Owing to the downshift of d-band center
originating from the introduction of Bi and Ni as well as the cubic
shape, the PdBiNi ternary nanocubes (NCs) exhibit excellent electrocatalytic
performance for the glycerol oxidation reaction (GOR). Specifically,
Pd 83 Bi 12 Ni 5 NCs with the lowest d-band
center exhibit a specific activity of 61.12 mA cm geo –2 and a mass activity of 5.34 A mg Pd –1 . Notably, the Faradaic efficiency (FE) toward C3
products exceeds 97%. In situ Fourier transform infrared spectroscopy
and density functional theory calculations show that key C3 intermediates
are easily desorbed from the catalyst surface, thereby suppressing
C–C bond cleavage and thus preventing overoxidation into low-value
products. In addition, Pd 83 Bi 12 Ni 5 NCs possess long-term durability over the course of 16 cycles (1
h/cycle) with an FE for C3 products between 92.5% and 97.6% upon scale-up
deployment in a flow electrolyzer, validating its feasibility in practical
operations.
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高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2024
·
IF 9.4
Xingyu Zhang,Chenliang Zhou,Shaoyuan Shi,Xuequan Jing,Zhi Zheng,Wenjing Yuan
Building narrow band gap semiconductors and fast separation of photogenerated electron-hole (e - -h + ) structures are of great significance for photocatalytic process. In this contribution, the CeO 2-x /C 3-y N 4 /Ce(CO 3 )(OH) double S-scheme heterojunctions with atomic vacancies tunable band gap (2.54 eV) have been designed and fabricated as a boost photocatalyst for enrofloxacin (ENR) photodegradation. Compared with the control samples, the experimental results indicate that the typical sample (CeO 2-x /C 3-y N 4 /Ce(CO 3 )(OH)-2) achieves the highest ENR photodegradation efficiency (93.6 %) in 240 min under a pH of 6, and the possible photodegradation pathways are also proposed. The superior performance is ascribed to the CeO 2-x /C 3-y N 4 /Ce(CO 3 )(OH) double S-scheme heterojunctions for selective recombination of photogenerated electrons with weak-reduction ability in conduction band (CB) of CeO 2-x , C 3-y N 4 and the photogenerated holes with weak-oxidation nature in valance band (VB) of C 3-y N 4 , Ce(CO 3 )(OH), which increase the retention rate of photogenerated electrons in CB of Ce(CO 3 )(OH) and photogenerated holes in VB of CeO 2-x to degrade ENR. This is the first systematic study of CeO 2-x /C 3-y N 4 /Ce(CO 3 )(OH) double S-scheme heterojunctions for ENR photodegradation.
研究领域:
环境科学
·
材料科学
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高影响因子
Journal of Cannabis Research
·
2026
·Vol. 8
·期 1
·90
·
IF 3.8
Nichols Niara A.,Dane A. John,Musah Rabi A.
Background Cannabidiol (CBD) is one of over 100 naturally occurring phytocannabinoids in Cannabis . While extensive research has evaluated the effects that CBD and other phytocannabinoids have on consumers, less attention has been directed towards studying the health impacts of the compounds formed when cannabinoids are burned. Such an investigation is highly desirable, as smoking remains the most common form of Cannabis consumption. Previous research has investigated the structures of CBD pyrolysis products that are of a molecular mass similar to or greater than CBD. However, studies of the lower molecular weight products formed when CBD is pyrolyzed at the temperatures of a burning cigarette are limited. This work investigated the identities of the small-molecule cracking products formed from the pyrolysis of CBD. Methods CBD standards were pyrolyzed within the temperature range of 400 °C – 800 °C and analyzed using two-dimensional gas chromatography – high-resolution mass spectrometry. A combination of mass spectral fragmentation patterns, retention index data, GC retention times, and comparison of the profiles of detected compounds with those of authentic standards were used to identify cracking products that eluted during the first 19 min of a 90-min analysis. Results This investigation revealed a mixture of pyrolysis products whose complexity increased with increasing temperature. A total of 86 compounds were detected, 81 of which were identified. They spanned the alkane (both cyclic and acyclic), alkene (both cyclic and acyclic), alkyne, substituted benzene, aromatic heterocycle, phenol, and ketone compound classes. Seventy-eight of the identified molecules are reported here for the first time as CBD pyrolysis products. Several are known to have adverse health effects, including genotoxicity and neurotoxicity. Others have been reported to possess health benefits such as anti-inflammatory and antioxidant properties. Conclusions The pyrolysis of CBD revealed a complex mixture of 86 C 3 - C 10 cracking products across all five temperatures analyzed. The largest number of compounds were formed at 800 °C, while the smallest number of products was observed at 400 °C. The vast majority of these compounds have not been reported in previous studies of CBD pyrolysis. Many of the identified products are known to have impacts on human health.
