JOURNAL OF CHROMATOGRAPHY A
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2024
·
IF 3.8
Suling Zhang,Hengli Liu,Defeng Fu,Hongting Zhao,Dong Zhang,Ting Lü
Metal–organic frameworks (MOFs) are promising materials for sample pretreatment. The performance improvement of powdered MOFs is hindered by their aggregation and difficult recovery. To overcome these issues, a biodegradable lightweight spherical aerogel was used as a support for the in situ growth of copper-based MOFs (MOF-199). Furthermore, Fe 3 O 4 nanoparticles were incorporated into the aerogel to achieve magnetic properties. Thus, hybrid aerogel spheres containing MOF-199 supported on magnetic oxidized cellulose nanofiber/carboxymethyl chitosan (MOF-199@mag-CNF/CMC) were fabricated. The effects of Fe 3 O 4 loading amount and organic-ligand concentration on the properties (spherical geometry and mechanical strength) of the hybrid aerogel spheres were studied. Their potential application in the extraction of benzodiazepines (BZPs) from urine samples prior to liquid chromatography–mass spectrometry was evaluated. The highly dispersed MOF-199 crystals on the spherical aerogel effectively overcame the inherent structural shrinkage of the bare aerogel spheres; thus, the MOF-199@mag-CNF/CMC aerogel spheres were robust and could withstand repeated use for at least eight consecutive extraction cycles. Further, MOF-199@mag-CNF/CMC exhibited improved BZP extraction efficiency, which was 2.5–11.6 times higher than that of bare Cu 2+ @mag-CNF/CMC aerogel spheres, primarily due to additional π–π interaction and H-bonding as well as improved specific surface area. Parameters influencing the extraction and desorption processes were also comprehensively investigated. Under optimal conditions, this method provided a wide linear range of 0.1–10 µg/L ( R 2 > 0.995) and good precision (2.8–6.7% for intra-day; 1.9–7.8 % for inter-day). The limits of detection and quantification ranged from 0.02 to 0.11 µg/L and from 0.06 to 0.33 µg/L, respectively. The recoveries for the urine samples spiked with three concentrations of BZPs ranged from 73.9 % to 114.1 %. The proposed method is simple, sensitive and eco-friendly and can be used for the determination of BZPs from urine for clinical and forensic examinations.
研究领域:
分析化学
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材料科学
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药物分析
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PubMed
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2019
·
IF 3.375
Hua Song,Xiaojuan Li,Bolong Jiang,Mingyue Gong,Tianzhen Hao
A highly active and stable MOF-199-supported ionic liquid [Hnmp][H2PO4] (IL-NP) adsorbent (Py/MOF) was successfully synthesized and characterized via XRD, SEM and TEM, TG-DTG, FT-IR, BET, and XPS technologies. The effects of different sulfides and interfering components present in model oils on the adsorptive desulfurization (ADS) performance of Py/MOF were studied. The results show that the regular octahedron crystalline structure of MOF-199 was well preserved and IL-NP fixed on the surface of MOF-199 presented like a flower after grafting ionic liquid IL-NP. The Py/MOF showed highly ordered canals, which are larger than those of MOF-199. Upon introducing IL-NP to MOF-199, the ADS activities were improved, which can be attributed to the improved intimate contact between sulfur compounds and adsorbent, the additional adsorption acidic sites for slightly basic sulfur compounds, and the increased pore size with mesoporous pores appearing. The ADS activity of Py/MOF adsorbing different sulfides was in the order of DBT > BT > 3-MTP > TP > 2,5-DMTP, and the effect of interfering component on ADS performance of Py/MOF was in the order of cyclohexene > toluene > water > ethanol. After 4 times of regeneration, the DBT removal onto Py/MOF was still at 93.8%, which decreased by 4.9% as compared to that of the fresh adsorbent.
