CARBOHYDRATE POLYMERS
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2023
·
IF 11.2
Jun Ye,Luying Liu,Wu Lan,Jian Xiong
Carboxymethyl cellulose (CMC)/polyvinyl alcohol (PVA) hydrogels loaded with soybean peptide (SPE) were fabricated via a freeze-thaw method. These hydrogels conquer barriers in simulated gastric fluid (SGF), and then release SPE in simulated intestinal fluid (SIF). The results of in vitro SPE release from these hydrogels showed that in SGF only a little of the SPE released, but in SIF the SPE was completely released. The released SPE had scavenging rates for DPPH and ABTS free radicals of 41.68 and 31.43 %. The pharmacokinetic model of SPE release from the hydrogels in SIF was studied. When the hydrogels are moved from SGF to SIF, the sorption of the shrinkage hydrogel network is entirely controlled by stress-induced relaxations. There are swollen and shrunken regions during SPE release. For SPE release into the SIF, SPE has to be freed from the weak bonds in the swollen regions by changes in the conformation of CMC and PVA. The release rate of SPE was found to be governed by the diffusion and swelling rate of the shrinkage hydrogel network. The Korsmeyer-Peppas equation diffusion exponents (n) for SPE release from the hydrogels are >2.063, indicating a super case II transport. These data demonstrate CMC/PVA hydrogels have potential applications in oral peptide delivery.
研究领域:
药学
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材料科学
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生物技术
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药理学
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PubMed
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JOURNAL OF CONTROLLED RELEASE
·
2023
·
IF 10.8
Donglin Xia,Xiaodong Zhang,Huang Hao,Wei Jiang,Chao Chen,Haoming Li,Linzi Feng,Jia Li,Yu Wu,Ling Zhang,Yong Hu
Developing a highly effective nano-drug delivery system with sufficient drug permeability and retention in tumors is still a major challenge for oncotherapy. Herein, a tumor microenvironment responsive, aggregable nanocarriers embedded hydrogel ( [email protected] ) was developed to inhibit the tumoral angiogenesis and hypoxia for enhanced radiotherapy. The antiangiogenic drug (recombinant human endostatin, Endo) loaded carboxymethyl chitosan nanoparticles (Endo-CMC NPs) was wrapped by 3D hydrogel to comprise the [email protected] After peritumoral injection, the Endo-CMC NPs were released, invaded deeply into the solid tumor , and cross-linked with intratumoral calcium ions . The cross-linking process enabled these Endo-CMC NPs to form larger particles, leading to long retention in tumor tissue to minimize premature clearance. This [email protected] , integrating the abilities of good tumoral penetration, long retention of anti-drug, and alleviation of hypoxia in tumor tissue, greatly improved the therapeutic effect of radiotherapy. This work provides a proof-of-concept of tumor microenvironment-responding and an aggregable nano-drug delivery system as promising antitumor drug carriers for effective tumor therapy.
研究领域:
肿瘤学
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纳米技术
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药学
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生物医学工程
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DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2023
·
IF 8.8
Bingxue Hu,Hongbin Pu,Da-Wen Sun
In this study, a high-performance, stable and homogeneous [email protected] /CMC/qPCR flexible film surface-enhanced Raman scattering (SERS) substrate was constructed by synergistically stabilizing and protecting bimetallic core–shell [email protected] nanorods ( [email protected] ) with carboxymethylcellulose (CMC) and fluorescent-quantitative-polymerase-chain-reaction (qPCR) film. The network structure of CMC immobilized and aligned [email protected] through coordination of carboxyl groups with surface Ag atoms to provide intensive and stable ‘hot spots’, and the qPCR bilayer film performed as carrier and barrier to protect [email protected] from oxidation, humidity and optical damage and improved the robustness and stability. The [email protected] /CMC/qPCR film was used for in-situ extraction and SERS detection of thiabendazole on nectarine (0.24 ppm) and lemon (0.27 ppm) with low detection of limits. Furthermore, it retained 98.6% SERS performance after storage for 90 days under ambient conditions, revealing the great potential in promoting the commercialization of the SERS technique for sensitive contaminants sensing with simple fabrication procedures, homogeneity, reproducibility and long-term stability.
