Analytical Methods
·
2025
·
IF 2.6
Yu-Lan Zhang,Cheng-Xiao Deng,Jian-Mei Zou,Jia-Le Hu,Wei Li,Jin-Fang Nie,Yun Zhang
Biothiol analysis holds critical importance in disease diagnosis, but the highly similar structures of biothiols pose a major obstacle to their practical detection. Herein, a straightforward yet efficient CoOOH nanoflake (CoOOH NF)-triggered dual-color fluorescence sensor array has been developed for the discrimination of biothiols. Owing to their high oxidase-like activity, CoOOH NFs efficiently catalyze the oxidation of fluorometric signal indicators, generating diverse fluorescence signals. However, the presence of biothiols induced structural degradation of CoOOH NFs via redox etching, thereby inhibiting the fluorescence reactions. Based on the differential reducing capacities of biothiols, the sensor array produced unique fluorescence response patterns, which were further analyzed using principal component analysis (PCA) and hierarchical cluster analysis (HCA). The results demonstrated that the sensor array could reliably discriminate three biothiols (glutathione (GSH), cysteine (Cys), and homocysteine (Hcy)) across a broad concentration range (0.5–100 μM), as well as their mixtures with varying molar ratios. Importantly, this strategy was successfully applied to distinguish cancer cells from normal cells and to analyze clinical serum samples, highlighting its potential for medical diagnostics.
研究领域:
分析化学
·
生物传感
·
医学诊断
·
纳米材料
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry A
·
2014
·Vol. 2
·期 33
·13299-13308
·
IF 0
Xiaming Feng,Weiyi Xing,Lei Song,Yuan Hu
In this work, a new MoS2/CoOOH hybrid material was successfully synthesized by a facile wet chemical method, and its structure was confirmed by X-ray diffraction and Raman spectroscopy. A morphological study showed that, due to the different sizes of the two components, the resulting MoS2/CoOOH hybrid displayed a disordered structure in which large MoS2 sheets had many independent and separate CoOOH nanoplatelets on the surface. The catalytic oxidation effect of MoS2/CoOOH hybrids on the thermal decomposition of epoxy resin was studied by thermogravimetric analysis-infrared spectrometry. It was found that the amount of organic volatiles of epoxy resin significantly decreased and non-flammable CO2 was generated after incorporating MoS2/CoOOH hybrids, which implied the reduced toxicity of the volatiles and obvious smoke suppression. Meanwhile, the incorporation of MoS2/CoOOH hybrids also resulted in a remarkable increase in the char residue of the epoxy composite, indicating the efficient catalytic carbonization of MoS2/CoOOH hybrids. Based on the X-ray diffraction and Fourier transform infrared results of the char residue, the possible mechanism of the reduced fire hazards and high char formation of the epoxy composites was proposed as the combination of the adsorption and synergistic catalytic effect of the MoS2/CoOOH catalyst, which would provide promising applications in the development of fire safety polymer materials.
研究领域:
材料科学
·
催化化学
✓ 已验证
DOI
Analytical Methods
·
2020
·Vol. 12
·期 42
·5081-5085
·
IF 2.596
Hongqi Chen,Huihui Wang,Wanying Xia,Jianguo Zhang,Lun Wang
In this work, we developed a simple and selective luminescence sensing system for detecting ascorbic acid (AA) based on NaGdF4:Yb,Er@NaYF4 upconversion nanoparticles (UCNPs) and oxidase-like CoOOH nanoflakes. When p-phenylenediamine (PPD) and oxidase-like CoOOH nanoflakes were added to the UCNPs solutions, PPD, as a typical substrate of oxidase, could be oxidized to PPDox. The luminescence intensity of UCNPs was quenched because PPDox could play a role as an energy acceptor. When AA was added to the above solution mixture, the CoOOH nanoflakes were destroyed, and then, the luminescence intensity was recovered. Under the best experimental conditions, the linear range for detection of AA was 0.8 to 280 μM, and the detection limit was 0.25 μM. Furthermore, the system could be applied to real sample analysis with satisfactory results.