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高影响因子
CANCER LETTERS
·
2026
·
IF 11.8
Jie Wang,Huihao Ma,Baozhi Feng,Yan Fu,Chunlin Lu,Mingyang Fei,Yuxin Zhang,Bin Dong,Ying Li,Jing Liu
Aldo-keto reductase family 1 member C3 (AKR1C3) is a pivotal metabolic enzyme involved in arachidonic acid (AA) metabolism and cancer metabolic reprogramming, which plays a critical role in the initiation and progression of glioblastoma (GBM). We integrated single-cell and transcriptome data to characterize AA metabolism features in GBM and identify the key gene AKR1C3. Using CCK8 assays, wound-healing assays, transwell assays, and mouse tumor formation experiments, we elucidated the effects of AKR1C3. Dual-luciferase reporter assays and ChIP-PCR experiments were performed to investigate the regulation of transcription factor JUN on AKR1C3 expression. RNA-seq analysis, combined with rescue experiments, demonstrated that AKR1C3 significantly regulates the RhoA/ROCK pathway. Arachidonic acid metabolism is closely associated with clinical outcomes in glioma, with AKR1C3 identified as a key gene within this pathway. AKR1C3 knockdown enhanced tumor cell proliferation, migration, and invasion, whereas AKR1C3 overexpression suppressed these malignant behaviors. In vivo experiments further confirmed the inhibitory effect of AKR1C3 on glioma progression. Dual-luciferase reporter and ChIP-PCR assays demonstrated that JUN acts as an upstream regulator of AKR1C3. ELISA results indicated that AKR1C3 overexpression reduced cellular PGD2 levels. RNA-seq analysis suggested that the RhoA/ROCK pathway was a downstream effector of AKR1C3, and exogenous PGD2 supplementation could reverse AKR1C3-mediated regulation of this pathway. We identified curcumin, a natural product with anti-cancer metabolic regulatory activity, as an upstream modulator that suppresses JUN expression, thereby activating the JUN/AKR1C3 axis and inhibiting malignant phenotypes in GBM cells. JUN/AKR1C3 axis influences glioma progression via modulating PGD2-mediated RhoA/ROCK Signaling.
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高影响因子
ACS Applied Materials & Interfaces
·
2020
·
IF 8.758
Gen Li,Zhonggang Wang
This paper presents a series of micro- and ultramicroporous polyaminals with BET surface areas up to 1304 m2 g–1, which are prepared from two triazine-based tetraamines and three dialdehydes or monoaldehyde through the A4 + B2 or A4 + B1 aminalization reaction. It is interesting to find that the para-substituted monomers are favorable to force the linking struts apart in the network to generate micropores (1.22 nm), whereas the meta-substituted monomers make the pores in the network squeezed by the twisted linking struts, resulting in the formation of ultramicropores (0.52 nm). Besides, the adsorption behaviors of the major components of natural gas, such as propane (C3H8), ethane (C2H6), methane (CH4), and carbon dioxide (CO2), are significantly different, strongly depending on the polarizabilities, critical temperatures, molecular sizes of gases, porosity parameters of polymers, and the interaction between gases and the polymer skeleton. At 298 K/1 bar, the polymers show high uptake for C3H8 (114.5 cm3 g–1) and C2H6 (84.2 cm3 g–1). Moreover, the adsorption selectivities of C3H8/CH4, C2H6/CH4, C3H8/C2H6, C3H8/CO2, C2H6/CO2, and CO2/CH4 also reach 296.3, 23.1, 9.0, 22.1, 4.1, and 5.0, respectively, exhibiting promising applications in adsorption/separation of C1–C3 hydrocarbons and stripping CO2 gas from natural gas under the ambient condition.
研究领域:
材料科学
·
化学工程
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高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2026
·
IF 9.6
Jianghong Ouyang,Ziwei Hang,Qichao Chen,Yan Qing,Yanmei Zheng,Zupeng Chen
Photocatalytic hydrogen peroxide (H 2 O 2 ) production presents a sustainable alternative to the energy-intensive anthraquinone process. However, its efficiency is limited by rapid charge recombination, and the need for sacrificial agents poses challenges for practical deployment. Herein, we develop an S-scheme cadmium sulfide/graphite phase carbon nitride (CdS/CN) heterojunction for H 2 O 2 photosynthesis coupled with glycerol (GLY) oxidation. The optimized CdS/CN demonstrates enhanced charge separation due to interfacial band bending and internal electric fields, achieving a 10.75-fold higher H 2 O 2 yield (3.01 mM) than pristine CN (0.28 mM). Moreover, GLY serves as a dual mediator that enables electron-proton synergy within the photocatalytic system, by acting as both a hole scavenger and a proton donor, effectively increasing H 2 O 2 production while simultaneously undergoing selective oxidation to yield high-value C3 oxidation derivatives such as dihydroxyacetone (DHA) and glyceraldehyde (GLAD), with >99% selectivity. Mechanism studies reveal that the photogenerated electrons drive two-electron O 2 reduction to H 2 O 2 while holes promote GLY oxidation. This electron-proton synergistic coupling system enables simultaneous solar-driven H 2 O 2 production and the selective oxidation of biomass, offering a sustainable pathway for green chemical manufacturing.
