Journal of Energy Storage
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2023
·
IF 9.4
Shuting Wei,Álvaro Pérez Ramos,Jing Peng,Álvaro Ridruejo,Peng Diao
Microemulsion-based redox flow batteries (RFBs) are gaining popularity due to the characteristics of microemulsions that decouple the solubility of redox species and ionic conductivity, affording a fantastic opportunity to simultaneously extend the electrochemical window and increase the ionic conductivity of electrolytes. In this work, we report a novel microemulsion-based RFB employing with 2-methylanthraquinone and ferrocene as anolyte and catholyte, respectively. Molecular dynamics and density function theory analysis investigated the electrochemical mechanism of redox species, including the intricate process of interface mass transport. The redox flow chemistry exhibits outstanding charge transfer rates and mass diffusion as well as good cycling stability under both cyclic voltammetry and linear sweep voltammetry. The flow cell demonstrated a coulombic efficiency of 96 %, voltage efficiency of 80 % and energy efficiency of 76.6 % after 300 cycles, making it one of the most stable and high-efficiency microemulsion-based RFBs reported so far. Although more advancement is still required to spark practical interest, this study opens a promising pathway to raise the energy density for redox flow batteries and is anticipated to inspire more in-depth studies of stable and high-efficient microemulsion-based RFBs.
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Journal of Materials Chemistry A
·
2025
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IF 9.5
Yuchen Zhao,Jingyun Guo,Bo Yang,Panyouwen Zhang,Xinyi Wan,Lei Wang,Pingwei Ye,Xinsheng Peng
Solar-driven interfacial water evaporation (SDIWE) technology is an promising way to solve the shortage of fresh water scarcity. However, it is still challenging to generate clean water from organic compound contaminated water through SDIWE. Herein, a 3D multilayer inverted cone solar evaporator based on flexible MOF/graphene oxide composite membrane (CFG membrane) is designed for efficient water evaporation and purification. The Co-Ferrocene (Co-Fc) MOF loaded in the CFG membrane expands the interlayer spacing of GO, providing channels for water transport and enhancing the photothermal performance. The 3D multilayer inverted cone structure enhances the absorption of sunlight through multiple reflections of light between different layers. Based on the above design, the 3D evaporator with three layer CFG membranes demonstrates an evaporation rate of 2.28 kg m-2 h-1 under 1-sun illumination, good salt-resistance and long-term stability. Meanwhile, the Co-Fc MOF in the evaporator acts as an effective Fenton catalyst and promote the generation of ˙OH for the degradation of organic pollutants in wastewater. The degradation rate of pollutants in mixed wastewater (MB: 80 mg L-1; TC: 40 mg L-1; phenol: 40 mg L-1) by CFG-3 evaporator is all over 95%. Almost no volatile organic compounds (VOCs) were detected in the distilled water. This may provide a promising strategy for the efficient solar-driven evaporation and treatment of organic wastewater.
研究领域:
环境科学
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材料科学
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化学工程
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纳米技术
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水处理
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能量转换
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Analytical Methods
·
2020
·Vol. 12
·期 41
·4956-4966
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IF 2.596
Wenzhan Li,Min Chen,Jintao Liang,Chunting Lu,Min Zhang,Fangrong Hu,Zhide Zhou,Guiyin Li
Herein, a label-free electrochemical aptasensor for alpha-fetoprotein (AFP) analysis was established. The AFP aptamer (AFP-Apt), as the recognition molecule, was immobilized on the surface of a screen-printed carbon electrode, which was modified by gold–platinum metallic nanoparticles and reduced graphene oxide–chitosan–ferrocene nanohybrids (Au–Pt NPs/RGO–CS–Fc), to build the AFP electrochemical aptasensor. The construction process of the aptasensor was characterized by scanning electron microscopy, X-ray photoelectron spectroscopy, Raman spectroscopy, and electrochemical impedance spectroscopy. With the addition of AFP, the formation of the AFP-aptamer conjugation blocked the electron transfer reaction, reducing the differential pulse voltammetric responses of the current of Fc in the RGO–CS–Fc nanohybrids. By optimizing the experimental parameters, AFP could be detected with the dynamic concentration range of 0.001 to 10.0 μg mL−1 and with a detection limit of 0.3013 ng mL−1. In addition, the approach was manifested to have good selectivity, reproducibility, and stability. The fabricated aptasensor had a good recovery rate of 102.36% to 118.09% in real human serum samples. This work demonstrates that the electrochemical aptasensor is a useful tool for analyzing AFP inexpensively, rapidly, and accurately.
