ADVANCED MATERIALS
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2023
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IF 29.4
Ruizhi Hu,Xiaoying Chen,Zhifang Li,Guojun Zhao,Li Ding,Liang Chen,Chen Dai,Yu Chen,Bo Zhang
Nanotechnology is revolutionizing cancer therapy, and catalyzes the emerging of ion-involved cancer-therapeutic modality, which unfortunately suffers from undesirable nanocarriers for efficient intracellular ion delivery. To radically extricate from this critical issue, the glutathione (GSH)-responsive organosilica network was employed to lock the liquid drops at the nanoscale via a general bottom-up strategy to achieve the systemic delivery of “ion drugs”. In this work, a sulfate radical generation donor (Na 2 S 2 O 8 ), as a paradigm “ion drug”, was entrapped into this liquid nanoparticle for efficiently delivering to the tumor region. After further surface engineering with pH-responsive tannic acid-Fe 2+ framework, these liquid nanoparticles achieved tumor-microenvironmental pH/GSH-dual responsive ion release (Fe 2+ / Na + / S 2 O 8 2− ) after reaching the tumor sites, where the Fe 2+ further triggered S 2 O 8 2− to generate toxic •SO 4 − and •OH, effectively executing cancer cell ferroptosis (Fe 2+ , ROS) and pyroptosis (Na + , ROS). Such a tumor-responsive/specific liquid nanoplatform is highly instructive for further ion-mediated nanomedicine and disease treatment. This article is protected by copyright. All rights reserved
研究领域:
纳米技术
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癌症治疗
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纳米医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF POWER SOURCES
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2018
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IF 6.945
Peng Zhang,Xiaotong Yang,Tong Wang,Nobuyuki Imanishi,Osamu Yamamoto,Miao Wang
We demonstrate a novel rechargeable energy storage system having a metallic lithium negative electrode and a liquid–solid hybrid positive electrode of Fe 3+ /Fe 2+ /Fe in N,N-Dimethylformamide, which are separated by an impermeable NASICON–type Li 1.4 Al 0.4 Ge 0.2 Ti 1.4 (PO 4 ) 3 –epoxy resin composite film with a lithium ion conductivity of ca. 5.0 × 10 −4 S cm −1 . The discharge curve for the battery shows two plateaus. The first plateau corresponds to Li + FeCl 3 = LiCl + FeCl 2 , while the second one is associated with 2 Li + FeCl 2 = 2 LiCl + Fe. In the process of reduction of Fe 3+ to Fe 2+ , it delivers a stable discharge capacity of ca. 110 mAh g FeCl3 −1 with a Coulombic efficiency higher than 95% and is capable of enduring over 60 circles at a high current density of 1.0 mA cm −2 without any catalyst. Furthermore, a stable discharge capacity up to ca. 455 mAh g FeCl3 −1 is achieved for conversion of FeCl 3 /FeCl 2 /Fe with a three–electron reaction. This work demonstrates a proof of feasibility of hybrid liquid–solid hybrid positive electrode, since these reactions are reversible confirmed by x–ray diffraction patterns and EDX mapping test.
研究领域:
材料科学
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电化学
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能源存储系统
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电池技术
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产品关联
DOI
高影响因子
COMPUTERS IN BIOLOGY AND MEDICINE
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2023
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IF 7.7
Jinyi Qian,Yuzhou Wang,Xiner Liu,Zijian Hu,Nan Xu,Yuetong Wang,Tianqiong Shi,Chao Ye
Acetoin was widely used in food, medicine, and other industries, because of its unique fragrance. Bacillus amyloliquefaciens was recognized as a safe strain and a promising acetoin producer in fermentation. However, due to the complexity of its metabolic network, it had not been fully utilized. Therefore, a genome-scale metabolic network model ( i JYQ746) of B. amyloliquefaciens was constructed in this study, containing 746 genes, 1736 reactions, and 1611 metabolites. The results showed that Mg 2+ , Mn 2+ , and Fe 2+ have inhibitory effects on acetoin. When the stirring speed was 400 rpm, the maximum titer was 49.8 g L −1 . Minimization of metabolic adjustments (MOMA) was used to identify potential metabolic modification targets 2-oxoglutarate aminotransferase ( serC , EC 2.6.1.52) and glucose-6-phosphate isomerase ( pgi , EC 5.3.1.9). These targets could effectively accumulate acetoin by increasing pyruvate content, and the acetoin synthesis rate was increased by 610% and 10%, respectively. This provides a theoretical basis for metabolic engineering to reasonably transform B. amyloliquefaciens and produce acetoin.
