COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2021
·
IF 4.539
Jinsheng Zhou,Yugui Sun,Zixiang Huang,Zhongkuan Luo,Bin Yu,Xianghui Zou,Huiyuan Hu
A novel g-C 3 N 4 @InVO 4 semiconductor catalyzed surface-initiated photo atom transfer radical polymerization without catalysts residues problem has been developed. This method proceeded in N-methyl pyrrolidone/aqueous under atmospheric conditions. To verify the versatility of this method and enhance the antifouling properties of polyvinyl alcohol (PVA) hydrogel, two types of fluorinated polymer brushes (p6F/p13F) were successfully constructed on PVA hydrogel surface instead of the subsurface. The chemical bonds between PVA matrix and fluorinated polymer brushes (p6F/p13F) enhanced the surface cross link density and resulted in an increase of thermal stability and mechanical properties. All fluorinated PVA hydrogels with excellent antifouling properties was able to tackle the biofouling problem in complex environment of the human body. In addition, all fluorinated PVA hydrogels was no cytotoxicity for L929 and NDHF according to ISO 10993.5:2009. g-C 3 N 4 @InVO 4 catalyzed SI-photoATRP provides a novel surface modification technology for various biological or medical materials in the industrial-scale application.
研究领域:
材料科学
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聚合物化学
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生物医学工程
·
表面科学
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DOI
高影响因子
Biomedical Materials
·
2020
·Vol. 15
·期 2
·025007
·
IF 3.174
Huaxin Lv,Sisi Cui,Hui Zhang,Xuejing Pei,Zhihua Gao,Junli Hu,Yifa Zhou,Yichun Liu
Its hydrophilic property and poor water resistance prevent the application of starch in electrospun nanofibers for biomedical applications. In this paper, we apply a periodate oxidation–adipic acid dihydrazide crosslinking strategy to electrospun starch nanofibers and develop a new nanofiber material with excellent mechanical strength, superior water resistance, and excellent cytocompatibility. The crosslinked starch nanofiber membranes exhibit a Young's modulus up to 2.65 MPa in the wet state, can maintain 91.0% of their initial mass after four weeks' incubation in simulated body fluid, and do not cause toxicity to L929 fibroblast cells. The control nanofibers prepared with a conventional glutaraldehyde crosslinking strategy show only a 60 kPa Young's modulus, retain only 31.9% of their initial mass after four weeks in simulated body fluid, and cause toxicity to cells. The crosslinked starch nanofibers with high mechanical strength, excellent water resistance and good biocompatibility are promising for biomedical applications.
研究领域:
材料科学
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生物医学工程
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纳米技术
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产品关联
DOI
PubMed
高影响因子
POLYMERS FOR ADVANCED TECHNOLOGIES
·
2022
·Vol. 34
·期 4
·1209-1219
·
IF 3.348
Wenju Hu,Haozhi Sun,Lixia Pan,Chaoqun Zhang,Xin Shen,Feng Su,Jie Song
The encapsulation and release of hydrophobic drugs from polymersomes are of great importance in drug delivery. A significant challenge is to enhance the encapsulation capacity of finding better drug-polymer compatibility. Herrin, poly(trimethylene carbonate)-b-poly(ethylene glycol) (PTMC-PEG) diblock copolymers were successfully synthesized by ring opening polymerization of trimethylene carbonate using monomethoxy poly(ethylene glycol) (mPEG) as macro-initiator and stannous octoate as catalyst. The resulting diblock copolymer were characterized by 1 H NMR, FTIR, GPC, and DSC techniques. Blank and paclitaxel (PTX) loaded micelles was prepared by co-solvent evaporation method and characterized by transmission electron microscope (TEM) and dynamic light scattering (DLS). The influence of hydrophilic/hydrophobic segment length to drug loading and release was explored. All micelles have the sustained hydrophobic drug release properties of the micelles. Moreover, the cytotoxicity of micelles was evaluated by MTT and live-dead cell staining assay using L929 cell lines, showing the good biocompatibility. Therefore, PTMC-PEG micelles could be a suitable material for the loading and releasing of hydrophobic drugs.
