CHEMICAL ENGINEERING JOURNAL
·
2021
·
IF 13.273
Donglin Liu,Mengjun Liu,Ying Wan,Xuesu Zhou,Shiping Yang,Lu An,Gang Huang,Qiwei Tian
Chemodynamic therapy (CDT) is a newly emerged, minimally invasive treatment with high selectivity, few side effects, and good prospects for clinical application. However, CDT does not effectively inhibit the growth of colon cancer, which has a strongly reducing tumor microenvironment owing to a high endogenous expression of H 2 S. To overcome this limitation, a new strategy is proposed to enhance the CDT of colon cancer by remodeling the microenvironment through depletion of endogenous H 2 S by CuFe 2 O 4 nanoparticles. After H 2 S depletion, the valence of Cu (II) and Fe (III) in CuFe 2 O 4 particles is reduced to Cu (I) and Fe (II) and photothermal properties of the nanoparticles are activated, both these effects enhance CDT. Further, in vitro and in vivo results demonstrate that endogenous H 2 S depletion by CuFe 2 O 4 particles induced three effects that synergistically enhanced the performance of CDT. In this study, the development of a new strategy to enhance the CDT of colon cancer is reported.
研究领域:
癌症研究
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纳米技术
·
治疗学
✓ 已验证
产品关联
DOI
高影响因子
Journal of Advanced Ceramics
·
2022
·Vol. 11
·期 3
·427-442
·
IF 11.534
Zhang Yu,Han Shuai,Wang Mingyuan,Liu Siwei,Liu Guiwu,Meng Xianfeng,Xu Ziwei,Wang Mingsong,Qiao Guanjun
One-dimensional nanofibers can be transformed into hollow structures with larger specific surface area, which contributes to the enhancement of gas adsorption. We firstly fabricated Cu-doped In 2 O 3 (Cu-In 2 O 3 ) hollow nanofibers by electrospinning and calcination for detecting H 2 S. The experimental results show that the Cu doping concentration besides the operating temperature, gas concentration, and relative humidity can greatly affect the H 2 S sensing performance of the In 2 O 3 -based sensors. In particular, the responses of 6%Cu-In 2 O 3 hollow nanofibers are 350.7 and 4201.5 to 50 and 100 ppm H 2 S at 250 °C, which are over 20 and 140 times higher than those of pristine In 2 O 3 hollow nanofibers, respectively. Moreover, the corresponding sensor exhibits excellent selectivity and good reproducibility towards H 2 S, and the response of 6%Cu-In 2 O 3 is still 1.5 to 1 ppm H 2 S. Finally, the gas sensing mechanism of Cu-In2O3 hollow nanofibers is thoroughly discussed, along with the assistance of first-principles calculations. Both the formation of hollow structure and Cu doping contribute to provide more active sites, and meanwhile a little CuO can form p–n heterojunctions with In 2 O 3 and react with H 2 S, resulting in significant improvement of gas sensing performance. The Cu-In 2 O 3 hollow nanofibers can be tailored for practical application to selectively detect H 2 S at lower concentrations.
研究领域:
材料科学
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纳米技术
·
化学
✓ 已验证
DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2019
·
IF 6.393
Shuqin Yang,Zhilong Song,Naibo Gao,Zhixiang Hu,Licheng Zhou,Jingyao Liu,Baohui Zhang,Guangzu Zhang,Shenglin Jiang,Hua-Yao Li,Huan Liu
Indium oxide (In 2 O 3 ) nanomaterials have been investigated extensively as promising candidates for gas sensor applications. Here, we fabricate near room temperature operable H 2 S-sensitive gas sensors based on In 2 O 3 colloidal quantum dots (CQDs). Room-temperature film deposition of In 2 O 3 CQDs followed by surface ligand exchange treatment through Cu inorganic salts was employed to construct the sensor devices. Combined with a moderate annealing treatment, the long-chain ligands surrounding the quantum dot surfaces were completely removed to enhance gas adsorption and carrier transport, simultaneously resulting in the formation of CuO that may act as a catalytic promoter or form p-n heterojunction for selective H 2 S detection. The sensors exhibited high response up to 90 toward 5 ppm of H 2 S with response/recovery time of 72 s/200 s respectively, suggestive of a performance improvement compared to the In 2 O 3 -based H 2 S sensors reported in existing literature. The power law analysis indicated that the main oxygen species adsorbed on the surfaces were O 2 − and O − with the proportion of approximate 1:1 at near room temperature. The gas-sensing mechanism was attributed to the decisive role of surface states in determining the electrical conduction of quantum dot gas sensors.
