CARBOHYDRATE POLYMERS
·
2024
·
IF 10.7
Fengsong Liu,Yifang Cao,Jiahao Ren,Yijia Xie,Xinglong Xiao,Yucong Zou,Hong Bai,Xiaowei Zhang,Ying Chen
Melt strength and moisture content are critical parameters in starch foam extrusion, as they dictate bubble expansion dynamics, which subsequently determine the foam's properties. Despite continuous advancements in the development and application of starch foams, challenges such as water resistance, mechanical strength, and antibacterial activity remain unresolved. This research investigates the influence of polyvinyl alcohol (PVA) polymerization and moisture content on the properties of extruded foam while also exploring the potential for enhancing antimicrobial functionality by incorporating carboxymethyl chitosan (CMCS) into conventional starch foams. The findings underscore the significance of melt strength and intermolecular entanglements in shaping foam characteristics, confirming that bioactive components effectively improve hydrophobicity, foaming characteristics, and antibacterial capabilities. Moreover, by precisely regulating PVA polymerization and moisture content, it became feasible to optimize foam properties and achieve the desired performance. Specifically, foam with a moisture content of 12 % and a PVA polymerization degree of 1700 exhibited exceptional performance, including the highest foaming ratio of 45.62, the minimal water absorption rate of 6.31 %, and the greatest recovery rate of 88.95 %. Furthermore, increasing CMCS concentrations substantially enhances the antibacterial properties of the foam, demonstrating its potential for application in antibacterial cushioning packaging and emphasizing its versatility and practicality.
研究领域:
材料科学
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高分子科学
·
包装工程
·
生物技术
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
·
2019
·
IF 4.029
Pengju Chen,Peng Xiao,Zhuan Li,Zeyan Liu,Dongmei Pu,Yang Li
A novel cristobalite aluminum phosphate particle ( c -AlPO 4 ) modified SiC whisker toughened mullite coating ( c -AlPO 4 -SiC w -mullite) was prepared on SiC coated carbon fiber reinforced SiC composites (C/SiC) by a new sol-gel method combined with air spraying to improve the oxidation resistance of SiC w -mullite coating. Results show that c -AlPO 4 -SiC w -mullite coatings with 10 and 20 wt.% of c -AlPO 4 exhibited obviously improved oxidation resistance at 1773 K in ambient air for 100 h than SiC w -mullite coating. Moreover, the oxidation resistance of c -AlPO 4 -SiC w -mullite coatings were rapidly declined when the c -AlPO 4 in c -AlPO 4 -SiC w -mullite coating were set to 30 and 40 wt.%. The c -AlPO 4 -SiC w -mullite coating with 20 wt.% of c -AlPO 4 showed most pronounced oxidation resistance, the weight loss rate after the oxidation in ambient air for 210 h was merely 3.00 × 10 −5 g·cm −2 h −1 . The failure of c -AlPO 4 -SiC w -mullite coating with 20 wt.% of c -AlPO 4 was due to the generation of penetrative micro-cracks and micro-holes in the coating, which cannot be self-healed by the silicate glass layer after long time oxidation at 1773 K.
研究领域:
材料科学
·
表面工程
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产品关联
DOI
高影响因子
International Journal of Polymeric Materials and Polymeric Biomaterials
·
2017
·
IF 1.515
Yan-Ling Luo,Xue-Yin Zhang,Jing-Yu Fu,Feng Xu,Ya-Shao Chen
Novel poly(N-isopropylacrylamide)/carboxymethyl chitosan/multiwalled carbon nanotube semi-interpenetrating nanohybrid hydrogels were prepared, and the chemical structure and morphology were characterized. The prepared hydrogels showed temperature and pH dual-responsiveness, and the one containing multiwalled carbon nanotubes (MWCNTs)–COOH possessed high maximal swelling ratios. The phase transition produced at pH of 6.8–7.4 and temperature of 35–40°C, hinging on the system compositions and charge ratios. The hydrogels were used to load hydrophilic anticancer drug, with high entrapped efficiency of about 44%. The drug release changed with temperature, pH, and MWCNTs–COOH contents. The designed hydrogels can be used for site-specific target delivery of protein or hydrophilic anticancer drug.
