Advanced Science
·
2024
·
IF 14.3
Lin Liu,Junpeng Shi,Jinyuan Wang,Linping He,Yan Gao,Peng Lin,Yutong Han,Ping'an Ma,Jun Lin,Yun Zhang
Pyroptosis possesses potent antitumor immune activity, making pyroptosis inducer development a promising direction for tumor immunotherapy. Persistent luminescence nanoparticles (PLNPs) are highly sensitive optical probes extensively employed in tumor diagnosis and therapy. However, a pyroptosis inducer based on PLNPs has not been reported yet. Herein, polyethylene glycol–poly lactic acid-co-glycolic acid (PEG–PLGA: PP) modified biodegradable CaS:Eu 2+ (CSE@PP) PLNPs are synthesized as a pyroptosis inducer for tumor immunotherapy for the first time. The synthesized CSE@PP possesses biowindow persistent luminescence (PersL) and pH-responsive degradation properties, allowing it to remain stable under neutral pH but degrade when exposed to weak acid (pH < 6.5). During degradation within the tumor, CSE@PP constantly releases H 2 S and Ca 2+ while its PersL gradually fades away. Thus, the PersL signal can self-monitor H 2 S and Ca 2+ release. Furthermore, the released H 2 S and Ca 2+ result in mitochondrial dysfunction and the inactivation of reactive oxygen species scavenging enzymes, synergistic facilitating intracellular oxidative stress, which induces caspase-1/GSDM-D dependent pyroptosis and subsequent antitumor immune responses. In a word, it is confirmed that CSE@PP can self-monitor H 2 S and Ca 2+ release and pyroptosis-mediated tumor Immunotherapy. This work will facilitate biomedical applications of PLNPs and inspire pyroptosis-induced tumor immunotherapy.
研究领域:
纳米技术
·
生物医学工程
·
癌症研究
·
免疫治疗
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMOSPHERE
·
2020
·
IF 5.778
Mengjie Wang,Haojing Zhang,Weifeng Chen,Taotao Lu,Huihui Yang,Xinhai Wang,Minghua Lu,Zhichong Qi,Deliang Li
Since iron oxide minerals are ubiquitous in natural environments, the release of graphene oxide (GO) into environmental ecosystems can potentially interact with iron oxide particles and thus alter their surface properties, resulting in the change of their transport behaviors in subsurface systems. Column experiments were performed in this study to investigate the co-transport of GO nanoparticles and hematite colloids (a model representative of iron oxides) in saturated sand. The results demonstrated that the presence of hematite inhibited GO transport in quartz sand columns due to the formation of less negatively charged GO-hematite heteroaggregates and additional deposition sites provided by the adsorbed hematite on sand surfaces. Contrarily, GO co-present in suspensions significantly enhanced the transport of hematite colloids through different mechanisms such as the increase of electrostatic repulsion, decreased physical straining, GO-facilitated transport of hematite (i.e., highly mobile GO nanoparticles served as a mobile carrier for hematite). We also found that the co-transport behaviors of GO and hematite depended on solution chemistry (e.g., pH, ionic strength, and divalent cation (i.e., Ca 2+ )), which affected the electrostatic interaction as well as heteroaggregation behaviors between GO nanoparticles and hematite colloids. The findings provide an insight into the potential fate of carbon nanomaterials affected by mineral colloids existing in natural waters and soils.
