Journal of Materials Chemistry B
·
2014
·Vol. 2
·期 32
·5187-5194
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IF 0
Dian Li,Yuting Zhang,Sha Jin,Jia Guo,Haifeng Gao,Changchun Wang
Intelligent nanomaterials that are able to respond to environmental stimuli for sequential release of multiple payloads are highly desirable in applications of drug delivery systems. In this study, a core/shell-structured nanocarrier with an acid-dissolvable magnetic supraparticle (MSP) as core and a redox-degradable poly(methylacrylic acid-co-N,N-bis(acryloyl)cystamine) (P(MAA-Cy)) as shell was prepared using the distillation-precipitation polymerization technique, in which the magnetic core and the polymer shell were loaded with different guest molecules. Under physiological conditions similar to the cytoplasm of tumour cells, this MSP@P(MAA-Cy) microsphere showed a sequential degradation profile of the shell and the core. With dyes of fluorescein isothiocyanate (FITC) loaded in the core and rhodamine in the shell, the produced MSP-FITC@P(MAA-Cy)-Rho microspheres were applied in HeLa cell and HEK 293T cell cultures, showing selective degradation of the microspheres in HeLa cells to release the rhodamine and FITC dyes in sequence. When two anticancer drugs, i.e., paclitaxel (TXL) and doxorubicin (DOX), were loaded separately into the core and the shell domains of the microspheres, the experimental results showed that the MSP-TXL@P(MAA-Cy)-DOX nanodrug exhibited better inhibitive efficacy than the free drugs under the same dosing level, demonstrating the great potential of this stimuli-sensitive drug delivery system for programmed and stimuli-responsive drug release characteristics.
研究领域:
生物医学工程
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药剂学
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材料科学
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DOI
PubMed
JOURNAL OF ALLOYS AND COMPOUNDS
·
2019
·
IF 4.175
Mingliang Ma,Yuying Yang,Wenting Li,Yong Ma,Zhouyu Tong,Weibo Huang,Liu Chen,Guanglei Wu,Huanli Wang,Ping Lyu
Yolk-shell magnetic Fe 3 O 4 /P(MAA-MBAA)-PPy/Au/void/TiO 2 microspheres have been prepared as visible light active photocatalyst . In this structure, the Fe 3 O 4 /P(MAA-MBAA)-PPy core-shell support provides magnetic properties for the catalyst and a large number of binding sites for the Au nanoparticles . In addition, coupling TiO 2 with Au nanoparticles can extend the range of absorbable sunlight and enhance electron hole separation. The test of degrading rhodamine B (RhB) under simulated visible light was used to verify the photocatalytic activity of the photocatalyst. The results showed that the photocatalyst exhibited favorable catalytic properties within 90 min in the case of using 4 mg itself. The improved performances were ascribed to the unique yolk-shell structure, which on the one hand greatly improves the light utilization, on the other hand favors full contact of the dye because of the porous appearance of the outer shell. Furthermore, the existence of magnetic core was beneficial to the recycling of the photocatalyst. And the recycling results demonstrated that the catalyst efficiency was maintained at 70.2% even after six recycling experiments. This work not only displays a new material for the degradation of organic dyes, but also provides a new approach for the synthesis of yolk-shell structure photocatalysts.
研究领域:
材料科学
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环境科学
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DOI
高影响因子
QUIMICA NOVA
·
2023
·Vol. 46
·期 1
·20-28
·
IF 0.8
Zhou Meng,Sun Chunyu,Zhao Hong
Reducing non-specific adsorption of proteins on the surface of magnetic nanoparticles (MNPs) is becoming increasingly important. In this paper, we proposed a novel surface modification procedure by grafting hyperbranched polyglycerol (HPG) onto the surface of MNPs (Fe3O4@SiO2@MAA), in which lots of hydroxyl groups from HPG not only provide the hydrates sheath to prevent non-specific adsorption of proteins, but also react with succinic anhydride to generate carboxyl groups that serve as active sites to specifically bind proteins. The protein adsorption experiments showed that the non-specific adsorption (0.07 μg mg-1) was reduced to 4.58% of that before modification. It also showed that the antigen binding capacity was 9.7 times higher than the original when detecting cardiac troponin I (cTnI) in human plasma samples, which indicated that the final synthesized MNPs had great application prospects in bio-separation and bioanalysis.