研究领域:
材料科学
·
传感器技术
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纳米科技
✓ 已验证
产品关联
DOI
高影响因子
Catalysts
·
2022
·Vol. 12
·期 2
·236
·
IF 4.501
Xinlei Yu,Xun Tao,Yunfei Gao,Lu Ding,Yanqin Wang,Guangsuo Yu,Fuchen Wang
Compared to the Claus process, selective H2S catalytic oxidation to sulfur is a promising reaction, as it is not subject to thermodynamic limitations and could theoretically achieve ~100% H2S conversion to sulfur. In this study, we investigated the effects of Co and Fe co-doping in ABO3perovskite on H2S selective catalytic oxidation. A series of LaFexCo1−xO3(x = 0, 0.2, 0.4, 0.6, 0.8, 1.0) perovskites were synthesized by the sol-gel method. Compared to LaFeO3and LaCoO3, co-doped LaFexCo1−xO3significantly improved the H2S conversion and sulfur selectivity at a lower reaction temperature. Nearly 100% sulfur yield was achieved on LaFe0.4Co0.6O3under 220 °C with exceptional catalyst stability (above 95% sulfur yield after 77 h). The catalysts were characterized by XRD, BET, FTIR, XPS, and H2-TPR. The characterization results showed that the structure of LaFexCo1−xO3changed from the rhombic phase of LaCoO3to the cubic phase of LaFeO3with Fe substitution. Doping with appropriate iron (x = 0.4) facilitates the reduction of Co ions in the catalyst, thereby promoting the H2S selective oxidation. This study demonstrates a promising approach for low-temperature H2S combustion with ~100% sulfur yield.Keywords:hydrogen sulfide;selective oxidation;perovskite oxides;oxygen vacancy
研究领域:
催化
·
材料科学
·
环境化学
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Nano Materials
·
2025
·
IF 5.5
Shiqi Wu,Yuxuan Ge,Yuan Peng,Yunsheng Chen,Zheng Zhang,Yixin Zhang
Diabetic wound healing is a great challenge among diabetic patients, and it is a complex dynamic process involving inflammatory and angiogenesis responses. Anti-inflammation and pro-angiogenesis are key issues in diabetic wound healing. Herein, an H2S/curcumin coreleasing biomineralized zinc sulfide (named HZSC) is developed to promote diabetic wounds healing. The prepared HZSC features a nanoscale size of 166 ± 6.4 nm as well as a unique structure of HA loading Cur and coating ZnS biomineralized nanoclusters. After being applied in the mildly acidic diabetic wound tissue, the prepared HZSC controllably coreleases H2S and curcumin to promote macrophage polarization to the M2 phenotype, reduce reactive oxygen species levels, as well as enhance angiogenic factors. According to the results of both in vitro/vivo studies, HZSC can affect macrophage phenotype polarization, stimulate vascular endothelial cell migration and tube formation, accelerate the wound transition into the repair and proliferation stages, and then promote the diabetic wound healing. RNA sequencing analysis supports that HZSC downregulates TNF, NF-κB, and JAK-STAT pathways while upregulating genes associated with anti-inflammation and pro-angiogenesis. Our findings introduce a therapeutic approach to promote diabetic wound healing through H2S/curcumin coreleasing, improving anti-inflammation and pro-angiogenesis.
