Bioactive Materials
·
2023
·
IF 18.9
Wenqian Zhang,Kangkang Zha,Yuan Xiong,Weixian Hu,Lang Chen,Ze Lin,Chenyan Yu,Wu Zhou,Faqi Cao,Hankun Hu,Bobin Mi,Guohui Liu
The diabetic wounds remain to be unsettled clinically, with chronic wounds characterized by drug-resistant bacterial infections, compromised angiogenesis and oxidative damage to the microenvironment. To ameliorate oxidative stress and applying antioxidant treatment in the wound site, we explore the function of folliculin-interacting protein 1 (FNIP1), a mitochondrial gatekeeper protein works to alter mitochondrial morphology, reduce oxidative phosphorylation and protect cells from unwarranted ROS accumulation. And our in vitro experiments showed the effects of FNIP1 in ameliorating oxidative stress and rescued impaired angiogenesis of HUVECs in high glucose environment. To realize the drug delivery and local regulation of FNIP1 in diabetic wound sites, a novel designed glucose-responsive HA-PBA-FA/EN106 hydrogel is introduced for improving diabetic wound healing. Due to the dynamic phenylboronate ester structure with a phenylboronic acid group between hyaluronic acid (HA) and phenylboronic acid (PBA), the hydrogel is able to realize a glucose-responsive release of drugs. Fulvic acid (FA) is added in the hydrogel, which not only severs as crosslinking agent but also provides antibacterial and anti-inflammatory abilities. Moreover, the release of FEM1b-FNIP1 axis inhibitor EN106 ameliorated oxidative stress and stimulated angiogenesis through FEM1b-FNIP1 axis regulation. These in vivo and in vitro results demonstrated that accelerated diabetic wounds repair with the use of the HA-PBA-FA/EN106 hydrogel, which may provide a promising strategy for chronic diabetic wound repair.
研究领域:
药理学
·
生物医学工程
·
伤口愈合
·
糖尿病
·
材料科学
✓ 已验证
DOI
PubMed
高影响因子
SOLAR ENERGY
·
2019
·
IF 4.674
Jiang He,Tianhui Li,Xueping Liu,Hang Su,Zhiliang Ku,Jie Zhong,Fuzhi Huang,Yong Peng,Yi-Bing Cheng
In this research, we investigated the influence of phase transition in four standard perovskite materials on the device stability under thermal cycling (TC) condition, which is listed in International Electrotechnical Commission (IEC) stability tests criteria. The evolution of morphology, phase structure and charge carrier dynamics of four type perovskite materials throughout thermal cycling were analyzed. It was found that the cubic to tetragonal phase transition of MAPbI 3 caused the quick degradation of the device, the α to δ phase transition in FAPbI 3 and FA 0.6 MA 0.4 PbI 3 resulted in sustained efficiency loss, while the FA 0.9 Cs 0.1 PbI 3 was more stable compared to above three perovskites under the same test condition. The FA 0.9 Cs 0.1 PbI 3 device retained nearly 88% of its initial efficiency after 200 temperature cycles between −30 °C and 85 °C, which could be ascribed to its successful stabilization of perovskite structure.
研究领域:
材料科学
·
光伏技术
·
物理化学
✓ 已验证
DOI
高影响因子
FOOD CHEMISTRY
·
2021
·
IF 7.514
Xiao Wang,Yuze Li,Yuming Jiang,Lingwei Meng,Zongxiu Nie
The analysis of free fatty acids (FFAs) in edible oils, especially their fine structure, can provide information for nutritional value evaluation and authentication. Here, a strategy based on epoxidation reaction by mCPBA combined with tandem MS was developed to identify and relatively quantify FFAs, including C C location isomers, which can rapidly distinguish different edible oils. Notably, low-abundant FFAs can be detected directly in the presence of high-abundant triacylglycerol (TAG) without complicated pretreatment. We identified a series of C C location isomers via mCPBA-nanoESI-MS/MS, among them, FA 24:1 (Δ13) and FA 24:1 (Δ17) were first identified in edible oils, and the predominant UFAs was FA 18:1 (Δ9), which occupies 98.35% of FA 18:1 in peanut oil while 89.68% in rapeseed oil. The results demonstrated that the proposed method could provide further in-depth C C positional information of oils, promoting the development of structural determination of fatty acids in food chemistry.