研究领域:
材料科学
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纳米技术
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生物化学
·
生物医学工程
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产品关联
DOI
高影响因子
JOURNAL OF SUPERCRITICAL FLUIDS
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2022
·
IF 4.514
Qianrui Xu,Pengcheng Gao,Yang Wang,Wenjie Jiang,Zhifei Wang,Yong Jiang,Zhen Jiao
Porous nanospheres have potential applications in reactions, catalysis and water treatment because of their high surface area, low density and high loading capacity. In this work, a reproducible and well-controlled way to fabricate hollow Polystyrene/Poly(divinylbenzene-co-methacrylic acid)@Fe 3 O 4 /Tannic acid@Ag (PS/P(DVB-co-MAA)@Fe 3 O 4 /TA@Ag) nanocomposites with high catalytic efficiency is developed. Firstly, hollow Polystyrene/Poly(divinylbenzene-co-methacrylic acid) (PS/P(DVB-co-MAA)) nanospheres with an open hole on the surface are produced by supercritical carbon dioxide (scCO 2 ) rapid depressurization methodology. The consequence shows that structure of polymer nanospheres is controllable by altering the reactive conditions, like temperature, pressure, solvent ratio, degree of cross-linking and time. Secondly, the magnetic Fe 3 O 4 and Ag nanoparticles are deposited onto the surface of hollow PS/P(DVB-co-MAA) nanospheres. The result indicates that hollow PS/P(DVB-co-MAA)@Fe 3 O 4 /TA@Ag nanocomposites are highly efficient in degrading dyes, displaying that the apparent rate coefficients of methylene blue (MB), rhodamine B (RhB) and 4-nitrophenol (4-NP) reduction are .0090 s −1 , 0.0239 s −1 , and 0.0073 s −1 , respectively. Besides, hollow PS/P(DVB-co-MAA)@Fe 3 O 4 /TA@Ag nanocomposites can be recycled at least seven times and show no significant loss in catalytic performance.
研究领域:
材料科学
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环境科学
·
化学工程
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产品关联
DOI
高影响因子
POLYMER TESTING
·
2022
·
IF 4.931
Xiaotao Wang,Zhuofan Chen,Yebin Yang,Huiling Guo,Yingkui Yang,Chak-Yin Tang,Xuefeng Li,Wing-Cheung Law
It is difficult to form nanoparticles by traditional polymerization methods, using the azobenzene monomer with large hindrance. In this work, distillation precipitation polymerization (DPP) with lowering the monomer content at the beginning and distilling the solvent at a constant speed. Monofunctional 6-(4-methoxy-4′-oxygen-azobenzene) hexyl methacrylate (Azo) as a photo-responsive monomer and methacrylic acid (MAA) as a pH responsive monomer, were used to synthesize UCNPs@SiO 2 @PAzo/MAA nanoparticles. After the SiO 2 was etched, UCNPs@PAzo/MAA nanocapsules (NCs) were formed. The trans isomer in the PAzo shell is converted into cis under 980 nm near-infrared (NIR) irradiation, leading to a variation of size and hydrophilicity of the nanocapsules. Controlled drug loading (∼17.5%) could be performed using UV irradiation, in which the pendant Azo groups have an cis “open” state and larger hydrophilicity. Under weak acid and NIR irradiation, the pendant Azo group with constant isomerization is like a “molecular impeller” agitator and the cumulative release rate of the doxorubicin (DOX) reaches 67.88%. Furthermore, UCNPs@PAzo/MAA nanocapsules were applied to the intracellular environment, and the cytotoxicity was studied. The cell images and cytotoxicity studies showed that the drug could be efficiently delivered to the nucleus by the UCNPs@PAzo/MAA nanocapsules in a controlled manner.