研究领域:
材料科学
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生物医药工程
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药剂学
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产品关联
DOI
高影响因子
INTERNATIONAL DAIRY JOURNAL
·
2022
·
IF 3.572
Xianglin Yue,Junru Sun,Ru Zhao,Jinsheng Zhang
Rapid screening and early warning of pathogenic bacteria in food is the key to prevent and control the spread of foodborne diseases . Biotin–streptavidin system and membrane filtration technology were combined to develop a novel nuclear magnetic resonance (NMR) immunosensor based on biomacromolecule O-carboxymethyl chitosan (O-CMCS) target gadolinium (Gd) probe for rapid detection of Salmonella anatum in milk. Under optimal experimental parameters, the proposed NMR immunosensor could detect Salmonella in milk with a limit of detection of 1.8 × 10 4 cfu mL −1 within 2 h. Furthermore, the immunosensor exhibited good specificity, sensitivity and reproducibility, which could achieve the direct determination of biological samples with complex composition. Hence, the developed assay might have great application potential for the rapid detection of Salmonella in food.
研究领域:
食品科学
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分析化学
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微生物学
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生物技术
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产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF CHEMICAL KINETICS
·
2026
·Vol. 58
·期 3
·106-118
·
IF 1.6
Chenyang Xu,Wenzhu Li,Linyi Zhang,Jiakai Xu,Peng Han,Bin Chen
Poly(chitosan)/hydroxyapatite (CS/HA) and carboxymethyl poly(chitosan)/hydroxyapatite (CMCS/HA) composite coatings were successfully fabricated via biomimetic mineralization, with their structural characteristics and properties systematically analyzed. As the CS concentration increased during fabrication, the growth morphology of CS/HA coating transitioned from clustered to sheet-like structures, forming dense and uniform composite coating with strong substrate adhesion and excellent biocompatibility. The CMCS/HA coatings exhibited a coral-like structure comprising spherical particles, which ensured higher substrate coverage and demonstrated superior corrosion resistance. At 20 g/L, coatings prepared by mixing pre-calcified solution A with CMCS and then adding biomimetic mineralization solution A (defined as YOCS), or by mixing pre-calcified solution A with a mixture of biomimetic mineralization solution A and CMCS (defined as FOCS), both show optimum structure. Coatings incorporating 30 g/L CS or 20 g/L CMCS in the biomimetic mineralization solution exhibited optimum corrosion resistance, antibacterial activity, and biocompatibility.
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产品关联
DOI
高影响因子
JOURNAL OF THE AMERICAN CERAMIC SOCIETY
·
2019
·Vol. 103
·期 1
·82-93
·
IF 3.094
Pengju Chen,Peng Xiao,Zhuan Li,Ling Pan,Jinwei Li,Zeyan Liu,Dongmei Pu,Yang Li
Mullite coating, SiC whiskers toughened mullite coating (SiC w -mullite), and cristobalite aluminum phosphate ( c -AlPO 4 ) particle modified SiC w -mullite coating ( c -AlPO 4 -SiC w -mullite) were prepared on SiC coated C/SiC composites using a novel sol-gel method combined with air spraying. Results show that molten SiO 2 formed by the oxidation of SiC whiskers and molten c -AlPO 4 improved the bonding strength between mullite outer coating and SiC–C/SiC composites due to their high-temperature bonding properties. The bonding strength between mullite, SiC w -mullite, c -AlPO 4 -SiC w -mullite outer coatings and SiC–C/SiC composites were 2.41, 4.31, and 7.38 MPa, respectively. After 48 thermal cycles between 1773 K and room temperature, the weight loss of mullite/SiC coating coated C/SiC composites was up to 11.61%, while the weight losses of SiC w -mullite/SiC and c -AlPO 4 -SiC w -mullite/SiC coatings coated C/SiC composites were reduced to 7.40% and 5.12%, respectively. The addition of appropriate SiC whiskers can considerably improve the thermal shock resistance of mullite coating owing to their excellent mechanical properties at high temperature. In addition, c -AlPO 4 particles can further improve the thermal shock resistance of SiC w -mullite coating due to their high-temperature bonding and sealing properties. No obvious micro-pores and cracks were observed on the surface of c -AlPO 4 -SiC w -mullite coating after 48 thermal cycles due to timely healing effect by formation of secondary mullite.
