SENSORS AND ACTUATORS B-CHEMICAL
·
2026
·
IF 8.3
Rujun Zhou,Lingyu Wang,Xinyuan Zhang,Shama Sadaf,Ying Wang,Si Luo,Hao Chen,Qiang Ling,Yusheng Zhang,Zhangwei Yu,Daru Chen
Methane, as the second most significant greenhouse gas globally, necessitates highly sensitive and rapid detection technologies for environmental protection. To take full advantage of lab-on-fiber gas sensing technology, this paper presents an optical fiber CH 4 sensor based on a functionalized Fabry-Perot interferometer (FPI). The sensor consists of a single-mode fiber (SMF), a hollow-core capillary (HCC), and a ZIF-8/Polydimethylsiloxane (PDMS) composite sensing membrane. Among them, ZIF-8 is synthesized via a room-temperature solvothermal method, with characterization data confirming its successful preparation. And the composite film is formed by uniformly mixing ZIF-8 with PDMS prepolymer and a crosslinking agent, followed by dip-coating onto HCC end face. The high specific surface area of ZIF-8 allows CH 4 molecules to be adsorbed onto its internal surface through van der Waals forces, leading to a change in the refractive index of the composite membrane and enabling highly sensitive CH 4 detection. The influence of ZIF-8 content on sensor performance is systematically investigated. Experimental results indicate that at a ZIF-8 content of 3 wt%, the sensor sensitivity is 12.95 pm/ppm within the methane concentration range of 0–400 ppm. Furthermore, the sensor exhibits response and recovery times of 1 min and 4 min, respectively, along with excellent reproducibility and stability. These results demonstrate that the proposed sensor achieves comprehensive sensing performance, featuring high sensitivity, rapid response/recovery, and excellent repeatability. It provides an effective solution for high-performance methane sensing and offers a new strategy for gas-oriented lab-on-fiber technology.
✓ 已验证
DOI
高影响因子
ACS ES&T Engineering
·
2025
·
IF 6.7
Lei Lu,Xu Cao,Xian-Wei Liu,Han-Qing Yu
Fenton-based advanced oxidation processes (AOPs) are widely applied for the degradation of recalcitrant organic pollutants in chemical industrial wastewaters. However, traditional systems often generate excessive iron sludge and face challenges in sustaining Fe2+ production, which reduces hydroxyl radical (·OH) utilization efficiency and increases treatment costs. Here, we present a FeS-modified micron-sized zerovalent iron (FeS-mZVI) catalyst that enhances continuous Fe2+ release and prevents FeOOH passivation. The FeS-mZVI/H2O2 system achieved nearly 90% COD removal of phenol within 2 h and maintained high efficiency in pilot-scale testing, achieving over 50% COD reduction in real industrial wastewater with a 47% reduction in operational costs compared to traditional Fenton processes. Mechanistic studies confirmed that ·OH, generated through a Fe2+-dominated homogeneous Fenton reaction, are the primary reactive species. These findings indicate that the FeS-mZVI/H2O2 system is a promising and practical approach for large-scale chemical industrial wastewater treatment, offering both economic and environmental advantages.
研究领域:
环境科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2019
·
IF 6.393
Ling-Xin Kong,Yan-Xin Zhang,Wei-Gang Zhang,Yun-Shan Zhang,Tie-Yi Yan,Peng-Cheng Geng,Biao Wang
Lab-on-tip technology opens a new door for optical fiber surface plasmon resonance (SPR) sensors. In this paper, we first demonstrate an ultra-compact reflective SPR microtip probe on the flat fiber end in experiment, which has a length of tens of microns and a diameter of several microns. Simulations and experiments show that this new fiber SPR microtip probe coated with a nano-goldfilm has excellent refractive index (RI) sensing characteristic and great potential for biochemical detection at single cell level. Based on the high RI sensitivity, a bio-probe assembled with Chitosan/Polysodium Styrene Sulfonate (Cs/PSS) nano-polyelectrolyte film and the sheep anti-human IgG-HRP is prepared to recognize human IgG specifically. Due to the high surface sensitivity, the SPR microtip probe exhibits an ultra-low detection limit for human IgG. Due to the high bulk sensitivity and high thermo-optical coefficient (TOC) of polydimethylsiloxane (PDMS), a reference temperature probe based on SPR microtip is proposed, which is used to compensate for the temperature cross-sensitivity of the bio-probe. This new SPR microtip probe can be used not only in optical fiber sensor, but also in Tip-Enhanced Near-Field Raman Microscopy and Scanning Near-Field Optical Microscope.
