JOURNAL OF NATURAL PRODUCTS
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2026
·
IF 3.7
Zheng-Biao Zou,Zi-Han Xu,Xiao-Wei Zhao,Chun-Lan Xie,Shan-Shan Nie,Lei Wang,Xian-Wen Yang
Abstract Eight new eremophilane sesquiterpenes (eremopenicillins A−H, 1−8) were isolated from the deep-sea-derived fungus Penicillium roseopurpureum, along with eight known congeners (9−16). Their structures were elucidated by comprehensive 1D and 2D NMR spectroscopy and HRESIMS analysis, combined with theoretical calculations on the electronic circular dichroism (ECD), NMR chemical shifts, and optical rotations (OR), as well as DP4+ probability analysis. Compounds 1 and 10 showed remarkable anti-neuroinflammatory activity. Quantitative proteomic analysis and molecular dynamics simulations identified NOS2 as their primary molecular target. These two compounds significantly alleviated neurotoxic damage in zebrafish models induced by lipopolysaccharide (LPS), aluminum chloride (AlCl3), and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). They not only show promising therapeutic potential for human neurodegenerative diseases, but also represent valuable candidates for the prevention and control of neurotoxic injury caused by environmental pollutants in aquaculture.
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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
·
2023
·Vol. 24
·期 2
·1469
·
IF 5.6
Fengjing Jia,Qun Yu,Ruolei Wang,Ling Zhao,Fuwen Yuan,Haidong Guo,Yunhui Shen,Feng He
Colorectal cancer (CRC) is a major health burden worldwide due to its high morbidity, mortality, and complex etiology.Fusobacterium nucleatum(Fn), a Gram-negative anaerobe found in 30% of CRC patients, promotes CRC carcinogenesis, metastasis, and chemoresistance. Effective antimicrobial treatment is an unmet need for the rising CRC burden. Antimicrobial peptides (AMPs) represent a new class of antimicrobial drugs. In our previous study, we did the structure-activity study of Jelleine-I (J-I) and identified several halogenated J-I derivatives Cl-J-I, Br-J-I, and I-J-I. To determine whether those J-I derivatives can be a new therapy for bacterial-associated CRC, here we tested the antibacterial activities of these AMPs againstFnand their effects on CRC development. We found that Br-J-I showed the highest anti-Fnactivity and Br-J-I may target membrane-associated FadA forFnmembrane disruption. More importantly,Fnpromoted the growth of CRC cells-derived xenograft tumors. Br-J-I suppressedFnload, colon inflammation, andFn-induced CRC growth. Of note, Br-J-I induced better anti-CRC effects than common antibiotic metronidazole and Br-J-I sensitized the cancer-killing effect of chemotherapy drug 5-fluorouracil. These results suggest that Br-J-I could be considered as an adjunctive agent for CRC treatment and AMPs-based combination treatment is a new strategy for CRC in the future.Keywords:colorectal cancer;fusobacterium nucleatum;antimicrobial peptides;adjunctive therapy;antimicrobial treatment
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Journal of Cleaner Production
·
2023
·
IF 11.1
Kang Li,Junjie Xie,Zhuonan Shi,Changli Min,Zichen Yin,Ruixin Ma,Shina Li
Rubidium and cesium are highly-priced and important rare alkali elements but they always co-exist with large amount of sodium and potassium in a complex system resulting very difficult and expensive to recover. Hexacyanoferrates (MHCFs) is one of the most efficient methods to separate Rb + and Cs + if we don't consider certain drawbacks such as too small particle size and too viscous liquids to be precipitated. In this study, a new kind of hexacyanoferrate, magnesium (II) hexacyanoferrate (RbCs–MgHCF) has been fabricated at room temperature and applied for the first time to recover Rb + and Cs + from high-salty solutions. Compared with traditional divalent transition elements, such as CuHCFs, ZnHCFs, NiHCFs, CoHCFs or FeHCFs, RbCs–MgHCF had excellent precipitation property and large particle size of about 300 nm. The structure, morphology and composition were characterized by Fourier transform infrared (FTIR), X-ray diffraction (XRD), Scanning electron microscopy (SEM), Inductively coupled plasma (ICP), and Energy dispersive spectroscopy (EDS). The effects of various factors (divalent metal cations, surfactant, Mg 2+ /(Rb + +Cs + ) mole ratio, pH value and titration rate) on the recovery of Rb + and Cs + were explored in 50 mL batch experiments. Scale-up experiment were conducted in 6 and 18 L. Results identified that deposition ratio for Cs + and Rb + were 99% and 95% among pH ranges of 4.0–11.0. The composition of RbCs–MgHCF was confirmed to be Rb 0.61 Cs 1.20 K 0.17 Mg 1.01 Fe(CN) 6 by ICP and EDS and the synthesis mechanism of RbCs–MgHCF is proposed.