研究领域:
食品化学
·
分析化学
·
质谱分析
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Current Drug Delivery
·
2022
·Vol. 20
·期 10
·1559-1568
·
IF 3.758
Yang Qingyun,Zhao Chuncao,Yang Jian,Zhao Jingyi,Feng Yi,Liu Minchen,Zhang Jiquan
Background: Rhodojaponin III (RJ-III), a characteristic diterpene of Rhododendron molle G. Don, has a wide range of pharmacological activities including anti-inflammatory, antihypertensive, and analgesic effects. However, further research and development have been limited because
of its intense acute toxicity and poor pharmacokinetic profile. Objective: In this study, we propose the construction of folic acid–conjugated mesoporous silica nanoparticles (FA-MSNs) as carriers to deliver RJ-III in an attempt to reduce acute toxicity and improve biomedical applications
by prolonging drug release and targeting delivery. Methods: FA-MSNs were synthesized and characterized. RJ-III was then loaded into FA-MSNs (RJIII@ FA-MSNs), and the in vitro drug release profile was assessed. Subsequently, the RJ-III@FAMSNs’ cytotoxicity and targeting efficiency
were explored in lipopolysaccharide-activated RAW 264.7 cells, and their acute toxicity was investigated in mice. Results: Spherical FA-MSNs were approximately 122 nm in size. Importantly, the RJ-III@FA-MSNs showed prolonged RJ-III release in vitro. Moreover, in lipopolysaccharide-activated
RAW 264.7 cells, RJ-III@FA-MSNs not only reduced the cytotoxicity of RJ-III (P < 0.01), but also showed a good targeting effect from the results of cellular uptake. Additionally, the acute toxicity results demonstrated that RJ-III@FA-MSNs improved the LD50 value of RJ-III
in mice by intraperitoneal injection 10-fold. Conclusion: This is the first study to use FA-MSNs as carriers of RJ-III to reduce the acute toxicity of RJ-III. The results confirm the potential for targeted delivery of RJ-III in inflammatory cells to enhance efficacy, as well as providing
data for future investigations on anti-inflammatory activity.
研究领域:
药剂学
·
毒理学
·
生物医学工程
✓ 已验证
DOI
PubMed
高影响因子
CONSTRUCTION AND BUILDING MATERIALS
·
2021
·
IF 6.141
Feifei Zhou,Ganghua Pan,Renjie Mi,Mimi Zhan
Enhancing the properties of concrete using C-S-H seed has been a challenging task due to its agglomeration in the cement matrix. Here, for ensuring synthetic C-S-H disperse well in the cement matrix, it was first synthesized in situ on fly ash (FA) by co-precipitation method, and the C-S-H grown in situ on FA (C-S-H@FA) was received. And then, its phase composition, morphology and particle size distribution were studied. After that, its effect on the hydration kinetics of cement, and the workability, strength development, pore structure, durability of concrete was explored. The results showed that the hydration of cement can be stimulated more dramatically by C-S-H@FA when compared with C-S-H, as well as the strength development of concrete. Besides, the addition of C-S-H@FA can refine the pores in concrete, and make concrete more compact than incorporating C-S-H. Furthermore, when C-S-H was replaced by C-S-H@FA, the carbonation resistance and drying shrinkage resistance of concrete was improved. Therefore, it can be concluded that the C-S-H grown in situ on FA has better dispersibility than C-S-H in concrete, improving the comprehensive properties of concrete more effectively.
