JOURNAL OF LUMINESCENCE
·
2022
·
IF 4.171
Yangqing Wu,Mei Wang,Shaolian Sun,Shan Shao,Ziyu Pan,Jinkai Li,Haoming Wei,Bingqiang Cao
X-ray excitation photodynamic therapy is a new photodynamic therapy mode that induces tumor cell apoptosis by indirectly stimulating photosensitizer on nanoparticles with X-ray as excitation light source and generating singlet oxygen. It solves the problem of light penetration in traditional photodynamic therapy and realizes the treatment of deep tumors. At present, the weak X-ray-induced luminescence restricts further development of X-ray photodynamic therapy. NaLuF 4 :Li + /Gd 3+ /Tb 3+ rare-earth nanoparticles with uniform size and regular morphology were synthesized by solvothermal method . The X-ray-induced luminescence intensity of NaLuF 4 :Li + /Gd 3+ /Tb 3+ NPs was improved by Li + and Gd 3+ ions co-doping. The light yield of NaLuF 4 :Li + /Gd 3+ /Tb 3+ NPs with 5% Li + ions doping was 1.4 times than that of reference sample due to the change of crystal field symmetry. Furthermore, the effective lifetime of persistent luminescence increased from 221.5 s to 251.9 s after 15% Li + ions doping. The thermoluminescence curves confirmed that the trap concentration was increased after Li + ions doping, which was responsible for enhancing persistent luminescence lifetime . Long persistent luminescence emission laid a foundation for further application in photodynamic therapy.
研究领域:
材料科学
·
医学
·
生物技术
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产品关联
DOI
高影响因子
Materials Today Communications
·
2022
·
IF 3.662
Yuhong Zhang,Nan Zhang,Pengcheng Wang,Xingke Zheng,Yibin Guo,Hang Liu
In this work, tungstate BaWO 4 phosphors doped Ho 3+ -Yb 3+ -Gd 3+ ions are successfully synthesized through solid-state reaction method. Under the excitation of a 980 nm laser, the up-conversion (UC) luminescence properties are investigated simultaneously. The blue (465 nm, 489 nm), green (541 nm) and red (665 nm) emission intensities of BaWO 4 : Ho 3+ /Yb 3+ /Gd 3+ samples are dramatically enhanced by 20.59, 9.83, 7.37, and 27.59 times more than those without Gd 3+ ions. The possible reason is discussed, which attributes to the energy transfer efficiency enhancement from Yb 3+ to Ho 3+ due to the lattice expansion induced by Gd 3+ ions. The temperature-sensing properties of BaWO 4 : Ho 3+ /Yb 3+ /Gd 3+ samples are also discussed based on the fluorescence intensity ratio (FIR) technology. The sensitivity of temperature measurement for BaWO 4 : Ho 3+ /Yb 3+ /Gd 3+ sample is higher than that of BaWO 4 : Ho 3+ /Yb 3+ . It proves that the codoped Gd 3+ ions can also increase the temperature sensitivity because the higher UC emission efficiency will lead to a high signal-to-noise ratio. The result provides an effective way to design UC luminescence materials with high temperature sensing properties.
研究领域:
材料科学
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光学材料
·
发光学
·
传感器技术
·
无机功能材料
✓ 已验证
DOI
高影响因子
JOURNAL OF SOLID STATE CHEMISTRY
·
2025
·
IF 3.5
Lanwei Qiu,Haochang Ye,Guangting Xiong,Wei Zhang,Yirong Huang,Qiuzhi Liang,Canhui Pan,Jinquan Chen,Zuyong Feng
Orange-red KLa(WO 4 ) 2 phosphors co-doped with Sm 3+ -Gd 3+ were synthesized via high-temperature solid-state reaction. Phase purity and crystal structure were confirmed by XRD, while SEM revealed non-uniform particle distribution. XPS verified elemental composition and suggested the chemical states of dopants. Under 403 nm excitation, KLa(WO 4 ) 2 : Sm 3+ exhibited intense orange–red emissions, dominated by the 4 G 5/2 - 6 Hᵢ (i = 5/2, 7/2, 9/2, 11/2) transition from 500 to 750 nm. Substitution by Gd 3+ lowers the local symmetry, as evidenced by the increased asymmetry ratio, resulting in a 1.88-fold increase in emission intensity. Notably, the optimized phosphor, KLa 0.8 Gd 0.15 (WO 4 ) 2 :0.05Sm 3+ , exhibits a high color purity (CP) of 99 % and excellent thermal stability retaining 85 % of its room-temperature emission intensity at 423K. When combined with a 405 nm InGaN chip, the fabricated LED displayed strong spectral overlap with chlorophyll and phytochrome absorption peaks, confirming its potential for plant-growth illumination.