研究领域:
光纤传感器
·
表面等离子体共振(SPR)技术
·
生化传感
·
纳米技术
·
显微镜
✓ 已验证
产品关联
DOI
高影响因子
ANALYTICA CHIMICA ACTA
·
2017
·
IF 4.95
Ya-Jie Zhang,Yi Cai,Yong-Liang Yu,Jian-Hua Wang
A miniature optical emission spectrometric (OES) system is developed by incorporating dielectric barrier discharge (DBD) microplasma as excitation source in a lab-on-valve (LOV) configuration for trace cadmium analysis. The entire system integrates bead injection (BI) sample pretreatment , post-column derivatization , in-situ nebulization and OES detection. Trace cadmium in sample solution is separated and preconcentrated by flowing through a 2-(5-Br-2-pyridylazo)-5-dethylaminophenol (5-Br-PADAP) loaded microcolumn in LOV, followed by elution with 20 μL of 0.1 M hydrochloric acid . The eluate after online derivatization with 5 μL of 0.2 M borate buffer solution containing 7.5% (v/v) ethanol is immediately transported into a pneumatic micronebulizer integrating DBD microplasma for cadmium excitation, and OES is recorded by using a charge coupled device (CCD) spectrometer. As a miniaturized analytical set-up, LOV provides an ideal sample-processing front-end with detection by DBD-OES, while introduction of DBD excitation source in LOV highly improves the analytical performances for trace metal species. With a sample volume of 1.0 mL, a detection limit of 0.06 μg L −1 and a linear range of 0.2–50 μg L −1 are achieved for cadmium, along with an enrichment factor of 38. The accuracy of the present system is confirmed by the determination of cadmium in certified reference materials, and further demonstrated by spiking recoveries of cadmium in real water samples.
研究领域:
分析化学
·
环境科学
✓ 已验证
DOI
PubMed
高影响因子
RSC Advances
·
2020
·Vol. 10
·期 17
·10006-10016
·
IF 3.119
Ruimin Li,Shiyong Xing,Shuai Zhang,Minghan Han
H-beta zeolites of 100–200 nm (named BEA-L) and 20–30 nm (named BEA-S) were treated by chemical liquid deposition (CLD) of tetraethyl orthosilicate (TEOS) to improve the selectivity of 2-phenyl linear alkylbenzene (2-LAB) from benzene alkylation with 1-dodecene. The results indicate that H-beta zeolite with a smaller crystal size has a longer lifetime due to shorter channels and less diffusion limitation. The deposited SiO2 layers passivated the external surface acid sites of the zeolite and made the pores narrower. BEA-L lost more external Brønsted acid sites than BEA-S with the same added amount of TEOS, which was due to the severe aggregation of BEA-S grains. This increased passivation gave BEA-L increased 2-LAB selectivity. And when the added amount of SiO2 was 7.20 wt% of the parent zeolite, the selectivity of 2-LAB over BEA-L significantly increased from 41.9% to 54.7% while that of BEA-S only increased by 2%.
