JOURNAL OF NANOBIOTECHNOLOGY
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2023
·Vol. 21
·期 1
·1-19
·
IF 10.2
Yuan Tiejun,Tan Minhong,Xu Yang,Xiao Qiyao,Wang Hui,Wu Chen,Li Fulun,Peng Lihua
Wound repair, along with skin appendage regeneration, is challenged by insufficient angiogenesis and neural regeneration. Therefore, promoting both proangiogenic and neuro-regenerative therapeutic effects is essential for effective wound repair. However, most therapeutic systems apply these strategies separately or ineffectively. This study investigates the performance of an all-in-one smart dressing (ASD) that integrates angiogenic functional materials and multiple biological factors within a light crosslinked hydrogel, forming a multi-functional dressing capable of facilitating simultaneous micro-vascularization and neural regeneration. The ASD uses a zeolite-imidazolate framework 67 with anchored vanadium oxide (VO 2 @ZIF-67) that allows for the on-demand release of Co 2+ with fluctuations in pH at the wound site to stimulate angiogenesis. It can simultaneously release CXCL12, ligustroflavone, and ginsenoside Rg1 in a sustained manner to enhance the recruitment of endogenous mesenchymal stem cells, inhibit senescence, and induce neural differentiation to achieve in situ nerve regeneration. The ASD can stimulate rapid angiogenesis and nerve regeneration within 17 days through multiple angiogenic and neuro-regenerative cues within one dressing. This study provides a proof-of-concept for integrating functional nanomaterials and multiple complementary drugs within a smart dressing for simultaneous angiogenesis and neural regeneration.
研究领域:
生物材料
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组织工程
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伤口愈合
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纳米技术
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产品关联
DOI
PubMed
高影响因子
Gels
·
2025
·Vol. 11
·期 10
·769
·
IF 5.3
Xun Zhong,Yuxuan Yang,Jiating Chen,Yudan Dong,Sheng Lei,Hui Zhao,Hong He,Lifeng Chen
Nano-silica is widely used to enhance gel properties, but its size, concentrations, and aggregation behaviors all matter. The influencing rules of these factors remain unclear especially in harsh reservoir conditions. This study presented a comprehensive investigation into the gelation, rheological, and plugging properties of phenolic polymer gels reinforced by modified nano-silica (GSNP) of different sizes and concentrations in harsh reservoir conditions. Specifically, the nano-silica was modified with a highly soluble silane, and gel properties were evaluated through rheological, differential scanning calorimetry (DSC), and sandpack flooding tests. The results showed that the incorporation of GSNP prolonged the gelation time, enhanced gel strength, and improved stability, allowing the gelation solution to enter deeper into the formation while maintaining long-time effectiveness. The optimal gel system was obtained with 0.4 wt.% GSNP-30, under which condition the storage modulus increased by approximately 14 times, and the content of non-freezable bound water more than doubled. This system exhibited plugging efficiency exceeding 80% in formations with permeabilities ranging from 1000 to 6000 millidarcy and enhanced the oil recovery factor by over 25%. The reinforcement mechanisms were attributed to the adsorption of GSNP onto polymer chains and its role in filling the gel matrix, which enhanced polymer hydrophilicity, suppressed polymer aggregation/curling, prevented ion penetration, and promoted the formation of a more uniform gel network. Careful optimization of nanoparticle size and concentration was essential to avoid the detrimental effects due to nanoparticle overfilling and aggregation. The novelty of this study lies in the practicable formulation of thermal and salt-tolerant gel systems with facile modified nano-silica of varying sizes and the systematic study of size and concentration effects. These findings offer practical guidance for tailoring nanoparticle parameters to cater for high-temperature and high-salinity reservoir conditions.
