Journal of Materials Chemistry B
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2024
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IF 6.1
Jingsong Lu,Yupei Wang,Xiaohan Gao,Ying Li,Neema Ufurahi Pambe,Abdul Fahad,Zeping Jin,zhijun He,Zhenhu Guo,Wensheng Xie,Shi Wang,Xiaodan Sun,Xiumei Wang,Jing Yu,Shenglei Che,Guifeng Zhang,Yen Wei,Lingyun Zhao
Enlightened by the great success of drug repurposing strategy in pharmaceutic industries, in the current study, material repurposing was proposed where the performance of carbonyl iron powder (CIP), a nutritional intervention agent of iron supplement approved by the US FDA for iron deficiency anemia in clinical was explored in anti-cancer treatment. Except for the abnormal iron metabolic characteristics of tumors that serving as potential targets for CIP-based cancer therapy under repurposing paradigm, the efficacy of CIP as catalyst in Fenton reaction, activator for dihydroartemisinin (DHA) and thus increase the chemo-sensitivity of tumors, as well as the potent agent for NIR-II photothermal therapy (PTT) was fully evaluated by an injectable alginate hydrogel form. The CIP-ALG gel could cause rapid temperature rise in the tumor site under NIR-II laser irradiation, leading to complete ablation in the primary tumor. Further on, such photothermal-ablation would lead to ATP release significantly and in the bilateral tumor model, both primary tumor ablation and inhibition of secondary tumor were observed simultaneously under synergistic tumor treatment of nutritional-photothermal therapy (NT/PTT). Material repurposing could thus be confirmed by our pioneering trial and the CIP-ALG meditated NT/PTT/immunotherapy would provide new choice of strategy for safe and efficient tumor therapy.
研究领域:
肿瘤学
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材料科学
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生物医学工程
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药学
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免疫疗法
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Acta Biomaterialia
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2022
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IF 10.633
Zixin Zhu,Xue Gou,Laiyi Liu,Tian Xia,Jiayi Wang,Yimeng Zhang,Chenjun Huang,Wei Zhi,Ran Wang,Xiaohong Li,Shengnian Luo
Wound healing from bacterial infections is one of the major challenges in the biomedical field. The traditional single administration methods are usually accompanied with side effects or unsatisfactory efficacy. Herein, we design dynamically evolving antibacterial and repair-promoting nanocomposites (NCs) by in situ self-assembling of zeolitic imidazolate framework-8 (ZIF-8) on the surface of barium titanate (BTO), and further loading with a small amount of ciprofloxacin (CIP). The new strategy of combining pH-stimulated drug delivery and ultrasound-controlled sonodyamics has the potential to dynamically evolve in infected wound sites, offering a multifunctional therapy. In vitro study demonstrates that the enhancement generation of reactive oxygen species through the sonodynamic process due to the heterostructures and a small amount of CIP released in an acidic environment are synergistically antibacterial, and the inhibition rate was >99.9%. In addition, reduced sonodynamic effect and Zn 2+ generated along with the gradual degradation of ZIF-8 simultanously promote cell migration and tissue regeneration . The in vivo study of full-thickness skin wounds in mouse models demonstrate a healing rate of 99.3% could be achieved under the treatment of [email protected] /CIP NCs. This work provides a useful improvement in rational design of multi-stimulus-responsive nanomaterials for wound healing. Statement of significance A novel piezoelectric nanocomposite was proposed to realize sonodynamic therapy and pH-stimulated drug releasing simultaneously in wound healing treatment. The dynamically evolving structure of the piezoelectric nanocomposite in acidic microenvironment has been theoretically and experimentally verified to contribute to a continuous variation of sonodymanic strength , which accompanied with the gradual releasing of drug and biocompatible Zn 2+ effectively balanced antibacterial and repair-promoting effects. Both of the in vitro and in vivo study demonstrated that the strategy could significantly accelerate wound healing, inspiring researchers to optimize the design of multi-stimulus-responsive nanomaterials for various applications in biomedical and biomaterial fields.
研究领域:
生物医学工程
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纳米技术
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伤口愈合
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抗菌材料
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组织工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Future Foods
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2025
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IF 7.2
Lei Dou,Zimu Zhang,Xiufang Huang,Yaobing Chen,Kai Luo,Jianquan Kan
Considering that the peptide from Idesia polycarpa Maxim.cake meal polypeptide (CIP) is a novel antioxidant agent, this study aimed to develop an efficient and safe food film by incorporating the CIP agent into a gelatin matrix. The films with different concentrations of CIP were characterised and applied in the preservation of nectarines. The results indicated that the CIPF/3% fraction exhibited significant moisture barrier properties, with a water vapor permeability (WVP) of only 8.12 % ± 0.09 %. Additionally, it demonstrated excellent mechanical and antioxidant properties, with scavenging capacities of 76.31 % ± 0.597 %, 65.98 % ± 0.444 %, and 60.98 % ± 0.231% for DPPH, ABTS, and hydroxyl radicals, respectively, surpassing those of other fractions. In nectarine freshness preservation, the Coating/3% fraction showed the best performance. It significantly reduced the weight loss rate of nectarines, improved fruit firmness, maintained the pH value, and minimized nutrient losses, including ascorbic acid and Total soluble sugars (TSS). Furthermore, it effectively preserved the bright surface color of nectarines and extended their shelf life. In summary, the specific environmental protection, safety, and preservation qualities of the CIPF/Coating in food packaging suggest a promising potential for its application.
研究领域:
食品科学
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高分子科学
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抗氧化技术
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食品保鲜
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材料表征
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可食用涂层
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农业副产物利用
✓ 已验证
产品关联
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2022
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IF 5.518
Mingliang Luo,Xiaodong Si,Mingzhong Li,Yige Huang,Qinpeng Li,Changheng Li
In this study, we designed a magnetic responsive hydrogel, also known as magnetorheological gel (MRG), based on a carbonyl iron particle@polyacrylamide (CIP@PAM) composite and a water-soluble PAM matrix to use as a temporary plugging agent (TPA) in the hydraulic fracturing of unconventional hydrocarbon reservoirs. The CIP@PAM composite was synthesized and characterized by Fourier transform infrared spectrometry (FT-IR), scanning electron microscopy (SEM), laser particle size analysis (LPSA) and vibrating sample magnetometry (VSM). The results show that a thin and uniform PAM layer was successfully coated on the surface of the CIPs, which plays a key role in enhancing the antioxidant capacity of the CIPs. Meanwhile, the CIP@PAM composite possesses a high saturation magnetization (148.8 emu/g). MRG as a TPA has a high gel strength and magnetorheological effect under a magnetic field intensity of 1 T, providing a breakthrough pressure up to 38.13 MPa at room temperature . Compared with the conventional temporary plugging agent, MRG as the temporary plugging agent possesses high magnetic responsiveness to easily control, good degradability and recyclability, providing great potential application in hydraulic fracturing.
研究领域:
材料科学
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化学工程
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石油工程
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纳米技术
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）