研究领域:
生物技术
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代谢工程
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微生物学
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产品关联
DOI
PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
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2025
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IF 9
Mian Li,Lian-Yu Qiu,Tian-Yang Zhang,Bin Xu,Dan Yang,Ting Ye,Heng Luo
Advanced oxidation processes (AOPs) based on Fe 2+ /persulfate (PS) have been widely applied in water treatment but face critical challenges: inefficient radical utilization due to excess Fe 2+ scavenging, unsustainable reactivity from irreversible Fe 2+ -to-Fe 3+ conversion, and ambiguous dominant reactive species (e.g., SO 4 − / OH vs. high-valent iron). Ferric oxalate complexes address these limitations by enabling light-driven iron photoreduction and the Fe 2+ /Fe 3+ cycle. However, direct comparisons of degradation efficiency, mechanisms, and environmental risks between Fe 2+ /PS and UV/Fe(C 2 O 4 ) 3 3− /PS remain scarce. Using iohexol as a model, this study directly compared the two systems. The UV/Fe(C 2 O 4 ) 3 3− /PS system achieved 98.8 % iohexol degradation in 60 min (vs. 69.9 % for Fe 2+ /PS) and reduced iron sludge by 70–80 %. Both systems relied on SO 4 − and OH, but UV/Fe(C 2 O 4 ) 3 3− /PS enhanced radical yield via photocatalytic iron cycling, whereas Fe 2+ /PS depended on Fe(IV). In Fe 2+ /PS, contributions were Fe(IV) (29.4 %) > SO 4 − (25.9 %) > OH (20.2 %); in UV/Fe(C 2 O 4 ) 3 3− /PS, SO 4 − (63.6 %) > OH (23.7 %) > Fe(IV) (23.7 %). Electrical energy per order (EE/O) analysis showed UV/Fe(C 2 O 4 ) 3 3− /PS consumed 1.166 kWh mM −1 , 60.2 % lower than Fe 2+ /PS (2.524 kWh mM −1 ). Acute toxicity tests with Vibrio fischeri exhibited 67.7 % inhibition in Fe 2+ /PS, significantly higher than 36.4 % in UV/Fe(C 2 O 4 ) 3 3− /PS. Ecological Structure-Activity Relationships (ECOSAR) modeling and disinfection by-products (DBPs) risk assessment further confirmed lower risks in UV/Fe(C 2 O 4 ) 3 3− /PS, with 50 % lethal concentration ((LC 50 ) for aquatic organisms 2.3-fold higher and genotoxicity potency 41.7 % lower than Fe 2+ /PS. These results bridge the efficiency-risk gap between the two systems and offer a three-dimensional (efficiency-cost-safety) framework for AOP selection.
研究领域:
环境工程
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水处理
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化学氧化
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毒理学
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自由基化学
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污染控制
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高级氧化工艺
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能源效率
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2022
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IF 9.965
Lan-ying Guo,Qi-sheng Xia,Jing-lei Qin,Mu Yang,Ting-yu Yang,Fang-tian You,Zhi-hua Chen,Bei Liu,Hong-shang Peng
Although photodynamic therapy (PDT) has been extensively studied as an established modality of cancer treatment, it still suffers from a few clinical limitations, such as skin phototoxicity and tumor hypoxia. To circumvent these hurdles, hollow silica mesoporous nanoparticles (HMSNs) loaded with photosensitizers were employed as the nanoplatform to construct multifunctional nanoparticles (NPs). Specifically, an ultra-uniform polydopamine (PDA) shell was highly controlled grown around HMSNs by photogenerated outwards-diffused 1 O 2 , followed by conjugation of folic acid-poly(ethylene glycol) and chelation of Fe 2+ ions. Thanks to the optimal thickness of light-absorbing PDA shell, the multifunctional NPs exhibited not only negligible skin phototoxicity but also efficient 1 O 2 generation and photothermal (PT)-enhanced • OH generation upon respective photoirradiation. Anti-tumor therapy was then performed on both 4 T1 tumor cells and tumor-bearing mice by the combination of 638 nm PDT and 808 nm PT-enhanced chemodynamic therapy (CDT). As a result, high therapeutic efficacy was achieved compared to single-modality therapy, with a cell inhibitory rate of 86% and tumor growth inhibition of 70.4% respectively. More interestingly, tumor metastasis was effectively inhibited by the synergetic treatment. These results convincingly demonstrate that our multifunctional NPs are very promising skin-safe PDT agents combined with CDT for efficient tumor therapy.
