CHEMICAL ENGINEERING JOURNAL
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2019
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IF 8.355
Daofei Lv,JiaYu Chen,Kexin Yang,Houxiao Wu,Yongwei Chen,Chongxiong Duan,Ying Wu,Jing Xiao,Hongxia Xi,Zhong Li,Qibin Xia
Using porous materials to selectively adsorb CO 2 from flue gas or natural gas is a promising method for mitigating CO 2 emission and purifying methane. Here, we synthesized an L-aspartic acid based microporous metal-organic framework (MIP-202) and studied its adsorptive separation performance for CO 2 /CH 4 and CO 2 /N 2 mixtures. Results show that MIP-202 had ultrahigh CO 2 /CH 4 (72.9 and 241.5 for CO 2 /CH 4 = 50/50 and 10/90, respectively) and CO 2 /N 2 (1,950,000 and 2129.1 for CO 2 /N 2 = 50/50 and 15/85, respectively) IAST selectivities at 298 K and 100 kPa. The high selectivity was verified by the calculations of Henery’s law selectivity and breakthrough experiments. Metropolis Monte Carlo simulation calculations show that CO 2 with greater polarizability and quadruple moment tends to occupy the pore walls of large cages with higher polarity, while the less polar CH 4 or N 2 majorly being adsorbed in the pore walls of small cages with lower polarity, resulting in the ultrahigh CO 2 /CH 4 and CO 2 /N 2 separation selectivities. MIP-202 exhibits low CO 2 adsorption enthalpy (17.2–30.7 kJ/mol), superior persistent reusability after five cyclic adsorption experiments, easy desorption performance at 298 K, moderate water and moisture stability, good stability under dry and humid SO 2 atmosphere, and low ligand cost ($36/kg). MIP-202 extrudates were prepared by an extrusion molding method using hydroxypropyl cellulose (HPC) as the binder and they retained 97.35% CO 2 uptake of MIP-202 powder at room temperature and pressure. This work shows that MIP-202 is an industrially promising material for the separation of CO 2 /CH 4 and CO 2 /N 2 mixtures.
研究领域:
材料科学
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环境科学
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DOI
高影响因子
IEEE SENSORS JOURNAL
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2026
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IF 4.5
Xin Yan,Lulu Wang,Rao Fu,Xiaobing Chen,Huina Tang,Shirong Zhang,Xue Zhou
The development of reliable diabetes management and precision medicine has driven the need for real-time glucose monitoring technologies that offer long-term stability. However, conventional enzymatic sensors are constrained by the inherent instability of enzymes. To address this limitation, we engineered a non-enzymatic optical fiber sensor by integrating molecularly imprinted polymer (MIP) technology with surface plasmon resonance (SPR). A key innovation lies in the successful construction of an MIP-based sensing interface featuring specific recognition cavities on a U-shaped optical fiber probe. Characterization confirmed its effective "imprinting-elution-rebinding" capability, while performance tests demonstrated a sensitivity of 9.875 nm/log(mM) within the 0.5-10 mM concentration range, coupled with a rapid response (time≤14 s) and outstanding specificity. The sensing strategy introduced here sets a new benchmark, delivering a powerful blend of specificity, speed, and stability that is essential for practical real-time glucose monitoring in complex biological media.
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Analytical Methods
·
2018
·Vol. 10
·期 42
·5112-5117
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IF 2.073
Yanru Qin,Jingfan Xie,Shuting Li,Changqun Cai,Xiaoming Chen,Guanqun Zhong,Chunyan Chen
Glycoproteins have extraordinary significance for the diagnosis of tumors and cancers. However, in untreated complex biological samples, highly selective and sensitive determination of glycoproteins is still a huge challenge. In this study, a boronate affinity surface molecularly imprinted resonance light scattering (RLS) sensor was constructed to detect glycoproteins. In the RLS sensor, 4-vinylbenzeneboronic acid, which was used as a functional monomer for molecularly imprinted polymers (MIPs), is pH sensitive and can reversibly bind to glycoproteins. In addition, 2-(dimethylamino) ethyl methacrylate was also applied as a pH-responsive component to prepare MIPs. The swelling/shrinking properties of the resultant MIPs are beneficial to rapidly remove template glycoproteins from MIPs. Combining the boronate affinity and MIPs, the RLS sensor can specifically recognize target glycoproteins from sample solutions and sensitively detect them. Under optimum conditions, the RLS sensor has a linear response to ovalbumin (OVA) in the range of 0.5–15 nM with a low detection limit of 0.13 nM. The RLS sensor has been successfully utilized for the detection of OVA in real human blood serum, with a good recovery of 94.0–104%. This approach will provide a promising way to detect glycoproteins in clinical diagnostics.