研究领域:
生物材料学
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药理学
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分子生物学
✓ 已验证
产品关联
DOI
高影响因子
ACS Sensors
·
2022
·
IF 9.618
Haoming Sun,Meng Cao,Pinhua Zhang,Xiaojing Tian,Manli Lu,Lulu Du,Kaifeng Xue,Guangliang Cui
Magnetism is a promising external intervention for gas sensitivity based on a heterogeneous interfacial structure caused by the regulation of the heterogeneous interface conductivity and the surface oxygen adsorption. In this study, Cu2O/NiO heterostructure-ordered nanoarrays were prepared with a two-dimensional (2D) electrodeposition in situ assembly method for H2S gas detection at room temperature under the action of a magnetic field. The nanoarrays were multibarrier structures with a strictly periodic structure that was greater than hundreds of microns in size. The experimental data confirmed that the response of 50 ppm of H2S based on the nanoarrays was improved by nearly 61% with a relatively weak magnetic field. Particularly at a low concentration (≤20 ppm), the effect of the magnetic field enhancement on the sensitivity was more obvious. We attributed the enhancement of the gas sensitivity with the magnetic field to the regulation of the Cu2O–NiO interface conductance and the surface oxygen adsorption. This study demonstrated that a magnetic field could significantly enhance the gas sensitivity based on heterostructures. Results of this study provide an important reference for the application of magnetism in gas detection and the design of new gas-sensitive materials.
研究领域:
材料科学
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传感器技术
·
物理化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Sensors
·
2023
·
IF 8.9
Manli Lu,Junyu Chi,Huijuan Chen,Zongxu Liu,Pengfei Shi,Zheng Lu,Liang Yin,Lulu Du,Li Lv,Pinhua Zhang,Kaifeng Xue,Guangliang Cui
Developing a respiratory analysis disease diagnosis platform for the H2S biomarker has great significance for the real-time detection of various diseases. However, achieving highly sensitive and rapid detection of H2S gas at the parts per billion level at low temperatures is one of the most critical challenges for developing portable exhaled gas sensors. Herein, Cu2O-multiwalled carbon nanotube (MWCNT) heterostructures with excellent gas sensitivity to H2S at room temperature and a lower temperature were successfully synthesized by a facile two-dimensional (2D) electrodeposition in situ assembly method. The combination of Cu2O and MWCNTs via the principle of optimal conductance growth not only reduced the initial resistance of the material but also provided an ideal interfacial barrier structure. Compared to the response of the pure Cu2O sensor, that of the Cu2O-MWCNT sensor to 1 ppm of H2S increased nearly 800 times at room temperature, and the response time decreased by more than 500 s. In addition to the excellent sensitivity with detection limits as low as 1 ppb, the Cu2O-MWCNT sensor was extremely selective with low-temperature adaptability. The sensor had a response value of 80.6 to 0.1 ppm of H2S at −10 °C, which is difficult to achieve with sensors based on oxygen adsorption/desorption mechanisms. The sensor was used for the detection of real oral exhaled breath, confirming its feasibility as a real-time disease monitoring sensor. The Cu2O-MWCNT heterostructures maximized the advantages of the individual components and laid the experimental foundation for future applications of highly sensitive portable breath analysis platforms for monitoring H2S.