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产品关联
DOI
PubMed
高影响因子
REACTIVE & FUNCTIONAL POLYMERS
·
2017
·
IF 3.151
Jianxian Zeng,Zhe Zhang,Zhihui Dong,Panfeng Ren,Yuan Li,Xiao Liu
An ion-imprinted blend membrane (Ru(III)-IIM) for selectively adsorbing ruthenium(III) from aqueous solutions was fabricated by blending poly(methyl methacrylate- co -2-hydroxyethyl methacrylate) P(MMA-HEMA) with polyvinylidene fluoride (PVDF). Firstly, P(MMA-HEMA) was successfully synthesized and characterized. Subsequently, combining with the ion-imprinting technology, a series of Ru(III)-IIMs were fabricated via the non-solvent induced phase inversion method. The results indicated that increasing the polymer concentration and extending the evaporation time led to transform the cross-section of membranes from macrovoid structure to a finger-like or tear-like even sponge structure, and also decreased the water flux. The contact angle tests showed the hydrophilicity of Ru(III)-IIMs were effectively improved by blending with P(MMA-HEMA), compared with the PVDF membrane. The adsorption experiments showed that the adsorption capacity of ruthenium(III) onto the Ru(III)-IIM was pH-dependent, and the maximum adsorption capacity reached 42.31 mg g − 1 at pH 2.0. The adsorption process was well described by the pseudo-second-order kinetic model and the Langmuir isotherm model. The selective adsorption was studied by using Ni(II) as an interfering ion. Compared with the non-imprinted membrane, the Ru(III)-IIM showed a higher selectivity for Ru(III), with a selectivity coefficient of 6.0 for Ru(III)/Ni(II). In addition, the Ru(III)-IIM had a high reusability and still maintained about 95% of its initial adsorption capacity for Ru(III) after eight cycles.
研究领域:
材料科学
·
环境科学
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DOI
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2020
·Vol. 31
·期 8
·2008906
·
IF 16.836
Qian Wang,Yunbo Feng,Min He,Weifeng Zhao,Li Qiu,Changsheng Zhao
An ideal guided bone regeneration membrane (GBRM) is expected not only to perform barrier function, but also to enhance osteogenesis and resist bacteria infection. However, currently available membranes have limited bioactivities. To address this challenge, a Janus GBRM (JGM) is designed and fabricated by sequential fractional electrospinning here. The random gelatin fibers loaded with hydroxyapatite (HAP) are designed as the inner face to promote the osteoblasts’ adhesion, proliferation, and osteogenic differentiation, meanwhile the aligned poly(caprolactone) (PCL) nanofibers loaded with poly(methacryloxyethyltrimethyl ammonium chloride- co -2-Aminoethyl 2-methylacrylate hydrochloride) (P(DMC-AMA)) are designed as the outer layer to resist epithelia invasion and bacterial infection. In vitro assays reveal that the inner face displays enhanced osteogenic effects, meanwhile the outer surface can regulate the epithelia to spread along the aligned direction and kill the contacted bacteria. Interestingly, the outer face can induce macrophages to polarize toward the M2 phenotype, thus manipulating a favorable osteoimmune environment. These results suggest that the JGM simultaneously meets the critical requirements of barrier, osteogenic, antibacterial, and osteoimmunomodulatory functions. Consequently, the JGM shows better in vivo bone tissue regeneration performance than the commercial Bio-Gide membrane. This work provides a novel platform to design multi-functional membranes/scaffolds, displaying great potential applications in tissue engineering.