研究领域:
分析化学
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生物传感器
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临床诊断
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高影响因子
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
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2013
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IF 2.487
Shian Zhong,Yanyue Kong,Ling Zhou,Chengyun Zhou,Xiaona Zhang,Yan Wang
In this study, we developed an efficient conversion process of dihydromyricetin to myricetin from Ampelopsis grossedentata extracts. The content of myricetin increased from 2.38% to 85.57%, demonstrating the successful dehydrogenation of dihydromyricetin. Molecularly imprinted polymers (MIPs) were prepared by surface imprinting method using silica microspheres as the support matrices and myricetin as template. The MIPs were applied for the selective adsorption of myricetin. The chemical structure of the MIPs was characterized by Fourier transform infrared spectroscopy and scanning electron microscopy. Static, dynamic and selective adsorption experiments showed that the MIPs exhibited good adsorption ability, rather fast template rebinding kinetics, and appreciate selectivity over structurally related compounds. Accordingly, the MIPs were applied as the selective sorbent in SPE to purify myricetin obtained through dehydrogenation, followed by HPLC-UV analysis. The recoveries of myricetin and dihydromyricetin were 92.7% and 55.6%, respectively. This study demonstrates the feasibility of using the developed MIP-SPE method to purify and enrich myricetin in the natural products.
研究领域:
药学
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分析化学
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天然产物化学
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DOI
PubMed
高影响因子
MOLECULES
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2020
·Vol. 25
·期 5
·1022
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IF 3.267
Yue Zhang,Yifang Xie,Leifang Zhang,Hang Zhao
Smoke inhalation causes acute lung injury (ALI), a severe clinical disease with high mortality. Accumulating evidence indicates that microRNA-155 (miR-155) and suppressor of cytokine signaling 1 (SOCS-1), as mediators of inflammatory response, are involved in the pathogenesis of ALI. In this paper, we explored the proinflammatory mechanism of miR-155 in smoke-inhalation-induced ALI. Our data revealed that smoke inhalation induces miR-155 expression, and miR-155 knockout (KO) significantly ameliorates smoke-inhalation-induced lung injury in mice. Neutrophil infiltration and myeloperoxidase (MPO), macrophage inflammatory protein 2 (MIP-2) and keratinocyte chemoattractant (KC) expressions were decreased in miR-155–/–mice after smoke inhalation as well. Real-time RT-PCR and immunoblotting results showed that SOCS-1 level was remarkably increased in miR-155–/–mice after smoke exposure. Furthermore, the experiments performed in isolated miR-155 KO pulmonary neutrophils demonstrated that the lack of SOCS-1 enhanced inflammatory cytokines (MIP-2 and KC) secretion in response to smoke stimulation. In conclusion, smoke induces increased expression of miR-155, and miR-155 is involved in inflammatory response to smoke-inhalation-induced lung injury by inhibiting the expression of SOCS-1.Keywords:acute lung injury;neutrophils;microRNA-155;suppressor of cytokine signaling-1
研究领域:
呼吸病学
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免疫学
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分子生物学
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PubMed
高影响因子
FOOD CHEMISTRY
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2021
·
IF 7.514
Rong-Rong Zhang,Xin-Tian Gan,Jin-Jin Xu,Qiao-Fen Pan,Hua Liu,Ai-Li Sun,Xi-Zhi Shi,Ze-Ming Zhang
A highly effective molecularly imprinted electrochemiluminescence sensor was constructed for prometryn determination in environmental and biological samples by using perovskite quantum dots coated with a molecularly imprinted silica layer (MIP/CsPbBr 3 -QDs) as the recognition and response element. MIP/CsPbBr 3 -QDs were immobilized on a glassy carbon electrode (GCE) through electropolymerization, and the electrochemiluminescence (ECL) response of MIP/CsPbBr 3 -QDs could be motivated under the condition of H 2 O 2 as co-reactant. ECL signal was selectively quenched with prometryn by hindering electron transfer and directly proportional to the logarithm of prometryn concentration (0.10–500.0 μg/L) with a correlation coefficient of 0.9960. Limits of detection in fish and seawater samples were 0.010 μg/kg and 0.050 μg/L, respectively. Excellent recoveries of 88.0%–106.0% were acquired for fish and seawater samples with a relative standard deviation below 4.2%. The constructed MIECL sensor based on MIP/CsPbBr 3 -QDs showed good stability, accuracy, and precision for sensitive detection of prometryn in aquaculture products and environmental samples.