研究领域:
环境科学
·
纳米技术
·
胶体化学
·
表面科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
COMPOSITES PART B-ENGINEERING
·
2022
·
IF 11.322
Shuai Liu,Xiwen Fan,Fang Yuan,Min Sang,Jianyu Zhou,Junshuo Zhang,Shouhu Xuan,Sheng Wang,Xinglong Gong
This work reported a biomimetic shear thickening fluid (STF) with thermally enhanced shear thickening effect for smart vibration attenuation system. It was developed by introducing Zr–fumarate metal-organic framework (MOF) crystals into a solvent mixture comprised of polyethylene glycol , polyacrylic acid and Ca 2+ , which endowed it with the cooperative effect of electrostatic and hydrophobic interactions . As the temperature raised from 25 to 35 °C, the STF containing 55 vol% MOF (STF-55) yielded a favorable shear thickening reinforcement with a notable viscosity growth of 1760-7953 Pa s. Besides, its storage modulus increased from 14 to 3036 Pa at 25–55 °C under a 0.1 Hz shear frequency, revealing a significant improvement in mechanical performance, as also demonstrated by transient shear rheological experiments. STF was incorporated into sandwich structures to improve the damping performance, with the natural frequency and damping ratio investigated at various ambient temperatures. Since the thermal enhanced viscosity could promote energy dissipation , the damping ratio of STF-55 filled sandwich structure obtained a substantial improvement from 0.85% to 1.93% at 25–55 °C. Thus, STF-55 based turbine blade and building damping pile were fabricated, which not only reduced the external vibration stimuli with average responsive accelerations of 7.3 and 0.8 m 2 s -1 , but also presented attenuated levels of 6.9 and 0.6 m 2 s -1 at increasing temperatures, respectively. In conclusion, this work provided guiding approach for highly adaptive vibration attenuation at high-temperature environment.
研究领域:
材料科学
·
机械工程
·
流变学
·
智能材料
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF POROUS MATERIALS
·
2024
·
IF 2.5
Lu Shun,Xiao Chaohu,Tian Qi,Mu Xiaotong,Yu Jiale,Hasi Qimeige,Zhang Yuhan,Chen Lihua
Although photothermal materials (PMs) are widely utilized in pure water and seawater, there is less research on the design and preparation of multifunctional photothermal materials with organic dye adsorption and oil displacement properties. In this study, biomass carbon aerogel (BC) was prepared through a simple Ca 2+ cross-linking and freeze-drying process. To enhance the antifouling performance of BC, hydrophilic and oleophobic chemical modification was conducted to obtain BC-SP. The contact angle of n-hexadecane can reach to 141.8°, which enable the extensive application of BC-SP in oil-bearing wastewater treatment. Notably, BC-SP exhibited exceptional light absorption efficiency (approximately 95%), excellent heat insulation performance (thermal conductivity 0.0650 W m − 1 K − 1 ), and rapid water transport capability. Under the irradiation of 1 kW m − 2 , the solar energy conversion efficiency can reach to 86.8%. After tested eight cycles, the evaporation efficiency remained relatively stable and can adsorb most organic dyes in dye wastewater. Therefore, the study of BC-SP in this paper may has broad practical application prospects.
研究领域:
材料科学
·
环境科学
·
化学工程
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
Food Bioscience
·
2024
·
IF 4.8
Tsekwi Gracious Rinwi,Da-Wen Sun,Ji Ma,Qi-Jun Wang
This study investigated the impact of isochoric freezing-thawing (ISF-T) cycles (C0–C5) on the quality of chicken breast. The results indicated a significant increase (P < 0.05) in pH from 5.41 to 5.96 after C1 to C4 before slightly decreasing to 5.72 (C5). Lightness (L*) varied between 50.13 and 44.55 across C1 to C4, with redness notably decreasing from −1.15 after C0 to −2.09 after C5 while yellowness (b) sharply increased from 2.65 (C0) to 4.65 (C5). Moisture content decreased from 74.01% to 68.13% after C5. WHC slightly reduced from 89.25% after C0 to 85.66% after C4, with an 83.78% reduction after C5. Cooking loss increased linearly across the ISF-T cycles from 18.08% reaching 24.14% after C5. Conversely, shear force decreased to 21.83 N after C5 from 25.21 N after C1. Protein solubility slowly increased to 88.79% after C3, then decreased to 72.84 after C5. The myofibrillar index remained stable until C3, then increased from 35.51 after C5. Lipid oxidation slowly increased to 0.27 mg MDA/kg after C3, then sharply increased to 0.44 mg MDA/kg after C5. In addition, Ca 2+ -ATPase activity showed that the samples obtained after C1 to C3 fluctuated between 23.59% and 24.71%, followed by a substantial reduction to 12.35% after C5. Furthermore, validation of the results by magnetic resonance imaging and nuclear magnetic resonance analysis confirmed the findings, suggesting that isochoric freezing could offer a viable solution to control temperature fluctuations, a challenging problem during meat storage and distribution in the cold chain food industry.