研究领域:
组织工程
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生物材料
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生物医学工程
·
再生医学
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产品关联
DOI
高影响因子
CHEMOSPHERE
·
2021
·
IF 7.086
Ji'an Sun,Lixin Wang,Yuge Wang,Weiyang Lv,Yuyuan Yao
The morphology and specific surface area of layered double hydroxide (LDH) are of great significance for optimizing the application of LDH in sewage treatment . Herein, we present a study of the relation between the catalytic property and the morphology of LDH via activating peroxymonosulfate (PMS) for degradation of organic pollutants. The results demonstrated that LDH nanoscrolls possessed a superior performance for methylene blue (MB) degradation, which achieved almost 100% removal in 40 min and the calculated apparent rate constant was about 2.1, 4.5 and 11.5 times higher than that of LDH nanosheets, Co 2+ and Co 3 O 4 , respectively. According to the results of X-ray photoelectrons spectroscopy (XPS) and electron paramagnetic resonance (EPR), 1 O 2 was confirmed to play a dominant role in the MB degradation, where the redox cycle of Co 3+ /Co 2+ provided the impetus for the reaction. Moreover, the pH and ion tolerance abilities of LDH nanoscrolls in PMS activating process were determined as well. Remarkably, CO 3 2− and H 2 PO 4 − could even promote the generation of •OH and 1 O 2 to facilitate the progress of reaction. Overall, these findings in the study may provide more opportunities in the preparation of high-efficiency catalysts and give insight into the accelerated degradation of refractory contaminants with surrounding anions.
研究领域:
环境科学
·
催化
·
水处理
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2024
·
IF 12.2
Hongyi Shu,Chuang Wang,Liu Yang,Dongcang Sun,Changtong Song,Xianhong Zhang,Dong Chen,Yuhong Ma,Wantai Yang
Nowadays, effluent treatment is a severe challenge mainly because of its complex composition, which includes oil, heavy metal ions, and dyes. Developing new intelligent membranes is one of the strategies to tackle these significant challenges in wastewater treatment . In this study, we fabricated asymmetric polyethylene glycol terephthalate (PET) membranes by grafting cross-linked poly (itaconic anhydride) (CL-PITA) nanoparticles onto the irradiated face. These nanoparticles were then functionalized with polyethyleneimine (PEI) and protonated with HCl to introduce numerous active electropositive amine groups. The fundamental purpose was to increase surface roughness, introduce numerous hydrophilic groups, and modify it to create a multi-functional PET membrane to separate complex environments. The promising results demonstrated that the protonated PET- g -ITA/DVB (10) -cat membrane exhibited excellent separation efficiencies (SE) for water/light oil, water/heavy oil and oil-in-water (O/W) emulsion. Compared to PET- g -ITA/DVB (0) -cat, it showed superior performance in SE for O/W emulsion and flux decay for water/light oil after 10 cycles. More interestingly, owing to numerous positively charged active amino groups and negativley charged carboxylate groups, the intelligent membrane exhibited a high removal rate of ca. 90 % for anionic dye (congo red) and heavy metals (Cu 2+ and Co 2+ ), showing great potential in complex water treatment environments.
研究领域:
环境科学
·
材料科学
·
水处理
·
膜技术
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产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2017
·
IF 7.504
Zhongxi Xie,Xiaoran Deng,Bei Liu,Shanshan Huang,Pingan Ma,Zhiyao Hou,Ziyong Cheng,Jun Lin,Shifang Luan
Photoinduced reversible addition–fragmentation chain transfer (RAFT) polymerization generally adopts high-energy ultraviolet (UV) or blue light. In combination with photoredox catalyst, the excitation light wavelength was extended to the visible and even near-infrared (NIR) region for photoinduced electron transfer RAFT polymerization. In this report, we introduce for the first time a surface NIR-light-initiated RAFT polymerization on upconversion nanoparticles (UCNPs) without adding any photocatalyst and construct a functional inorganic core/polymer shell nanohybrid for application in cancer theranostics. The multilayer core–shell UCNPs (NaYF4:Yb/Tm@NaYbF4:Gd@NaNdF4:Yb@NaYF4), with surface anchorings of chain transfer agents, can serve as efficient NIR-to-UV light transducers for initiating the RAFT polymerization. A hierarchical double block copolymer brush, consisting of poly(acrylic acid) (PAA) and poly(oligo(ethylene oxide)methacrylate-co-2-(2-methoxy-ethoxy)ethyl methacrylate) (PEG for short), was grafted from the surface in sequence. The targeting arginine–glycine–aspartic (RGD) peptide was modified at the end of the copolymer through the trithiolcarbonate end group. After loading of doxorubicin, the UCNPs@PAA-b-PEG-RGD exhibited an enhanced U87MG cancer cell uptake efficiency and cytotoxicity. Besides, the unique upconversion luminescence of the nanohybrids was used for the autofluoresence-free cell imaging and labeling. Therefore, our strategy verified that UCNPs could efficiently activate RAFT polymerization by NIR photoirradiation and construct the complex nanohybrids, exhibiting prospective biomedical applications due to the low phototoxicity and deep penetration of NIR light.
