Food Chemistry-X
·
2024
·
IF 6.5
Shan Jiang,Pengfei Jiang,Dingding Feng,Meiran Jin,Hang Qi
The flavor of algae was one of the key factors for consumer acceptance. The objective of this study was to investigate the characteristic volatile compounds in cooking and seasoned cooking edible brown seaweeds ( Undaria pinnatifida and Laminaria japonica ). The gas chromatography-ion mobility spectrometry (GC-IMS) and electronic nose (E-nose) analysis showed that baking resulted in significant difference in flavor of brown seaweeds. However, the overall effect of cooking was not as significant as that of the seasoning solution treatment. Additionally, brown seaweeds treated with the seasoning solution were more acceptable. Undaria pinnatifida was found to contain 72 volatile flavor compounds, while Laminaria japonica had a total of 70. This study proved the applicability of GC-IMS combined with E-nose technology to detect the changes of volatile components of brown seaweeds after processing, providing beneficial knowledge and basic theory for the deep processing of brown seaweeds.
研究领域:
食品科学
·
海洋生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
RESPIRATORY RESEARCH
·
2025
·
IF 5
Xuanrong Bao,Hanbing Hu,Yu Dun,Yuedong Tang,Fuli Liu,Jian Zhou,Weichun Mo,Jie Shen
Background E-cigarette or vaping product use-associated Lung Injury (EVALI) has become a public health concern since 2019, with vitamin E acetate (VEA) identified as a potential causative agent. While previous studies have used whole-body VEA aerosol exposure or intratracheal instillation models, these approaches may introduce confounding exposure routes or do not fully reflect real-world vaping conditions. To better understand VEA-induced EVALI, there remains a need for an animal model that isolates airway exposure and closely mimics human vaping behaviour. Methods We utilized a nose-only exposure system to develop a mouse model of EVALI, with VEA aerosol generated by a commercially available vaping device. Puffs were generated at a volume of 55 mL over 3 s, delivered every 30 s for 1 h per day, up to 6 consecutive days. Lung injury was assessed through histopathological analysis, and airway function was measured via invasive airway function test. Ultrastructural changes in mouse alveoli were analyzed with transmission electron microscopy. Alveolar macrophages were assessed for pro-inflammatory polarization and functional impairment. Potential pathogenic mechanisms were explored with RNA-seq analysis. Results Our findings revealed acute lung injuries, characterized by pulmonary edema and typical histopathological findings. Additionally, we observed changes in airway functions with altered respiratory patterns and decreased lung dynamic compliance. Transmission electron microscopy further revealed type II pneumocyte hypertrophy, type I pneumocyte swelling, and prolonged activation of alveolar macrophages with electron-dense phagocytic contents. We also demonstrated macrophage dysfunction with sustained pro-inflammatory polarization and impaired efferocytosis function. The persistent inflammation of the lung was also characterized by the increased level of pro-inflammatory cytokines in the bronchoalveolar lavage fluid, especially IL-6. RNA-seq analysis highlighted pathways related to T cell activation, cytokine signaling, and leukocyte migration. Conclusion This study established a mouse model using a nose-only VEA aerosol exposure system to examine the respiratory effects of VEA in EVALI. Our results revealed that VEA inhalation triggered acute lung injury, accompanied by early signs of airway dysfunction. The findings support the hypothesis that VEA drives EVALI pathogenesis through both direct cytotoxic effects and macrophage-mediated inflammation. Our findings offer new insights into the mechanisms of EVALI and present a valuable model for future research. Supplementary Information The online version contains supplementary material available at 10.1186/s12931-025-03343-1.
研究领域:
呼吸病学
·
毒理学
·
免疫学
·
分子生物学
·
转化医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
TOXICOLOGICAL AND ENVIRONMENTAL CHEMISTRY
·
2019
·
IF 0.971
Yu Wang,Jiayi Li,Rui Zhou,Lincai Yang,Peisheng He,Lixuan Chen,Liying Luo,Haowen Chen,Lian Wei
The protective effects of vitamin E (45, 150, and 500 mg/kg/d) against reproductive toxicity induced in male Kunming mice by intragastric administration of 120 mg/kg/d bisphenol A was investigated. After two weeks, relative organ weights, sperm counts, sperm abnormality rates and serum testosterone concentrations were determined. Epididymal sperm counts were significantly decreased, sperm abnormality was increased, and serum testosterone concentrations were dramatically reduced following bisphenol A exposure. Vitamin E treatment led to a marked increase in sperm numbers and a decrease in the proportion of malformed sperm in a dose-related manner; serum testosterone levels were also restored. This suggests that vitamin E could be used as prophylactic agent for preventing bisphenol A-induced reproductive toxicity.