研究领域:
材料科学
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陶瓷基复合材料
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涂层技术
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高温材料
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热障涂层
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DOI
高影响因子
International Journal of Applied Ceramic Technology
·
2023
·Vol. 20
·期 3
·1740-1752
·
IF 2.1
Ling Pan,Pengju Chen,Peng Xiao,Ling He,Wei Zhou,Yang Li
The mullite and ytterbium disilicate (β-Yb 2 Si 2 O 7 ) powders as starting materials for the Yb 2 Si 2 O 7 /mullite/SiC tri-layer coating are synthesized by a sol–gel method. The effect of SiC whiskers on the anti-oxidation properties of Yb 2 Si 2 O 7 /mullite/SiC tri-layer coating for C/SiC composites in the air environment is deeply studied. Results show that the formation temperature and complete transition temperature of mullite were 800–1000 and 1300°C, respectively. Yb 2 SiO 5 , α-Yb 2 Si 2 O 7 , and β-Yb 2 Si 2 O 7 were gradually formed between 800 and 1000°C, and Yb 2 SiO 5 and α-Yb 2 Si 2 O 7 were completely transformed into β-Yb 2 Si 2 O 7 at a temperature above 1200°C. The weight loss of Yb 2 Si 2 O 7 /(SiC w –mullite)/SiC tri-layer coating coated specimens was 0.15 × 10 −3 g cm −2 after 200 h oxidation at 1400°C, which is lower than that of Yb 2 Si 2 O 7 /mullite/SiC tri-layer coating (2.84 × 10 −3 g cm −2 ). The SiC whiskers in mullite middle coating can not only alleviate the coefficient of thermal expansion difference between mullite middle coating and β-Yb 2 Si 2 O 7 outer coating, but also improve the self-healing performance of the mullite middle coating owing to the self-healing aluminosilicate glass phase formed by the reaction between SiO 2 (oxidation of SiC whiskers) and mullite particles.
研究领域:
材料科学
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陶瓷学
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产品关联
DOI
高影响因子
INTERNATIONAL DENTAL JOURNAL
·
2026
·Vol. 76
·期 5
·109821
·
IF 5.2
Aiqing Zhang,Yichang Cao,Huishan Zhao,Dangchao Sun,Lina Gao,Xiaqing Liu,Hui Jia,Qi Yang,Shuwei Gao,Binpeng Zhang,Haiyan Du,Ying Li
Objective Carbon fiber-reinforced polyetheretherketone (CF/PEEK) possesses the elastic modulus similar to that of natural bone, yet its inherent surface hydrophobicity and bio-inertness restrict its application in oral implantation. To overcome this limitation, this study proposes the layer-by-layer surface functionalization strategy to construct the multifunctional CF/PEEK-based composite that integrates long-term antibacterial activity with synergistic osteogenic functions. Methods After sulfonation of CF/PEEK with 98% H₂SO₄, the polydopamine-assisted nanohydroxyapatite (PDA-nHA) intermediate layer and the zinc-loaded carboxymethyl chitosan (Zn/CMCS) coating were sequentially constructed, yielding the SCP-PHA-Zn/CMCS composite. A series of Characterizations including surface morphology, in vitro mineralization, antibacterial evaluation, cytocompatibility, osteogenic property, and osteogenesis-related gene mRNA expression levels were performed to assess in vitro biocompatibility and osteogenic performance. Results SEM showed SCP-PHA-Zn/CMCS possessed the 3D porous network, with uniformly deposited PDA-nHA presenting a fibrous network after Zn-CMCS wrapping. After SBF immersion, spherical apatite particles deposited on all samples. Water contact angles of SCP-PHA and SCP-PHA-Zn/CMCS were significantly lower than SCF/PEEK. SCP-PHA-Zn/CMCS significantly inhibited Staphylococcus aureus and Escherichia coli . All groups showed good biocompatibility and long-term biosafety. rBMSCs on SCP-PHA-Zn/CMCS showed the highest adhesion density, proliferation, ALP activity, matrix mineralization, and osteogenesis-related gene mRNA expression