研究领域:
纳米技术
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癌症治疗
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生物医学工程
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材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of the Taiwan Institute of Chemical Engineers
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2023
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IF 5.7
Guangbing Liu,Xiaoyang Tian,Lichun Fu,Yawei Qian,Yanhong Zhang,Chen Ling,Yuwei Pan
Background Nowadays, antibiotic pollution is increasingly serious and posing a huge threat to ecology and human health. Therefore, it is vital to find effective approaches to remove antibiotics. Methods In this study, boron (B) was adopted to accelerate the surface and solution Fe 2+ recycle in Fe 3 O 4 /peracetic acid (PAA) system, which showed excellent performance for antibiotics removal. Significant findings According the XPS analysis and experiments detection, both recycle of surface and solution Fe 2+ could be enhanced in the presence of boron in Fe 3 O 4 /PAA system. 74.0% sulfamethazine (SMT) could be removed within 60 min in Fe 3 O 4 /PAA system while 93.4% could be removed within only 20 min in B/Fe 3 O 4 /PAA system and the value of k in B/Fe 3 O 4 /PAA system (0.136 min −1 ) was also much higher than that in Fe 3 O 4 /PAA system (0.028 min −1 ). The effect of boron, Fe 3 O 4 , PAA dosage and initial pH on removing SMT in Fe 3 O 4 /PAA system were also conducted. Quenching experiments and EPR experiments demonstrated that · OH, organic radicals (R-O · ) and Fe(IV) exhibited 63.1%, 17.3%, and 16.2% role in removing SMT, respectively. Possible SMT degradation pathway and the toxicity of transformation products were analyzed. B/Fe 3 O 4 /PAA exhibited superior resistance to inorganic ions and nature organic matters, good recycle ability, excellent adaptability to various pollutants, and efficient performance for antibiotics removal in natural fresh water.
研究领域:
环境科学
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水处理
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化学工程
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污染控制
✓ 已验证
产品关联
DOI
高影响因子
Journal of Water Process Engineering
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2024
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IF 6.3
Jiayang Huang,Yunchang Xie,Chunhui Dai,Hao Cui,Chao Zeng
Sulfidated FeOCl is prepared as a heterogeneous photo-Fenton catalyst. And the surface sulfidation of FeOCl can remarkably accelerate the photoinduced charge separation and transfer, while also increase Fe 2+ /Fe 3+ atomic ratio, leading to the boosted photo-Fenton activity in the presence of H 2 O 2 . Under irradiation of natural sunlight (light intensity: ∼80 mW·cm −2 ), over 10 mg sulfidated FeOCl catalyst with using 20 μL 15 % H 2 O 2 , 91.2 % of ofloxacin solution (50 mg·L −1 ) and 97.5 % of sulfisoxazole solution (60 mg·L −1 ) can be degraded in 80 min, and 99.6 % of phenol solution (625 mg·L −1 ) is decomposed in 4 h. Under irradiation of a white Light-Emitting Diode (LED) lamp (light intensity: 5 mW·cm −2 ), 99.8 % of ofloxacin solution is decomposed after treatment for 4 h. Moreover, this photo-Fenton degradation system displays a stable activity in a wide range of pH (1−10), diverse water bodies, and various coexisting ions with concertation from 1 mM to 500 mM. Moreover, sulfidated FeOCl catalyst coated on a frosted glass sheet exhibits excellent stability for degrading ofloxacin even in seven continuous cycles. Particularly, the non-toxicity of the treated ofloxacin, sulfisoxazole, and phenol solution, have been proven by testing their toxic effects on cabbage seed, bacteria, and human embryonic kidney cell, respectively.
研究领域:
环境科学
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催化
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光化学
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水处理
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材料科学
✓ 已验证
产品关联
DOI
高影响因子
Heliyon
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2023
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IF 4
Yan Guo,Jinfu Wang,Yanjie Hua,Mengya Jiang,Wanyue Xu,Yanpeng Shi,Jiehong Yang,Haitong Wan,Ruchun Yang
Ischemic acute kidney injury (AKI) is a prevalent disorder among hospitalized patients worldwide. Astragaloside IV (AS-IV) has been shown to protect against ischemic AKI. However, the specific effects and mechanisms of AS-IV on alleviating kidney ischemia-reperfusion (I/R) injury remain unclear. The objective of this research was to elucidate the regulatory targets and mechanisms through which AS-IV protects kidney I/R injury. A combination of network pharmacology, molecular docking, molecular dynamics (MD) simulation, pharmacodynamic study and Western blot were employed to explore the underlying mechanisms. Network pharmacology revealed that ferroptosis was a potential mechanism of AS-IV against kidney I/R injury. Molecular docking and MD simulations demonstrated strong binding affinity between the GPX4/SLC7A11 and AS-IV. The experimental verification demonstrated that AS-IV improved cell proliferation, decreased the level of ROS and Fe 2+ , and increased the expressions of GPX4 and SLC7A11 as same as Ferrostatin-1 in OGD/R-injured HUVECs. In conclusion, AS-IV had a significant inhibition on ferroptosis in kidney I/R injury, providing a new perspective for drug development on kidney I/R injury. Definitely, further exploration in vivo is necessary to fully understand whether AS-IV alleviates kidney I/R injury through inhibiting endothelial ferroptosis.