研究领域:
生物医学工程
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分析化学
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高影响因子
Polymers
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2020
·Vol. 12
·期 10
·2419
·
IF 3.426
Fang Wang,Sheng Hu,Fengna Shi,Kexin Huang,Jiarui Li
Herein, a composite structure, consisting of Cu nanoparticles (NPs) deposited onto carbon nanotubes and modified with ferrocene-branched chitosan, was prepared in order to develop a nonenzymatic electrochemical glucose biosensor ferrocene-chitosan/carbon nanotube@ Cu (Fc-CHIT/CNT@Cu). The elemental composition of the carbon nanohybrids, morphology and structure were characterized by various techniques. Electrochemical impedance spectroscopy (EIS) was used to study the interfacial properties of the electrodes. Cyclic voltammetry (CV) and chronoamperometry methods in alkaline solution were used to determine glucose biosensing properties. The synergy effect of Cu NPs and Fc on current responses of the developed electrode resulted in good glucose sensitivity, including broad linear detection between 0.2 mM and 22 mM, a low detection limit of 13.52 μM and sensitivity of 1.256 μA mM−1cm−2. Moreover, the modified electrode possessed long-term stability and good selectivity in the presence of ascorbic acid, dopamine and uric acid. The results indicated that this inexpensive electrode had potential application for non-enzymatic electrochemical glucose detection.Keywords:carbon nanotube;chitosan;copper nanoparticles;ferrocene;electrochemical sensor;glucose;non-enzymatic
研究领域:
生物医学工程
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分析化学
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高影响因子
Polymers
·
2019
·Vol. 11
·期 10
·1716
·
IF 3.164
Feng Guo,Guiying Li,Songmei Ma,Hengquan Zhou,Xinyi Chen
A temperature, glutathione (GSH), and H2O2multi-responsive composite nanocarrier (MSN-SS-Fc@β-CD-PNIPAM) based on β-cyclodextrin-poly(N-isopropylacrylamide) (β-CD-PNIPAM) star polymer capped ferrocene modified mesoporous silica nanoparticles (MSN-SS-Fc) was successfully prepared. The surface of the mesoporous silica was first modified by ferrocene (Fc) via a disulfide bond (–SS–) to form an oxidizing and reducing site and then complexed with a β-CD-PNIPAM star shaped polymer through host–guest interactions as a nano-valve to provide temperature responsive characteristics. The structure and properties of the complex nanoparticles were studied by FTIR, TGA, EDS, Zeta potential, and elemental analysis. Doxorubicin (DOX) and Naproxen (NAP), as model drugs, were loaded into nanocarriers to assess drug loading and release behaviour. The release of drugs from nanocarriers was enhanced with an increase of the GSH, H2O2concentration, or temperatures of the solution. The kinetics of the release process were studied using different models. This nanocarrier presents successful multi-stimuli responsive drug delivery in optimal stimuli and provides potential applications for clinical treatment.Keywords:disulfide bond;ferrocene;multi-responsive;nanocarrier;MSNs
研究领域:
材料科学
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药物递送
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生物医学工程
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高影响因子
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
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2017
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IF 3.012
Qing Zhu,Jing Bao,Danqun Huo,Mei Yang,Huixiang Wu,Changjun Hou,Yanan Zhao,Xiaogang Luo,Huanbao Fa
In this work, we have been successfully developed a new electrochemical sensor for the simultaneous determination of ascorbic acid (AA), dopamine (DA) and uric acid (UA) using ferrocene hybrid (Fc)/three dimensional graphene hydrogel (3DGH) nanocomposite . The composite materials were characterized using different techniques, such as scanning electron microscopy (SEM), atomic force microscopy (AFM), ultraviolet-visible spectrometer (UV–vis). The electrochemical detection methods using for the individual and simultaneous detection of AA, DA and UA were cyclic voltammetry (CV), differential pulse voltammetry (DPV) and amperometric (i–t). Due to the excellent properties and unique structure of the nanocomposite, this sensor exhibited sharp peaks for the oxidation of AA, DA and UA as compared with the bare glassy carbon electrode (GCE). The linear responses of AA, DA and UA were observed from 20 to 450 μM, 10–180 μM and 8–400 μM with detection limits (S/N = 3) of 0.183 μM (AA), 0.042 μM (DA) and 0.067 μM (UA), respectively. In addition, the developed 3DGH-Fc/GCE electrode showed well anti-interference ability, great stability and excellent reproducibility. Moreover, the analytical application of this electrochemical sensor was successfully conducted for the determination of these species in human serum samples. These features implicate the potential applicability of the developed 3DGH-Fc/GCE biosensor in the development of is promising for the simultaneous determination of DA, AA and UA.