levels, significantly outperforming the other groups and demonstrating the best in vitro osteogenic capacity. Conclusion To address the surface hydrophobicity and bioinertia of CF/PEEK, this study successfully constructed the multifunctional SCP-PHA-Zn/CMCS composite using sulfonation pretreatment and the layer-by-layer functionalization assembly strategy. The obtained material exhibited favorable physicochemical properties, excellent biocompatibility and antibacterial performance, and significantly promoted the adhesion and proliferation of rBMSCs, enhanced ALP activity, matrix mineralization, and osteogenesis-related gene mRNA expression levels, demonstrating outstanding in vitro osteogenic capacity. These findings provide experimental evidence and a novel design strategy for the clinical translation of CF/PEEK in oral implantation and bone defect repair. Download: Download high-res image (282KB) Download: Download full-size image
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DOI
高影响因子
MACROMOLECULAR MATERIALS AND ENGINEERING
·
2022
·Vol. 307
·期 7
·2100878
·
IF 4.402
Shan Wang,Weifang Zhang,Jiayu Yan,Guihua Meng,Lin Cui,Wenjuan Li,Zhiyong Liu,Xuhong Guo
The healing of severe skin injury is a complicated process and the development of hydrogel dressing with antibacterial and stimuli responsive abilities is necessary. Recently, reduced graphene oxide (RGO) has been widely used in hydrogel dressings due to its good conductivity and photothermal effects. However, there still exist some problems in the fabrication of RGO-modified hydrogels, especially in the green preparation and dispersion process of RGO. In this work, macromolecular carboxymethyl chitosan (CMCS) is chosen as the reducing agent for the green preparation of RGO. Hydrogels with antibacterial and stimulus-responsive properties are constructed via Schiff base condensation between CMCS and oxidized pectin (OP). Over 95% cell viability is observed, which is critical for medical applications. RGO endows the hydrogels with relatively good conductivity, self-healing properties, and mechanical strength. The diameters of bacteriostasis circle of the hydrogel for Escherichia coli and Staphylococcus aureus increase by 0.2 and 0.8 cm respectively after exposure to NIR for 5 min, resulting from the photothermal antibacterial properties of the hydrogel provided by RGO. This study provides guidance for the design and application of multifunctional wound dressing.
研究领域:
材料科学
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生物医学工程
·
药学
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DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
·
IF 8.2
Congnan Cen,Feifei Wang,Yifan Wang,Huan Li,Linglin Fu,Yan Li,Jian Chen,Yanbo Wang
For food packaging, a novel composite film was prepared by solution casting method using hydroxyethyl cellulose (HEC), carboxymethyl chitosan (CMCS), and zinc oxide nanoparticles as raw materials. The composite film successfully compounded the nanoparticles, as deduced by spectroscopy, crystallography and morphology observation. The addition of CMCS and ZnO enhanced the solvent resistance (the water solubility of the composite film was reduced by 94.3 %) and UV shielding ability (the UV shielding capacity of the composite film was increased by 45.73 %) of the composite film, thus improving the application prospects of the composite film in water-rich foods. In addition, the synergistic effect of CMCS and ZnO helped the composite film to efficiently inhibit the pathogenic bacteria Listeria monocytogenes and Pseudomonas aeruginosa (rate of inhibition>99.99 %) in food. The addition of CMCS and ZnO also significantly improved the elasticity (improve 494.34 %) and maximum load capacity (improve 142.24 %) of the composite film.