研究领域:
分析化学
·
纳米技术
·
生物化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MICROCHEMICAL JOURNAL
·
2021
·
IF 4.821
Kongxiang Wei,Honghong Rao,Xin Xue,Mingyue Luo,Zhonghua Xue
Nanozymes-catalyzed 3,3′,5,5′-tetramethylbenzidine (TMB) reaction systems have been extensively used for fabricating colorimetric sensors, but they still require advanced instruments like color analysis software or ultraviolet spectrophotometers to achieve accurate quantitative analysis. Herein, we explored an alternative strategy to convert a color readout to a temperature readout of a CoOOH nanoflakes-TMB colorimetric reaction system, and successfully fabricated a simple and facile photothermometric sensor of acid phosphatase (ACP) by using a common thermometer as the reader. It mainly performed based on the strong photothermal effect of the oxidation product (TMBox) of TMB upon an 808 nm near-infrared (NIR) laser irradiation, which showed a close relationship with the ACP content with a lower limit of detection (LOD) of 0.037 mU/mL for photothermometric ACP determination. This photothermometric method was proved to be suitable for not only sensing ACP but also screening its inhibitor in human serum, and providing a simple, rapid, convenient, low cost, and portable organic chromogenic substrate-based sensing platform.
研究领域:
分析化学
·
生物传感器
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
APPLIED SURFACE SCIENCE
·
2021
·
IF 6.707
Guojuan Hai,Jianfeng Huang,Liyun Cao,Koji Kajiyoshi,Long Wang,Liangliang Feng
The development of heterostructure electrocatalysts with abundant active sites as binderless electrodes is crucial for the improvment of the catalytic efficiency. Herein, the CoOOH/W 18 O 49 heterojunction grown on nickel foam (abbreviated as Pre-CoOOH/W 18 O 49 /NF) was fabricated via a facile solvothermal method. It is found that in situ electrochemical reconstruction induces the amorphization of the non-stoichiometric tungsten oxide and effectively changes the interfacial interaction, which enables the electrons at the heterojunction interfaces to be redistributed. The Co 2+ /Ni 2+ ions successfully optimize the valence configuration of tungsten (W) sites, leading to a high proportion of W 4+ and Co 3+ /Ni 3+ active sites. Simultaneously, the potential of the flat band becomes more negative than the reduction potential of hydrogen for the water splitting, so as to achieve enhanced intrinsic hydrogen evolution activity. As expected, the reconstruction contributes to more efficient electrocatalytic activity compared with that of the direct hydrogen/oxygen evolution in alkaline solution. The activated CoOOH/W 18 O 49 /NF electrode (abbreviated as Act-CoOOH/W 18 O 49 /NF) with the optimized amorphous-crystalline interface shows low overpotentials of 89 and 198 mV at 10 and 20 mA cm −2 for HER and OER, respectively. It only needs 1.55 V (10 mA cm −2 ) decomposition voltage for overall water splitting and retains a high stability at least 50 h.
研究领域:
材料科学
·
电化学
·
催化
·
能源材料
✓ 已验证
产品关联
DOI
高影响因子
APPLIED SURFACE SCIENCE
·
2017
·
IF 3.387
Yuan-Zi Xu,Cheng-Zong Yuan,Xue-Ping Chen
In this article, we describe a NiSe@CoOOH core-shell nanostructure nanowires supported on nickel foam(NiSe@CoOOH NWs/NF) have been successfully synthesized by a facile approach for the first time. The NiSe@CoOOH NWs/NF has been confirmed by XRD, SEM images, TEM images, XPS, EDX and HRTEM. The NiSe@CoOOH NWs/NF, as a 3D oxygen-evolving and nonprecious-metal catalyst, shows high catalytic performance for oxygen evolution reaction.
研究领域:
材料科学
·
电化学
✓ 已验证
产品关联
DOI
高影响因子
Journal of Materials Chemistry B
·
2018
·Vol. 6
·期 18
·2843-2850
·
IF 4.776
Shi Gang Liu,Lei Han,Na Li,Na Xiao,Yan Jun Ju,Nian Bing Li,Hong Qun Luo
Nanozymes are increasingly exploited as components in bioanalysis and diagnostics. Here, we report a fluorescence and colorimetric dual-mode assay for alkaline phosphatase (ALP) activity employing oxidase-like cobalt oxyhydroxide (CoOOH) nanoflakes. Colorless o-phenylenediamine (OPD), a substrate for oxidase, can be oxidized to a product (OxOPD) with yellow color and orange fluorescence in a CoOOH nanoflake solution. But, ascorbic acid (AA) is able to reduce CoOOH to cobalt ion (Co2+), which causes the decomposition and collapse of the CoOOH nanoflakes, and thereby the CoOOH nanoflakes are deprived of the oxidase-like property. Based on this principle, the fluorescence and colorimetric dual-mode detection of AA was achieved. Alkaline phosphatase (ALP) can make L-ascorbic acid-2-phosphate (AAP) hydrolyze to yield AA. As a result, with the help of AAP, the selective and sensitive dual-mode assay of ALP activity has been realized successfully by using fluorescence and UV-vis absorption spectroscopies. Quantitative analysis of ALP in human serum samples and an ALP inhibitor investigation were performed using this sensing system. Given the economical and sensitive properties, the proposed method based on CoOOH nanoflakes has great potential for not only probing ALP activity in biological systems but also screening potential ALP inhibitors. Meanwhile, in this study, a new insight has been provided into the application of CoOOH nanoflakes in the development of sensitive and convenient sensors.