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APPLIED ORGANOMETALLIC CHEMISTRY
·
2019
·Vol. 33
·期 3
·e4778
·
IF 3.259
Jicheng Xu,Zhilong Pu,Xuechao Xu,Yuanyuan Wang,Dongya Yang,Tao Zhang,Fengxian Qiu
With the gradual exhaustion of land mineral resources, oceans and lakes have attracted world attention because they are abundant in inorganic mineral resources including lithium, potassium, rubidium and cesium. Lithium is becoming the key material in manufacturing of primary and secondary batteries used in various portable devices and hybrid/electric vehicles. Rubidium has been widely applied inglobal positioning satellites, magneto-optic modulators, solid-state lasers, phosphors, and glass manufacturing. In this work, a novel dual-functional magnetic ion imprinting polymer (Fe 3 O 4 @SiO 2 @IIPs) powder was prepared using 12-crown-4 (12C4) and 18-crown-6 (18C6) as functional monomer, and characterized by FT-IR, elemental analysis, XRD, TGA, SEM and TEM. The adsorption performance of Fe 3 O 4 @SiO 2 @IIPs for simultaneous adsorption of lithium and rubidium from simulative salt lakes was evaluated by batches of experiments at various pH values, contact time, and initial concentrations. Kinetic experiments show that the adsorption process followed the pseudo second order kinetic model. Langmuir adsorption isotherm model and Freundlich adsorption equilibrium data were fitted; the results show that Langmuir isotherm model is more suitable for the adsorption process. Additionally, Fe 3 O 4 @SiO 2 @IIPs exhibit specificity towards Li(I) and Rb(I) and low competitive behavior with Na(I), K(I) and Mg (II). Additionally, the selectivity properties, reusability and adsorption thermodynamic were also investigated. The obtained results show that the prepared Fe 3 O 4 @SiO 2 @IIPs material remains high adsorption capacities after five cycles, exhibits excellent abilities to simultaneously and selectively recover Li + and Rb + and have a promising application in the simultaneous adsorption of lithium and rubidium ions.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2026
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IF 6.7
Ning-Yu Lei,Qian-Qian Zou,Xin Wang,Wei-Wei He,Xiao-Xiao Song,Jun-Yi Yin
Abstract Morchella spp., a kind of prized edible mushrooms, is widely cultivated and consumed in China. The α-(1 → 4)-glucans have been identified as one of their major polysaccharides, yet the classification of these glucans as glycogen analogs remains ambiguous and restricts subsequent research. This study aimed to comprehensively characterize glycogen-like α-glucans (30-fractions) isolated from Morchella sextelata across five geographical origins and evaluated structural variations. The α-glucans shared a conserved α-(1 → 4)-backbone, which was confirmed by HILIC–UHPLC–ESI––MS/MS fingerprinting and NMR spectra. TEM revealed typical glycogen α-particles (125–185 nm) and β-particles, further supported by Raman spectra combined with PCA. While SEC-MALLS revealed geographically varied Mw (1141.0–2174.0 × 104 g/mol), their core structures appeared to be highly conserved. They consistently showed near-spherical conformation, low-viscosity, and shear-thinning rheological behavior. This systematic structural identification confirms the glycogen-like nature of the target glucan and provides fundamental structural support for its potential exploitation in functional foods and nanodelivery systems.
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ACS Catalysis
·
2026
·
IF 13.6
Qi Wang,Yimin Xuan,Ke Gao,Liang Teng,Longzhen Zhang,Jin Wang,Xianglei Liu
Abstract Solar-driven thermochemical CO2 splitting is a scalable and promising approach for establishing a carbon-neutral energy system. However, its extremely high conversion temperatures greatly limit its energy efficiency and widespread application. This extreme temperature requirement is fundamentally dictated by the thermodynamic bottleneck of lattice-oxygen activation. Here, we propose an interfacial charge regulation strategy that couples photogenerated carriers with thermochemical lattice-oxygen redox within a heterostructured perovskite-ceria composite. This design creates multimodal synergy among light-driven charge generation, interfacial charge regulation, and thermally activated lattice-oxygen redox. For the designed CaMn0.875Ti0.125O3/CeO2 composite, in situ characterizations and theoretical calculations reveal that charge redistribution facilitates the electronic population of metal−oxygen antibonding states. This targeted electronic population weakens specific metal−oxygen bonds, modulating the local oxygen vacancy formation energy and promoting highly reactive CO2·− radical anion formation. Consistent with this field-driven interfacial regulation, the composite delivers a CO yield of 1017.48 μmol g−1 at a substantially lowered operating temperature of 860 °C, a 300-fold enhancement over the purely thermal baseline. Ultimately, this work moves beyond conventional charge-separation models by identifying rational interfacial field engineering as an electronic strategy to modulate local defect thermodynamics for high-efficiency CO2-to-fuel conversion.