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DOI
高影响因子
NANOTECHNOLOGY
·
2016
·Vol. 27
·期 31
·315101
·
IF 3.573
Jia Liu,Yating Zhao,Yu Cui,Yang Yue,Yikun Gao,Qinfu Zhao,Jie Liu,Siling Wang
A structurally controllable fluorescence-labeled hollow mesoporous carbon (HMC) was simply prepared to improve the oral bioavailability of insoluble drugs and further trace their delivery process in vivo. The hollow structure was derived from an inverse replica process using mesoporous silica as a template and the fluorescent label was prepared by doping the carboxylated HMC with a confinement of Eu3+/Gd3+-EDTA. The physicochemical properties of the composites were systematically characterized by transmission electron microscopy, Fourier transform infrared spectroscopy and photoluminescence spectra tests prior to studying their effects on drug-release behavior and biodistribution. As a result, the thickness of the carrier's shell was adjusted from 70 nm to 130 nm and the maximum drug loading was up to 73.6%. The model drug carvedilol (CAR) showed sustained release behavior compared to CAR commercial capsules, and the dissolution rate slowed down as the shells got thicker. AUC0-48h and Tmax were enlarged 2.2 and 6.5 fold, respectively, which demonstrated that oral bioavailability was successfully improved. Bioimaging tests showed that the novel carbon vehicle had a long residence time in the gastrointestinal tract. In short, the newly designed HMC is a promising drug carrier for both oral bioavailability improvement and in vivo tracing.
研究领域:
药剂学
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生物医学工程
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材料科学
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产品关联
DOI
PubMed
高影响因子
DALTON TRANSACTIONS
·
2023
·Vol. 52
·期 9
·2619-2630
·
IF 4
Xuejiao Wang,Xiaowen Feng,Maxim S. Molokeev,Huiling Zheng,Qiushi Wang,Chunyan Xu,Ji-Guang Li
Phosphors that exhibit tunable broadband emissions are highly desired in multi-functional LEDs, including pc-WLEDs and pc-NIR LEDs. In this work, broadband emissions were obtained and modulated in the unexpectedly wide spectral range of 517–609 nm for (Lu0.99−xGdxBi0.01)2WO6 phosphors by tuning the Gd3+ content (x = 0–0.99). The effects of Gd3+ doping on phase constituents, particle morphology, crystal structure, and photoluminescence were systematically investigated. Broadband green emission was obtained from Gd3+-free (Lu0.99Bi0.01)2WO6 phosphors (x = 0), whose emission intensity was enhanced by 50% with 5 at% Gd3+ (x = 0.05). The phase transition happened when x > 0.50 and the broadband red-NIR emission was obtained when x = 0.75–0.99. Three luminescence centers were proved to be responsible for the broadband green emissions via crystal structure, spectral fitting and fluorescence decay analysis. A pc-WLED with a high color rendering index (Ra = 91.3), a stable emission color, and a low color temperature (3951 K) was fabricated from the (Lu0.94Gd0.05Bi0.01)2WO6 broadband green phosphor, and an LED device that simultaneously emits high color rendering index white light and NIR light was obtained with the (Gd0.99Bi0.01)2WO6 broadband red-NIR phosphor. Night vision and noninvasive imaging were also demonstrated using the latter LED device.