研究领域:
药理学
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分子生物学
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细胞生物学
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肾病学
✓ 已验证
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
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2021
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IF 13.273
Hui He,Yuexin Wang,Juan Li,Shanliang Jiang,Subhan Sidra,Wenxue Gong,Ying Tang,Yang Hu,Rule Wei,Dongxiao Yang,Xuesheng Li,Zhongxing Zhao
High light adsorption and fast charge separation are crucial for photo-Fenton catalytic activity of MOFs. Herein, bottom-up design was proposed to fabricate polypyrrole (PPy C ) nanowires in MIL-88B(Fe) cages as photo-Fenton catalyst for Sulfamethoxazole (SMX) efficient degradation. Pyrrole was prior anchored into MIL-88B(Fe) cluster via Fe-N coordination, and then the additional monomer pyrrole was further triggered bottom-up polymerization in confined cages of MIL-88B(Fe) and formed PPy C @Py-MIL(Fe) composite. These PPy C nanowires were dispersed in Py-MIL(Fe) cages and tightly connected with MOFs clusters via Fe-N bonding. Characterization proved that: (1) Interfacial Fe-N can significantly promote the efficient electron transport from PPy C nanowires to Py-MIL(Fe), enhance optical absorption property, and construct strong Lewis acidic sites and ligand vacancies in PPy C @Py-MIL(Fe). (2) The confined PPy C nanowire via Fe-N connection remarkably promote photo-generated electron-hole separation, Fe 2+ |Fe 3+ redox ability of MOF, and improved photo-electric corrosion ability. As a result, it significantly enhanced the photo-Fenton catalytic performance for SMX degradation. Catalytic oxidation was attributed to the generation of ‧OH species that oxidized 93% SMX in 60 min, showing ultra-rapid degradation and TOC removal rates of 33.7 min −1 ·mg·g −1 and 8.68 min −1 ·mg·g −1 respectively, which was about 4–220 times higher than those reported state-of-the-art catalysts. Additionally, the PPy C @Py-MIL(Fe) catalyst showed minimal loss in catalytic activity even after recycling for 10 times, exhibiting good recycling stability compared to many MOFs. Systematic analysis shown that in-situ anchored growth of polypyrrole in confined porous cages of MOF can effectively enhance the catalytic activity and stability of MIL-88B(Fe), and has great development potential applications for photo-Fenton catalytic degradation of organic pollutants.
研究领域:
环境科学
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材料科学
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催化
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水处理
✓ 已验证
产品关联
DOI
高影响因子
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
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2023
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IF 6.7
Youzhi Wang,Huifang Wang,Guoqing Yang,Qingjing Hao,Kan Yang,Huizhen Shen,Yulong Wang,Jinxin Wang
It is well known that chronic obstructive pulmonary disease (COPD) patients are always trapped in the vicious circle of inflammation and oxidative stress , therefore anti-inflammatory and antioxidant bifunctional agents may interrupt this vicious cycle in COPD. Phosphodiesterase 4 (PDE4) inhibitors, as anti-inflammatory drugs, have been used for COPD treatment in clinical, and the PDE4 inhibitors with antioxidant properties may be a good strategy to design bifunctional agents for COPD. Sappanone A was the first PDE4 inhibitor with antioxidant properties we identified from natural products in our previous study, which was used by us as a hit compound to design new bifunctional agents for COPD in this study. 27 derivatives of sappanone A including homoisoflavonoids , aurones and chalcones were designed and synthesized by innovatively fusing the antioxidant pharmacophore of catechol from polyphenols and the pharmacophore of catechol ether abstracted from the PDE4 inhibitors of the catechol ether class such as rolipram , roflumilast and apremilast respectively. All the compounds were assayed for the PDE4 inhibitory and radical scavenging against 2, 2-diphenyl-1-picrylhydrazyl (DPPH) activities in vitro. Herein we obtained a series of bifunctional compounds with better PDE4 inhibitory activity than sappanone A, and their free radical scavenging activities were superior to edaravone in vitro. In addition, they can reduce tumour necrosis factor-alpha (TNF-α) production induced by lipopolysaccharide (LPS) in RAW264.7 macrophages and malondialdehyde (MDA) production induced by Fe 2+ in mouse lung homogenate . Meanwhile, it showed outstanding abilities in reducing Fe 3+ and complexing Fe 2+ . 6o , as the candidate anti-inflammatory and antioxidant bifunctional compound, exhibited good drug-likeness, ADME (Absorption, Distribution, Metabolism, Excretion) properties and human liver microsomal stability. In vivo, 6o (50 mg/kg and 100 mg/kg, i. p.) distinctly prevented LPS-induced serum levels of TNF-α in mice. In conclusion, the preliminary investigation provided a novel class of PDE4 inhibitors with antioxidant properties as bifunctional agents for the potential treatment of COPD, which can interrupt the vicious cycle of chronic inflammation and oxidative stress in COPD.