研究领域:
化学工程
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材料科学
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高影响因子
NANOTECHNOLOGY
·
2025
·Vol. 36
·期 40
·405701
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IF 2.8
Wenbo Li,Xuyang Jiang,Xia Wang,Zhuojiao Liu,Xin Wang,Wen Zheng,Chenhui Yang,Aibo Zhang
Metal–organic frameworks (MOFs) of MOF-199 with three distinct morphologies—cubic (hexahedral)-A, octahedral-B and tetradecahedral-C—were prepared by solvothermal method via adjusting the amount of coordination modulator of lauric acid. Meanwhile, absorbing hybrids of MOF-199@multi-walled carbon nanotubes (MWCNTs) with a three-dimensional structure were constructed via π–π stacking interactions between benzene ring π-electrons in the organic ligand of MOF-199 and π electronic of MWCNTs. Scanning electron microscopy images demonstrated that MOFs particles with three distinct morphologies were obtained, with an average particle size of approximately 2 μm. The aim of this study is to investigate the influence of MOF morphology on the absorption performance. Due to the increased number of facets and relatively abundant heterogeneous interfaces of tetradecahedral MOF-199-C, the RLmin of MOF-199-C@MWCNTs hybrids reach up to −48.16 dB, which is higher than that of cubic MOF-199-A@MWCNTs (−23.21 dB) hybrids and octahedral MOF-199-B@MWCNTs (−45.77 dB) hybrids. The results indicated that increasing the number of facets promotes multiple scattering and internal reflection of electromagnetic waves, which increases the heterogeneous interfaces and promotes absorption performance.
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高影响因子
JOURNAL OF SOLID STATE CHEMISTRY
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2021
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IF 3.498
Abid Hussain Shah,Chen Yuan,Weiyi Hao,Wenhao Gu,Shuyu Liang,Zain Ul Abideen,Fazli Wahid,Fei Teng
In this work, we mainly investigate the adsorption properties of the simulated single and mixture wastewaters over porous Bi 2 MoO 6 @BiOCl@MOF-199 (BMO@BOC@MOF-199), including methylene blue (MB), rhodamine blue (RhB), methyl orange (MO) and chromium (VI). It is found that BMO@BOC@MOF-199 has a high adsorption capacity for MB, but a poor adsorption capacity for MO. Specifically, for single MB solution, 67%, 80% and 96% of MB are adsorbed by BMO@BOC, MOF-199 and BMO@BOC@MOF-199, respectively. The higher adsorption capacity of BMO@BOC@MOF-199 could be due to its higher surface area and larger pore volume . For single MO solution, nevertheless, only 16%, 13% and 7% of MO are adsorbed by BMO@BOC, MOF-199 and BMO@BOC@MOF-199, respectively. The different adsorption efficiency for MB and MO could be relative to their different molecular structures, which have different electrostatic interactions with adsorbent surface. For single RhB and single Cr(VI) solution, BMO@BOC@MOF-199 has adsorbed 30% RhB and 10% Cr(VI). In RhB-MO mixture solution, 32% RhB and 9% MO can be adsorbed by BMO@BOC@MOF-199, while in Cr(VI)–RhB-MO mixture solution, 7% Cr(VI), 3% RhB and 42% MO can be adsorbed by BMO@BOC@MOF-199. It is seen that in RhB-MO mixture solution, the adsorption efficiencies of RhB and MO by BMO@BOC@MOF-199 do not obviously change as compared to single RhB and single MO solution, while in Cr(VI)–RhB-MO mixture solution, the adsorption efficiency of MO has increased by 5 times, compared to single MO solution; but the adsorption efficiency of RhB has decreased by 9.7 times as compared to single RhB solution, and the adsorption efficiency of Cr(VI) has decreased slightly, compared to single Cr(VI) solution. The results are mainly attributed to the competitive adsorption on the adsorbent surface. This work can help us to understand the adsorption process for practical wastewater.