研究领域:
毒理学
·
生殖健康
·
营养学
✓ 已验证
产品关联
DOI
高影响因子
FOOD HYDROCOLLOIDS
·
2019
·
IF 5.839
Hongqiang Chen,Like Mao,Zhanqun Hou,Fang Yuan,Yanxiang Gao
The role of the oil droplets in emulsion gelation (as active or inactive fillers) was modified by additional emulsifiers, and structures and functionalities of emulsion gels were evaluated. Emulsion gels based on denatured protein (whey protein isolate) were prepared via an acid-induced approach, and four emulsifiers, including glycerol monostearate (MG), tween 20 (TW), modified starch (OSA) and gum Arabic (GA) were tested. The including of MG or TW led to delayed onset of gelation, and the emulsion gels formed were of lower gel strength (described as storage modulus and fracture force), compared with the emulsion gels without additional emulsifiers. Increase in the content of MG or TW resulted in the gels with lower water holding capacity , and slight changes in swelling ratio. The presence of OSA or GA allowed faster gelation of the emulsions, forming gels with higher storage modulus and fracture force. Increase in the content of OSA or GA did not affect WHC of the gels, but contributed to higher swelling ratios. Microstructural observation indicated that the emulsion gels with OSA or GA had smaller pore size. When vitamin E was incorporated within the gels, the emulsifiers presented different effects on its degradation kinetics. Vitamin E degraded much faster in the systems with higher content of MG or TW, and lower retention ratios were obtained after the storage (55 °C for 12 days). On the contrary, the emulsion gels with OSA or GA provided good protection for vitamin E, and increase in the content of the emulsifiers allowed higher retention ratios.
研究领域:
食品科学
·
营养学
✓ 已验证
产品关联
DOI
高影响因子
RSC Advances
·
2016
·Vol. 6
·期 55
·50267-50277
·
IF 3.289
Heyu Li,Maochun Wang,Gareth R. Williams,Junzi Wu,Xiaozhu Sun,Yao Lv,Li-Min Zhu
Vitamin A palmitate and vitamin E TPGS, common derivatives of the unstable vitamins A and E, were successfully incorporated into biodegradable gelatin nanofibers via electrospinning. Electron microscopy showed that smooth cylindrical fibers were produced, albeit with a small amount of beading visible for the vitamin-loaded systems. The diameters of the fibers decrease with the addition of vitamins. The presence of the vitamins in the fibers was confirmed by IR spectroscopy, and X-ray diffraction showed them to exist in the amorphous physical form post-electrospinning. The addition of vitamins did not affect the hydrophilic properties of the gelatin nanofibers. Fibers containing vitamin A or E alone showed a sustained release profile over more than 60 hours, and those incorporating both vitamins showed similar release characteristics, except that the extent of release for vitamin A was increased. Antibacterial tests demonstrated that materials loaded with vitamin E were effective in inhibiting the growth of E. coli and S. aureus. The fibers could promote the proliferation of fibroblasts during the early stages of culture, and enhance the expression of collagen-specific genes. In vivo tests determined that the fibers loaded with vitamins have better wound healing performance than a commercially used antiseptic gauze and casting films.
研究领域:
生物医学工程
·
材料科学
·
药学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF BIOMATERIALS APPLICATIONS
·
2018
·
IF 2.082
Yude Liu,Lian Rao,Hongguan Zhang,Yanyou Cen,Kaili Cheng
Herb borneol is usually used in clinics for the treatment of central nervous system illness, for its ability of blood–brain barrier permeability, although its poor water solubility and poor bioavailability limit its clinical application to some degree. In this study, we developed a novel nanoparticle combining the benefits of vitamin E d-ɑ-tocopheryl poly(ethylene glycol) succinate (E-TPGS) (or TPGS) and guar gum to get TPGS-g-guar gum as a drug delivery system to carry borneol, which could improve the solubility of borneol and increase the drug-loading capacity efficiently. The results showed that TPGS-g-guar gum nanoparticles delivery system was suitable to carry borneol and release the drug effectively, and TPGS-g-guar gum/borneol nanoparticles would be a potential platform for improving the treatment of central nervous system illness and cerebrovascular disease.
