Frontiers in Bioengineering and Biotechnology
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2023
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IF 5.7
Liang Zixing,Li Xiaofeng,Chen Xiaofang,Zhou Jiawei,Li Yanan,Peng Jianhui,Lin Zhousheng,Liu Gai,Zeng Xiancheng,Li Cheng,Hang Lifeng,Li Hailiang
Introduction: Photodynamic therapy (PDT) and photothermal therapy (PTT) are widely used in the treatment of tumors. However, their application in the treatment of clinical tumors is limited by the complexity and irreversible hypoxia environment generated by tumor tissues. To overcome this limitation, a nanoparticle composed of indocyanine green (ICG) and Fe-MOF-5 was developed.Methods: We prepared F-I@FM5 and measured its morphology, particle size, and stability. Its enzyme like ability and optical effect was verified. Then we used MTT, staining and flow cytometry to evaluated the anti-tumor effect on EMT-6 cells in vitro. Finally, the anti-tumor effect in vivo has been studied on EMT-6 tumor bearing mice.Results: For the composite nanoparticle, we confirmed that Fe-MOF-5 has the best nanozyme activity. In addition, it has excellent photothermal conversion efficiency and generates reactive oxygen species (ROS) under near-infrared light irradiation (808 nm). The composite nanoparticle showed good tumor inhibition effect in vitro and in vivo, which was superior to the free ICG or Fe-MOF-5 alone. Besides, there was no obvious cytotoxicity in major organs within the effective therapeutic concentration.Discussion: Fe-MOF-5 has the function of simulating catalase, which can promote the decomposition of excessive H2O2 in the tumor microenvironment and produce oxygen to improve the hypoxic environment. The improvement of tumor hypoxia can enhance the efficacy of PDT and PTT. This research not only provides an efficient and stable anti-tumor nano platform, but also has broad application prospects in the field of tumor therapy, and provides a new idea for the application of MOF as an important carrier material in the field of photodynamic therapy.
研究领域:
癌症治疗
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纳米技术
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光动力疗法
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光热疗法
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
ACS ES&T Engineering
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2025
·
IF 6.7
Yuwen Qi,Fuyu Li,Chunhui Zhang,Xuejiao Tang,Cuiping Wang,Yanna Liang,Hongwen Sun,Baoshan Xing
Severe harmful effects of per-fluoroalkyl and polyfluoroalkyl substances (PFAS) to ecology and human health have led many countries to continuously upgrade their control for PFAS, which poses higher requirements for the efficient removal of PFAS in water to ensure water resource security. In the present study, the three-dimensional/two-dimensional (3D/2D) structure of metal oxide immobilized on a carbon substrate of the Fe-based metal–organic frameworks (Fe-MOF) heat treatment derivative H:MIL-101(Fe) was constructed. H:MIL-101(Fe) could completely remove PFOA from pure water within 5 min, and complete recovery was achieved within 30 s. H:MIL-101(Fe) exhibited stable properties and can maintain its initial adsorption percentage after four cycles of PFAS adsorption. It was found that the high hydrophobic interface of H:MIL-101(Fe) was formed by partial carbonization during the Fe-MOF heat treatment, and a large number of unsaturated ═C–H bonds on the unstructured benzene ring were generated. Furthermore, cationic chelating agent, such as cetyltrimethylammonium bromide, were mixed with PFAS to synthesize more hydrophobic long-chain complexes; six PFAS containing 4–8 carbon atoms could be completely coadsorbed in surface water within 10 min at pH 7.0, mainly depending on the mechanism of hydrophobic interaction. This study develops a novel adsorption material that can match PFAS types to realize the effective coadsorption of PFAS in water, which provides new insights for removal of PFAS with different carbon chains based on improving hydrophobic interactions between adsorbents and adsorbates.
研究领域:
环境科学
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材料科学
✓ 已验证
产品关联
DOI
高影响因子
Journal of Materials Chemistry C
·
2024
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IF 5.7
Yuedan Wang,Tao Yang,Panpan Hao,Changhui Li,Mufang Li,Yan Tan,Dong Wang
The Fe-MOF@PANI/Carbon fiber was prepared by solvothermal method and used as the gate of organic photoelectrochemical transistor (OPECT). The ratio of Fe-MOF to PANI was optimized to enhance the photoelectric signal transduction. In addition, the vertical configuration of devices was adopted to improve the sensor property. Under light illumination, the device shows good photoelectric conversion ability, periodic stability and duration stability. The uric acid biosensor was prepared by modifying the gate with urate oxidase. The sensitivity of sensors in the absence of light and under illumination is compared. The results show that the sensitivity of the sensor is significantly improved to 91.65 mV/decade under light. The linear relationship is good in the range of 1 nM-5 mM, with a correlation coefficient of R2=0.9506. The sensor can also be used under bending conditions and has been successfully applied to the detection of uric acid in human sweat samples, providing a viable solution for wearable electronic devices.
