Pharmaceutics
·
2026
·Vol. 18
·期 3
·
IF 6.9
Heng Li,Zhiyue Zhang,Yu Wang,Ting Mou,Jiaqi Tian,Chong Huang,Lu Zhao,Zeyang Ge,Dandan Wang,Chunlin Zong
Background/Objectives: Jaw osteomyelitis (OM) is a refractory purulent inflammation caused by bacterial infection, characterized by persistent infection, excessive bone resorption, and resultant bone defects. Currently, mainstream therapies for jaw OM struggle to eradicate persistent infections, avoid antibiotic resistance, and repair infected bone defects, posing a critical challenge in clinical practice.Methods: Herein, the Fe3O4@ZIF-8 core–shell nanoparticles (NPs) platform designed for jaw OM treatment consisted of Fe3O4as the core and zeolitic imidazolate framework-8 (ZIF-8) as the shell.Results: The core–shell platform not only integrated the pH-responsive degradation capability of ZIF-8 but also retained the superparamagnetism of Fe3O4NPs. In the acidic, infectious microenvironment, Fe3O4@ZIF-8 NPs underwent continuous degradation, releasing Zn2+, thereby conferring potent antibacterial activity. The specific antibacterial mechanism of the nanoparticles lies in the fact that high concentrations of Zn2+directly disrupted bacterial cell membranes and inhibited the bacterial heat shock response. This dysregulates bacterial proteostasis, rendering the bacteria more sensitive to external adverse stresses, ultimately leading to bacterial death. With ZIF-8 framework degradation, the encapsulated Fe3O4NPs were released. Under static magnetic field (SMF) synergy, Fe3O4NPs collaborated with Zn2+to promote bone regeneration and repair infected bone defects in jaw OM lesions.Conclusions: As a multifunctional core–shell platform, Fe3O4@ZIF-8 NPs meet the dual clinical needs of antibiosis and osteogenesis, offering a promising translational strategy for jaw OM therapy.
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高影响因子
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2022
·Vol. 29
·期 23
·35204-35216
·
IF 5.19
Song Xu,Mo Jingqian,Fang Yuting,Luo Shumin,Xu Jingjing,Wang Xu
We prepared a double-layer magnetic nanocomposite Fe 3 O 4 @ZIF-8@ZIF-67 by layer-by-layer self-assembly. Fe 3 O 4 @ZIF-8@ZIF-67 was used to remove tetracycline from an aqueous solution via a combination of adsorption and Fenton-like oxidation. Depending on the outstanding porous structure of the Fe 3 O 4 @ZIF-8@ZIF-67, a high adsorption capacity for tetracycline was 356.25 mg g −1 , with > 95.47% removal efficiency within 100 min based on Fenton-like oxidation. To better understand the mechanisms involved in integrated adsorption and Fenton-like oxidation, various advanced characterization techniques were used to monitor the changes in morphology and composition of Fe 3 O 4 @ZIF-8@ZIF-67 before and after removal of tetracycline. Scanning electron microscopy/energy-dispersive X-ray spectroscopy (SEM/EDS), Fourier transform infrared spectroscopy (FTIR), and X-ray diffraction (XRD) all supported adsorption and Fenton oxidation of tetracycline. This study extends the application of Fe 3 O 4 @ZIF-8@ZIF-67 for environmental remediation. Graphical abstract
研究领域:
环境科学
·
材料科学
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高影响因子
Nanoscale
·
2015
·Vol. 7
·期 46
·19568-19578
·
IF 7.394
Dan Yang,Guixin Yang,Shili Gai,Fei He,Guanghui An,Yunlu Dai,Ruichan Lv,Piaoping Yang
Near-infrared (NIR) light-induced cancer therapy has gained considerable interest, but pure inorganic anti-cancer platforms usually suffer from degradation issues. Here, we designed metal–organic frameworks (MOFs) of Fe3O4/ZIF-8-Au25 (IZA) nanospheres through a green and economic procedure. The encapsulated Fe3O4 nanocrystals not only produce hyperthemal effects upon NIR light irradiation to effectively kill tumor cells, but also present targeting and MRI imaging capability. More importantly, the attached ultrasmall Au25(SR)18− clusters (about 2.5 nm) produce highly reactive singlet oxygen (1O2) to cause photodynamic effects through direct sensitization under NIR light irradiation. Furthermore, the Au25(SR)18− clusters also give a hand to the hyperthemal effect as photothermal fortifiers. This nanoplatform exhibits high biocompatibility and an enhanced synergistic therapeutic effect superior to any single therapy, as verified by in vitro and in vivo assay. This image-guided therapy based on a metal–organic framework may stimulate interest in developing other kinds of metal–organic materials with multifunctionality for tumor diagnosis and therapy.