研究领域:
材料科学
·
光学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
DALTON TRANSACTIONS
·
2021
·Vol. 50
·期 43
·15688-15695
·
IF 4.39
Minghui Li,Jun Zhou,Ruoshan Lei,Huanping Wang,Feifei Huang,Shiqing Xu
Nowadays, there is enthusiastic effort to develop luminescent thermometers used for remote and high-sensitivity temperature readout over a wide sensing range. Herein, Pr3+ and Gd3+ co-doped ZrO2 nanocrystals are designed, prepared and investigated by XRD, Raman spectroscopy, XPS, TEM, EDS, DRS, PLE and PL spectroscopy. Upon 275 nm irradiation, the PL spectrum of ZrO2:Pr3+,Gd3+ is found to be composed of a narrow emission peak at 314 nm (Gd3+ 6P7/2–8S7/2), a broad defect-related emission band at 400 nm, and several emission peaks in the wavelength region of 585–700 nm (Pr3+ 1D2–3H4, 3P0–3H6, and 3P0–3F2), which exhibit different thermal responses owing to the effects of the various non-radiative relaxation processes and trap energy levels. Accordingly, the luminescence intensity ratio (LIR) between the Pr3+ 1D2–3H4 and Gd3+ 6P7/2–8S7/2 transitions demonstrates excellent relative sensing sensitivity values ((2.32 ± 0.01)% K−1–(8.32 ± 0.05)% K−1) and low temperature uncertainties (0.08 K–0.28 K) over a wide temperature sensing range of 303 K to 573 K, which are remarkably better than those of many other luminescence thermometers. What is discussed in the present study may be conducive to broadening the research region of RE3+ doped luminescence thermometric phosphors, especially for materials with rich 4f–4f transition lines and defect-related luminescence.
研究领域:
材料科学
·
光学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
LANGMUIR
·
2016
·
IF 3.993
Hongli Du,Jiani Yu,Dongcai Guo,Weitao Yang,Jun Wang,Bingbo Zhang
Gd3+-ion-doped upconversion nanoparticles (UCNPs), integrating the advantages of upconversion luminescence and magnetic resonance imaging (MRI) modalities, are capturing increasing attention because they are promising to improve the accuracy of diagnosis. The embedded Gd3+ ions in UCNPs, however, have an indistinct MRI enhancement owing to the inefficient exchange of magnetic fields with the surrounding water protons. In this study, a novel approach is developed to improve the MR imaging sensitivity of Gd3+-ion-doped UCNPs. Bovine serum albumin (BSA) bundled with DTPA-Gd3+ (DTPAGd) is synthesized both as the MR imaging sensitivity synergist and phase-transfer ligand for the surface engineering of UCNPs. The external Gd3+ ion attachment strategy is found to significant improve the MR imaging sensitivity of Gd3+-ion-doped UCNPs. The relaxivity analysis shows that UCNPs@BSA·DTPAGd exhibit higher relaxivity values than do UCNPs@BSA without DTPAGd moieties. Another relaxivity study discloses a striking message that the relaxivity value does not always reflect the realistic MRI enhancement capability. The high concentration of Gd3+-ion-containing UCNPs with further surface-engineered BSA·DTPAGd (denoted as UCNPs–H@BSA·DTPAGd) exhibits a more pronounced MRI enhancement capability compared to the other two counterparts [UCNPs–N@BSA·DTPAGd and UCNPs–L@BSA·DTPAGd (−N and –L are denoted as zero and low concentrations of Gd3+ ion doping, respectively)], even though it holds the lowest r1 of 1.56 s–1 per mmol L–1 of Gd3+. The physicochemical properties of UCNPs are essentially maintained after BSA·DTPAGd surface decoration with good colloidal stability, in addition to improving the MR imaging sensitivity. In vivo T1-weighted MRI shows potent tumor-enhanced MRI with UCNPs–H@BSA·DTPAGd. An in vivo biodistribution study indicates that it is gradually excreted from the body via hepatobiliary and renal processing with no obvious toxicity. It could therefore be concluded, with improved MR imaging sensitivity by an internal and external incorporation of Gd3+ strategy, that UCNPs–H@BSA·DTPAGd presents great potential as an alternative in tumor-targeted MR imaging.