研究领域:
材料科学
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电化学
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生物传感器
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可穿戴技术
✓ 已验证
产品关联
DOI
高影响因子
MICROCHEMICAL JOURNAL
·
2023
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IF 4.8
Zijing Xu,Dalan Jin,Xiaoyi Lu,Yonglun Zhang,Weilu Liu
Ovalbumin (OVA) is the main allergen in vaccines, and the sensitive detection of it could protect hypersensitive people. However, traditional detection technologies usually require natural antibodies, natural enzymes and long analysis time, which is not conducive to transportation, preservation and rapid detection. To solve this problem, the sandwich colorimetric strategy using Ni-Fe-MOF nanozyme linked with magnetic silicon dioxide surface molecularly imprinted particles (MSi-MIPs) are proposed for the first time to rapidly detect OVA in vaccines. The high sensitivity of this strategy depends on the sandwich structure of surface molecularly imprinted nanoparticles, OVA and nanozymes. Ultra-thin Ni-Fe-MOF nanozyme exhibits large specific surface area and more peroxidase active sites. This has enabled the establishment of a specific and stable detection tool for OVA in vaccines. Under the optimal conditions, the assay exhibited a wide linear response range of 2.5 to 25 ng mL −1 . The low limit of detection (1.02 ng mL −1 ) and the short analysis time (20 min) demonstrated the great potential of the strategy for OVA detection in vaccine samples.
研究领域:
生物化学
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免疫学
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材料科学
✓ 已验证
产品关联
DOI
高影响因子
Journal of Environmental Chemical Engineering
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2023
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IF 7.7
Jiashu Liu,Lin Zhao,Hongzhi Geng,Bin Wang,Xuejiao Tong,Yihan Li,Daying Chen,Peizhe Sun,Yongkui Yang
Trichloroethylene (TCE) commonly exists in contaminated water as a persistent toxic pollutant . The advanced oxidation of persulfate (PS) is a promising method for degrading organic pollutants . Heterogeneous Fe-carbon composites prepared by pyrolysis with metal–organic frameworks (MOFs) have attracted attention. However, the intrinsic relationship between the physicochemical properties and catalytic performance of MOF-derived carbon compounds via PS is unclear. This study investigates TCE removal by Fe-MOF-derived carbon (MFC) with PS. The effects of the precursor template structure, pyrolysis temperature, and coexisting substances on TCE removal over the MFC/PS system are examined. Fe-MOF-derived from different precursor templates presented different TCE removal rates of 75.2–85.0%. The pyrolysis temperature of MFC alters the pore size, phase composition, and other properties, thereby affecting electron transport in the materials and catalyzing the degradation process. The total TCE removal reached 85.8% with MFC600, derived from MF88B and pyrolyzed at 600 ℃. This catalyst demonstrated excellent performance for PS degradation over a wide pH range (3−9). Moreover, free-radical and nonradical pathways coexist in the MFC600/PS system. During the TCE degradation process, oxygen vacancies, Fe species (Fe 0 , Fe 3 N, Fe 3 C, and Fe 3 O 4 ), and N species (pyridinic N and graphitic N) were active centers in the material and played a major role in catalytic degradation. They participated in the subsequent generation of HO•, SO 4 • - , and •O 2 - , and 1 O 2 . Furthermore, a possible degradation mechanism is proposed. This study elucidates the control of the physicochemical properties of carbon-based catalysts by exploiting MOF diversity.
研究领域:
环境科学
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材料科学
✓ 已验证
产品关联
DOI
高影响因子
Materials Science and Engineering B-Advanced Functional Solid-State Materials
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2025
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IF 4.6
Yiqing Wu,Xiangmei Ma,Bin Wang,Yanan Li,Shengtao Gao
The detrimental effects of ultraviolet (UV) and electromagnetic (EM) radiation on human health and physiological functions are well documented. The development of efficient shielding materials to mitigate these effects is therefore an urgent necessity. In this study, Zn/Ti-LDH@Ce/Fe-MOF@PPy composites were successfully prepared by hydrothermal synthesis and interfacial polymerisation. The properties of the composites were compared and analysed with those of pure Zn/Ti-LDH and Ce/Fe-MOF, and the results show that the prepared materials have excellent comprehensive properties, with a broad EAB of 5.2 GHz and a RL min of −46.2 dB at 14.8 GHz at the thickness of 3 mm, while exhibiting excellent UV shielding capability.The present study offers novel concepts and efficacious methodologies for the engineering of high-performance microwave absorbing and UV shielding materials.