研究领域:
材料科学
·
医学诊断
·
纳米技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FUEL
·
2025
·
IF 7.5
Guopei Zhang,Cong Wang,Xiaoyang Zhang,Yong Dong,Zhaomin Li,Leteng Lin
A novel Cu 2 LaO 4 /ZSM-5 sorbent was synthesized using the sol–gel method, and the role of H 2 S in enhancing Hg⁰ removal was investigated through experimental and theoretical approaches. Mercury removal performance was evaluated in a fixed-bed reactor under simulated syngas conditions, revealing that H 2 S significantly promoted removal efficiency, achieving 95.6 % at 200 °C. In contrast, H 2 and CO inhibited Hg 0 removal by depleting surface oxygen species. The addition of H 2 S mitigated these effects, facilitating Hg 0 adsorption and oxidation via a Langmuir–Hinshelwood mechanism. Density functional theory (DFT) calculations confirmed strong chemisorption of Hg 0 and H 2 S on the Cu 2 LaO 4 surface, with adsorption energies of −123.71 kJ/mol and −168.98 kJ/mol, respectively. The reaction to form HgS had a manageable energy barrier of 25.80 kJ/mol and an exothermic enthalpy of −196.82 kJ/mol, with HgS formation as the rate-limiting step. This study highlights the effectiveness of Cu 2 LaO 4 /ZSM-5 for mercury capture and its potential application in industrial syngas purification.
研究领域:
环境科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
Scientific Reports
·
2024
·Vol. 14
·期 1
·1-14
·
IF 3.8
Shen Cong,Yan Jing,Ai Zhipeng,Huang Hongbing,Mo Lin,Liang Bangzhi,Zhang ChangHui
Adding corrosion inhibitors is considered to be a cost-effective way to inhibit metal corrosion. In this study, we report the synthesis of a bi-mannich base corrosion inhibitor (BMT) with an impressive inhibition efficiency on carbon steel in H 2 S and HCl co-existing solution. At the BMT concentration of 9 ppm, the inhibition efficiency (η) of 96.9%, 97.6% and 98.0% were determined by weight loss, potentiodynamic polarization and electrochemical impedance spectroscopy, respectively. The adsorption of BMT on the carbon steel surface follows the Langmuir adsorption isotherm, and the calculated free energy indicates that the adsorption is a spontaneous process. This research also delves into understanding the adsorption behavior and corrosion inhibition mechanism of BMT on carbon steel surfaces through quantum chemistry calculations. The results of this study provide guidance for the application of BMT as a corrosion inhibitor in sour and acid environments.
研究领域:
材料科学
·
电化学
·
量子化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FASEB JOURNAL
·
2025
·Vol. 39
·期 5
·e70420
·
IF 4.2
Min Zhu,Xiaofang Fan,Nan Zhang,Hui Wang,Jianshe Ma,Xianghong Yin,Junyan Cai,Linjing Cong,Ran Chen,Junming Fan,Xiaoxia Kong,Bin Geng,Yongsheng Gong,Congkuo Du
Endothelial pyroptosis, a pro-inflammatory programmed cell death, promotes endothelial inflammation and is a pivotal process in the initial stage of acute lung injury (ALI). Hydrogen sulfide (H 2 S), a gasotransmitter primarily dependent on cystathionine γ-lyase (CSE) in the cardiovascular and respiratory systems, plays a protective role during ALI. Nonetheless, the modulatory role and precise molecular mechanism of endothelial endogenous CSE/H 2 S in the pathogenesis of ALI remain elusive. Herein, we prepared an ALI mouse model using intratracheal administration of LPS (5 mg/kg), and lung injury was assessed by evaluating pulmonary edema, inflammatory response, and endothelial pyroptosis. In this model, H 2 S production from pulmonary tissues declined in a time-dependent manner, accompanied by a compensatory elevation of CSE protein levels. Treatment with the H 2 S donor (NaHS) attenuated pulmonary edema, inflammatory cell infiltration, endothelial pyroptosis, and reduced serum levels of tumor necrosis factor-alpha (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6). Meanwhile, the inducible deletion of CSE in endothelial cells exacerbated these changes. The blocking effect of CSE/H 2 S on endothelial pyroptosis (evidenced by caspase-11 activation and GSDMD-NT formation) was also confirmed in cultured pulmonary microvascular endothelial cells (PMECs). Mechanistically, H 2 S-mediated regulation of sirtuin-1 (SIRT1) expression and activation (via sulfhydration) contributed to the modulatory process. Collectively, we uncovered that endothelial endogenous CSE/H 2 S alleviates endothelial pyroptosis by activating SIRT1, thereby preventing LPS-induced acute lung injury. Graphical In the LPS-induced ALI model, caspase-1-independent pyroptosis was activated. The expression of activated caspase-11 and GSDMD-NT was increased, accompanied by pulmonary edema and inflammatory infiltration. Endothelial CSE/H 2 S deficiency aggravated endothelial pyroptosis and acute lung injury. Mechanistically, endothelial endogenous CSE/H 2 S mediated the expression and activation of sirtuin-1 (SIRT1) via sulfhydration, one of the post-translational modifications. Activated SIRT1 inhibited the activation of caspase-11 and GSDMD-NT to inhibit endothelial pyroptosis, thereby alleviating acute lung injury.