研究领域:
环境科学
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分析化学
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PubMed
高影响因子
IEEE TRANSACTIONS ON NANOBIOSCIENCE
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2026
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IF 4.2
Wanlu Zheng,Weixin Kong,Na Zhang,Zhong Li,Ya-nan Zhang
reusable optical fiber surface plasmon resonance (SPR) sensor for quantitative detection of Pseudomonas aeruginosa is presented. To achieve repeatable measurement, this study used aptamer DNA as the functional monomer and polydopamine as the cross-linking agent to construct a molecularly imprinted nanofilm on the sensing surface. After elution treatment, molecularly imprinted cavities with high matching shape and size to the target molecule are formed in the nanofilm. Experimental results demonstrated that the sensors enhanced by molecular imprinting technology achieved an increase in resonance wavelength response from 10.677 nm to 24.98 nm, a reduction in response time from 22 minutes to 16 minutes, and an improvement in detection limit from 0.00985 OD to 0.00105 OD, compared with sensors only modified with functional monomers. Moreover, to address the problem of temperature interference in practical applications, a Fabry-Perot interferometer (FPI) is innovatively integrated. By taking advantage of the temperature sensitivity but bacterial insensitivity of FPI, the influence of temperature changes on SPR measurement is quantified, effectively providing temperature compensation and further improving the environmental adaptability of the sensor. This study provides a novel, reliable, and cost-effective detection solution for marine environmental microbial monitoring.
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DOI
PubMed
高影响因子
RSC Advances
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2015
·Vol. 5
·期 81
·66147-66154
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IF 3.84
Xiaohong Zhu,Hui Li,Hui Zhou,Shian Zhong
A novel protein imprinted polymer, which combined the surface imprinting technology and magnetic halloysite nanotubes (MHNTs), was prepared for selective separation of a template protein. In this work, MHNTs were synthesized through the coprecipitation method based on encapsulation of Fe3O4 nanoparticles in halloysite nanotubes. The surface of the MHNTs was modified with vinyl groups through reaction with 3-(methacryloyloxy)propyl trimethoxysilane. Subsequently, the modified MHNTs were used as a support, N-isopropylacrylamide and methacrylic acid as bifunctional monomers, N,N′-methylene bisacrylamide as the crosslinking agent, and ammonium persulphate and N,N,N′,N′-tetramethylethylenediamine as initiators. The resulting polymer was named MHNTs@BSA-MIP, which was characterized by transmission electron microscopy, Fourier transform infrared spectroscopy, X-ray diffraction, and vibrating sample magnetometry. The MHNTs@BSA-MIP exhibited high adsorption (48.4 mg g−1), good selectivity, rapid kinetic binding (45 min), fast magnetic separation (10 s), and favorable reproducibility (relative standard deviation <8% for batch-to-batch evaluation). The prepared MHNTs@BSA-MIP is suitable for separation and provides a significant reference for other proteins in proteomics.
研究领域:
材料科学
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生物化学
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纳米技术
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高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2025
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IF 5.4
Yingying Wang,Fuyu Zhang,Mengshuo Du,Bihe Chen,Yifeng Xu,Wenzhi Tang,Zhonghong Li
Highly toxic Pb(Ⅱ) and Cd(Ⅱ) persist in water and soil, disrupting ecosystems while threatening human health through bioaccumulation. Metal-organic frameworks (MOFs) as adsorbents toward heavy metal ions have garnered significant research attention. However, their adsorption capacity and retrieval are limited by small pore size and powder form. Herein, we designed a defective MIP-202 composite aerogel (DMCA) to efficiently remove Pb(Ⅱ) and Cd(Ⅱ). Mixed ligand (mercaptosuccinic acid) and modulator (butyric acid) were involved in the synthesis of MIP-202, and competed with the original amino acid ligand for binding to Zr clusters leading to the disruption of the original structure of MIP-202 and defect formation. Defective MIP-202 (D-MIP-202) possessed larger BET surface area (from 35.79 to 129.57 m 2 /g) and pore size (from 6.16 to 11.78 nm). Moreover, D-MIP-202 powder and sodium alginate were synthesized into DMCA with abundant adsorption sites and porous structures to enhance the sorption capacities, which were 434.7 mg/g (Pb(II)) and 202.6 mg/g (Cd(II)). The adsorption process primarily occurs on the heterogeneous surface of the material and represents a spontaneous chemisorption behavior. The adsorption mechanism is attributed to chelation, and ion exchange. This study presents an effective strategy for the remediation of heavy metal ions in aqueous systems.
