Tingting Yan,Jinghe Sun,Yuying Zhang,Chengrong Wen,Jingfeng Yang
Enteromorpha prolifera polysaccharide (EP2) protection against acute alcoholic liver injury (AALI) in mice was investigated. By integration of physiological indicators, gut microbiota, and short-chain fatty acids (SCFAs), the mechanism of EP2 in alleviating AALI was disclosed. The results showed that EP2 significantly ameliorated alcohol-induced abnormal transaminase activities, liver and intestinal systemic inflammation, and intestinal environmental disorders. EP2 significantly reduces liver and serum LPS contents by 1.69-fold and 1.54-fold. Furthermore, inhibition of the NF-κB signaling pathway by EP2 reduced the production of proinflammatory cytokines such as TNF-α (1.83-fold), IL-6 (11.09-fold), and IL-1β (1.99-fold). EP2 restored SCFAs to normal levels by upregulating the abundance of beneficial bacteria (Colidextribacter, Ruminococcus, unclassified_Lachnospiraceae, and Akkermansia). The alleviation of AALI by EP2 occurs through protection of the intestinal mucosal barrier and reduction of LPS permeating in serum. The decrease in LPS inactivates the NF-κB signaling pathway and prevents inflammation. In short, EP2 regulates the gut–liver axis and inflammation, alleviating effects in AALI mice.
To address the ecological problem caused by the accumulation of green tide Enteromorpha prolifera and the challenge of remediating organic pollutants in water bodies, this study utilized Enteromorpha prolifera as raw materials to synthesize a novel nitrogen-doped biochar (NBPBC) catalyst through ball-milling and pyrolysis. The resulting catalyst was applied to activate peroxymonosulfate (PMS) for antibiotic tetracycline (TC) degradation. The optimized NBPBC exhibited a large specific surface area (62.0022 m 2 /g) and a high content of graphitic nitrogen. Experimental results showed that the NBPBC/PMS system achieved 100% removal efficiency towards TC within 60 min with a rate constant k = 0.06629 min − 1 , significantly outperforming systems without ball-milling or nitrogen doping. Additionally, NBPBC maintained good a catalytic activity and stability after six cycles, with the TC degradation efficiency remaining above 80%. Mechanistic studies revealed that the catalytic mechanism was dominated by ∙O 2 − , with synergistic contributions from ∙OH, 1 O 2 and SO 4 ∙ − . This work achieves the high-value utilization of Enteromorpha prolifera waste and provides an efficient strategy for aquatic organic pollutant remediation, offering a dual-win solution to ecological and environmental challenges. Graphical abstract A novel N-doped biochar catalyst based on Enteromorpha prolifera was synthesized through a ball-milling and single-step pyrolysis method, which can effectively activate PMS to realize the rapid degradation of organic pollutants and the high-value utilization of Enteromorpha prolifera .
危险品化学品经营许可证（带存储）