研究领域:
环境科学
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材料科学
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高影响因子
International Journal of Nanomedicine
·
2025
·
IF 6.5
Maopu Tu,Xiaoyu Deng,Bin Lai,Jiao Liu,Yingzhou Tao,Shaohua Xu,Xiaodong Li,Xiaoqiang Niu,Zhixin Li,Jiahui Huang,Jiaxin Li,Shengxun Mao,Xi Ouyang,Jiaqing Cao
Background Chemodynamic therapy (CDT) is a promising antitumor strategy that damages tumor cells by generating reactive oxygen species (ROS) to induce oxidative stress. However, antioxidant mechanisms in tumor cells greatly reduce CDT efficacy.Methods We propose using MOF-199 nanoparticles (NPs) with tumor microenvironment responsiveness as a carrier for miR-4521 to construct miR-4521@MOF-199 for cancer treatment. Polyacrylamide gel electrophoresis evaluated MOF-199’s loading and protective capacity for miR-4521. In vitro and in vivo experiments assessed the system’s antitumor effect and biosafety, with mechanisms explored.Results The miR-4521@MOF-199 NPs effectively protected and delivered miR-4521 to tumor cells. Within high-glutathione (GSH) tumor microenvironments, NP degradation released both miR-4521 and Cu2+. The increased intracellular Cu2+ triggered tumor cell apoptosis via ROS-mediated CDT while activating cuproptosis through proteotoxic stress. Concurrently, miR-4521 disrupts the oxidative stress defense mechanisms of tumor cells by inhibiting FOXM1 expression, thereby enhancing the efficacy of CDT. Furthermore, the silencing of FOXM1 can further impede tumor progression through gene regulatory mechanisms. Experimental results demonstrate that miR-4521@MOF-199 exhibits potent antitumor efficacy and high biocompatibility via synergistic CDT, gene therapy, and cuproptosis.Conclusion This multifunctional nanosystem exhibits potent antitumor effects and low toxicity, providing a promising research direction for multimodal combinatorial cancer therapy based on CDT.
研究领域:
生物医学工程
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肿瘤学
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纳米技术
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基因治疗
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PubMed
高影响因子
APPLIED ORGANOMETALLIC CHEMISTRY
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2019
·Vol. 33
·期 5
·e4865
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IF 3.259
Chao Duan,Chaoran Liu,Xin Meng,Wanli Lu,Yonghao Ni
In this work, we prepared high-performance and recyclable nanocatalysts that consist of small and well-dispersed silver nanoparticles (Ag NPs) immobilized onto Cu- based metal–organic framework (MOF-199 s) supported by carboxymethylated cellulose fibers (CCFs). The as-prepared green nanohybrid catalysts, namely Ag NPs@ MOF-199 s/CCFs, were characterized using SEM, TEM, XRD and FT-IR techniques. The catalytic performances showed that Ag NPs@ MOF-199 s/CCFs catalysts exhibited a very high catalytic efficiency towards the reduction of 4-nitrophenol to 4-aminophenol. The enhanced catalytic performances are attributed to the improved dispersity, small particles of Ag NPs stabilized by the MOF-199 s, and the porous catalyst structures. The introduction of cellulose fiber further facilitates the reuse and sustainability of the nanohybrid catalysts, showing a stable and high reusability (more than 91% of catalytic activity) even after five runs.
研究领域:
材料科学
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环境科学
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高影响因子
RSC Advances
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2016
·Vol. 6
·期 114
·113144-113151
·
IF 3.289
Xiaolin Cao,Guangyang Liu,Yongxin She,Zejun Jiang,Fen Jin,Maojun Jin,Pengfei Du,Fengnian Zhao,Yanxin Zhang,Jing Wang
MOF-199/Fe3O4 nanoparticles were explored for the first time to purify environmental water samples and adsorb neonicotinoid insecticides as hybrid adsorbents. The composites were successfully synthesized by an in situ method at room temperature with electrostatic interaction to chemically stabilize the nanoparticles and metal ions. The nanoparticles were uniformly encoded with metal organic frameworks (MOFs). With the lowest loading amount of Fe3O4 applied to magnetic solid-phase extraction (MSPE) of six neonicotinoid insecticides in environmental water samples followed by high performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS) analysis, the extraction efficiency was the highest. The main influencing factors including the solution ionic strength, solution pH, extraction time, desorbing organic solvent, and solvent volume, were also evaluated. Considering the adsorbing conditions and insecticide structures, the adsorbing mechanism was preliminarily discovered to be largely dependent upon the π–π interaction with the benzene ring in MOF-199 and delocalized large π bonds in the insecticide molecules. Under optimal conditions, the limits of detection (LODs) were 0.3–1.5 ng mL−1 with a signal-to-noise ratio (S/N) of 3. All the analytes exhibited good linearity with correlation coefficients (r2) of higher than 0.9947. The relative standard deviations (RSDs) for six neonicotinoid insecticides in environmental samples in five replicates ranged from 1.5% to 11.6%, and good recoveries from 88.0% to 107.0% were obtained, indicating that the MOF-199/Fe3O4 composites are feasible for analysis of trace analytes in environmental water samples.