研究领域:
材料科学
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分析化学
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食品安全
·
纳米技术
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产品关联
DOI
PubMed
高影响因子
MOLECULAR PHARMACEUTICS
·
2020
·
IF 4.321
Lan Cui,Xiayi Feng,Wentao Liu,Hao Liu,Qian Qin,Shuangxia Wu,Suqin He,Xinchang Pang,Dong Men,Chengshen Zhu
The surface charge of nanocarriers inevitably affects drug delivery efficiency; however, the cancer cell specificity, anti-inflammatory effects, and charge-reversal points remain to be further addressed in biomedical applications. The aim of this study was to comprehensively assess the cancer cell specificity of DOX-loaded mesoporous silica-chitosan oligosaccharide-carboxymethyl chitosan nanoparticles (DOX@MSNs-COS-CMC) in MCF-7 and HeLa cells, inhibit the production of inflammatory cytokines, and improve the drug accumulation in the tumor site. Intracellular results reveal that the retention time prolonged to 48 h in both HeLa and MCF-7 cells at pH 7.4. However, DOX@MSNs-COS-CMC exhibited a cell type-dependent cytotoxicity and enhanced intracellular uptake in HeLa cells at pH 6.5, due to the clathrin-mediated endocytosis and macropinocytosis in HeLa cells in comparison with the vesicular transport in MCF-7 cells. Moreover, Pearson’s correlation coefficient value significantly decreased to 0.25 after 8 h, prompting endosomal escape and drug delivery into the HeLa nucleus. After the treatment of MSNs-COS-CMC at 200 μg/mL, the inflammatory cytokines IL-6 and TNF-α level decreased by 70% and 80%, respectively. Tumor inhibition of DOX@MSNs-COS-CMC was 0.4 times higher than free DOX, alleviating cardiotoxicity and inflammation in the HeLa xenograft tumor model. Charge-reversible DOX@MSNs-COS-CMC could be a possible candidate for clinical therapy of cervical carcinoma.
研究领域:
药理学
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肿瘤学
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生物医学工程
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纳米技术
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DOI
PubMed
高影响因子
FOOD CHEMISTRY
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2022
·
IF 9.231
Bingxue Hu,Da-Wen Sun,Hongbin Pu,Zhibin Huang
Cellulose material holds considerable promise for effective surface-enhanced Raman scattering (SERS) substrate construction due to its extensive availability, chemically modifying capacity, ease of manufacture, high flexibility and low optical activity. A large-area, high-sensitivity, stable and uniform Au@Ag nanorods (NRs)-CMC substrate was successfully developed via electrostatic repulsion by using negatively-charged core–shell Au@Ag NRs as SERS active plasmonic nanomaterial, combined with negatively-charged carboxymethylcellulose (CMC) hydrogel for nanoparticles stabilization, homodisperse and protection. The obtained Au@Ag NRs-CMC substrate showed excellent sensitivity for the detection of thiram residues in fruits containing low and abundant pigment interferents, such as apples and blueberries, with detection limits of 58 and 78 ppb, respectively. Additionally, it retained more than 80% SERS performance after storage for 9 months under ambient conditions, demonstrating its great potential in facilitating the commercialization of cellulose-based SERS technology for cost-effective detection of food contaminants with advantages of facile preparation procedure, uniformity, reproducibility and long-term stability.
研究领域:
材料科学
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分析化学
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食品安全
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纳米技术
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产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
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2022
·
IF 16.744
Mingming Chen,Zheng Yan,Jingde Luan,Xun Sun,Wengang Liu,Xin Ke
In this work, a hydrophilic polypyrrole carboxymethyl cellulose aerogel (PPY/CMC) with a 3D structure was prepared via in-situ polymerization of pyrrole monomers with carboxymethyl cellulose as the substrate. The adsorption experiments showed that tetracycline can be effectively removed in a wide range of pH (4–10), and the adsorption capacity was 689.39 mg/g when the pH value was 6. The pseudo-second-order kinetic and Langmuir models better fitted the kinetic and isotherm data, which revealed that the adsorption was homogeneous and dominated by chemisorption. The experiment of adsorption thermodynamics showed that the adsorption process was spontaneous and endothermic. Zeta potential, FT-IR and XPS results indicated that the adsorption mechanism included π-π EDA interaction, hydrogen bonding and electrostatic interaction. Through Density Functional Theory (DFT) and Frontier Orbital Theory (FOT) simulation, the microscopic adsorption mechanism was further explored on the molecular and electronic scales. It is confirmed that TC was adsorbed onto PPY/CMC aerogels mainly through π-π EDA interaction in sandwich (S) configuration and parallel-displaced (PD) configuration, thus ensuring high adsorption efficiency. Compared with various adsorbent materials reported recently, the PPY/CMC aerogels have the advantages of higher adsorption capacity, excellent pH buffering capacity, simple preparation process and quickly removal of pollutants.