研究领域:
材料科学
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药学
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纳米技术
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生物医学工程
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DOI
高影响因子
TALANTA
·
2023
·
IF 6.1
Simin Chen,Yiqi Qie,Zhendong Hua,Haoyue Zhang,Youmei Wang,Bin Di,Mengxiang Su
Phytocannabinoids and their synthetic analogs (natural and synthetic cannabinoids) are illicit drugs that are widely abused worldwide. Wastewater-based epidemiology (WBE) is an objective approach for the estimation of population-level exposure to a wide range of substances, especially drugs of abuse. However, the concentrations of cannabinoids in wastewater are extremely low (frequently at the levels of nanograms per liter), and the existing pretreatment procedures for wastewater have the disadvantages of time-consumption or low extraction recoveries. This study aimed to propose a novel poly (methacrylic acid- co -ethylene glycol dimethacrylate)-functionalized polydopamine-coated Fe 3 O 4 nanoparticle (Fe 3 O 4 @ [email protected] (MAA- co -EGDMA)) as an adsorbent, and provide a highly sensitive quantitative analytical technique for the detection of five synthetic cannabinoids (SCs: 5 F-EDMB-PINACA, FUB-APINACA, MDMB-4en-PINACA, MDMB-FUBINACA, and PB-22) and one cannabis-related human metabolite (THC-COOH) in wastewater. The magnetic adsorbents were fully characterized by transmission electron microscopy (TEM), infrared spectroscopy (IR), vibrating sample magnetometry (VSM) and X-ray photoelectron spectroscopy (XPS). Subsequently, an MSPE-UHPLC-MS/MS method was developed and validated for the determination of six trace analytes in wastewater. The validation results showed that the method has limits of quantification as low as 0.1–1.0 ng/L. Additionally, the recoveries ranged from 62.81 to 124.02%, and the relative standard deviations (RSDs) of intraday and interday precision were less than 15%. This MSPE-UHPLC-MS/MS method was successfully applied to real wastewater samples, and the whole analytical process of one sample from pretreatment to the obtained quantitative results was completed in less than 30 min. Thus, the proposed method based on Fe 3 O 4 @ [email protected] (MAA- co -EGDMA) is a convenient, rapid, sensitive and reliable method for the determination of trace psychoactive drugs in wastewater.
研究领域:
分析化学
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环境科学
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纳米技术
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药理学
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产品关联
DOI
PubMed
高影响因子
RSC Advances
·
2020
·Vol. 10
·期 42
·25402-25407
·
IF 3.119
Xiaodong Lv,Peng Gao
Based on the electron-transfer mechanism between the template and quantum dots (QDs), an optical sensor was structured. It is a phenol sensor, which has the room-temperature phosphorescence (RTP) property of Mn-doped ZnS QDs and high selectivity of molecular imprinted polymers (MIPs). On the surface of the silane modified Mn-doped ZnS QDs, the phenol sensor was prepared by double cross-linker precipitation polymerization in the absence of any stabilizer and additive. Double cross-linkers, divinylbenzene (DVB) and ethyleneglycol dimethacrylate (EGDMA), make a great contribution to the imprinted polymerization with hydrogen-bonding interaction. Then, as a result of the functional monomer, methacrylic acid (MAA), a carboxylic acid was grafted onto the surface of ZnS QDs:Mn@MIPs. Under optimal conditions, the phenol determination experiment had a linear range of 5.0 to 55 μmol L−1 with a correlation coefficient of 0.9984, and a high imprinting factor (IF) of 3.43. In addition, the prepared ZnS QDs:Mn@MIPs were successfully used to detect phenol in real water samples. Therefore, this work provided a highly selective and sensitive RTP probe for phenol determination.
研究领域:
分析化学
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材料科学
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环境科学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2020
·
IF 4.192
Fan Yang,Jincheng Wang,Shiqiang Song,Pinhua Rao,Runkai Wang,Shihui Liu,Liqi Xu,Feng Zhang
A novel type of temperature and pH dual-stimuli-responsive microspheric soil conditioner was prepared for the controlled release of urea. First, poly(N-isopropylacrylamide-co-methacrylic acid) [P(NIPAM-co-MAA)] was synthesized, and the microspheric soil conditioner was prepared on the basis of chitosan-coated P(NIPAM-co-MAA) via the emulsion cross-linking method. The structure and morphology of the microsphere were characterized by Fourier transform infrared spectroscopy, hydrogen nuclear magnetic resonance, polarization optical microscopy, and scanning electron microscopy. The microsphere showed controlled release behavior in different temperature and pH conditions, indicating good stimuli responsiveness. The plant experiment revealed that the microsphere can effectively promote plant growth in acidified soil and high-temperature conditions, and the pH value of acidified soil could be improved. In addition, the microsphere possessed good biodegradation property in the soil. Therefore, the multi-responsive microspheric soil conditioner owns a great potential value to amend soil conditions and promote plant growth in agriculture applications.
研究领域:
农业科学
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土壤学
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材料科学
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环境科学
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）