研究领域:
医学
·
分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS ES&T Engineering
·
2024
·
IF 7.4
Peijin Zou,Zhuangzhuang Ma,Zihuan Tang,Xiaotong Gao,Xiaoxiong Hou,Lichao Jia
Achieving the real-time detection of hydrogen sulfide (H2S) based on metal oxide semiconductor (MOS) gas sensors is of great significance for rapid disease diagnosis. However, the high-power consumption and poor selectivity severely limit its practice application. In this study, a platinum nanoparticle (Pt NPs)-loaded porous metal–organic framework (MOF)-derived SnO2 material was successfully synthesized to optimize the H2S-sensing performance at room temperature. The optimized Pt-loaded porous SnO2-based gas sensor exhibited remarkably high sensitivity (712–10 ppm), fast response (21 s), good selectivity, and extremely low detection limit for H2S (10 ppb) at room temperature. The in-depth analysis demonstrated that the porous structure of Sn-MOF can provide adequate active reaction sites for gas molecules. Moreover, the uniform distribution of surface-loaded Pt NPs can initiate electron and chemical sensitization effects, thereby improving the sensing performance. The successful application of Pt NPs provides a novel approach to improve the room-temperature (RT) sensing performance of metal-oxide-semiconductor-based gas sensors.
研究领域:
材料科学
·
医学诊断
·
传感器技术
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Ying Yin,Wentai Guo,Qiangyu Chen,Zhimin Tang,Zheng Liu,Ruibin Lin,Ting Pan,Jiezhao Zhan,Li Ren
Diabetic wound healing presents a significant medical challenge and requires multistep interventions due to comprehensive wound environments, such as hyperglycemia, bacterial infection, and impaired angiogenesis. However, current multistep interventions are complicated and need on-demand sequential release and synergy of multicomponents. Herein, a H2S-releasing cascade nanozyme (FeS@Au), which is composed of ultrasmall gold nanocluster (AuNC) loaded on ferrous sulfide nanoparticle (FeSNP), is developed as a single component to regulate glucose level, eliminate infection, and promote angiogenesis, achieving multistep interventions for comprehensive diabetic wound treatment. The glucose oxidase-like activity of AuNC catalyzes glucose into gluconic acid and H2O2, which not only lowers the local glucose level but also decreases the local pH and increases H2O2 level to boost the peroxidase-like activity of FeSNP to generate abundant hydroxyl radical (reactive oxygen species, ROS), inducing ferroptosis-like death in drug-resistant bacteria. Additionally, FeSNP release H2S in the acidified environment to upregulate hypoxia-inducible factor-1 to enhance vascularization through upregulating the expression of vascular endothelial growth factor (VEGF) and other angiogenesis-related genes, reducing the damage to endothelial cells caused by excessive ROS produced by the nanozyme. In a full-thickness MRSA-infected diabetic rat model, FeS@Au significantly eliminates bacteria, enhances angiogenesis, promotes collagen deposition, and accelerates wound healing. This work presents a single nanozyme with H2S-release for multistep interventions, providing a versatile strategy for healing extensive tissue damage caused by diabetes.
研究领域:
生物医学工程
·
药理学
·
纳米医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）