研究领域:
材料科学
·
土木工程
✓ 已验证
DOI
高影响因子
BMC Pharmacology & Toxicology
·
2021
·Vol. 22
·期 1
·1-11
·
IF 2.483
Li Danni,Liu Shaogang,Zhu Jiahao,Shen Liqun,Zhang Qi ying,Zhu Hua
Background The development of novel and effective drugs for targeted human hepatocellular carcinoma still remains a great challenge. The alkaloid nitidine chloride (NC), a component of a traditional Chinese medicine, has been shown to have anticancer properties, but doses at therapeutic levels have unacceptable side effects. Here we investigate folic acid modified D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS-FA) as a potential carrier for controlled delivery of the drug. Methods Synthesized TPGS-FA was characterized by FTIR, UV-visible and 1 H NMR spectroscopy, and TPGS loaded with NC was evaluated for its ability to induce apoptosis in Huh7 cells by Annexin V/PI and MTT assays, and observed by laser scanning confocal microscopy and inverted phase contrast microscopy. Results TPGS-FA/NC complexes were prepared successfully, and were homogenious with a uniform size of ~ 14 nm diameter. NC was released from the TPGS-FA/NC complexes in a controlled and sustained manner under physiological conditions (pH 7.4). Furthermore, its cytotoxicity to hepatocarcinoma cells was greater than that of free NC. Conclusions TPGS-FA is shown to be useful carrier for drugs such as NC, and TPGS-FA/NC could potentially be a potent and safe drug for the treatment of hepatocellular carcinoma.
研究领域:
药学
·
肿瘤学
·
纳米技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MICROPOROUS AND MESOPOROUS MATERIALS
·
2021
·
IF 5.455
Hui Chen,Yan Zhang,Xiangying Xin,Nannan Feng,Deqiao Wu,Junwei Zhang,Bing Fang,Nan Zhang
In order to improve the degradation rate of silica framework and the targeted release ability of tumor drugs, this paper used a one-pot synthesis method to synthesize a redox with a silsesquioxane framework disulfide bridge and a particle size of about 150 nm. The triggered biodegradable organic-inorganic hybrid nanocapsule is a new and unique hollow mesoporous nanocapsule that is sequentially coupled with bovine serum albumin (BSA) and folic acid (FA) for the targeted release of adriamycin. As a “control gate”, BSA can prevent the premature release of drugs until the BSA coating “opens the door” in response to Glutathione(GSH) to achieve drug release. FA specifically recognizes the folate receptor on the tumor surface to achieve tumor targeting. Under acidic PH and GSH, it can achieve accelerated and complete release of drugs, and effectively consume intracellular GSH, help break the redox barrier in hypoxic cells, cause oxidative stress, and effectively inhibit tumor growth.
研究领域:
纳米技术
·
药学
·
癌症研究
·
材料科学
✓ 已验证
DOI
高影响因子
Solar RRL
·
2026
·Vol. 10
·期 6
·e70324
·
IF 4.8
Zhicheng Wang,Xiaoshan Li,Kaipeng Chen,Zhipeng Fu,Guangmian Jiang,Yanlin Li,Linhu Xiang,Xin Liu,Tian Hou,Wanqi Luo,Pingping Yang,Xiaoran Sun,Meng Zhang
In the research of perovskite solar cells (PSCs), the introduction of passivation layers is a key strategy for enhancing both efficiency and stability. Employing the well-established dip-coating method in conjunction with effective passivation solutions for the preparation of passivation layers not only improves the power conversion efficiency (PCE) and stability of PSCs but also extends the applicability of this approach in the development and commercialization of PSCs. This work introduces a novel passivation method, termed the DATsO-TBA-Dip coating (DTD) passivation method, which combines DATsO, 2-butanol (TBA), and the dip-coating method. The DTD passivation method was applied to PSCs on glass substrates of different sizes (2 cm × 1.6 cm and 2.5 cm × 2.5 cm). The results demonstrated excellent film quality and significant enhancement in passivation performance. The optimized device achieved a maximum PCE of 22.5% (0.105 cm 2 ), representing a 2.2% improvement over the best-performing untreated device. Additionally, the open-circuit voltage ( V OC ) increased to 1.08 V, and the fill factor (FF) improved to 80.9%. Beyond the remarkable photoelectric performance, devices treated with the DTD passivation method also exhibited significantly improved stability, retaining 80% of the initial PCE after 1200 h.