研究领域:
环境科学
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材料科学
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化学工程
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分析化学
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产品关联
DOI
高影响因子
CARBOHYDRATE POLYMERS
·
2022
·
IF 10.723
Ming Zhao,Zhenhai Chen,Li Hao,Huayao Chen,Xinhua Zhou,Hongjun Zhou
Inefficient use of traditional pesticides causes serious environmental pollution. Stimuli-responsive pesticide formulations improve the utilization efficiency of target pests and reduce harm to non-target organisms and the environment. Herein, multi-stimuli-responsive avermectin (AVM) polyurea microcapsules ( [email protected] ) are prepared by interfacial polymerization with modified carboxymethyl cellulose CMC-SS-NH 2 as the wall material and hexadecane as the temperature-responsive core. The microcapsules are 3.90 μm in size and the encapsulation efficiency of AVM is 88.23 %. The photostability of [email protected] is 5-times that of AVM solution. The insecticidal effect of AVM solution and AVM emulsifiable concentrate (EC) decreases to 13.3 % and 16.6 %, respectively, after UV irradiation for 180 min, whereas that of [email protected] still remains at 50.0 %. [email protected] has better foliar affinity and releases under the stimuli of temperature, glutathione , pH, cellulase , and urease . Hence, it has high insecticidal activity and biosafety. This smart controlled-release pesticide formulation provides a promising solution for green agriculture.
研究领域:
农业科学
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环境科学
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材料科学
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化学
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产品关联
DOI
PubMed
高影响因子
CMC-Computers Materials & Continua
·
2026
·Vol. 88
·期 2
·
IF 2.4
Junyi Wang,Jianghai Geng,Jiaqi Liu,Haibin Zhu
In intelligent manufacturing and remanufacturing systems, the thermal safety of the power distribution infrastructure is crucial for ensuring production continuity, equipment reliability, and operational resilience. Traditional temperature monitoring methods often have problems such as high deployment costs, strong environmental sensitivity, or limited physical interpretability in distributed workshop environments. To address these limitations, this study proposes a physically information-driven intelligent thermal color-changing fault identification framework. Based on thermochromic experiments, irreversible color-changing coatings are selected, which are combined with a visual-based computing pipeline for autonomous overheating detection. The framework proposes a thermal fault temperature identification algorithm based on the self-organizing map (SOM) neural network, which improves the generalization ability through RGB channel normalization; multiple random initialization and optimal screening mechanisms are introduced to explore the global optimal solution in the weight space, addressing the issues of sensitive initial weights and easy falling into local minima; the best matching unit (BMU) identification strategy is used to achieve efficient mapping from the RGB feature space to the physical temperature quantity. This algorithm can effectively convert physical color information into a visual temperature field, providing a new idea for thermal fault monitoring and temperature identification of power distribution lines in manufacturing workshops. To evaluate its engineering applicability, a noise resistance experiment with dual scenarios, dual samples, and five noise levels was designed, quantitatively analyzing the absolute error (AE) and F1 score of the algorithm under different noise levels. Laboratory case studies show that under moderate noise interference ( σ < 0.04), the algorithm still maintains a high recognition accuracy, verifying its robustness and practical potential in complex industrial site environments. This study embeds the physically constrained material response mechanism into the intelligent visual framework, establishing a new paradigm for computer vision-based manufacturing systems.
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DOI
高影响因子
REPRODUCTIVE TOXICOLOGY
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2023
·
IF 3.3
Kaiqi Chen,Xiaoqian Lu,Dan Xu,Yu Guo,Ying Ao,Hui Wang
Corn oil, sodium carboxymethyl cellulose (CMC-Na), and dimethyl sulfoxide (DMSO) are widely used as solvents or suspensions in animal experiments, but the effects of prenatal exposure to them on fetal development have not been reported. In this study, Kunming mice were given a conventional dose of corn oil (9.2 g/kg·d), CMC-Na (0.05 g/kg·d) or DMSO (0.088 g/kg·d) during gestation days 10–18, and the pregnancy outcome, fetal physical development, serum phenotype, and multi-organ function changes were observed. The results showed that corn oil decreased serum triglyceride level in males but increased their serum testosterone and CORT levels, and affected female placenta and female/male multi-organ functions (mainly bone, liver, kidney). CMC-Na increased female/male body lengths and tail lengths, decreased serum glucose and total cholesterol levels in males as well as increased their serum LDL-C/HDL-C ratio and testosterone level, decreased female serum bile acid level, and affected male/female placenta and multi-organ functions (mainly bone, liver, hippocampus). DMSO decreased male body weight and serum glucose level, decreased male/female serum bile acid levels, and affected male/female placenta and multi-organs functions (mainly bone, hippocampus, adrenal gland). In conclusion, prenatal exposure to a conventional dose of corn oil, CMC-Na or DMSO could affect fetal physical development and multi-organ functions, and has the characteristics of "multi-pathway, multi-organ and multi-target". This study provides the experimental basis for the rational selection of solvents or suspensions in pharmacology and toxicology studies.