研究领域:
药剂学
·
神经科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
LWT-FOOD SCIENCE AND TECHNOLOGY
·
2022
·
IF 6.056
Xianghua Wang,Maorun Fu,Xiaoqian Qu,Jingjing Liu,Jianwen Bu,Shaoran Feng,Handong Zhao,Wenxiao Jiao,Fei Sun
(E)-2-Hexenal is one of the most prevalent and abundant volatile substances in fruits. Many researchers have attempted fumigation with (E)-2-hexenal to control fungal diseases with poor or no results; the key is the inability to maintain an effective concentration for a long time. Therefore, a new starch-based antifungal coating with (E)-2-hexenal microcapsules was prepared. The obtained results showed that the microcapsule embedding rate reached 78.95% by orthogonal optimization experiments and that the (E)-2-hexenal-based coating was effective at reducing the lesion diameter of apple fruit during storage at 25 °C after Penicillium expansum infection, and in other fruits; it also achieved a good antifungal effect. Moreover, the activities of the main defense-related enzymes and the expression of key genes involved in the salicylic acid (SA) signaling pathway, such as CHI, GLU, PAL , NPR1 , and PR1 , were enhanced by (E)-2-hexenal-based coating treatment. These findings suggest that the (E)-2-hexenal-based coating has the dual effect of direct antifungal and induction of apple system resistance. E2H-based coating is a promising approach to control postharvest Penicillium expansum in fruit.
研究领域:
植物病理学
·
食品科学
·
分子生物学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
·
2020
·Vol. 101
·期 8
·3186-3192
·
IF 2.614
Xia Jiaojiao,Zou Bin,Zhou Ruoyu,Adesanya I Onyinye
BACKGROUND In order to improve the stability of vitamin E and broaden its scope of application, an effective solution is to convert vitamin E into its derivatives. This work developed a new Candida rugosa lipase (CRL) nanogel based on modification of ionic liquid with vinyl functional groups. This novel CRL nanogel was used in the preparation process of vitamin E succinate based on the principle of non-aqueous enzymology. At the same time, various factors including enzyme concentration, substrate molar ratio, reaction temperature and reaction time, that affect the yield of vitamin E succinate were optimized and analyzed. RESULTS Different solvents with various hydrophobicity parameters (Log P values) from −1.3 to 3.5 were studied, it was found that dimethyl sulfoxide (DMSO) had the lowest Log P value among organic solvents but vitamin E succinate had the highest yield in DMSO. Furthermore, the effect of different operating conditions, such as molar ratios of substrate, enzyme concentration, reaction temperature and reaction time was studied. Under the optimal process conditions (enzyme concentration 6 mg mL −1 , substrate molar ratio 4:1, reaction temperature 55 °C and reaction time 15 h), the product yield was 62.58 ± 1.16%. CRL and CRL nanogel were characterized using Fourier-transform infrared (FTIR) spectroscopy and scanning electron microscopy (SEM). It was shown that CRL nanogel influenced the catalytic behavior of lipase significantly by changing the structure and surface properties of CRL. CONCLUSION Novel lipase nanogel was an excellent biocatalyst for enzymatic synthesis of vitamin E succinate. © 2020 Society of Chemical Industry
研究领域:
生物化学
·
酶工程
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SPECTROSCOPY LETTERS
·
2015
·
IF 0.852
Bo Zhang,Yanbin Su,Lei Chen,Zhuofu Wu,Fengrong Zhang,Yanwen Su,Gang Zhao,Zhengqiang Li
The characteristic changes in UV-visible and Raman spectra of lithocholic acid on E-2-Butenal for antiglioma are the maximum absorption peak of E-2-Butenal from 302 to 319 nm, the decreases of Raman signal of 1688 cm−1 and 1641 cm−1 in E-2-Butenal by lithocholic acid with the phenomenon of 1688 cm−1 splitting, and the disappearance of the band at 932 cm−1, which clearly displays the change of wagging in methyl. In the presence of mitochondrial protein deriving from glioma, the above mentioned effects of lithocholic acid on E-2-Butenal are more significant by Raman spectra detections. The molecular targets of lithocholic acid on E-2-Butenal are carbonyl group, conjugated double bonds, and methyl, respectively. The study concludes that the interaction between lithocholic acid and E-2-Butenal decreases the carbonyl group bond strength in E-2-Butenal and then changes the structure and function of E-2-Butenal. The internal cause of the interaction between lithocholic acid and E-2-Butenal leading to the change of the carbonyl group bond strength is the electronic delocalization near the carbonyl group bond in E-2-Butenal. Since E-2-Butenal derives from glioma in the process of lipid peroxidation of mitochondria, our investigation significantly contributes to understanding the mechanism of action of lithocholic acid as a potential antiglioma drug.