研究领域:
环境科学
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材料科学
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污染控制化学
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吸附分离
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功能材料
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高影响因子
MICROCHIMICA ACTA
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2026
·Vol. 193
·期 4
·233
·
IF 5.4
Gao Xiang,Hou Yujiao,Lin Fang,Wen Limei,Guo Yali,Kong Weijun,Hu Junping,Yang Jianhua
An electrochemical (EC) molecularly imprinted polymer (MIP) sensor for therapeutic drug monitoring of olanzapine (OLZ) has been developed. A “rime-like” gold-platinum nanostructured film (Au-Pt NF) was fabricated on a screen-printed carbon electrode (SPCE) via an one-step hydrogen bubble dynamic template (HBDT) method, followed by electropolymerization of a polyaniline-based MIP. The Au-Pt NF/SPCE served as an ideal three-dimensional conductive substrate with a large active area and enhanced electron-transfer capability, endowing the specific MIP sensor with high sensitivity. Using [Fe(CN) 6 ] 3−/4− as a redox probe, the sensor quantified OLZ by the decrease in differential pulse voltammetry current caused by target binding. It exhibited two linear ranges (0.005–0.4 µM and 0.4–10 µM) with a detection limit of 0.94 nM, and demonstrated high selectivity, reproducibility, and stability. The sensor achieved recoveries of 96.7–102.7% for OLZ in tablets, urine, and whole blood. This work provides a reliable, all-EC sensing platform with strong potential for rapid OLZ monitoring in clinical settings.
Section
Graphical
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高影响因子
ANALYTICA CHIMICA ACTA
·
2020
·
IF 5.977
M.R. Ali,M.S. Bacchu,M. Daizy,C. Tarafder,M.S. Hossain,M.M. Rahman,M.Z.H. Khan
s In this experiment, a highly effective electrochemical sensor based on a molecularly imprinted polymer has been developed for ultrasensitive detection of dimetridazole. The sensor was made by incorporating of dimetridazole as a template molecule during the electropolymerization of poly-arginine on a glassy carbon electrode. The modified electrode GCE/P-Arg@MIP was characterized by voltammetric and microscopic techniques. Differential pulse voltammetry method was used to detect target analyte under the optimum condition. The DPV response to dimetridazole was linear at 0.1 × 10 −9 to 10 × 10 −6 mol L −1 ( R 2 = 0.996), with a method detection limit (S/N = 3) of 0.1 × 10 −9 mol L −1 . Moreover, the proposed sensor shows satisfactory recovery ranges for the determination dimetridazole in commercially available egg, milk and honey samples.
研究领域:
分析化学
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食品科学
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环境监测
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DOI
PubMed
高影响因子
ADVANCES IN POLYMER TECHNOLOGY
·
2020
·
IF 1.539
Jingbo He,Li Zhang,Longhua Xu,Feifan Kong,Zhixiang Xu
The excessive use and ingestion of residues of sulfonamides harm the human body and the environment. To meet the requirements of the maximum residue limit specified by the Ministry of Agriculture of China, a rapid detection method urgently needs to be developed. In the present study, a molecularly imprinted polymer (MIP) that could selectively recognize sulfadiazine (SDZ) was prepared using SDZ as the template molecule and methacrylic acid as the functional monomer. Using MIP as biomimetic antibody and [email protected]@SiO2 nanozyme as a marker, a new biomimetic immunoassay was developed to detect sulfadiazine. Under the optimal conditions, the limit of detection () and sensitivity () of this method were 0.09 and 6.1 mg/L, respectively. To determine the accuracy of this method, honey and milk samples spiked with sulfadiazine were analyzed, with recoveries in the range of 70.8%-90.2%. The method was also used for the quantitative analysis of sulfadiazine residues in milk powder and milk samples, producing results which correlated well with those obtained by high-performance liquid chromatography.
研究领域:
分析化学
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食品科学
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环境科学
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高影响因子
危险品化学品经营许可证（带存储）