研究领域:
材料科学
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生物医学工程
·
高分子化学
·
癌症研究
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产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2022
·
IF 5.518
Pengyao Guo,Xiaomin Hu
To improve the degradation efficiency of g-C 3 N 4 (CN), transition metal elements (Fe and Co) were doped into CN. A novel Co, Fe co-doped CN (Co/Fe-CN) photocatalysts with small size and irregular flake structure were successfully prepared by thermal polymerization of melamine . Co/Fe-CN has a large specific surface area (55.76 m 2 /g), which provides more adsorption sites and reaction sites for the activation of peroxymonosulfate (PMS). Good visible light response performance (474 nm) and suitable band gap (2.83 eV) ensure that it could be excited by visible light. The active species of • O 2 - , 1 O 2 , • OH and SO 4 •- could be stably produced in Co/Fe-CN/Vis/PMS system with appropriate redox potential . Meanwhile, Co and Fe elements doped in CN also could effectively activate PMS and promote the generation of active species. Besides, the continuous generation of photogenerated electrons promoted the cycling of Co 3+ /Co 2+ and Fe 3+ /Fe 2+ , and further enhanced the degradation efficiency of Co/Fe-CN/Vis/PMS towards Levofloxacin (LVFX). LVFX could be rapidly removed, reaching 92.1% within 50 min under visible light illumination, and the kinetic rate constant of LVFX was 0.0638 min -1 . The quenching experiments verified that the 1 O 2 was the main active species in the reaction process. The cycling experiments revealed that the Co/Fe-CN/Vis/PMS system had favorable stability and applicability. This work provides a simple preparation method to fabricate bimetallic co-doped CN for the enhancement of degradation rate in the Photocatalyst/Vis/PMS system.
研究领域:
环境科学
·
材料科学
·
光催化
·
水处理
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产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2018
·
IF 6.735
Kaixin Zhu,Changzi Jin,Chunxiao Zhao,Ruisheng Hu,Zoltán Klencsár,Ganeshraja Ayyakannu Sundaram,Dávid F. Srankó,Rile Ge,Junhu Wang
Simple-controlled synthesis of multiple porous and monodisperse cobalt-iron oxides were realized by varying the prepared conditions via a template-assisted glycol solvothermal process. The obtained materials were characterized by X-ray diffraction, transmission electron microscopy, scanning electron microscopy, Mössbauer spectroscopy and nitrogen adsorption/desorption measurement. It was found that the amounts of metal precursors and the Co:Fe ratio significantly influenced the morphology, the crystallinity, as well as the textural and electronic properties of the cobalt-iron products. The different cobalt-iron oxides with various shells were employed into the catalytic activation of peroxymonosulfate (PMS) for Orange II degradation, among which, multi-shelled cobalt ferrite microsphere was certified to perform the best activity due to the coefficient contribution of higher content of octahedral Co 2+ , more exposed active sites and the reservoir effect. Sulfate and hydroxyl radicals were crucial reactive species in Orange II degradation, proved by the scavenger quenching test. This work shows that cobalt-iron oxide microspheres with such architecture make differences in the PMS-mediated aqueous organics degradation system, which extends the perspective and application of such functional oxides in the environmental field.
研究领域:
环境科学
·
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）