CHEMICAL ENGINEERING JOURNAL
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2021
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IF 13.273
Jiabei Luo,Yazhi Xing,Chuanyue Sun,Liqiang Fan,Haibo Shi,Qinghong Zhang,Yaogang Li,Chengyi Hou,Hongzhi Wang
Bioelectrical signal is the basis of the rapidly growing field of physiological activity research, clinical diagnosis, therapeutic applications and neural science. However, current bioelectrical signal monitor methods face challenges such as skin mismatch, impedance defect, insufficient cycle performance, tissue damage, and scar/biofilm interface formation. Here, we report a sterilizable bio-adhesive interface based on ion-conducting organohydrogel with skin-compliance for precise and motion-robust epidermal bioelectrical signals monitoring. The interface material is based on silk fibroin-reinforced organohydrogel, which is formed by UV curing. The interface material represents energy storage efficiency up to 97%, extremely low impedance (less than40 Ω) at physiologically relevant frequencies and the electrocardiogram (ECG) signals measurement maintains accurate even after multiple disinfections (100 times) by 75% ethanol. Hence, this interface material can be used for multiple times in long-term bioelectrical signals monitoring during daily life. We further investigated the capabilities of the interface in an auditory brainstem response test and realized its ability to achieve competitive monitoring sensitivity in clinical diagnosis as non-invasive electrodes.
研究领域:
生物医学工程
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材料科学
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生物技术
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神经科学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
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2024
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IF 4
Xiaoyan Shen,Xiaofen Wu,Hui Qi,Dongning Wei,Ming Deng,Keqin Wang,An Liu,Liang Chen
This study focused on the efficiency of enzymatic synthesis for theaflavins (TFs) and SII types of thearubigins (SII-TRs) in suspended fermentation of different varieties of tea leaves. The results showed that the content of catechins in tea variety-Xiaoxianghong 21-3 (XXH21-3) was the highest among the five kinds of fresh tea leaves, and it had the strongest ability of transforming catechins to TFs and SII-TRs. The total amount of catechins for XXH 21-3 decreased rapidly and the conversion ratio of TFs reached the highest level of 13.96% after 20 min, the residual catechins was the lowest (3.08%) and the conversion rate of SII-TRs was the highest (13.02%) after 120 min during the suspended fermentation of five varieties tea leaves. Among the six catechin types, epicatechin gallate (ECG), epigallocatechin gallate (EGCG) and epigallocatechin (EGC) were consumed in large quantities, and the residues were all less than 5% in the final stage of fermentation, of which ECG consumption was the fastest, followed by EGCG. These results demonstrated that the concentration of catechins and PPO activities were positively correlated with the formation of TFs and SII-TRs, POD activity was positive correlation with synthesis of SII-TRs and negative correlation with TFs.
研究领域:
食品科学
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茶叶化学
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酶学
✓ 已验证
产品关联
DOI
高影响因子
TOXICON
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2013
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IF 2.924
Ying Zhang,Li Zhong,Bin Zhou,Jin-yu Chen,Chun-mei Li
To more fully understand the mechanism by which persimmon tannin (PT) inhibited phospholipase A 2 (PLA 2 ) and the structural requirements of PT for the inhibition, the interactions between PLA 2 and seven characteristic structural elements of PT including epigallocatechin-3-gallate (EGCG), myricetin, epicatechin-3-gallate (ECG), epicatechin-3-gallate-(4β → 8, 2β → O → 7)-epicatechin-3-gallate (A-type ECG dimer), epigallocatechin-3-gallate-(4β → 8, 2β → O → 7)-epigallocatechin-3-gallate (A-type EGCG dimer), epicatechin-(4β → 8, 2β → O → 7)-epicatechin (A-type EC dimer) and epicatechin-(4β → 8)-epicatechin (B-type EC dimer) were studied by enzymatic and spectroscopic methods. Molecular docking was also used to explore the possible residues involved in the interactions. The results revealed that A-type EGCG dimer and A-type ECG dimer showed higher inhibitory effects on the catalytic activity of PLA 2 than monomers and B-type dimer. They induced greater conformational changes in PLA 2 than other structural elements. In addition, molecular docking studies revealed that expect for lysine residues, other residues such as Trp18, Try27, Gly29, His47 and Tyr63 were involved in the interactions. We propose that A-type EGCG and ECG dimer units may be structural requirements for the interaction between PT and PLA 2 . Our data provide an additional structural basis for anti-PLA 2 activity of persimmon tannin.
研究领域:
生物化学
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药理学
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分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2023
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IF 5.2
Xiaoyu Ma,Xinming Shi,Yang Wang,Weijie Xiong,Caihua Xiong,Jinhao Yang,Lijun You,Shaoyun Wang
Conductive hydrogels with stretchability, breathability and long-term stability have attracted increasing attention for the applications in interactive wearable devices , artificial prosthetics, and intelligent robots. In this paper, a stretchable (up to 254 %), well breathable (vapor transmission up to 1.231×10 −2 g·cm −2 ·h −1 ), and stable conductive (1.21 S/m) hydrogel films (Gel/PPy/Ag) was prepared by gel-template immersion method using gelatin as gel networks, polypyrrole (PPy) and silver (Ag) as conductive reinforcing filler and Span 80 as emulsion template. The film could maintain flexibility and conductivity after stored in an environment of –20 °C or 25 °C for 20 days. The excellent frost resistance and water retention ensured the practical application of the porous organic hydrogel film with environmental adaptability and long-term stability. The strain sensor made from the Gel/PPy/Ag films presented excellent sensitivity (GF reached 2.034), good durability, fast response (0.34 s) and recovery ability (0.36 s). It monitored weak and vigorous human motions effectively and sensitively. The Gel/PPy/Ag flexible electrodes realized the real-time sensitive detection of human Electrocardiogram (ECG) and electromyogram (EMG) signals and precision sensing control of the manipulator arm. The Gel/PPy/Ag hydrogel and the prepared flexible electronic devices have broad application prospects in the field of health monitoring, motion monitoring, operation control and other soft electronic devices.
研究领域:
材料科学
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生物材料
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柔性电子
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可穿戴技术
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生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
ACS Nano
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2023
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IF 17.1
Yue Hou,Yazhen Li,Yingqi Li,Da Li,Tailin Guo,Xu Deng,Hongping Zhang,Chaoming Xie,Xiong Lu
Hydrogels with robust wet adhesion are desirable for applications in aqueous environments. Wet adhesion arising from synergy between hydrophobic and catechol components in mussel foot proteins has been highlighted. However, optimizing hydrogels with multiple components is challenging because of their complex structure–property relationships. Herein, high-throughput screening of a series of hydrophobic alkyl monomers and adhesive catechol derivatives was used to systematically develop wet adhesive hydrogels. Short alkyl chains promote wet adhesion by repelling water at the adhesive interface, whereas long alkyl chains form strong hydrophobic interactions inside the hydrogel network that impede or dissipate energy for wet adhesion. The optimized wet adhesive hydrogel, containing short alkyl chain, was applied for rapid hemostasis and wound healing because of the synergistic effect of catechol and alkyl groups and its immunomodulation ability, which is revealed through a transcriptomic analysis. Conductive nanocomponents were incorporated into the optimized hydrogel to produce a wearable device, which was used for continuous monitoring human electrocardiogram (ECG) during swimming, and in situ epicardial ECG on a porcine living and beating heart. This study demonstrated an efficient and generalized molecular design strategy for multifunctional wet adhesive hydrogels.
研究领域:
材料科学
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生物医学工程
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生物材料
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组织工程
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生物技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）