研究领域:
分析化学
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生物医学工程
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高影响因子
ORGANOMETALLICS
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2018
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IF 4.051
Chu Tang,Yang Du,Qian Liang,Zhen Cheng,Jie Tian
Owing to the lack of target-directed therapies, triple-negative breast cancer (TNBC) is difficult to effectively treat. In this article, a novel organometallic histone deacetylase (HDAC) inhibitor, Fc-SelSA, based on the selenocyanide (SelSA) zinc-binding motif, was synthesized using a ferrocenyl group as the cap to confer activity against TNBC. The synthesized Fc-SelSA was evaluated for bioactivity in vitro and in vivo. An enzymatic assay showed that Fc-SelSA was a potent HDAC inhibitor with a half-maximum inhibitory concentration (IC50) of 14.8 nM. Molecular docking studies of Fc-SelSA with HDAC suggested that the ferrocenyl unit overlaps with the phenyl group of suberoylanilide hydroxamic acid (SAHA) and the amido group of Fc-SelSA can form hydrogen bonds with the D98 and G151 residues of HDAC, but SAHA and SelSA do not show similar interactions. Moreover, Fc-SelSA reactivated the estrogen receptor alpha (ERα) expression, sensitized TNBC cells to the antagonist tamoxifen, and exerted more potent antitumor effects against TNBC MDA-MB-231 tumor xenografts in comparison to SelSA with no obvious side effects. Our results indicate that Fc-SelSA is a potent oral anticancer candidate for HDAC-targeted TNBC therapy and deserves further investigation for clinical application.
研究领域:
肿瘤学
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药理学
·
分子生物学
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高影响因子
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
·
2025
·Vol. 172
·期 3
·036503
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IF 3.3
Xiaoyan Wang,Hao Zheng,Huiling Chen,Bin Qiu,Yunliang Liu,Qing Ye
Interleukin-6 (IL-6) is a common proinflammatory cytokine and can be adopted as an important biomarker for several diseases including nasopharynx cancer, pancreatitis, infections, and cardiovascular. It is thus necessary to design an effective method for monitoring IL-6. Herein, by preparing gold nanoparticles/graphdiyne (Au/GRD) nanohybrid with simple electroless deposition as the sensing substrate and UiO-66 metal–organic frameworks/ferrocene (UiO/Fc) as the signaling-amplifier, a highly efficient sandwich-type electrochemical immunosensing (SEI) platform was proposed for IL-6 determination. The superior electrical properties, easy preparation, high surface area, and stability of Au/GRD make it a desirable substrate to immobilize the primary antibody of IL-6. Meanwhile, the unique structure of UiO-66 is beneficial to immobilizing the Fc probe and the secondary antibody. By optimizing experimental conditions, the Fc current obtained at the as-designed SEI platform increases along with IL-6 increase, and the related linearity is 0.5 pg ml−1–1200.0 pg ml−1 coupled with a low detection limit of 0.2 pg ml−1. It is expected the as-designed SEI platform based on Au/GRD and UiO/Fc shows potential applications for IL-6 analysis.
研究领域:
生物医学工程
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分析化学
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纳米技术
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高影响因子
EUROPEAN JOURNAL OF PHARMACOLOGY
·
2023
·
IF 5
Min Fang,Hongling Hou,Bo Feng,Tianzhu Zhang,Xiaomei Zhu,Zhen Liu
Intracerebral hemorrhage (ICH) is the most devastating subtype of stroke, nevertheless specific treatments with conclusive clinical benefit in improving outcomes of ICH remain lacking. The present study applied dl-3-n-butylphthalide (NBP), a compound approved for the treatment of ischemic stroke and rarely studied in ICH, to an experimental animal model of ICH, aiming to evaluate the therapeutic effects of NBP on ICH and the potential mechanisms. The results showed that rats receiving NBP administration exhibited a structural and functional restoration of brain after ICH mainly manifested as alleviation of neuronal apoptosis , suppression of neuroinflammation and oxidative stress , neurovascular remodeling, and eventually improvement of neurological deficits. In addition, several protein targets of NBP were revealed, which mainly play molecular functions of ribonucleoside triphosphate phosphatase activity, pyrophosphatase activity, hydrolase activity and GTPase activity, and participate in the biological process of brain development by regulating the formation of cellular components such as spindles, polymeric cytoskeletal fibers, microtubules and synapses, through mediating pathways such as VEGF signaling pathway, Fc epsilon RI signaling pathway, ECM-receptor interaction, Fc gamma R-mediated phagocytosis , peroxisome and so on, guiding the mechanism exploration of NBP therapy to some extent. Taken together, the study added some new evidence to the application of NBP in ICH treatment.