研究领域:
药学
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高分子化学
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药物递送系统
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生物医学工程
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产品关联
DOI
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
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2021
·
IF 5.268
Wei Liu,Xingtong Dong,Han Qin,Lei Sui,Jian Wang
The guided bone regeneration (GBR) membrane is intended to provide sufficient space for alveolar bone regeneration and meanwhile prevent the invasion of gingival epithelium. In this study, three-dimensional porous reduced graphene oxide/hydroxyapatite (3D rGO/HA) membrane with two different sides was prepared using a two-step electrochemical method. One side of this composite membrane facing the bone defect was formed by 3D porous rGO with HA deposited on the frame of the 3D structure, and the other side of the membrane presented a dense 2D rGO surface to prevent the invasion of the gingival epithelium. The morphology, phase composition, and physical properties of the 3D rGO/HA composite membrane were characterized. Then the cell morphology, viability, and proliferation of pre-osteoblasts (MC3T3-E1 cells) on the 3D porous structure surface of membranes were evaluated and alkaline phosphatase (ALP) secretion as an indication of osteogenic differentiation was also investigated. Meanwhile, cell morphology, viability, and proliferation of HUVEC and L929 cells on the dense structure surface were examined. Finally, a cranial defect model of rat was employed to evaluate the effect of 3D rGO/HA as a GBR membrane in vivo. The results revealed the 3D rGO/HA membrane had good biocompatibility for MC3T3-E1 and HUVEC cells and could significantly enhance ALP secretion. Furthermore, this membrane also promoted the repair of calvarial defects in vivo . These results demonstrated that 3D porous rGO/HA composite membrane with a porous side and another dense side represents great application potential as an ideal GBR membrane.
研究领域:
生物材料
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组织工程
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生物医学工程
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骨科
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牙科材料
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产品关联
DOI
PubMed
高影响因子
RSC Advances
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2015
·Vol. 5
·期 38
·30303-30309
·
IF 3.84
Yangling Li,Ying Tan,Kun Xu,Cuige Lu,Xuechen Liang,Pixin Wang
An in situ hydrogel based on oxidation cholesterol starch (OCS) and O-carboxymethyl chitosan (CMCT) that is completely devoid of potentially cytotoxic small molecule cross-linkers and does not require complex manoeuvres or catalysis has been formulated and characterized. The network structure was created by Schiff base formation. The mechanical properties, internal morphology and swelling ability of the injectable hydrogel were examined. Rheological measurements demonstrated that increasing the concentration of the monomer improved the storage modulus. SEM showed that the hydrogel possessed a well-defined porous structure. In addition, the Schiff base reaction was acid sensitive. Under acid conditions, the hydrogel could hydrolyse quickly compared with high pH conditions. Doxorubicin (DOX) was used as a model drug to investigate the control and release properties of the hydrogel. The cytotoxic potential of the hydrogel was determined using an in vitro viability assay with L929 cells as a model and the results revealed that the hydrogel was non-cytotoxic.
研究领域:
材料科学
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生物医学工程
·
药剂学
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产品关联
DOI
高影响因子
KEY ENGINEERING MATERIALS
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2018
·
IF 0
Yang Zi Zhao,You Fa Wang
Being one of the three elements of tissue engineering, three-dimensional porous structure scaffold plays an important role in tissue engineering. As it not only prvovide cells for the life, but also serves as a template to guide tissue regeneration and control of organizational structure and other functions. In this study, hyaluronic acid and gelatin are successfully cross-linked by 1-ethyl- (3-dimethylaminopropyl) -carbodiimide hydrochloride (EDC) , and compound β-TCP microspheres to prepare porous hydrogel scaffolds. The microspheres were analyzed by X-ray diffraction (XRD). The scaffolds were characterized by scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR). At the same time, the compressive strength, swelling ratio, degradation of the scaffold were tested. To assess the in vitro cell compatibility of the scaffolds, mouse L929 fibroblasts were seeded onto scaffolds for cell morphology and cell viability studies. The results showed that the pore size of the porous scaffold can be adjusted by changing the ratio of gelatin to hyaluronic acid (HA), increasing the proportion of hyaluronic acid in a certain range, pore size will be significantly increased. With the increase of the proportion of hyaluronic acid in the scaffold, the swelling ratio and the degradation rate also increased. The compressive strength of the scaffold increased with the increase of the proportion of gelatin. The appropriate ratio of β-TCP can promote cell growth and proliferation.