研究领域:
材料科学
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环境科学
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生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
APPLIED SURFACE SCIENCE
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2024
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IF 6.3
Junfei Wu,Hai-Bo Liu,Jing Wang
In this work, core–shell structured Fe 3 O 4 @PCN-333 (Fe) composite was constructed using a self-template method, in which Fe 3 O 4 microspheres not only serve as magnetic centers but also provide Fe (III) for the preparation of PCN-333 (Fe). PCN-333 (Fe) uniformly grew as a shell on the surfaces of the microspheres, and the shell thickness was approximately 38 nm. The composite exhibited high adsorption performance, with maximum adsorption capacities of 471.7, 303.3 and 314.5 mg/g for chlortetracycline, tetracycline and oxytetracycline, respectively. The adsorption of tetracycline antibiotics (TCs) was based on the Langmuir and pseudo-second-order model, and external diffusion and pore diffusion were the rate-limiting steps in adsorption. The strong adsorption capacity was attributed to the mechanism of π–π interaction, coordination bonds, electrostatic interaction, hydrogen bonding, and van der Waals force. Fe 3 O 4 @PCN-333 (Fe) composite displayed good stability in the aqueous solution, strong TCs adsorption capacity, high selectivity, anti-interference performance for adsorbing TCs, fast recovery with external magnetic field, reusability, thus effectively reducing the cost for removing water pollutants. These features make the composite a potential material for removing TCs in the environment.
研究领域:
环境科学
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材料科学
✓ 已验证
产品关联
DOI
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
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2025
·
IF 3.9
Lu Zhang,Jianhao Qiu,Zongpeng Zou,Shengwei Tang,Wenxiang Tang
This work demonstrates the rational design of a Z-scheme CdS/Fe-MOF heterojunction for photo-Fenton processes utilizing in situ generated H2O2 under visible light. The photocatalysts were synthesized by depositing CdS nanoparticles onto MIL-53(Fe), optimizing interfacial charge transfer and light absorption, and ensuring effective spatial segregation of photogenerated carriers, thereby maintaining robust redox potentials. The modified CdS/Fe-MOF exhibited exceptional catalytic performance, achieving 92% degradation of 40 mg·L–1 tetracycline within 15 min, surpassing pure CdS (43%) and MIL-53(Fe) (30%) by factors of 2.3 and 3.3, respectively. Mechanistic studies identified on-site H2O2 generation through two-step oxygen reduction (236 μmol·L–1) and its subsequent activation by Fe3+/Fe2+ cycling to produce ·OH as key pathways, with h+, ·O2–, 1O2, and ·OH collectively driving pollutant degradation. The prepared photocatalysts demonstrated remarkable stability (>90% efficiency after five cycles) and structural integrity, attributed to the robust heterojunction interface. This study provides deep insight into designing Z-scheme photo-Fenton catalysts and advancing sustainable wastewater treatment.
研究领域:
环境催化
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材料化学
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光化学
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环境污染治理
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纳米材料
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可持续水处理
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
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2021
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IF 9.229
Jiulong Wang,Weike Wang,Jianguo Li,Xueyang Mu,Xinyue Yan,Zerui Wang,Jinbu Su,Tao Lei,Chengbing Wang
Solar-driven interfacial steam generation (SDISG), as an emerging green and renewable approach to overcome water shortage, is very suitable for remote locations, developing countries, and disaster zones because it does not require an additional energy supply. However, the traditional metal-based and carbon-based absorbers always suffered from fragility (or rigidity) and the complex preparation process, which dramatically inhibited their transportation and installation in areas with poor infrastructure. Therefore, there is an urgent need to develop a universal method to fabricate flexible solar evaporators. Herein, a novel solar evaporator that integrates a flexible matrix (Cu mesh or textile) and a hierarchical Fe-MOF-74 photothermal absorber component is perfectly prepared for the rapid and efficient SDISG. Notably, the results show that Fe-MOF-74-based flexible textile matrix composites exhibit outstanding light absorption (83.81%), low thermal conductivity (0.1730 W/m K), super hydrophilic properties (within 50 ms, the contact angle is close to 0°), excellent salt resistance, high evaporation rate (1.35 kg/m2 h), and photothermal conversion efficiency (η is 81.5% under one sun, stable for 30 days). Owing to the flexibility, recyclability, and above-mentioned excellent performance, the prepared hierarchical Fe-MOF-74-based flexible composite systems are more practical for transportation, large-scale production, and stable and efficient applications. As a result, this work offers new insight into the future development of the combination of a MOF-based photothermal absorber and flexible substrates, as well as for the application of interfacial solar seawater desalination, and provides a new reference for other applications.