研究领域:
药理学
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药物化学
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呼吸医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2024
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IF 9.4
Mengwei Ye,Weikang Zhang,Hongwei Xu,Peiyu Xie,Luming Song,Xiaohan Sun,Yian Li,Siling Wang,Qinfu Zhao
Combination therapies have attracted significant attention because they address the limitations of monotherapy while improving overall efficacy. In this study, we designed a novel nanoplatform, named GOx@Fe-DMSN@PDA (GFDP), by integrating Fe 2+ into dendritic mesoporous silica nanoparticles (DMSN) and selecting glucose oxidase (GOx) as the model drug loaded into the DMSN pores. Additionally, we coated the surface of the DMSN with polydopamine (PDA) to confer pH/near infrared (NIR) light-responsive controlled-release behavior and photothermal therapy (PTT). The introduction of Fe 2+ into the DMSN framework greatly improved biodegradability and enhanced the peroxidase (POD)-like activity of GFDP. In addition, GOx could consume glucose and generate hydrogen peroxide (H 2 O 2 ) within tumor cells to facilitate starvation therapy and enhance cascade catalysis. The PDA coating provided the DMSN with an intelligent response release ability, promoting efficient photothermal conversion and achieving the PTT effect. Cellular tests showed that under NIR light irradiation, GFDP exhibited a synergistic effect of PTT-enhanced starvation therapy and cascade catalysis, with a half-maximal inhibitory concentration (IC 50 ) of 2.89 μg/mL, which was significantly lower than that of GFDP without NIR light irradiation (18.29 μg/mL). The in vivo anti-tumor effect indicated that GFDP could effectively accumulate at the tumor site for thermal imaging and showed remarkable synergistic therapeutic effects. In summary, GFDP is a promising nanoplatform for multi-modal combination therapy that integrates starvation therapy, PTT, and cascade catalysis.
研究领域:
纳米技术
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癌症治疗
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材料科学
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生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2022
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IF 5.518
Pengyao Guo,Xiaomin Hu
To improve the degradation efficiency of g-C 3 N 4 (CN), transition metal elements (Fe and Co) were doped into CN. A novel Co, Fe co-doped CN (Co/Fe-CN) photocatalysts with small size and irregular flake structure were successfully prepared by thermal polymerization of melamine . Co/Fe-CN has a large specific surface area (55.76 m 2 /g), which provides more adsorption sites and reaction sites for the activation of peroxymonosulfate (PMS). Good visible light response performance (474 nm) and suitable band gap (2.83 eV) ensure that it could be excited by visible light. The active species of • O 2 - , 1 O 2 , • OH and SO 4 •- could be stably produced in Co/Fe-CN/Vis/PMS system with appropriate redox potential . Meanwhile, Co and Fe elements doped in CN also could effectively activate PMS and promote the generation of active species. Besides, the continuous generation of photogenerated electrons promoted the cycling of Co 3+ /Co 2+ and Fe 3+ /Fe 2+ , and further enhanced the degradation efficiency of Co/Fe-CN/Vis/PMS towards Levofloxacin (LVFX). LVFX could be rapidly removed, reaching 92.1% within 50 min under visible light illumination, and the kinetic rate constant of LVFX was 0.0638 min -1 . The quenching experiments verified that the 1 O 2 was the main active species in the reaction process. The cycling experiments revealed that the Co/Fe-CN/Vis/PMS system had favorable stability and applicability. This work provides a simple preparation method to fabricate bimetallic co-doped CN for the enhancement of degradation rate in the Photocatalyst/Vis/PMS system.
研究领域:
环境科学
·
材料科学
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光催化
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水处理
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）