研究领域:
食品科学
·
材料科学
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产品关联
DOI
PubMed
高影响因子
POLYMERS FOR ADVANCED TECHNOLOGIES
·
2025
·Vol. 36
·期 3
·e70136
·
IF 3.4
Ping Xie,Jing He,Yangjun Ou
Photothermal therapy is a promising adjunctive treatment technique requiring a nanoplatform with excellent biocompatibility, photothermal stability, and precise targeting capabilities. This study aims to develop such a nanoplatform by synthesizing two new manganese(II)-based coordination polymers. The polymers were created by integrating 1,4-bis(imidazol-1-yl)benzene with the ternary ligand tris( p -carboxyphenyl)phosphane oxide, resulting in the formulas {[Mn 3 (L) 2 (bib) 3 (H 2 O) 7 ]·12H 2 O} n (CP 1 ) and {[Mn(HL)(bib)]·H 2 O} n (CP 2 ). These structures, with large surface areas and porosity, enhance drug loading efficiency. Doxorubicin (DOX) was successfully incorporated into a biocompatible HA/CMCS hydrogel-CP composite (HA/CMCS-CPs@DOX), forming a robust nanotherapeutic platform. Under near-infrared light irradiation, these metal-hydrogel composites effectively induced localized hyperthermia, aiding ocular melanoma treatment. We evaluated the effect of HA/CMCS-CP 2 @DOX on the cell proliferation of the uveal melanoma cell line, and the regulatory effects of the system on lncRNA ARAP1-AS1/miR-149-3p/S100A4 were also explored.
研究领域:
材料科学
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癌症治疗
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药物递送系统
·
分子生物学
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产品关联
DOI
高影响因子
CHEMISTRY & BIODIVERSITY
·
2023
·Vol. 20
·期 8
·e202300831
·
IF 2.9
Fengyun Chen,Ansar Javeed,Qiuyu Zeng,Quan Zhang,Bingnan Han
Bacterial infected environments and resulting bacterial infections have been threatening the human health globally. Due to increased bacterial resistance caused by improper and excessive use of antibiotics, antibacterial biomaterials are being developed as alternatives to antibiotics in some cases. Herein, an advanced multifunctional hydrogel with excellent antibacterial properties, enhanced mechanical properties, biocompatibility and self-healing performance, was designed through freezing-thawing method. This hydrogel network is composed of polyvinyl alcohol (PVA), carboxymethyl chitosan (CMCS), protocatechualdehyde (PA), ferric iron (Fe) and an antimicrobial cyclic peptide actinomycin X2 (Ac.X2). The double dynamic bonds among protocatechualdehyde (PA), ferric iron (Fe) and carboxymethyl chitosan containing coordinate bond (catechol-Fe) as well as dynamic Schiff base bonds and hydrogen bonds endowed the hydrogel with enhanced mechanical properties. Successful formation of hydrogel was confirmed through ATR-IR and XRD, and structural evaluation through SEM analysis, whereas mechanical properties were tested with electromechanical universal testing machine. The resulting PVA/CMCS/Ac.X2/PA@Fe (PCXPA) hydrogel has favorable biocompatibility and excellent broad-spectrum antimicrobial activity against both S. aureus (95.3 %) and E. coli (90.2 %) compared with free-soluble Ac.X2, which exhibited subpar performance against E. coli reported in our previous studies. This work provides a new insight on preparing multifunctional hydrogels containing antimicrobial peptides as antibacterial material. Graphical
研究领域:
生物材料学
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医学
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药剂学
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）