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高影响因子
AICHE JOURNAL
·
2014
·Vol. 61
·期 1
·35-45
·
IF 2.581
Feng Xu,Jing-Wen Xu,Bi-Xia Zhang,Luo Yan-Ling
Novel tri-armed star polystyrene-block-poly(N-isopropylacrylamide) block copolymers with trimesic acid as central molecules were synthesized by successive two-step atom transfer radical polymerization, and confirmed by Fourier-transform infrared spectra, 1 H nuclear magnetic resonance, and laser light scattering gel chromatography system. The copolymers could self-assemble into spherical core-shell micelles in aqueous media independent on drug loading. Physicochemical properties of the blank and drug-loaded micelles were examined by surface tension, fluorescence spectroscopy, UV-vis, transmission electron microscope, and dynamic light scattering measurements. The copolymer micelles exhibited thermo-triggered phase transition, with low critical solution temperature of 33.7 and 34.6°C, varying with copolymer compositions. The critical aggregate concentrations were 11.62 and 47.61 mg L −1 , and hydrodynamic diameters from 200 to 220 nm. Water-insoluble 10-hydroxycamptothecine was encapsulated into the micelle aggregates to investigate the change in the resulting physicochemical parameters, thermo-triggered in vitro drug release, and the applicability as drug targeting release carriers. MTT assays were carried out to uncover cytotoxicity of the newly developed micelle-based drug formulations. © 2014 American Institute of Chemical Engineers AIChE J , 61: 35–45, 2015
研究领域:
材料科学
·
药学
·
肿瘤学
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高影响因子
Frontiers in Immunology
·
2020
·
IF 5.085
Wu Wen-Jun,Tan Ying,Liu Xiao-Ling,Yu Feng,Zhao Ming-Hui
To investigate the fine epitope(s) of anti-C1q A08 antibodies and their roles in complement activation in lupus nephritis, C1q A08 and related peptides with various amino acid sequences around A08 were synthesized. Anti-C1q A08 antibodies from 10 lupus nephritis patients were purified from plasmapheresis samples, and four monoclonal antibodies against C1q A08 were screened and identified from mouse hybridoma cells, to study the fine epitope(s) of C1q A08 using ELISA and Biolayer Interferometry (BLI). The biofunction of anti-C1q A08 antibodies for complement classical pathway activation was investigated by C3 activation assay. Anti-C1q A08 antibodies and anti-C1q antibodies were also detected in the sera of female BALB/C mice immunized by C1q A08 peptides. None of the anti-C1q A08 antibodies, which were affinity purified from the 10 lupus nephritis patients, could bind intact C1q coated on microtitre plates, neither could the anti-C1q antibodies bind to C1q A08 peptides coupled on resin, indicating that the human anti-C1q antibodies and anti-C1q A08 antibodies may recognize different epitopes of C1q. One of the four C1q A08 mAbs (32-4) bound to the six amino acids of N-terminus of C1q A08, while another C1q A08 mAb (17-9) bound to eight or 10 amino acids of C-terminus of A08. The third and fourth C1q A08 mAb (1A12 and 4B11) bound to the whole sequence of A08. Only 32-4 mAb bound to the intact C1q coating on an ELISA plate, whereas 17-9 mAb, 1A12 mAb, and 4B11 mAb could not. However, using a BLI assay, 17-9 mAb, 1A12 mAb, and 4B11 mAb, but not 32-4 mAb, could bind to intact C1q. Furthermore, 1A12 mAb and 4B11 mAb, but not 32-4 and 17-9 mAb, could inhibit the activation of complement classical pathway. Anti-C1q A08 antibodies were detected in all the female BALB/C mice in the experimental group but not in the control group. Two out of six in the experimental group developed anti-C1q antibodies. C1q A08 is a half-cryptic epitope of C1q involving N-terminal six amino acids of C1q A08, and this is important to the activation of a complement classical pathway, and some anti-C1q A08 antibodies were able to prevent this process. Epitope spreading of C1q occurred in the mice immunized with C1q A08 peptides.
研究领域:
免疫学
·
风湿病学
·
分子生物学
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高影响因子
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