研究领域:
纳米医学
·
肿瘤学
·
生物材料
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高影响因子
MICROCHEMICAL JOURNAL
·
2025
·
IF 5.1
Shuyang Sun,Mengdi Yao,Yu Gao,Ping Wang,Chengke Wang
A colorimetric method for fish freshness monitoring was developed. After coating magnetic Fe 3 O 4 nanoparticle with zeolitic imidazolate framework-8 (ZIF-8), the horseradish peroxidase (HRP) was adsorbed onto it with high efficiency due to the large surface area of ZIF-8, the mesoporous SiO 2 was further decorated onto the Fe 3 O 4 @ZIF-8@HRP to form Fe 3 O 4 @ZIF-8@HRP@SiO 2 nanostructure, in order to minimize the release of HRP, and enhance the stability and catalytic activity of HRP. The morphology, elemental composition, surface functional groups of Fe 3 O 4 @ZIF-8@HRP@SiO 2 were characterized by transmission electron microscopy, X-ray diffraction, energy dispersive spectroscopy, Fourier transform infrared spectroscopy. Hypoxanthine (HX), which formed due to the degradation of adenosine triphosphate in fish, can be oxidized by xanthine oxidase and generated H 2 O 2 intermediate. Thereafter, in the presence of H 2 O 2 , HRP within Fe 3 O 4 @ZIF-8@HRP@SiO 2 nanostructure would catalyze the oxidation of 3,3′,5,5′-tetramethylbenzidine (TMB) to a blue product of TMBox, allowing an indirect colorimetric sensing of HX content. Under optimal conditions, HX was selectively and sensitively detected in the range of 0–100 μM, with a detection limit of 0.133 μM. Finally, the proposed method was applied to determine the HX content in grass carp continuously stored at 4 °C and 30 °C for 96 h.
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2025
·
IF 9
Yunxiang Bai,Xinxue Qiu,Deqiang Chen,Junwei Zheng,Liangliang Dong,Chunfang Zhang
Magnetic mixed matrix membranes (MMMs) show great potential for enhancing O 2 /N 2 separation efficiency by leveraging the inherent magnetic property differences between O 2 (paramagnetic) and N 2 (diamagnetic). However, one of the major challenges is the establishment and precise control of magnetic channels between magnetic fillers and polymer matrix. To address this issue, herein, ZIF-8 wrapped Fe 3 O 4 nanoparticles (Fe 3 O 4 @ZIF-8) were synthesized using a step-by-step assembly method, and then integrated into polymer of intrinsic microporosity (PIM-1) matrix to develop MMMs with well-defined magnetic channels for O 2 /N 2 separation. In comparison with Fe 3 O 4 , Fe 3 O 4 @ZIF-8 nanoparticles exhibited significantly enhanced compatibility with the polymer matrix, thereby facilitating uniform dispersion and improving interfacial adhesion. Gas permeation experiments revealed that the magnetic PIM-1/Fe 3 O 4 @ZIF-8 MMMs demonstrated enhanced O 2 /N 2 separation performance due to the combined effects of magnetic responsiveness and the presence of ZIF-8 magnetic channels. Under a magnetic field strength of 56mT, the magnetic MMM with a 4 wt% loading of Fe 3 O 4 @ZIF-8 exhibited optimal O 2 /N 2 separation performance with O 2 permeability of 710 Barrer and O 2 /N 2 selectivity of 3.64. These values represented a significant improvement of 42% and 24%, respectively, compared to pure PIM-1 membrane. Moreover, the simultaneous improvement of permeability and selectivity enabled the achievement of Robeson’s 2008 upper bound for O 2 /N 2 separation, underscoring the great potential of Fe 3 O 4 @ZIF-8 nanoparticles for designing magnetic MMMs with favorable structural attributes and exceptional separation efficiency.