研究领域:
生物材料
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组织工程
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生物医学工程
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材料科学
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产品关联
DOI
Polymer Chemistry
·
2016
·Vol. 7
·期 14
·2553-2564
·
IF 5.687
Yating Jia,Weizhong Wang,Xiaojun Zhou,Wei Nie,Liang Chen,Chuanglong He
Poly(glycerol sebacate) (PGS) has been explored extensively for tissue engineering applications due to its elastomeric mechanical properties and biocompatibility, but its relatively low mechanical strength and poor hydrophilicity restrict its practical applications in tissue engineering. In this study, we developed new biodegradable elastomeric copolyesters poly(glycerol-co-sebacic acid-co-L-lactic acid-co-polyethylene glycol) (PGSLP) by simultaneously introducing L-lactic acid (LLA) and polyethylene glycol (PEG) into the PGS network. The synthesized copolyesters were well-characterized to evaluate their physicochemical properties, mechanical strength and in vitro degradation properties, and their biocompatibility was also evaluated by a combination of in vivo and in vitro experiments. It is found that the PGSLP exhibited typical elastic properties, and possessed better hydrophilicity, water uptake capacity as well as improved degradation behaviors compared to PGS, which were beneficial for tissue engineering applications. More importantly, the physicochemical properties of PGSLP could be tuned in a wide range by changing the content of LLA and PEG, and their mechanical properties were visibly influenced by the curing conditions such as curing time. Furthermore, the L929 mouse fibroblast cells cultured on the PGSLP exhibited high viability, good spreading and proliferation, and PGSLP implants did not induce obvious inflammatory reaction but promoted neovascularization after subcutaneous implantation in Sprague-Dawley rats for 5 weeks. Hence, the developed PGSLP copolyesters may offer a much better choice of scaffolds than PGS for practical tissue engineering applications.
研究领域:
生物材料
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组织工程
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生物医学工程
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材料科学
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产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Ga Liu,Shengfei Bao,Jiahao Shi,Chunyu Xie,Fuying Liao,Lingshuang Wang,Fan Zheng,Rui L. Reis,Subhas C. Kundu,Bo Xiao,Xiao Yang,Lian Duan
Pathogenic bacterial invasion leads to severe inflammation that hinders wound healing, and it has become a major medical threat worldwide. Photodynamic therapy (PDT) has emerged as a promising strategy for treating microbial infection; however, developing a dressing with PDT effect and excellent biological functions poses a formidable challenge. Herein, a novel cationic pyrimidine-modified conjugated microporous polymer, BPyMe-CMP, was rationally designed and synthesized via a Sonogashira-Hagiwara and S N2 substitution reaction. The BPyMe-CMP exhibited weak interfacial charge transfer resistance and demonstrated superior photoinducible carrier separation, thereby displaying an excellent photoelectric response. Consequently, the BPyMe-CMP could readily generate reactive oxygen species under visible light irradiation to kill bacteria. In addition to enhancing the photogenerated electron transfer process, BPyMe-CMP also provided abundant attraction sites for bacteria to reinforce the antibacterial ability. The deposition of BPyMe-CMP onto polyvinyl alcohol-modified silk fibroin (SF/PVA) film served as a wound dressing to promote healing. The in vitro and in vivo experiments revealed that the SF/PVA@BPyMe-CMP induced M2-type macrophage polarization, promoted L929 fibroblast migration, exhibited bactericidal activity, and induced angiogenesis, which synergistically accelerated the healing of methicillin-resistant Staphylococcus aureus -infected wounds. This study provides data support to advance the construction of a multi-functional wound dressing based on pyrimidination and cationization for the treatment and rapid healing of infected wounds.