研究领域:
生物化学
·
纳米技术
·
分析化学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MICROCHIMICA ACTA
·
2019
·Vol. 186
·期 2
·1-8
·
IF 5.479
Kong Weisu,Tan Qingqing,Guo Haiyu,Sun Han,Qin Xia,Qu Fengli
A method is described for photoelectrochemical determination of the activity of alkaline phosphatase (ALP). It employs an indium tin oxide (ITO) electrode modified a CdS quantum dots@graphene (CdS@GR) composite and hexagonal cobalt oxyhydroxide (CoOOH) nanosheets. The CdS@GR nanocomposite was synthesized by assembling the CdS quantum dots onto a GO film to receive a basic photocurrent response of the ITO. This is further improved by covering it with CoOOH nanosheets. Secondly, 2-phospho-L-ascorbic acid (AAP) is added as a substrate for ALP. Its hydrolysis yields ascorbic acid which reduces CoOOH to form cobalt(II) ion. As a result, the CoOOH nanosheets decompose. This is accompanied by a reduction of the photocurrent. The effect was used to design a selective and sensitive assay of determination of the activity of ALP. Under the optimized experimental conditions, response is linear in the 10 to 300 U·L −1 ALP activity range. The detection limit is 1.5 U·L −1 at a signal-to-noise ratio of 3.
Indium tin oxide (ITO) was coted with CdS@graphene and CoOOH to obtain a material with superior photoelectrochemical properties. The detection of alkaline phosphatase (ALP) was accomplished by using 2-phospho-L-ascorbic acid (AAP) which is hydrolyzed by ALP to release ascorbic acid (AA) which reduces CoOOH to Co 2+ .
研究领域:
分析化学
·
生物化学
·
纳米技术
·
电化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Analysis and Testing
·
2018
·Vol. 2
·期 4
·332-341
·
IF 0
Wei Yin Hui,Li Xin Yu,Gao Jie,Liu Jia Jun,Yuan Dan,Yin Bin Cheng,Wang Jian
As an antibiotic, tetracycline has been widely used against bacterial infection or as feed additives for growth promotion, which may lead to the enrichment of antibiotic residues in animals or their products. Therefore, the detection of tetracycline is closely related to human health. The morphological transformation of CoOOH nanoflakes induced by tetracycline was monitored by scanning electron microscope images, dark-field light scattering images and optical spectra, which found that tetracycline could decompose CoOOH nanoflakes into small nanoparticles with low light scattering signal. As a result, the reduced light scattering of CoOOH nanoflakes was proportional to the increased concentration of tetracycline in the range of 1.0–250 μmol/L, and the limit of determination (LOD) was 0.23 μmol/L (3σ/k). Most foreign substances did not interfere in the analysis of tetracycline. Furthermore, the concentration of tetracycline in different milk samples detected with the standard addition method was so low that it accorded with the safety regulation, which was similar to the detection result with high-performance liquid chromatography (HPLC).