研究领域:
材料科学
·
化学工程
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高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2024
·
IF 12.2
Puyue Liu,Yiming Dong,Xiaoxuan Li,Yu Zhang,Zhi Liu,Yingying Lu,Xuewen Peng,Ruifang Zhai,Yiping Chen
The misuse and overuse of chloramphenicol poses severe threats to food safety and human health. In this work, we developed a magnetic solid-phase extraction (MSPE) pretreatment material coated with a multilayered metal – organic framework (MOF), Fe 3 O 4 @ (ZIF-8) 3 , for the separation and enrichment of chloramphenicol from fish. Furthermore, we designed an artificial-intelligence-enhanced single microsphere immunosensor. The inherent ultra-high porosity of the MOF and the multilayer assembly strategy allowed for efficient chloramphenicol enrichment (4.51 mg/g within 20 min). Notably, Fe 3 O 4 @ (ZIF-8) 3 exhibits a 39.20% increase in adsorption capacity compared to Fe 3 O 4 @ZIF-8. Leveraging the remarkable decoding abilities of artificial intelligence, we achieved the highly sensitive detection of chloramphenicol using a straightforward procedure without the need for specialized equipment, obtaining a notably low detection limit of 46.42 pM. Furthermore, the assay was successfully employed to detect chloramphenicol in fish samples with high accuracy. The developed immunosensor offers a robust point-of-care testing tool for safeguarding food safety and public health.
研究领域:
食品安全
·
分析化学
·
生物医学工程
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RSC Advances
·
2018
·Vol. 8
·期 13
·6887-6892
·
IF 2.936
Shanshan Li,Dongyan Li,Long Sun,Yuewei Yao,Cheng Yao
We fabricated a novel aminophenylboronic acid functionalized magnetic Fe3O4/zeolitic imidazolate framework-8/APBA (denoted as Fe3O4/ZIF-8/APBA). First, Fe3O4 was coated by zeolitic imidazolate framework-8 (denoted as Fe3O4/ZIF-8) using the hydrothermal method. Next, the phenylboronic acid functionalized triethoxysilane reagent was synthesized by 3-aminophenylboronic acid and 3-isocyanatopropyltriethoxysilane, which was modified on the surface of the Fe3O4/ZIF-8 nanocomposite through the sol–gel technique and electrostatic interaction as well as π–π stacking interaction. The synthetic Fe3O4/ZIF-8/APBA exhibited high adsorption capacity and good specificity toward glycoproteins. Moreover, the Fe3O4/ZIF-8/APBA possessed high saturation magnetization (51.41 emu g−1) and achieved better separation in the presence of an external magnetic field. Above all, the as-designed Fe3O4/ZIF-8/APBA was successfully used to capture glycoproteins and identify the horseradish peroxidase (HRP) tryptic digest. This study provides a facile strategy to embellish the aminophenylboronic acid onto the nanocomposite substrate and develop a new material for the specific recognition and enrichment of glycoproteins and low-abundance glycopeptides in proteomics research.