研究领域:
催化
·
化工
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Omega
·
2025
·
IF 4.3
Zhengyao Zhang,Zhi Li,Yuhang Jin,Xu Gao,Zekai Zhu,Hangyu Zhang,Bin Wu,Bo Liu
Colloidal gold immunochromatography has emerged as a pivotal platform for point-of-care diagnostics, yet challenges persist in stabilizing nanoparticle-antibody interactions and ensuring batch-to-batch reproducibility. To address these limitations, we engineered a nanogold-affinity peptide probe for the rapid detection of the lung cancer biomarker carcinoembryonic antigen (CEA), leveraging phage-display-derived peptides as biorecognition elements. The probe was synthesized by conjugating CEA-specific affinity peptides to polyethylene glycol (PEG)-functionalized gold nanoparticles (AuNPs) via covalent amide bonding, ensuring precise orientation and enhanced colloidal stability. Systematic optimization of reaction parameters, including the PEGylation time, peptide-to-nanoparticle ratios, and centrifugation conditions, yielded a robust preparation protocol. The resulting immunochromatographic test strip demonstrated a detection limit of 2.5 ng/mL for CEA, surpassing the clinical threshold of 5 ng/mL, and exhibited 91.7% accuracy in clinical serum samples. Notably, the substitution of antibodies with synthetic affinity peptides reduced costs by approximately 8-fold while maintaining high specificity and resistance to nonspecific binding. This work not only advances the integration of biomolecular engineering and nanotechnology for diagnostic applications but also establishes a scalable framework for developing stable, low-cost biosensors targeting macromolecular biomarkers.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
OPTICS EXPRESS
·
2025
·Vol. 33
·期 19
·40647-40660
·
IF 3.3
Hongtao Li,Hongtao Li,Hongtao Li,Hongtao Li,Jiaoyan Dai,Jiaoyan Dai,Jiaoyan Dai,Weisheng Wang,Weisheng Wang,Weisheng Wang,Yuxuan Liu,Yuxuan Liu,Yuxuan Liu,Lei Huang,Lei Huang,Liang Lu,Liang Lu,Liang Lu,Jialiang Lv,Jialiang Lv,Jiping Lin,Jiping Lin,Jiping Lin,Lili Liang,Lili Liang,Benli Yu,Benli Yu,Benli Yu
For efficiently diagnosing early-stage breast cancer, current existing MUC1 biomarker detection methods suffer from common issues of low sensing sensitivities. In this study, a single-core two-channel optical fiber optofluidic on-chip sensor is employed to high-sensitivity detect breast cancer biomarker MUC1 protein, where a Mach-Zehnder interferometer (MZI) waveguide and a fiber Bragg grating (FBG) inscribed into the device by using a femtosecond laser direct writing technique. To improve the device’s sensitivity, two microfluidic channels are etched using hydrofluoric (HF) solution, and Au nanobipyramids (Au NBPs) material on an optical fiber is used to excite and realize the localized surface plasmon resonance (LSPR) enhancement. Thus, the device’s refractive index (RI) sensitivity increases from 25.07 to 580.22 nm/RIU. FBG compensates the device’s temperature sensitivity, achieving at -0.139 nm/℃. On the basis of the advanced LSPR enhancement strategy, the sensor can not only specifically sense MUC1 protein with an ultra-low limit of detection (LOD) of 20.74 aM, it can also detect MUC1 protein in real serum background with a LOD of 42.07 aM. The obtained ultra-low LOD is lower than most existing state-of-the-art MUC1 detection technologies. This study paves what we believe to be a new universal way for developing advanced high-sensitivity lab-in-fiber optofluidic sensing strategy.
研究领域:
肿瘤学
·
生物医学工程
·
分子诊断
·
光学传感
·
转化医学
·
纳米生物技术
·
液体活检
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Nano
·
2024
·
IF 15.8
Kexin Liu,Hao Wang,Fengyuan Zhu,Ziyong Chang,Ran Du,Yulin Deng,Xiaoyue Qi
Abnormal secretion and dysrhythmias of cortisol (CORT) are associated with various diseases such as sleep disorders, depression, and chronic fatigue. Wearable devices are a cutting-edge technology for point-of-care detection and dynamic monitoring of CORT with inspiring convenience. Herein, we developed a minimally invasive skin-worn device with the advanced integration of both interstitial fluid (ISF) sampling and target molecule sensing for simultaneous detection of CORT via a microneedle-based sensor with high sensitivity, excellent efficiency, and outstanding reproducibility. In the microneedle patch, swellable hydrogel was employed as the adsorption matrix for ISF extraction. Meanwhile, europium metal–organic frameworks (Eu-MOF) wrapped in the matrix played a vital role in CORT recognition and quantitative analysis. The wearable and label-free Eu-MOF-loaded microneedle patch exhibited high sensitivity in CORT detection with the detection limit reaching 10–9 M and excellent selectivity. Molecular dynamics simulation–driven mechanism exploration revealed that the strong interface interaction promoted fluorescence quenching of Eu-MOF. Moreover, in vitro and in vivo investigation confirmed the feasibility and reliability of the sensing method, and excellent biocompatibility was validated. Overall, a sensitive approach based on the wearable Eu-MOF microneedle (MN) patch was established for the simultaneous detection of CORT via visible fluorescence quenching with exciting clinical-translational ability.