研究领域:
食品科学
·
肉类加工
·
物理化学
·
生物物理学
✓ 已验证
产品关联
DOI
高影响因子
Petroleum Science
·
2023
·
IF 5.6
Xiang-Yu Wang,Ming-Wei Zhao,Xu-Hao Wang,Peng Liu,Meng-Yao Fan,Teng Li,Zhen-Feng Ma,Ying-Jie Dai,Cai-Li Dai
Fracturing fluid property play a critical role in developing unconventional reservoirs. Deep eutectic solvents (DESs) show fascinating potential for property improvement of clean fracturing fluids (CFFs) due to their low-price, low-toxicity, chemical stability and flexible designability. In this work, DESs were synthesized by mixing hydrogen bond acceptors (HBAs) and a given hydrogen bond donor (HBD) to explore their underlying influence on CFF properties based on the intermolecular interactions. The hydrogen-bonding, van der Waals and electrostatic interactions between DES components and surfactants improved the CFF properties by promoting the arrangement of surfactants at interface and enhancing the micelle network strength. The HBD enhanced the resistance of CFF for Ca 2+ due to coordination-bonding interaction. The DESs composed of choline chloride (ChCl) and malonic acid show great enhancement for surface, rheology, temperature resistance, salt tolerance, drag reduction, and gel-breaking performance of CFFs. The DESs also improved the gel-breaking CFF-oil interactions, increasing the imbibition efficiencies to 44.2% in 74 h. Adjusting HBAs can effectively strengthen the intermolecular interactions (e.g., HBA-surfactant and HBD-surfactant interactions) to improve CFF properties. The DESs developed in this study provide a novel strategy to intensify CFF properties.
研究领域:
石油工程
·
化学工程
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
ENVIRONMENTAL POLLUTION
·
2023
·
IF 8.9
Lin Zhang,Yin Lin,An-Xin Lu,Jun-Xia Liu,Jing Li,Chong-Huai Yan
Today's women of childbearing age with a history of high lead (Pb) exposure in childhood have large Pb body burdens, which increases Pb release during pregnancy by promoting bone Pb mobilisation. The purpose of this study was to investigate the metabolic mechanisms underlying bone Pb mobilisation and explore the bone metabolism-related pathways during pregnancy. Drinking water containing 0.05% sodium acetate or Pb acetate was provided to weaned female rats for 4 weeks followed by a 4-week washout period, and then rats were co-caged with healthy males of the same age until pregnancy. Blood and bone tissues of the female rats were collected at gestational day (GD) 3 (early pregnancy), GD 10 (middle pregnancy), and GD 17 (late pregnancy), respectively. Pb and calcium concentrations, biomarkers for bone turnover, bone microstructure, serum metabolomics, and metabolic indicators were intensively analyzed. The results demonstrated that pre-pregnancy Pb exposure elevated blood lead levels (BLLs) at GD17, accompanied by a negative correlation between BLLs and trabecular bone Pb levels. Meanwhile, Pb-exposed rats had low bone mass and aberrant bone architecture with a larger number of mature osteoclasts (OCs) compared to the control group. Moreover, the metabolomics uncovered that Pb exposure caused mitochondrial dysfunction, such as enhanced oxidative stress and inflammatory response, and suppressed energy metabolism. Additionally, the levels of ROS , MDA, IL-1β, and IL-18 involved in redox and inflammatory pathways of bone tissues were significantly increased in the Pb-exposed group, while antioxidant SOD and energy metabolism-related indicators including ATP levels, Na + -K + -ATPase, and Ca 2+ -Mg 2+ -ATPase activities were significantly decreased. In conclusion, pre-pregnancy Pb exposure promotes bone Pb mobilisation and affects bone microstructure in the third trimester of pregnancy, which may be attributed to OC activation and mitochondrial dysfunction.