研究领域:
材料科学
·
化学
·
生物化学
·
蛋白质组学
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Journal of Materials Chemistry B
·
2015
·Vol. 3
·期 10
·2185-2191
·
IF 4.726
Jiangnan Zheng,Zian Lin,Guo Lin,Huanghao Yang,Lan Zhang
This work reports a novel metal–organic framework (MOF)-based metal affinity platform for the rapid and highly specific separation of histidine-rich proteins using zeolitic imidazolate framework-8 coated magnetic nanocomposites (denoted as Fe3O4@ZIF-8). The coating of the ZIF-8 layer on the Fe3O4 core was performed in aqueous solution at room temperature and merely took 10 minutes. The monodisperse Fe3O4@ZIF-8 has an average diameter of 190 nm, displays superparamagnetism with a saturation magnetization value of 47.9 emu g−1, and possesses a large external surface area of 131.0 m2 g−1. Due to the high density of low-coordinated Zn atoms on the surface of ZIF-8, Fe3O4@ZIF-8 exhibited a large adsorption capacity for model histidine-rich proteins (>6000 mg g−1 for bovine hemoglobin) and relatively low adsorption capacities for other proteins which contain fewer surface-exposed histidine residues. Moreover, Fe3O4@ZIF-8 showed excellent recyclability (more than 10 times) with high recovery (88.4%). In addition, Fe3O4@ZIF-8 can be used to selectively separate hemoglobin from a protein mixture and human blood samples. The good results demonstrate the potential of Fe3O4@ZIF-8 in the separation of histidine-rich proteins.
研究领域:
生物化学
·
材料科学
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高影响因子
JOURNAL OF CHROMATOGRAPHY A
·
2024
·
IF 3.8
Yanbo Tian,Abdul Majid,Yuewei Zhang,Liju Tan,Huiru Li,Na Wang,Jiangtao Wang
In this study, molecularly imprinted polymers (MIPs) were prepared for the specific recognition of organophosphorus pesticides and a rapid, efficient and simple method was established for the detection of dimethoate (DIT) in food samples. Fe 3 O 4 magnetic nanoparticles were synthesized by co-precipitation, and Fe 3 O 4 /ZIF-8 complexes were prepared by a modified in-situ polymerization method, and then magnetic molecularly imprinted polymers (MMIPs) were prepared and synthetic route was optimized by applying density functional theory (DFT). The morphological characterization showed that the MMIPs were coarse porous spheres with an average particle size of 50 nm. The synthesized materials are highly selective for the organophosphorus pesticide dimethoate with an adsorption capacity of 461.50 mg·g −1 and are effective resistance to matrix effects. A novel method for the determination of DIT in cabbage was developed using the prepared MMIPs in combination with HPLC. The practical results showed that the method can meet the requirements for the determination of DIT in cabbage with recoveries of 85.6–121.1 % and detection limits of 0.033 μg·kg −1 .
研究领域:
食品科学
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分析化学
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2017
·
IF 2.843
Lei Yang,Yuzhuo Jin,Xiangchen Fang,Zhenmin Cheng,Zhiming Zhou
Magnetic core–shell structured Pd-based catalysts (Fe3O4@M/Pd, M = SiO2, AlOOH, TiO2, Cu3(BTC)2, and ZIF-8) were prepared and applied to semihydrogenation of phenylacetylene. The catalysts were characterized by various techniques, and it was found that the predominant chemical state of Pd species on the catalyst surface was PdO2, which was stable under the reaction condition (40 °C and 0.1 MPa H2). Among all the catalysts studied, Fe3O4@ZIF-8/Pd showed the highest selectivity to styrene, which was also superior to conventional catalysts such as Pd/C, Pd/Al2O3 and Lindlar catalyst. The high selectivity of Fe3O4@ZIF-8/Pd was mainly ascribed to the electronic effect between PdO2 and ZIF-8. Further investigation revealed that the phenylacetylene hydrogenation on Fe3O4@ZIF-8/Pd was solvent-dependent with the activity increasing with the solvent polarity. Among eight solvents tested, methanol was the most effective, with high and stable selectivity to styrene (around 92%) at complete conversion of phenylacetylene (≥99.5%) during five consecutive cycles.