✓ 已验证
产品关联
DOI
高影响因子
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2018
·Vol. 25
·期 26
·26069-26078
·
IF 2.8
Peng Na,Wang Kaifeng,Lin Siwu,Wu Libin
Photolysis of the widely used beta-blocker propranolol (PRO) was investigated in the presence of fulvic acid (FA) and inorganic ions under simulated solar irradiation. PRO undergoes direct photolysis proceeding mainly via degradation of the triplet excited state, 3 PRO*. FA and inorganic ions inhibited photolysis of PRO in the order of FA > Fe 3+ > Cl − > Ca 2+ > Mg 2+ > NO 3 − > K + . An antagonistic effect between FA and inorganic ions toward the suppression of PRO photolysis was exhibited. The binding behaviors of PRO, FA, and inorganic ions were examined through fluorescence quenching experiments, which showed that inorganic ions affected the binding between FA and PRO through competing for the binding sites of FA or PRO. The correlation analysis demonstrated a positive correlation between the binding constant ( K OC ) of FA-PRO and the inhibition rate of FA on PRO photolysis. The observed rate constants of photolysis ( k obs ) have opposite correlations with the concentration of singlet oxygen ( 1 O 2 ). These findings strongly suggest that inorganic ions decrease the inhibition effect of FA on PRO photolysis via restraining the complexation of FA-PRO and production of 1 O 2 .
研究领域:
环境科学
·
药理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CERAMICS INTERNATIONAL
·
2022
·
IF 5.532
Xianju Zhou,Shouchun Zhao,Jie Zhang,Guotao Xiang,Sha Jiang,Li Li,Yongjie Wang,Yanhong Li,Chuan Jing,Lu Yao,Hongmei Yang,Zhen Wang
As a new generation of luminous material , perovskite quantum dots (PQDs) possess many excellent properties. However, PQDs suffer from dramatic decrease of optical performance when affected by high temperature. In this paper, methamidine acetate (FA + ) and manganese divalent cation (Mn 2+ ) codoped CsPbCl 3 quantum dots (QDs) were synthesized. The introduced FA + and Mn 2+ were designed to substitute Cs + (A sites) and Pb 2+ (B sites), respectively. By comparison with CsPbCl 3 :Mn 2+ QDs, the results show that the CsPbCl 3 :FA + ,Mn 2+ QDs improve the blue exciton luminescence by 15% and the red Mn 2+ ions luminescence by 37%. Furthermore, CsPbCl 3 :FA + ,Mn 2+ QDs demonstrate super thermal stability by maintaining 97% of Mn 2+ emission when the temperature is raised to 70 °C even after 6 thermal cycles. Simultaneously, the UV light and water stability of CsPbCl 3 :FA + ,Mn 2+ QDs have also been obviously enhanced. The powder of the coped PQDs have been fabricated into a white LED which exhibits Color Rendering Index (CRI) of 88.2 and Correlated Color Temperature (CCT) of 5745 K. It shows that CsPbCl 3 :FA + ,Mn 2+ QDs not only reduce the Pb 2+ ions toxicity problem but also boost the thermal stability and thermal cyclability, which may open up more possibilities for the applications in optoelectronic devices.