研究领域:
分析化学
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环境科学
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DOI
高影响因子
FOOD CHEMISTRY
·
2026
·
IF 10.4
Qingyi Wei,Xiaojian Fei,Hongbin Pu
Allyl isothiocyanate (AITC) was effectively encapsulated within HKUST-1. • HKUST-1@AITC exhibits a humidity-responsive release mechanism. • The vapor released from HKUST-1@AITC inhibits microbial growth. • HKUST-1@AITC significantly prolonged the shelf life of strawberries. Allyl isothiocyanate (AITC), a volatile compound predominantly found in mustard essential oil, has attracted significant attention as a potent natural antimicrobial agent for postharvest preservation of horticultural products. However, its high volatility, hydrophobicity, and pungent odor limit its application. In this study, a water-unstable metal–organic framework, HKUST-1 (MOF-199), was fabricated using a solvothermal method and functioned as a carrier of AITC. AITC was successfully encapsulated into HKUST-1 via impregnation, yielding HKUST-1@AITC with excellent humidity-responsive release behavior. As the relative humidity (RH) increased from 43% to 98%, the cumulative release rate of AITC rose from 41.06% to 54.82%. Moreover, HKUST-1@AITC and vapor-phase diffusion of AITC released from HKUST-1@AITC have shown to exhibit superior antibacterial activity. Application in strawberries showed that HKUST-1@AITC reduced weight loss by 25.05%, alleviated firmness loss by 39.89%, and effectively extended the storage duration to 7 days. Overall, HKUST-1@AITC shows potential use in active packaging to improve preservation of horticultural products.
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高影响因子
RSC Advances
·
2016
·Vol. 6
·期 81
·77358-77365
·
IF 3.289
Ting-Ting Li,Jinjie Qian,Yue-Qing Zheng
Metal–organic frameworks (MOFs) have been demonstrated as suitable metal sources and sacrificial templates for the preparation of porous transition-metal oxide nanomaterials. Herein, porous CuO micro-polyhedra assembled from numerous nanoparticles are synthesized simply by employing a Cu-based MOF as a precursor via a one-step calcination process under an air atmosphere. Benefitting from their high porosity and large specific surface area, porous CuO materials exhibit excellent electrocatalytic performances toward water oxidation in pH 9.2 KBi solution. A low catalytic onset potential at 1.05 V vs. NHE (NHE = normal hydrogen electrode) is obtained based on electrochemical measurements. A faradaic efficiency of nearly 98% and a stable catalytic current density of 2.2 mA cm−2 are achieved under an applied potential of 1.30 V vs. NHE over an electrolysis period of 10 h. In addition, based on the Tafel plot, the required overpotentials are only ∼410 mV and ∼510 mV for achieving the catalytic current densities of 0.1 mA cm−2 and 1.0 mA cm−2, respectively. The excellent performances make it an appealing candidate as a potential catalyst for green energy applications.