研究领域:
分析化学
·
纳米技术
·
食品安全
·
药物分析
✓ 已验证
产品关联
DOI
SENSORS AND ACTUATORS B-CHEMICAL
·
2022
·
IF 9.221
Yanyun Zou,Jinyang Chen,Qingli Chai,Ting Zhu,Shasha Zeng,Yucheng Liu
As a class of intelligent materials, stimuli-responsive hydrogels enable attractive sensors for sensitive and selective detection along with the potential for low production costs. Herein, we proposed a stimuli-responsive colorimetric sensor based on Cu 2+ -crosslinked alginate hydrogel loaded with CoOOH nanozyme. Upon binding of Cu 2+ to pyrophosphate ion (PPi), the hydrogel would be disassembled by PPi, which controlled the release of CoOOH nanoflakes . Interestingly and importantly, it was found that PPi and PPi-Cu 2+ could further enhance the catalytic activity of the released CoOOH nanozyme. Since alkaline phosphatase (ALP) can catalyze the hydrolysis of PPi to phosphate ion (Pi), a sensitive colorimetric sensor for ALP detection was constructed based on PPi-triggered controlled release and enhancing activity of CoOOH nanozyme. The as-constructed sensor exhibited good linear response to ALP over the range from 0.1 to 250 mU/mL with a detection limit of 0.07 mU/mL. Additionally, this sensor was also extended to measure two typical ALP inhibitors (Na 3 VO 4 and EDTA) with reasonable results. Last but not least, it was confirmed that the detection results of ALP in real serum samples with the proposed sensor were in accordance with the data from clinical test, which indicates the robustness and practicability of this stimuli-responsive colorimetric sensor.
研究领域:
材料科学
·
分析化学
·
生物传感器
✓ 已验证
DOI
高影响因子
Journal of Materials Chemistry A
·
2024
·
IF 10.7
Yiqing Wei,Huichao He,Shuyuan Yang,Yongcai Zhang,Xin Zhou,Zhigang Zou,Yong Zhou
In unbiased tandem cells, the production of C2+ products from CO2 reduction on the cathode is dependent on the effective supply of charge from the photoanode. At present, the development and understanding of efficient photoanodes remain challenging. A CoOOH nanosheet coupled CdIn2S4 film (CoOOH/CdIn2S4) was investigated as a photoanode to drive solar benzyl alcohol oxidation. Relative to the CdIn2S4 photoanode, lower carrier recombination, better activity and faster kinetics were achieved on the CoOOH/CdIn2S4 photoanode for benzyl alcohol oxidation to benzaldehyde. Several investigations jointly revealed that the oxidation of benzyl alcohol to benzaldehyde on the CoOOH/CdIn2S4 photoanode is mediated through the formation of hydroxyl radicals and the slight change of β-CoOOH into γ-CoOOH. Additionally, CoOOH coupling with CdIn2S4 is more energetically favourable for benzyl alcohol oxidation to benzaldehyde. Consequently, the CoOOH/CdIn2S4 photoanode shows high Faraday efficiency and selectivity for benzyl alcohol oxidation. In the CoOOH/CdIn2S4 photoanode–Cu2O cathode unbiased tandem cell, benzaldehyde and ethanol can be selectively produced from benzyl alcohol oxidation and CO2 reduction, respectively. Additionally, the CoOOH/CdIn2S4 photoanode can work stably to drive the unbiased cell, and 88% of its initial activity can be maintained after 4 h of reaction.
研究领域:
材料科学
·
电化学
·
太阳能转换
·
催化
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2024
·
IF 9.4
Zhilong Zhang,Xingyu Zhan,Bo Hong,Xinqing Wang,Peisong Tang,Yangbin Ding,Yingchun Xia,Yunxiong Zeng
Peroxymonosulfate (PMS) is widely employed to generate oxygen-containing reactive species for ciprofloxacin (CIP) degradation. Herein, cobalt oxyhydroxide @activated carbon (CoOOH@AC) was synthesized via a wet chemical sedimentation method to activate PMS for degradation of CIP. The result suggested AC can support the vertical growth of CoOOH nanosheets to expose high-activity Co-contained edges, possessing efficient PMS activation and degradation activity and catalytic stability. In the presence of 3.0 mg of optimal CoOOH@AC and 2 mM PMS, 96.8 % of CIP was degraded within 10 min, approximately 11.6 and 9.97 times greater than those of CoOOH/PMS and AC/PMS systems. Notably, it was disclosed that the optimal CoOOH@AC/PMS system still exhibited efficient catalytic performance in a wide pH range, different organics and common co-existing ions. Quenching experiments and electron paramagnetic resonance indicated that both radical and non-radical processes contributed to the degradation of CIP, with 1 O 2 and direct electron transfer accounting for the non-radical pathway and SO 4 •− and •OH serving as the main radical active species. Finally, possible CIP degradation pathways were proposed based on high-performance liquid chromatography-mass spectrometry. This study provided an alternate method for wastewater treatment based on PMS catalyzed by cobalt-based hydroxide.
研究领域:
环境科学
·
化学工程
·
材料科学
·
废水处理
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）