研究领域:
材料科学
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生物医学工程
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伤口愈合
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抗菌治疗
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产品关联
DOI
高影响因子
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
·
2024
·
IF 3.6
Yu Jiang,Zhou Wan,Qi Liu,Xinxin Li,Bo Jiang,Mudan Guo,Pengjue Fan,Siyi Du,Doudou Xu,Chen Liu
Titanium (Ti) implants are widely used in orthopedic and dental applications due to their excellent biocompatibility and mechanical properties. However, bacterial adhesion and subsequent biofilm formation on implant surfaces pose a significant risk of postoperative infections and complications. Conventional surface modifications often lack long-lasting antibacterial efficacy, necessitating the development of novel coatings with enhanced antimicrobial properties. This study aims to develop a novel Ag-TiO2-OTS (Silver-Titanium dioxide-Octadecyltrichlorosilane, ATO) nanocomposite coating, through a chemical plating method. By employing a ‘resist-killing-disintegrate’ approach, the coating is designed to inhibit bacterial adhesion effectively, and facilitate pollutant removal with lasting effects. Characterization of the coatings was performed using spectroscopy, electron microscopy, and contact angle analysis. Antibacterial efficacy, quantitatively evaluated against E. coli and S. aureus over 168 h, showed a significant reduction in bacterial adhesion by 76.6% and 66.5% respectively, and bacterial removal rates were up to 83.8% and 73.3% in comparison to uncoated Ti-base material. Additionally, antibacterial assays indicated that the ratio of the Lifshitz-van der Waals apolar component to electron donor surface energy components significantly influences bacterial adhesion and removal, underscoring a tunable parameter for optimizing antibacterial surfaces. Biocompatibility assessments with the L929 cell line revealed that the ATO coatings exhibited excellent biocompatibility, with minimal cytotoxicity and no significant impact on cell proliferation or apoptosis. The ATO coatings provided a multi-functionality surface that not only resists bacterial colonization but also possesses self-cleaning capabilities, thereby marking a substantial advancement in the development of antibacterial coatings for medical implants.
研究领域:
材料科学
·
生物医学工程
·
表面化学
·
微生物学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2024
·
IF 9.4
Shiyu Xiong,Xingwei Ding,Ling Zhou,Ziqian Liu,Wenyan Jiang,Fanrong Ai,Kaiyong Cai
The management of diabetic wounds (DW) is a significant challenge within the medical field. Effectively regulating the levels of reactive oxygen species (ROS) at the wound site and orchestrating the inflammatory response are effective strategies for DW treatment. In this study, a novel hydrogel was developed by cross-linking polyboronic acid-modified carboxymethyl chitosan with herbal active ingredient rosmarinic acid (RA), an active herbal ingredient, through dynamic boronic esters formation. In this RA hydrogel (RAgel), RA serves both as an active pharmaceutical ingredient and as a linker for the creation of a dynamic covalent hydrogel, which can decrease the potential toxicity of chemical crosslinking agents and improve the utilization of RA. RAgel demonstrated potential for controlling RA loading and responsiveness to ROS and glucose levels in a diabetic wound environment. Additionally, the intrinsic antioxidant and antibacterial properties of RA were effectively preserved and enhanced upon integration into RAgel. Furthermore, RAgel not only promoted the migration of L929 cells, a key aspect of tissue repair, but also induced M2 polarization in macrophages,while inhibiting the secretion of pro-inflammatory cytokines. In a murine model of diabetic wound healing, RAgel significantly enhanced the proliferation of both the epidermal and granulation tissues. It also exerts a marked anti-inflammatory effect and promotes collagen deposition, thereby expediting the overall wound healing process. The reported RAgel formulation has potential to address the complex challenges associated with diabetic wound management.