研究领域:
生物医学工程
·
分析化学
·
材料科学
·
可穿戴技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
WATER RESEARCH
·
2023
·
IF 12.8
Shanqi Zhou,Mengru Fu,Siyuan Ling,Zhihua Qiao,Kailun Luo,Cheng Peng,Wei Zhang,Juying Lei,Bingsheng Zhou
The extensive utilization of both legacy and novel brominated flame retardants (BFRs) leads to high environmental concentrations, which would be bioaccumulated by organisms and further transferred through the food webs, causing potential risks to humans. In this study, five BFRs, that showed high detection frequencies and concentrations in sediments from an e-waste dismantling site in Southern China, namely 2,3,4,5,6-pentabromotoluene (PBT), hexabromobenzene (HBB), 1,2-bis(2,4,6-tribromophenoxy) ethane (BTBPE), decabromodiphenyl ethane (DBDPE), and decabromodiphenyl ether (BDE209), were selected as target pollutants in the lab-constructed aquatic food web as part of a micro-ecosystem, to investigate their distribution, bioaccumulation, and trophic transfer patterns. The significant correlations between different samples in the food web indicated that the dietary uptake appeared to influence the levels of BFRs in organisms. Significant negative correlations were observed between the trophic level of organisms and the lipid-normalized concentrations of BTBPE and DBDPE, indicating the occurrence of trophic dilution after 5-month exposure. However, the average values of bioaccumulation factors (BAFs) were from 2.49 to 5.17 L/kg, underscoring the importance of continued concern for environmental risks of BFRs. The organisms occupying higher trophic levels with greater bioaccumulation capacities may play a pivotal role in determining the trophic magnification potentials of BFRs. This research provides a helpful reference for studying the impacts of feeding habits on bioaccumulation and biomagnification, as well as for identifying the fate of BFRs in aquatic environment.
研究领域:
生态学
·
环境科学
·
毒理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
REACTIVE & FUNCTIONAL POLYMERS
·
2026
·
IF 5.4
Somayeh Mirsadeghi,Hamed Zandavar,Alireza Soroush,Seied Mahdi Pourmortazavi
Renewable NC/PbO/Pb 3 O 4 nanofibers engineered for Cr(VI) waste treatment; • Dual-oxide valence synergy enhances interfacial stability and Pb O site density; • Rapid uptake and high time-point adsorption capacity (754 mg g −1 ) in representative realistic concentration; • Thermo-mechanistic modeling links kinetics to matrix-filler energetics; • Pb leaching ≤7.9 μg L −1 ; safe operation verified across regeneration cycles. Electrospun nitrocellulose (NC) nanofibers embedded with dual lead oxides (PbO/Pb 3 O 4 ; 2.5 wt% each oxide) were developed as a reusable adsorbent for hexavalent Chromium [Cr(VI)] capture while enabling a “blueprint-style” thermo-mechanistic performance profiling. SEM confirmed uniform nanofibers with an average diameter of 111.1 nm, and FTIR verified oxide incorporation through characteristic Pb-O/Pb-O-Pb vibrations in the low-wavenumber region. N 2 physisorption indicated a slight but steady rise in accessible porosity after oxide embedding. Surface area (BET) increased from 1.34 to 1.83 m 2 g −1 , and total pore volume from 0.055 to 0.0687 cm 3 g −1 . This change aligns with particle decoration or embedding that enhances interfacial voids without forming microporosity. Under dilute optimization conditions (C 0 = 5–30 mg L −1 ), the composite achieved 98% Cr(VI) removal at pH 3, an adsorbent dosage of 0.03 g, and a contact time of 25 min. To verify performance under representative high-strength industrial loading, kinetics were further evaluated at the controlled Cr(VI) solution prepared at the measured barium chromate production-line concentration (C 0 = 470 mg L −1 ), yielding rapid uptake with q t = 754 mg g −1 at 25 min. Equilibrium modeling followed Langmuir behavior ( q m = 367.5 ± 18.4 mg g −1 , K L = 4.33 ± 0.68 L mg −1 , R 2 = 0.98; R L = 0.044–0.0076), with more favorable apparent Langmuir-derived free-energy descriptors for the composite than for neat NC (ΔG°:-1.57 ± 0.45 to −3.62 ± 0.39 kJ mol −1 ), while kinetics were best described by the pseudo-second-order model (R 2 = 0.99; q e = 441.7 ± 12.6 mg g −1 ). The nanofiber retained 70.1 ± 2.1% of its adsorption capacity after 25 adsorption-desorption cycles, and Pb leaching remained low (2.8–7.9 μg L −1 ; 0.006–0.017% of embedded Pb), well below relevant guideline/action thresholds. A Comparative Performance Index (CPI) integrating capacity, affinity, and energy criteria demonstrated consistent performance under varied operating conditions. This thermo-mechanistic framework links laboratory adsorption descriptors with early process-screening criteria, providing a basis for subsequent continuous-flow validation. Download: Download high-res image (270KB) Download: Download full-size image
✓ 已验证
DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2024
·
IF 8
Kang Yang,Shuaibo Shi,Shaolong Han,Jinyu Wu,Sichen Li,Rui Zhu,Shengdi Tai,Kun Zhang
Despite the tremendous advances that have been made in selective detection of a wide range of inorganic anions and cations, a single fluorescent probe possessing a high discrimination ability for these ions and their analogues is still very rare. Herein we propose a mononuclear europium-macrocycle complex Eu - 2 l which employs the imine bond interaction sites and embeds europium ion into a Schiff-base macrocyclic cavity interior to construct the dual-emission matrix for the lab-on-a-molecule fluorescent probe . Eu - 2 l not only allows the conventional spectral analysis for significant intensity changes of emission bands but also enables the statistical analysis for different levels of fluorescence sensing signals. As a result, this novel fluorescent platform Eu - 2 l shows the great real-time, selective, sensitive and quantitative detection ability for PO 4 3- or Al 3+ among common inorganic ions . Furthermore, when sensing signals of anions and cations on different fluorescence channels are systematically evaluated by principal component analysis (PCA) and hierarchical cluster analysis (HCA) methods, Eu - 2 l allows the high-through discrimination of not only 18 anions and 12 cations but also several analogues and their proportional mixtures, even in real environmental water sample. This work enriches the PO 4 3- and Al 3+ chemosensors , highlights huge benefits of the combination multi-emission fluorescent matrix and statistical analysis methods and thus provides a vital reference to construct the lab-on-a-molecule probe by a single chemical entity for multianalyte detection and discrimination in various fields.
研究领域:
分析化学
·
生物化学
✓ 已验证
DOI
高影响因子
ANALYTICAL CHEMISTRY
·
2024
·
IF 6.7
Hang Ao,Wencheng Xiao,Wenrui Hu,Jie Wu,Huangxian Ju
This work designed a DNA conformation-regulated hemin switch for rapid chemiluminescent (CL) detection of a monoclonal antibodies. This switch was performed with an affinity probe and an inhibition probe, which were conveniently prepared by hybridizing hemin-labeled DNA1 with KHL peptide-labeled DNA2 and binding biotin-labeled DNA3 to streptavidin, respectively. In the absence of the target antibody, streptavidin-DNA3 could hybridize with hemin-DNA1/KHL-DNA2 to release KHL-DNA2, which led to the loss of hemin activity due to the affinity hindrance of streptavidin-DNA3. After the KHL peptide was recognized by the target antibody, the strand replacement hybridization could be inhibited by the bound antibody, which retained the high catalytic activity of hemin overhung on the antibody-bound affinity probe for a CL reaction, leading to a “signal-on” process for CL antibody detection. Using a KHL-specific antibody, anti-proprotein convertase subtilisin/kexin type 9 antibody (PCSK9-Ab), as a target model and common L012–1,2,4-triazole–H2O2 CL system, the designed switch showed a detection range of 10 ng mL–1 to 1 μg mL–1 with a detection limit of 4.16 ng mL–1 (56.2 pM) and a short analytical time of 6.5 min. The proposed quick method could simply be used for lab-on-chip CL detection of PCSK9-Ab in situ-secreted from PCSK9-6E3 hybridoma cells, which showed an accuracy of 90.2% compared with the statistical results from general fluorescence imaging, providing a potential technique for screening specific hybridoma cells.
研究领域:
生物化学
·
分析化学
·
生物技术
·
分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）