研究领域:
生物化学
·
药物学
·
肿瘤学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF WUHAN UNIVERSITY OF TECHNOLOGY-MATERIALS SCIENCE EDITION
·
2022
·Vol. 37
·期 4
·765-772
·
IF 1.271
Du Yonggang,Shi Gonghui,Wang Jiaming,Wang Yiming,Wang Xuhua,Wang Liwei,Yang Jinhui,Ren Shitong
The bio-based epoxy nanocomposite (GAER/DOPO-POSS) was prepared from gallic epoxy resin (GAER) and polyhedral oligomeric silsesquioxane (which containing 9,10-dihydrogen-9-oxo-10-phosphorus-phenanthrene-10-oxide groups, called DOPO-POSS). The polyhedral oligomeric silsesquioxane containing epoxy groups (E-POSS) was grafted onto aminated graphene oxide (E-GO), then the novel POSS-E-GO was obtained. The POSS-E-GO was used as modifier for GAER/DOPO-POSS nanocomposite. The influences of POSS-E-GO content on mechanical properties, dynamic mechanical properties and thermal stability of GAER/DOPO-POSS nanocomposites were determined. The experimental results show that POSS-E-GO can significantly improve the toughness of the GAER/DOPO-POSS nanocomposite. When 0.5wt% POSS-E-GO was added in GAER/DOPO-POSS nanocomposite, the impact strength of the nanocomposite was 4.74 kJ/m 2 higher than that in the absence of POSS-E-GO, meantime the initial thermal degradation temperature was 277 °C.
研究领域:
材料科学
·
化学工程
✓ 已验证
DOI
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2021
·
IF 3.764
Guo Haowen,Wu Xilei,Zhuang Yuan,Guo Zhikai,Han Xiaohong,Chen Guangming
With the development of the alternative refrigerant technology, the thermophysical properties of hydrofluoroolefin (HFO) refrigerants have attracted much attention. Among these thermophysical properties, the thermal conductivity of refrigerants is a key parameter of phase change and convective heat transfer process of refrigeration cycle and also an important basis for the selection of alternative refrigerants. Therefore, studies on the thermal conductivity of refrigerants are of great significance. At present, many studies emphasized on the thermal conductivity of refrigerants, but there is no public report on the investigation of the saturated liquid thermal conductivity of HFO-1336mzz(E). On the basis of the current state, the thermal conductivities of HFO-1336mzz(E) by means of the general models were first predicted, then the thermal conductivities of the saturated liquid phase of HFO-1336mzz(E) in the temperature range of 253.15–353.15 K were measured based on the transient hot wire method. A comparison of prediction and experimental data was developed, and a special equation of the saturated liquid thermal conductivity for HFO-1336mzz(E) was recommended.
研究领域:
热力学
·
制冷技术
✓ 已验证
DOI
高影响因子
JOURNAL OF CONTROLLED RELEASE
·
2021
·
IF 9.776
Lina Liang,Yan Peng,Liyan Qiu
Inducing mitochondrial malfunction is an appealing strategy to overcome tumor multidrug resistance (MDR). Reported here a versatile mitochondrial-damaging molecule, vitamin E succinate (VES), is creatively utilized to assist MDR reversal of doxorubicin hydrochloride (DOX·HCl) via a nanovesicle platform self-assembled from amphiphilic polyphosphazenes containing pH-sensitive 1H-benzo-[d]imidazol-2-yl) methanamine (BIMA) groups. Driven by multiple non-covalent interactions, VES is fully introduced into the hydrophobic membrane of DOX·HCl-loaded nanovesicles with loading content of 23.5%. The incorporated VES also offers robust anti-leakage property toward DOX·HCl under normal physiological conditions. More importantly, upon release within acidic tumor cells, VES can target mitochondria and result in various dysfunctions including excessive generation of reactive oxygen species (ROS), mitochondrial membrane potential (Δ Ψ m ) loss, and inhibited adenosine triphosphate (ATP) synthesis, which contribute to cell apoptosis and insufficient energy supply for drug efflux pumps . Consequently, the killing-effect of DOX·HCl is significantly enhanced toward drug resistant cancer cells at the optimal mass ratio of DOX·HCl to VES. Further in vivo antitumor investigation on nude mice bearing xenograft drug-resistant human chronic myelogenous leukemia K562/ADR tumors verifies the extremely enhanced anti-tumor efficacy of the dual drug-loaded nanovesicle with the tumor inhibition rate (TIR) of 82.38%. Collectively, this study provides a s safe, facile and promising strategy for both precise drug delivery and MDR eradication to improve cancer therapy.
研究领域:
肿瘤学
·
药物递送系统
·
生物化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）