研究领域:
药剂学
·
伤口愈合
·
材料科学
·
糖尿病
·
免疫学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
·
2019
·
IF 2.121
Mingzhi Zhu,Hongwei Wu,Weiji Weng,Ranjith Kumar Kankala,Pei Wang,Xia Zhou,Ruimin Long,Shibin Wang,Haiwang Huang,Yanhua Xia,Yuangang Liu
In order to overcome the side effects of pancreatic transplantation and insulin injection treatment for type I diabetes, we established a drug delivery system employing nanoparticle embedded microcapsules (NEMs). The system co-encapsulated chitosan nanoparticles with γ-aminobutyric acid and β-TC-6 cells for combined drug and cell therapy in diabetes mellitus (DM). The NEMs, which were formed via high-voltage electrostatic method, had an excellent sphericity with a smooth surface. The average size NEM was 245.52 ± 22.00 μm, which indicated a good size for cell encapsulation. Haemolysis rate of NEMs at concentrations of 100, 200 or 300 mg/mL were all below 5%. Relative viability rates of L929 cells with the same concentrations at 24, 48 or 72 h were all above 80%. We implanted bioactive NEMs into type 1 DM mice to evaluate the effect of the combined therapy. The level of blood glucose in the group receiving the combined therapy decreased during the first 2 weeks of treatment. During the next week, the level of blood glucose stayed in a safe range. Body weight continuously increased during the postoperative period after combined therapy group. Oral glucose tolerance test (OGTT) performed after 24 d showed that the level of blood glucose combined therapy reached the maximum peak of 13.04 mmol/L, lower than 16.56 mmol/L for the cell therapy group. This primary study indicated that microencapsulation technology and combined therapy are promising for the treatment of type I diabetes mellitus.
研究领域:
药学
·
生物医学工程
·
糖尿病研究
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2023
·Vol. 58
·期 11
·4840-4852
·
IF 4.5
Wang Xinyu,Zhang Qinan,Zhu Hongyi,Wu Fang,Qiao Yanxiu,Jia Kaihong,Xiang Yong,Hu Xiaoran
Piezoelectric generators (PEGs) have applications in future wearable and implantable technologies, but suffer from insufficient flexibility, poor biocompatibility, facile biodegradation, and low energy output. In this work, a design concept for a piezoelectric elastomer is proposed. Uniquely, we focus on developing a complete “green” design concept, considering the selection of a bio-based monomer, polymer fabrication, and biodegradation. The piezoelectric elastomer, which was prepared by the copolymerization of lactate, 1,4-butanediol, and sebacate monomers, is capable of generating an output voltage of 303.75 mV cm −2 and an output current of 1.92 × 10 –2 mA cm −2 , which are 7.11 times and 4.01 times, respectively, higher than those of a conventional polyvinylidene fluoride–trifluoroethylene copolymer (PVDF-TrFE)-based PEG under the same measurement conditions. Such efficient piezoelectric conversion is attributed to the reduced elastic modulus of the elastomer, which resulted from the random polymerization between piezoelectric lactate monomers and linear 1,4-butanediol and sebacate monomers. As a result, the elastomer generates a greater piezoelectric charge on deformation than traditional PVDF-TrFE. Further, the relative growth rate of L929 mouse fibroblast cells grown on the modified elastomer was unaffected, demonstrating the good biocompatibility of the piezoelectric elastomer. On the basis of the overall environmentally friendly product cycle and high piezoelectric output, this PEG shows promise for applications in future wearable and implantable technologies. Graphical abstract
研究领域:
材料科学
·
生物医学工程
·
可持续材料
·
能量收集
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）