研究领域:
纳米技术
·
医学成像
·
材料科学
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
DALTON TRANSACTIONS
·
2020
·Vol. 49
·期 35
·12327-12337
·
IF 4.174
Mingyue Xu,Bin Chi,Zhiyuan Han,Yuting He,Feng Tian,Zushun Xu,Ling Li,Jing Wang
Gd3+ and Tm3+ doped Prussian blue (Gd/Tm–PB) with high uniformity and dispersibility was synthesized by a facile solvothermal method. The conditions for the synthesis of Gd/Tm–PB were explored. Through the regulation of the ratio of Gd3+/Tm3+, the Gd/Tm–PB particles with the optimal size (about 150–200 nm) and the best fluorescence and photothermal effect were obtained. On the basis of the optimal Gd/Tm–PB, further coated by polydopamine (PDA) functionalized metal–organic frameworks (MOFs), a multifunctional platform Gd/Tm–PB@ZIF-8/PDA for cancer diagnosis and treatment was established. Doxorubicin (DOX) was selected as a drug model and the drug loading of Gd/Tm–PB@ZIF-8/PDA was found to be 81 mg g−1. Cytotoxicity analysis indicated that Gd/Tm–PB@ZIF-8/PDA was highly biocompatible. The DOX release at different pH values and GSH concentrations revealed an excellent pH/GSH-triggered drug release. Through the combination of the near infrared photothermal performance of Gd/Tm–PB, chemo-photothermal therapy can be achieved to further improve the anti-cancer efficiency. In addition, the Gd/Tm–PB@ZIF-8/PDA nanoparticles can be tracked by fluorescence imaging (FOI) and magnetic resonance imaging (MRI). Cell FOI and in vivo MRI experiments showed the potential application of Gd/Tm–PB@ZIF-8/PDA in dual mode imaging guided therapy. In vivo antitumor experiments demonstrated the higher anticancer efficacy of Gd/Tm–PB@ZIF-8/PDA with a combined effect of chemo-photothermal therapy. This work provides a new strategy for nano-drug carriers in the direction of integrated diagnosis and treatment.
研究领域:
纳米技术
·
生物医学工程
·
癌症研究
·
材料科学
·
药学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nanoscale
·
2018
·Vol. 10
·期 40
·19052-19063
·
IF 7.233
Yanlei Liu,Xiao Zhi,Wenxiu Hou,Fangfang Xia,Jingpu Zhang,Lexiang Li,Yuping Hong,Hao Yan,Chen Peng,Jesus Martinez de la Fuentea,Jie Song,Daxiang Cui
The development of multifunctional nanoparticles for tumor theranostics has become a research hotspot. Despite the advantages of non-invasive precision diagnostics and efficient drug-delivery, these nanoparticles bring two significant issues: (i) a potential toxic effect and (ii) difficult clearance. To solve these issues, carbon dots (C-dots) are key potential candidates owing to their unique properties, such as excellent biocompatibility and rapid renal clearance. However, their small size leads to a short circulation time in the blood, which causes non-sufficient tumor accumulation for antitumor therapy. To reach the balance between an efficient accumulation in a tumor and rapid clearance from the body, herein we report a new multifunctional nanoprobe: photosensitizer (chlorine e6, Ce6)-loaded assembled C-dots (A-C-dots@Ce6). The A-C-dots@Ce6 were assembled from negatively-charged discrete C-dots using Gd3+ ions as a “glue”. which also provided another function of in vivo nanoprobe monitoring via magnetic resonance (MR) imaging. Moreover, the nanoprobe exhibited an acidic pH-dependent disassembly and drug-release property. Benefiting from these advantages, the nanoprobe showed a targeted antitumor effect in A549 tumor-bearing mice under laser irradiation and gradual disassembly in the tumor for later body clearance. Therefore, the nanoprobe potentially provides a new strategy to solve the above balance issue, and brightens the future for antitumor monitoring and treatment.