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Nature Communications
·
2026
·
IF 18.1
Zhai Mengde,Wu Tianhao,Du Kaihuai,Chen Cheng,Shibayama Naoyuki,Narmandakh Khongorzul,Khan Abdul Haseeb Hassan,Wang Ying-Chiao,Shang Juan,Staykov Aleksandar,Song Jun Tae,Ida Shintaro,Wang Pangpang,Yamada Sunao,Tamada Kaoru,Zhao Shuai,Wang Aili,Guo Zhanglin,Matsushima Toshinori,Miyasaka Tsutomu,Cheng Ming
Self-assembled molecules are widely used as bottom interfacial layers in inverted perovskite solar cells, yet their application to perovskite top surfaces remains poorly understood. Here, we develop two self-assembled molecules for perovskite surface modification and interfacial optimization with the hole transport layer. Through solvent engineering, ordered and uniform molecular packing is achieved on the perovskite surface. These molecules optimize surface energetics and promote efficient hole transfer when coupled with a homologous hole transport layer. Their large molecular dipoles tune interfacial energy alignment and reduce energetic offsets, thereby accelerating charge extraction from the perovskite layer. This dipole-driven interfacial modulation is effective in both normal and inverted device architectures. As a result, a power conversion efficiency of 26.18% (certified 26.23%) is achieved in normal-structure devices, together with improved operational stability under maximum power point tracking. This work establishes a viable strategy for perovskite surface engineering using self-assembled molecules.
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EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
·
2022
·Vol. 2022
·期 21
·e202200176
·
IF 2.551
Guanyu Ma,Yun Tang,Leyi Chen,Lubing Qin,Quanli Shen,Likai Wang,Zhenghua Tang
Graphical We report a novel homoleptic alkynyl-protected Au(I)9-Ag(I)9 cluster, which features an intriguing ichthyomorphic assembled core structure. It shows distinct absorbance feature and luminescence properties in solution and in the solid state. Interestingly, it has excellent catalytic performance in both the hydrogen evolution reaction and the reduction of 4-nitrophenol. We report the structure analysis, optical property, and catalytic implications of homoleptic alkynyl-protected Au(I)-Ag(I) nanocluster, namely Au 9 Ag 9 (C≡CAr F ) 18 (abbreviated as Au9 Ag9 hereafter). Single crystal X-ray diffraction analysis disclosed that, the core of Au 9 Ag 9 cluster features intriguing ichthyomorphic assembled structure driven by metallophilic interactions and Au-acetylide linkages. The Au 9 Ag 9 nanocluster is fluorescent in both solution and solid state, and it has much higher quantum yield in solid state. In the electrochemical hydrogen evolution reaction (HER) test, Au 9 Ag 9 nanocluster exhibits a favorable overpotential of 274 mV at 10 mA cm −2 with a Tafel slope of 99 mV dec −1 , which markedly surpass than the [Au(C≡C-Ar F )] f and [Ag(C≡C-Ar F )] f control samples. Furthermore, Au 9 Ag 9 nanocluster shows much higher activity than the other two to catalyze the reduction of 4-nitrophenol.
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Nano Research
·
2023
·Vol. 17
·期 5
·4437-4443
·
IF 9.9
Zhong Junsen,Huang Bingkun,Yang Kunjie,Ma Zuju,Du Lingyu,Luo Ning,Tang Fengjiao,Hou Chuanxin,Jiang Fuyi,Kang Litao
The electrochromic (EC) mechanisms of inorganic materials are usually based on reversible cation insertion/extraction or metal deposition/dissolution, which are plagued by ion trapping and dendrite growth, respectively. In this paper, a novel conversion-type electrochromic mechanism is proposed, by making good use of the CuI/Cu redox couple. This CuI-based electrochromic system shows a neutral color switching from transparent and dim grey. By simply increasing the bleaching voltage, \({{\rm{I}}_3}^ - /{{\rm{I}}^ - }\) redox couple can be further activated. The generated \({{\rm{I}}_3}^ - \) will readily react with Cu, effectively improving the conversion reversibility and thereby rejuvenating the degraded electrochromic performance. Thanks to the well-designed electrode and the self-healing ability, this conversion electrochromic system achieves rapid response times ( t coloring : 23 s, t bleaching : 6 s), decant optical modulation amplitude (26.4%), high coloration efficiency (86.15 cm 2 ·C −1 ), admirable cyclic durability (without performance degradation after 480 cycles) and excellent optical memory ability (transmittance variation < 1% after 10 h open-circuit storage). The establishment of this conversion-type electrochromism may inspire the exploration of novel electrochromic materials and devices.