研究领域:
材料化学
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电化学
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纳米材料
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能源催化
·
无机功能材料
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DOI
高影响因子
JOURNAL OF SEPARATION SCIENCE
·
2026
·Vol. 49
·期 8
·e70506
·
IF 3.6
Shaojing Huang,Suling Zhang,Huanhuan Yao,Zhiwei Huang,Dong Zhang,Ying Pan,Ting Lü,Hongting Zhao
Dextromethorphan is a widely used clinical antitussive, while its enantiomer, levomethorphan, is a controlled substance. Chiral separation and trace detection of the two enantiomers in biological samples are critically important. Herein, a micro-solid-phase extraction method coupled with enantioselective ultra-high performance liquid chromatography–mass spectrometry (UHPLC–MS) was proposed for the analysis of methorphan enantiomers. MOF-199/cellulose aerogel spheres fabricated via a facile in situ growth strategy were employed as the sorbent. By immersing Cu 2+ -rich cellulose aerogel in H 3 BTC (1,3,5-benzene tricarboxylate) solutions at varied concentrations, MOF-199/cellulose aerogels with tunable MOF-199 loadings (28.8%, 38.1%, 43.8%) were fabricated. Characterization results verified that MOF-199 was uniformly anchored in the pore channels of cellulose aerogel, which not only enhanced its specific surface area from 33.9 to 143.6 m 2 /g, but also mitigated the aggregation and poor recyclability of powdered MOF-199. The electrostatic attraction, chelation, and hydrogen-bonding interactions accounted for the effective extraction for dextro- and levo-methorphan. Under optimized conditions, this method exhibited favorable linearity in the range of 0.02–10.0 µg/L, with intra- and inter-day precisions of 4.9%–5.0% and 7.7%–9.7%, respectively. The limits of detection were 0.01–0.02 µg/L, respectively. Recoveries of dextro- and levo-methorphan from urine and hair samples were in the ranges of 88.9%–119.3% and 78.6%–115.7%, respectively. This method provides an effective strategy for the determination of methorphan enantiomers in biological samples, featuring rapid pretreatment, low organic solvent consumption, as well as facile operation.
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PubMed
高影响因子
Chemosensors
·
2024
·Vol. 12
·期 9
·187
·
IF 3.7
Yuyu Peng,Chunyan Wang,Gen Li,Jianguo Cui,Yina Jiang,Xiwang Li,Zhengjie Wang,Xiaofeng Zhou
In this study, a MOF-199/Ag@Au SERS sensing structure was successfully synthesized by combining metal–organic frameworks (MOFs) with surface-enhanced Raman scattering (SERS) technology for the efficient detection of dopamine (DA), a biomarker for neurological diseases, in serum. Using electrochemical methods, a copper-based MOF (MOF-199) was synthesized in situ on copper substrates and further deposited with silver nanoparticles (AgNPs). Subsequently, gold nanoshells were encapsulated around these silver cores by in situ chemical deposition. This preparation process is simple, controllable, and inexpensive. Furthermore, a novel Azo reaction-based DA SERS method was proposed to detect 1 pM DA, which represents an improvement in sensitivity by two orders of magnitude compared to previous unlabeled SERS detection methods and by four orders of magnitude compared to another SERS approach proposed in this work. There was an excellent linear relationship (R2= 0.976) between the SERS signal at 1140 cm−1and the DA concentration (0.001 M~1 pM). The results indicate that the MOF-199/Ag@Au sensor structure can successfully achieve both the qualitative and quantitative detection of DA in serum, thus providing a robust technical basis for the application of SERS technology in the field of clinical neurological disease screening.
研究领域:
生物医学工程
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神经科学
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分析化学
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高影响因子
MICROPOROUS AND MESOPOROUS MATERIALS
·
2018
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IF 3.649
Guangyang Liu,Lingyun Li,Xiaodong Huang,Shuning Zheng,Donghui Xu,Xiaomin Xu,Yanguo Zhang,Huan Lin
A novel magnetic copper-based metal organic framework (M-MOF-199) has been successfully prepared using Fe 3 O 4 –graphene oxide (GO) nanocomposite for solid phase extraction of five triazole pesticides from environment water samples. High-performance liquid chromatography coupled with tandem mass spectrometry was used for sample quantification and determination. The results suggest that Fe 4 O 3 –GO is a thin single-layer structure anchoring Fe 3 O 4 and M-MOF-199 is coated on its surface. Under the optimized conditions, the limits of detection of the triazole pesticides are 0.05–0.1 (S/N = 3) with correlation coefficients larger than 0.992. The recoveries in spiked water samples are 72.3%–91.53% with relative standard deviations ranging from 1.5% to 9.1%. Furthermore, the results show that M-MOF-199 is a promising hybrid adsorbent for magnetic dispersive solid phase extraction and removal of triazole pesticides from environmental water samples.
研究领域:
分析化学
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环境科学
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高影响因子
危险品化学品经营许可证（带存储）