研究领域:
纳米技术
·
生物医学工程
·
药学
·
材料科学
·
医学影像
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产品关联
DOI
PubMed
高影响因子
Optical Materials Express
·
2021
·Vol. 11
·期 9
·2828-2838
·
IF 3.442
Taisen Li,Jin Liu,Xinzhi Wang,Abdur Raheem Aleem,Yao Wang,Matt J. Kipper,Laurence A. Belfiore,Jianguo Tang
Multimodal nanoprobes are of great significance in clinical diagnosis, because they integrate the advantages of multiple imaging methods. The combination of multiple imaging modes provides more comprehensive and complex information than single-mode imaging, which can greatly improve clinical diagnoses. In this paper, Gd3+ and Tb3+ co-induced polyelectrolyte nanoaggregates (GTIPAs) are introduced as a novel dual-mode imaging probe. Containing gadolinium and terbium, GTIPAs are regular spherical nanoparticles, whose diameters are about 150 nm. As a fluorescent nanomaterial, GTIPAs have strong and stable luminescence intensity. At the same time, as an MRI contrast agent, GTIPAs exhibit a good contrast effect and a high longitudinal relaxation rate. In addition, the polyelectrolytes reduce the cytotoxicity of the complexes, confering excellent biocompatibility and water solubility. Therefore, GTIPAs are non-toxic luminescence/magnetic resonance dual-mode imaging probes.
研究领域:
纳米技术
·
医学成像
·
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF LUMINESCENCE
·
2017
·
IF 2.686
Wangmei He,Yunfei Xie,Qingguo Xing,Peilong Ni,Yingchao Han,Honglian Dai
Herein, a polyacrylic acid sol-gel method was presented to synthesize rare earth doped calcium phosphate nanocrystals (RE-CaP) as cell bioimaging agent. The effects of calcination temperature, calcination time and PAA concentration on phase composition , morphology, size and luminescence were discussed. In addition, the hemolysis, cytotoxicity, cell uptake and cell imaging of resulting RE-CaP nanocrystals were investigated. Results show that the increases in calcination temperature and time promote the transformation of product from impure crystalline phase (CaCO 3 , CaO) to pure CaP phase. The rise of calcination temperature results in significant enhancement of luminescence intensity. PAA concentration does not influence the crystalline phase composition and its increase leads to a little increase in luminescence intensity. In addition, the co-doping of Gd 3+ improves the luminescence intensity of Eu 3+ emissions. This method achieves the doping of Eu 3+ ions in the crystallographic Ca 2+ I and Ca 2+ II sites of HAP with a preferable occupation at Ca 2+ II site. The resulting RE-CaP nanocrystals (PAA: 0.6 mg/mL, Eu/Gd = 2:1.5, 600 °C, 3 h) show good biocompatibility and can be easily uptaken by cancer cells. The internalized nanocrystals show stable and strong red luminescence under visible wavelengths excitation. In summary, PAA sol-gel method can be used to synthesize biocompatible RE-CaP luminescent nanomaterials for cell bioimaging.
研究领域:
材料科学
·
纳米技术
·
生物医学工程
·
细胞生物学
✓ 已验证
产品关联
DOI
高影响因子
Advanced Optical Materials
·
2022
·Vol. 10
·期 10
·2102200
·
IF 10.05
Chong Zhao,Yingkui Li,Wanggui Ye,Xiaofei Shen,Zicheng Wen,Xuanyi Yuan,Yongge Cao,Chaoyang Ma
Colloidal all-inorganic lead halide perovskite nanocrystals (LHP NCs) feature with tunable high-efficiency photoluminescence from blue to red for optoelectronic applications but suffer from instability under water moisture, UV light illumination, high-temperature shock, as well as oxygen erosion. Previous work to improve LHP NCs stability was mainly focused on either glass bulk sealed LHP quantum dots (QDs) with low quantum efficiency, or mesoporous silica matrixes confined LHP QDs with organic ligands still existing. Here, a facile, noncolloidal, ligand-free LHP QDs growth with physical confinement is proposed by integrating the growth of perovskite QDs with the fabrication process of hydrophobic silica-aerogel powders (SAPs). As a result, the as-synthesized mono- and mixed-cesium-lead-halide QDs @ SAPs composites show tunable photoluminescence from purple to deep red. Besides, the Pr 3+ ions doped CsPbBr 3 QDs @ SAPs composites exhibit moderate quantum efficiency, excellent stability under UV illumination, water moisture as well as temperature variation. Furthermore, performances of white LED device encapsulated Pr 3+ doped composite with blue GaN chip and commercial red (Sr, Ca)AlSiN 3 :Eu 2+ phosphor are evaluated. This work demonstrates a facile and general strategy for synthesizing high-stable all-inorganic cesium-lead-halide QDs for applications in white LED and display devices.
研究领域:
材料科学
·
光电技术
·
纳米技术
·
光子学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）