研究领域:
毒理学
·
生殖生物学
·
代谢组学
·
骨生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2020
·Vol. 55
·期 11
·4701-4716
·
IF 3.553
Ma Jianfeng,Zhao Hongxia,Shang Yazhuo,Peng Changjun,Liu Honglai,Zheng Shuzhen,Wang Tao,Qi Shuai,Ran Qianping
Abstract The presence of a highly alkaline environment or large amounts of Ca 2+ in concrete exerts a great influence on the dispersion of graphene oxide (GO) particles. Therefore, the development of a highly efficient GO dispersant to adapt to complex concrete environments is important. In this work, novel phosphate-modified small molecular polydentate polymers were synthesized and used as efficient dispersants for cement and high-concentration GO solutions. The chemical structure of the polymers was confirmed by 1 H NMR and IR spectroscopy, and the effect of adsorption groups on the adsorption ability of polymers was studied by using adsorption experiments and theoretical calculations. Results showed that the dispersant inositol hexaphosphate–methoxy polyether (IHP-MP) features a high adsorption equilibrium constant and strong adsorption ability. IHP-MP exhibited not only good water-reducing and slump-retaining properties but also remarkable cement hydration-retarding effects due to its numerous phosphate groups. IHP-MP could be used as an auxiliary GO dispersant with the comb polymer PCE to effectively reduce the viscosity and improve the stability of GO solutions. SEM, TGA and IR characterization indicated that IHP-MP strongly interacts with the surface groups of GO particles. Graphic Abstract
研究领域:
材料科学
·
化学工程
·
聚合物化学
·
土木工程
✓ 已验证
DOI
高影响因子
JOURNAL OF FOOD ENGINEERING
·
2022
·
IF 6.203
Qingyin Dai,Xi Huang,Ruijing Jia,Yanyuan Fang,Zhiyong Qin
An antimicrobial composite film based on sodium alginate (SA)/cellulose nanofibers (CNFs) containing peanut red skin extract (PSE) was prepared by crosslinking with Ca 2+ for the purpose of fruit preservation. The bioactive chemical constituents present in PSE were investigated using liquid chromatography–mass spectrometry (LC–MS). The SA/CNFs/Ca 2+ /PSE (SCCP) film exhibited high strength, good water resistance, and excellent ultraviolet barrier performance. The release behavior and antioxidant and antibacterial activity of the SCCP film were investigated, and its applicability to fruit preservation was evaluated. Higher radical scavenging activity of the film was observed in the ABTS assay radical compared with the DPPH assay, especially in 10 % ethanol; the maximum ABTS scavenging activity was 99.28 %. For surfaces covered by the SCCP film, the rates of fruit decay and weight loss were lower than in the control group. Furthermore, the films exhibited significant antibacterial effects against both gram-negative and gram-positive bacteria.
研究领域:
食品科学
·
材料科学
·
生物技术
·
化学
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Guanhua Qiu,Duo Wang,Peihan Xie,Zelun Li,Niqiang Zhou,Xiaoqian Zhang,Xiaobo Wang,Jiali Tang,Jun Cao,Junjie Liu,Danke Su
Microwave ablation (MWA) holds promise as a tumor treatment modality, yet incomplete ablation with low-frequency MWA (iMWA) remains a significant obstacle to survival, while the high-frequency MWA poses safety concerns. To address these challenges, we introduce a novel bimetallic iMWA nanosensitizer, CFT-NPs, constructed via metal-coordination interactions between tannic acid (TA) and iron/calcium dual metal ions (Fe 3+ /Ca 2+ ). The Fe 3+ /Ca 2+ in CFT-NPs work in harmony to convert electromagnetic energy into heat, thereby bolstering the effectiveness of iMWA while maintaining good biosafety. Furthermore, the pH-triggered rupture of CFT-NPs release TA, Fe 3+ , and Ca 2+ . The liberated Fe 3+ undergoes reduction by TA, and when combined with Ca 2+ , they trigger ferroptosis and Ca 2+ overload respectively, significantly amplifying the therapeutic effects of iMWA. Utilization iMWA with CFT-NPs results in lipid oxidation, mitochondrial dysfunction, and disruption of redox balance, both in vitro and in vivo . Notably, this nanosensitizer exerts a robust antitumor effect, effectively inhibiting tumor growth and downregulating the expression of matrix metalloproteinases, which is associated with tumor metastasis. Collectively, this innovative study offers a promising approach to overcome the challenges of incomplete ablation and biological safety, enhancing the antitumor efficacy of iMWA..