研究领域:
神经科学
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药理学
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实验医学
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PubMed
高影响因子
CLINICA CHIMICA ACTA
·
2025
·
IF 2.9
Yanghe Liu,Sijie Yin,Shiyue Chen,Chunlei Zhang,Nasifu Lubanga,Ping Tai,Mengqiu Xiong,Boyue Fan,Xincheng Yang,Xinyi Xia,PanFei Hou,Bangshun He
Helicobacter pylori ( H. pylori ) is a risk factor of gastrointestinal diseases. Vacuolating cytotoxin A (VacA) is a key component of the pathogenicity of H. pylori for gastric diseases , and detection for virulence genotypes facilitates precise clinical diagnosis and individual treatment. Hence, a more accurate, convenient, and highly sensitive detection method is urgently needed. In this study, we developed a method based on fluorescence-colorimetric dual-indicator loop-mediated isothermal amplification (FC-LAMP), allowing for naked-eye readout, using a constant temperature water bath within 40 min in clinical settings. Such an excellent sensitivity and specificity, and user-friendly operation approach achieved a limit of 10 −6 ng/μl for 16 s rRNA detection of H. pylori , and 100 % specificity for 55 clinical gastric fluid samples compared with the immunofluorescence staining (IFS) and quantitative polymerase chain reaction (qPCR) as reference methods. In short, this study offers a new strategy for detection of H. pylori and its virulence genotype in primary hospitals and in limited resources settings, facilitating individualized precision eradication of H. pylori .
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高影响因子
BIOELECTROCHEMISTRY
·
2024
·
IF 4.8
Guiyin Li,Bo Wang,Shengnan Li,Xinhao Li,Ruijie Yan,Xiaohong Tan,Jintao Liang,Zhide Zhou
Golgi protein 73 (GP73) is a novel tumor marker in the early diagnosis and prognosis of hepatocellular carcinoma (HCC). Herein, a competitive electrochemical aptasensor for detecting GP73 was constructed using reduced graphene oxide-ferrocene-polyaniline nanocomposite (rGO-Fc-PANi) as the biosensing platform. The rGO-Fc-PANi had larger specific surface area, excellent conductivity and outstanding electroactive performance, which served as nanocarrier for GP73 aptamer (GP73 Apt ) binding and as redox nanoprobe for record electrical signal. Then, a complementary chain (cDNA) was fixed to the electrode by hybridization with GP73 Apt . When GP73 was present, a competitive process happened among cDNA, GP73 Apt and GP73, formed the GP73-GP73 Apt stable chemical structure and made cDNA detach from the sensing electrode, resulting in enhancement of electrical signal. The difference in the corresponding peak current before and after the competition can be used to indicate the quantitative of GP73. Under optimal conditions, the DPV current response showed a good log-linear relationship with GP73 concentrations (0.001 ∼ 100.0 ng/mL) with a detection limit of 0.15 pg/mL (S/N = 3). It was successfully used for GP73 detection in human serum with RSDs ranging from 1.08 % to 6.96 %. Therefore, the aptasensor could provide an innovative technology platform and hold a great potential in clinical application.
研究领域:
生物医学工程
·
肿瘤学
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DOI
PubMed
高影响因子
BIOELECTROCHEMISTRY
·
2025
·
IF 4.5
Zhide Zhou,Haimei Li,Xiaohua Deng,Yuxuan Shi,Jiahang Huang,Yu Zhou,Xiaohong Tan,Jintao Liang,Guiyin Li
Cardiovascular disease (CVD) is the leading cause of death worldwide, particularly in the developing countries. Low-density lipoprotein (LDL), a critical biomarker for the early detection and intervention of CVD, provides valuable diagnostic and prognostic information for CVD. Herein, we developed a dual-signal electrochemical aptasensor for LDL detection based on a peroxidase-like nanozyme composed of reduced graphene oxide@molybdenum disulfide-ferrocenecarboxylic acid (rGO@MoS 2 -Fc). In the process of electrochemical testing, rGO@MoS 2 -Fc achieved the synergistic amplification of electrochemical signals both an enhanced Fc oxidation current detected by differential pulse voltammetry (DPV), and an increased hydrogen peroxide (H 2 O 2 ) decomposition current via amperometric current-time (i-t) analysis. The DPV signal, corresponding to Fc oxidation, exhibited a logarithmic linear response over a broad LDL concentration ranged from 0.001 to 100.0 μg/mL, with a limit of detection (LOD) as low as 0.91 ng/mL. Meanwhile, the i-t signal, arising from H 2 O 2 decomposition, displayed a linear range of 1.0 to 80.0 μg/mL and an LOD of 0.80 μg/mL. This dual-signal strategy exhibited good selectivity, reproducibility, stability and self-calibration capability. Analysis of human serum samples showed that the proposed strategy is expected to be a powerful method for early-stage CVD diagnosis and clinical management.
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高影响因子
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