研究领域:
催化化学
·
材料科学
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高影响因子
Journal of Environmental Health Science and Engineering
·
2025
·Vol. 23
·期 2
·1-17
·
IF 2.8
Huang Jiaru,Li Jinhuan,Lu Chunmiao,Wang Xu,Xu Jingjing
A magnetic double-layer metal-organic framework composite (Fe 3 O 4 @ZIF-8@ZIF-67) was successfully synthesized through a facile layer-by-layer self-assembly method at room temperature and thoroughly characterized using various techniques. The composite Fe 3 O 4 @ZIF-8@ZIF-67 was explored as an adsorbent for the removal of two harmful organic pollutants, Congo red (CR) and tetracycline hydrochloride (TC). Some essential parameters, including initial concentration, adsorbent dose, contact time, pH, and temperature, were systematically optimized. Under optimal conditions, Fe 3 O 4 @ZIF-8@ZIF-67 demonstrated the maximum adsorption capacities of 276.77 mg/g for CR and and 356.12 mg/g for TC, respectively. The double-layer structure endowed Fe 3 O 4 @ZIF-8@ZIF-67 high adsorption efficiency for CR (99.44%) than the pristine Fe 3 O 4 @ZIF-8 (73.26%). Adsorption kinetics and isotherms studies revealed that the adsorption process followed pseudo-second-order kinetics and Langmuir model, indicating a monolayer chemisorption-dominated mechanism. Furthermore, the spent Fe 3 O 4 @ZIF-8@ZIF-67 was regenerated through a Fenton-like oxidative degradation reaction, maintaining a removal efficiency above 70% after three consecutive cycles. With its facile synthesis, cost-effectiveness, mild operating conditions, and high selectivity for anionic dyes, Fe 3 O 4 @ZIF-8@ZIF-67 emerges as a highly promising material for advanced wastewater treatment applications.
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JOURNAL OF MATERIALS SCIENCE
·
2026
·
IF 3.9
Ma Kuanjie,Li Nana,Lu Guochao,Zhang Lianwei,Hu Zhiwei,Liu Wenjing,Cai Yurong
To address the need for rapid desorption in protein adsorption applications, we developed and characterized magnetic core–shell nanoparticles composed of a zeolite imidazolate framework-8 (ZIF-8) coating on magnetite (Fe 3 O 4 ) cores (Fe 3 O 4 @ZIF-8). This nanostructure integrates the pH-sensitive properties of ZIF-8 with the magnetic responsiveness of Fe 3 O 4 , enabling rapid separation within one minute via an external magnetic field. In the synthesis of Fe 3 O 4 @ZIF-8, the particle size of the ZIF-8 shell was found to increase concurrently with the molar ratio of zinc nitrate hexahydrate to 2-methylimidazole. The resulting shells were uniformly distributed on the surface of the Fe 3 O 4 cores. Furthermore, a positive correlation was observed between the ZIF-8 particle size and the adsorption capacity for histidine-rich proteins. In adsorption experiments using bovine hemoglobin (BHB) as a model protein, Fe 3 O 4 @ZIF-8 achieved an adsorption capacity of 1013.5 mg/g within 3 min, representing 87% of its maximum adsorption potential. Saturation adsorption, with a capacity of 1164.3 mg/g, was reached within 8 min. Importantly, the pH-responsive nature of the ZIF-8 component facilitated highly efficient desorption. A high release efficiency of 90% was achieved in just 1 min using a phosphate buffer at pH 5.2. This dual pH- and magnetic-responsive system demonstrates significant potential for applications requiring fast and controllable protein adsorption and desorption, positioning it as an ideal tool for targeted protein recovery in various biochemical and industrial processes.
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