研究领域:
药理学
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毒理学
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发育生物学
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动物科学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF FOOD ENGINEERING
·
2026
·
IF 5.8
Ziang Guo,Bingxue Yang,Xiaowei Huang,Zhihua Li,Paraskevi Paximada,Xiaobo Zou
This study investigated how the degree of substitution (DS) of carboxymethyl cellulose (CMC) regulates the stability and gastrointestinal fate of Pickering emulsions stabilized by β-cyclodextrin/carboxymethyl cellulose colloidal particles (β-CCC). After 28 days of storage, the highest curcumin retention was observed in the DS = 1.2 systems, reaching 87.20% at 4 °C and 81.74% at 25 °C. Rheological analysis revealed superior freeze-thaw resistance but reduced thermal stability in high-DS emulsions. Under simulated gastrointestinal conditions, higher DS led to the formation of larger droplet aggregates, with D [4,3] increasing from 116 ± 5.36 μm (DS 0.7) to 143 ± 4.28 μm (DS 1.2). This structural evolution was accompanied by enhanced lipolysis, with final free fatty acid release increasing from 24.41% to 41.61%. Consistently, curcumin bioaccessibility increased with DS, ranging from 41.54% to 54.38%. Overall, tailoring the DS provides an effective strategy to regulate emulsion stability and digestion behavior for lipophilic nutrient delivery.
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高影响因子
Polymers
·
2026
·Vol. 18
·期 2
·263
·
IF 4.9
Ruiying Zhang,Yuanyuan Liu,Chaoqun Ji,Fengwei Sun,Shan Lin,Xu Cao,Qiang Wang,Lihui Chen,Jianguo Li
Flexible, intelligent color-changing windows with excellent color-switching capability and fast response time rely significantly on conductive composite layers composed of electrochromic materials and flexible, transparent substrates. Herein, we developed a high-performance electrochromic film (CPC) with mechanical, humidity, and temperature insensitivity by coating sodium carboxymethyl cellulose (CMC)-dispersed PEDOT:PSS onto a CA film. In the CPC system, CMC not only effectively enhances interfacial bonding and compatibility between the hydrophobic CA film and the hydrophilic PEDOT:PSS but also enables uniform and stable deposition of PEDOT:PSS on the CA film. As a result, the designed CPC demonstrates a high optical modulation capability (the transmittance changes from 60.1% to 3%) and a response time of 2 s. In addition, the CPC features the advantages of mechanical-, humidity-, and temperature-insensitive electrochromic distinctions, where it outputs the stable coloring efficiency with 100-time bending treatment, various temperatures, and humidity in an all-day outdoor environment. The developed CPC electrochromic film offers new insights into promoting the structural simplification and sustainability of electrochromic materials.
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CARBOHYDRATE POLYMERS
·
2024
·
IF 10.7
Shengkai Liu,Huiling Li,Xi Li,Wei Wang,Chunguang Rong,Mengjie Yang,Yonggui Wang,Jing Wang,Yabei Xu,Daxin Liang,Yanjun Xie
The titanium-based lithium ion sieve (HTO), renowned for its exceptional adsorption performance and cyclic stability, was utilized in addressing the global shortage of lithium resources. However, the recovery and reuse efficiency of HTO in powder form is relatively low, which limits its application in industrial fields. To address this issue, this study utilized carboxymethyl cellulose (CMC) as the principal matrix material, while polyvinyl alcohol (PVA) played a dual function as both matrix and crosslinker, negating the necessity for supplementary crosslinking materials. Employing water as the only solvent, HTO was embedded into the CMC-PVA blended film matrix. It was observed that augmenting the CMC content substantially elevates the adsorptive capability of the film. However, this enhancement comes at the cost of reduced mechanical robustness and diminished stability in solution. Consequently, by balancing the influence of adsorptive capacity and stability through fine-tuning the CMC-to-PVA ratio. Even when HTO powder is encapsulated within the film, the adsorption film retains the excellent adsorption properties of HTO, achieving an adsorption capacity for lithium of 29.21 mg g −1 within 12 h. This study provides an innovative pathway and ideas for the large-scale, low-cost production of sustainable lithium-ion adsorption materials.
研究领域:
材料科学
·
环境科学
·
化学工程
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DOI
PubMed
高影响因子
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