研究领域:
肿瘤学
·
生物医学工程
·
材料科学
·
癌症治疗
✓ 已验证
产品关联
DOI
高影响因子
Acta Biomaterialia
·
2023
·
IF 9.7
Yulin Jiang,Juehan Wang,Dan Sun,Zheng Liu,Lin Qi,Meixuan Du,Jing Wang,Yubao Li,Ce Zhu,Yong Huang,Yueming Song,Limin Liu,Ganjun Feng,Li Zhang
The strategies for modulating the local inflammatory microenvironment to inhibit intervertebral disc degeneration (IVDD) have garnered significant interest in recent years. In this study, we developed a "self-contained" injectable hydrogel capable of storing Mg 2+ while carrying nucleus pulposus (NP) cells, with the aim of inhibiting IVDD through immunoregulation . The hydrogel consists of sodium alginate (SA), poly(N-isopropylacrylamide) (PNIPAAm), silicate ceramics (SC), and NP cells. When injected into the NP site, PNIPAAm gelates instantly under body temperature, forming an interpenetrating network (IPN) hydrogel with SA. Ca 2+ released from the SC can crosslink the SA in situ , forming a SA/PNIPAAm hydrogel with an interpenetrating network (IPN) encapsulating the NP cells. Moreover, inside the hydrogel, Mg 2+ released from SC are effectively encapsulated and maintained at a desirable concentration. These Mg 2+ facilitates the local cell matrix synthesis and promotes immunomodulation (upregulating M2 / downregulating M1 macrophage polarization), thus inhibiting the IVDD progression. The proposed hydrogel has biocompatibility and is shown to enhance the expression of collagen II (COL II) and aggrecan . The potential of the injectable hydrogel in IVD repair has also been successfully demonstrated by in vivo studies. Statement of significance • A unique injectable hydrogel consisting of sodium alginate (SA), poly(N-isopropylacrylamide) (PNIPAAm), silicate ceramics (SC) and nucleus pulposus cells, has been created for intervertebral disc repair applications. • This is the first “self-contained” cell delivery system capable of releasing and subsequently storing Mg 2+ in the hydrogel reservoir for localized treatment. • The role of Mg 2+ in regulating the macrophage polarity transformation (from pro-inflammatory M1 to anti-inflammatory M2 phenotype) has been unveiled in the context of intervertebral disc repair.
研究领域:
生物材料
·
组织工程
·
再生医学
·
生物医学工程
·
骨科
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
·
IF 8.2
Xiangfei Yin,Yinchun Hu,Min Kang,Junjie Hu,Baogang Wu,Yeying Liu,Xuanyu Liu,Miaomiao Bai,Yan Wei,Di Huang
Excessive bleeding is the leading cause of death in accidents and operations. Ca 2+ crosslinked carboxyl nanocellulose (CN)/montmorillonite (MMT) composite (CaCNMMT) sponges were prepared by uniform mixing and directional freeze-drying methods which was inspired by the coordination mechanism of blood clot formation and coagulation cascade activation in natural hemostasis process. Carboxyl nanocellulose (CaCN) sponge has instantaneous water absorption capacity, and CaCNMMT sponges could further activate clotting factors. Therefore, CaCNMMT sponges achieved quick hemostasis by efficient concentrating blood, inducing hemocyte aggregation and stimulating coagulation cascade activation based on the synergistic effects of CN and MMT. Blood clotting index of CaCNMMT (15.90 ± 0.52 %) was significantly lower than CaCN (59.3 ± 1.43 %), and APTT time (22 ± 2 s) was almost equivalent to MMT (20 ± 2 s). CaCNMMT sponge showed good quick hemostatic effect on massive hemorrhage in both tail-breaking and liver injury model which provided a new strategy for the application of MMT in hemostatic and trauma treatment fields.
研究领域:
材料科学
·
生物材料
·
止血
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）