研究领域:
材料科学
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环境科学
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能源科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
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2022
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IF 9.136
Minghui Xiang,Zhen Lu,Siyang Li,Hui Li,Chen Wang,Jin Zhang,Lide Jin,Chunyang Li
In recent years, new heterogeneous catalysts derived from metal organic frameworks (MOFs) have been widely used in advanced oxidation processes (AOPs). In this work, zeolite imidazole framework-67 (ZIF-67) and sulfide nanozero-valent iron (S-Fe) were used as precursors to prepare S-Fe/Co bimetallic nanoparticles embedded in graphitized carbon (S-Fe/Co@GC) and used to activate peroxymonosulfate (PMS) to degrade tetrabromobisphenol A (TBBPA). Morphological and structural characterization indicated that S-Fe/Co@GC compared to pre-carbonization, the pore size of the material became larger, formed a graphite carbon skeleton with excellent electrical conductivity. In a 0.2 g/L S-Fe/Co@GC and 0.6 mM PMS system, 96.1% of TBBPA (20 mg/L) was degraded within 30 min, and the degradation yielded a total organic carbon (TOC) removal of 56.2% in 60 min. This excellent catalytic activity was attributed to the synergistic effect of graphitic carbon, sulfide nanozero-valent iron and metallic cobalt. Radical quenching experiments and electron paramagnetic resonance (EPR) technology indicated that reactive oxygen species (ROS) included HO • , SO 4 •− , O 2 •− and 1 O 2 , among which O 2 •− plays a leading role in the degradation of TBBPA. Based on the LC-MS analysis of the degradation intermediates, the degradation pathway of TBBPA in the S-Fe/Co@GC/PMS system was proposed. In addition, S-Fe/Co@GC showed a low ion leaching rate, and the regenerated S-Fe/Co@GC still had high catalytic performance. This work will extend the development of MOFs encapsulate functional nanoparticle materials for environmental remediation.
研究领域:
环境科学
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材料科学
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2021
·
IF 13.273
Su Ding,Jinquan Wan,Yan Wang,Zhicheng Yan,Yongwen Ma
In this work, persulfate (PS) activation by a novel functioned metal-organic framework catalyst was investigated for the targeted degradation of DMP, a toxic phthalate pollutant. The catalyst, a molecularly imprinted water-stable Fe-MOF-74 (Fe-MOF-74@SiO 2 @MIP), showed excellent capability of PS activation, high selectivity and efficient targeted degradation performance of DMP. The results of total organic carbon indicated that DMP was mineralized during the catalysis. EPR measurement and quenching experiments suggested the coexistence of SO 4 •− and • OH, and SO 4 •− was predominant in this system. It was found that increasing catalyst loading (0.01 - 0.05 g L -1 ) inhibited the DMP elimination, due to the aggravated radical consumption. A higher pseudo-first order rate of DMP degradation was observed with an increasement of PS (5.2 - 52 mM) and temperature (15 - 45 °C). Besides, coexisting chloride ions (Cl − ) promoted the DMP degradation at the concentration 1 mM, but decreased the degradation performance at other concentrations. According to EPR and XPS analysis, the effect of Cl − was ascribed to the formation chlorine radicals, which changed the radical distribution and the catalytic site property. Chlorinated intermediates were detected by LC-MS, confirming the involvement of Cl-related radicals. Finally, possible degradation pathways were proposed.
研究领域:
环境科学
·
催化化学
✓ 已验证
DOI
高影响因子
Small
·
2025
·
IF 12.1
Pengwei Tan,Shuyang Shen,Ying Zheng,Yushu Tang,Yuanyuan Luo,Zheng Zhang,Dong Men,Guotao Duan
Electrochemical transistor (ECT) biosensors can achieve ultrahigh sensitivity, while keeping challenges for large biomolecules due to their sizes over the thickness of the electric double layer (EDL) causing a failure of sensing reaction. Here, wafer-level Ni/Fe-metal-organic framework (MOF) films and corresponding ECT biosensors are fabricated for the detection of coronavirus nucleocapsid protein, which realize an ultralow detection limit of 1 fg mL −1 and a wide detection range of 1 fg mL −1 to 100 pg mL −1 . A 3D Debye space, originating from the unique stacking structure of nanosheets and nanoparticles in Ni/Fe-MOF film, is proposed to explain such ultrahigh sensitivity, which ensures the immune-binding and sensing process of the nucleocapsid protein large molecules located in the effective EDL space. Moreover, an appropriate Ni/Fe molar ratio is optimized to enhance the transmission of carriers, thus improving the signal-to-noise ratio and the sensing response. The Ni/Fe-MOF-ECT biosensors will find applications in highly sensitive detection for large biomolecules, and the 3D Debye space may be a design model for constructing other biosensors.
研究领域:
材料科学
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生物传感
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医学检测
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）