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ACS Catalysis
·
2026
·
IF 13.6
Guosong Wang,Dong Zhang,Yihui Song,Haitao Meng,Dan Li,Chong Peng
Abstract Hydrodeoxygenation (HDO) of lignin derivatives is a promising strategy for biomass utilization, but its catalytic performance is often unsatisfactory for non-noble metal catalysts. This hinders the industrialization process of biomass utilization. Herein, we obtained a FeNi-Cop catalyst with a tightly coupled interface between FeNi alloy and NiO by a hydrotalcite-derived strategy. The effect of this interface on the p-cresol HDO was studied by XRD, HRTEM, H2-TPR, NH3-TPD, XPS, in situ FTIR, and DFT calculations. FeNi-Cop catalyst facilitates hydrogen activation and can promote the dehydration reaction of methylcyclohexanol, a key intermediate, through the electronic regulation of the interface and acid sites. High space-time yield (STY) of methylcyclohexane was obtained, and good catalytic performance could be maintained after 10 cycles. This tightly coupled alloy/oxide interface provides a feasible approach for the design of non-noble metal catalysts.
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Nature Communications
·
2022
·Vol. 13
·期 1
·1-13
·
IF 17.694
Xiao Kui,Zhang Niyuan,Li Feifei,Hou Dayong,Zhai Xiaoyi,Xu Wanhai,Wang Gelin,Wang Hao,Zhao Liang
Medicinal applications of gold complexes have recently attracted attention due to their innovative antitumor mechanisms. In this work, two hypercoordinated carbon-centered gold clusters PAA4 and PAA5 are quantitatively synthesized by an intramolecular 6- exo - dig cyclization of polymetalated precursors. The on-bench and in vitro experimental studies demonstrate that the characteristic hypercarbon-tetragold(I) multi-center bonding in PAA4 and PAA5 not only guarantees their stability under common physiological conditions, but also facilitates a glutathione (GSH)-triggered prompt and synergetic release of active Au(I) ions in the GSH-overexpressed and acidic microenvironment of human bladder cancer EJ cells. The instantly massive release of coordination unsaturated Au(I) ions causes the efficient inhibition of thioredoxin reductases and then induces a rapid pro-oxidant response, consequently causing the occurrence of accelerated ferroptosis of EJ cells. As a result, these hypercarbon-centered gold(I) cluster prodrugs show high cytotoxicity to bladder cancer cell lines and thus exhibit a significant inhibition effect towards bladder tumors in vivo. Correlation of the synergetic domino dissociation of carbon-polymetal multi-center bonding in metal clusters with the accelerated ferroptosis of cancer cells provides a strategy for metallo-prodrugs and opens a broader prospect for the biological application of metal cluster compounds.
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JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2026
·
IF 2.4
Jun Wang,Junmeng Sha,Gang Li,Teng Liu,Chunxiang Huang,Xueni Sun,Hui Shao
Abstract The thin-film release solution for photoresists, formulated with propylene glycol methyl ether (PM) and cyclopentanone (CPO), is widely used in semiconductor processes; however, it is difficult to separate due to concentration-dependent effects. This research focused on examining the vapor–liquid phase equilibria of three binary mixtures composed of the extractive distillation entrainer N-methylpyrrolidone (NMP) and the close-boiling components─propylene glycol monomethyl ether (PM) or cyclopentanone (CPO)─namely, the NMP–PM, NMP–CPO, and CPO–PM systems. In contrast, the intermolecular interactions between NMP and PM are stronger than those in the other two systems. Furthermore, the relative volatility of CPO compared to PM is also influenced by NMP. The experimental data have demonstrated excellent thermodynamic consistency upon verification. A regression analysis of binary-system vapor-liquid equilibrium data was conducted using the Wilson, NRTL, and UNIQUAC models, with the UNIQUAC model demonstrating superior predictive performance. At solvent molar fractions of 0.7, 0.8, and 0.9, employing the UNIQUAC model, compositional impacts on PM/CPO relative volatility were evaluated to estimate the minimum equilibrium stages necessary for effective distillative separation. This research has demonstrated the feasibility and effectiveness of using NMP for extraction and distillation separation of PM/CPO at both experimental and theoretical levels.
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