研究领域:
材料科学
·
光学
✓ 已验证
产品关联
DOI
高影响因子
Materials
·
2024
·Vol. 17
·期 22
·5628
·
IF 3.1
Xiaomin Zhang,Xiangrui Gao,Yue Yuan,Guangqin Yang,Yanchen Li
Fly ash (FA) is the main solid waste emitted from coal-fired power plants. Due to its high yield, low utilization rate, and occupation of a large amount of land, it exerts enormous pressure on the Earth’s environment. With the deepening of the concept of sustainable development, exploring the reuse of industrial waste such as FA has become a key strategy. If FA can be combined with commonly used jewelry in people’s lives, it will be of great significance to promote the high-net-worth utilization of FA. Therefore, this study synthesized a fly-ash-based composite material with color-changing function and combined it with necklaces as the main material. In the first stage, after blending fly ash and slag, an alkaline activator with a total mass of 10% was added. When the proportion of fly ash was 60%, the compressive strength of the prepared fly-ash-based composite material reached 10.1 MPa. This was attributed to the reaction between sodium silicate in the alkaline activator and free CaO, MgO, and other substances in the fly ash to form hydrated silicate colloids, which solidify the fly ash and transform it into a complex three-dimensional network skeleton. In the second stage, a UV resistant coating with thermochromic function was obtained by blending acrylic resin, TiO2, and a thermosensitive color-changing agent. It was applied to the surface of fly-ash-based composite materials, and the results showed that as the content of the color-changing agent increased, the number of pores on the surface of the coating gradually decreased. When the content of color-changing agent was 10%, the prepared 10%FAB not only had good surface color but also had good thermal stability, UV absorption ability, superhydrophobicity, and mechanical properties. Therefore, 10%FAB was selected as the basic material for jewelry design. In the third stage, the traditional Chinese technique of “gold inlaid with jade” was utilized to develop jewelry applications for the FA composites. As such, 10%FAB was processed into necklaces, which not only had modern design aesthetics but also had good color-changing effects above 30 °C. And after a long period of UV aging experiments, the necklace did not show any wrinkles, bubbles, or other phenomena. Due to the excitation of TiO2hole–electron pairs, the necklace’s UV absorption ability was further improved. This study demonstrates the potential application of industrial waste in decorative products, expands the high-end utilization of fly ash as a low-cost material, and provides new ideas for building a low-carbon lifestyle.
研究领域:
材料科学
·
环境科学
·
艺术设计
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nanoscale
·
2026
·
IF 5.2
Le Luo,Xiaoming Mo,Yusheng Song,Zhentao Du,Sheng Cao,Jinju Zheng,Bingsuo Zou,Jialong Zhao
Quantum-confined CsPbBr3 nanoplatelets (NPLs) are appealing candidates for ultraviolet (UV)/blue photodetectors due to their strong excitonic binding energy and large absorption coefficient. However, the inherent soft lattice and surface defects of CsPbBr3 NPLs lead to poor operational stability, limiting their practical applications. Here, we report an A-site alloying strategy that enhances the structural rigidity and defect formation energy of CsPbBr3 NPLs. The strategy synergistically employs short-chain tetrolic acid (TLA) ligands to passivate uncoordinated Pb2+ ions and formamidinium (FA+) cations to compensate for Cs+ vacancies. This dual repair strategy enhanced both the conductivity and UV irradiation stability of CsPbBr3-based NPLs. As a result, the self-powered UV photodetectors based on Cs0.73FA0.27PbBr3-TLA NPLs exhibited a responsivity of 89 mA W-1, a specific detectivity of 3.99 × 1012 Jones, and an on/off ratio approaching 106 at 0 V bias. Even after 30 days of ambient storage, the device maintained excellent photoresponse and a high specific detectivity of 1.73 × 1012 Jones. Clear images obtained with a custom-built 2D imaging system corroborate the fast response and excellent stability of the device. These results underscore the efficacy of the combined lattice and surface engineering approach for realizing high-performance, durable perovskite NPL-based UV photodetectors.
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）