RSC Advances
·
2020
·Vol. 10
·期 60
·36862-36872
·
IF 3.119
Mengru Cai,Liuying Qin,Longtai You,Yu Yao,Huimin Wu,Zhiqin Zhang,Lu Zhang,Xingbin Yin,Jian Ni
Metal organic frameworks (MOFs) are widely used in drug carrier research due to their tunability. The properties of MOFs can be adjusted through incorporation of mono-substituents to obtain pharmaceutical carriers with excellent properties. In this study, different functional groups of –NH2, –CH3, –Br, –OH and –CH2CH are connected to MOF-5 to analyse the effect of mono-substituent incorporation on drug delivery properties. The resulting MOFs have similar structures, except for Br–MOF. The pore size of this series of MOFs ranges from 1.04 nm to 1.10 nm. Using oridonin (ORI) as a model drug, introduction of the functional groups appears to have a significant effect on the drug delivery performance of the MOFs. The IRMOFs can be ranked according to drug-loading capacity: MOF-5 > HO–MOF-5 > H3C–MOF-5 = Br–MOF-5 > H2N–MOF-5 > CH2CH–MOF-5. The ORI release from ORI @IRMOFs is explored at two different pH values: 7.4 and 5.5, and the ORI@IRMOFs are ranked according to the cumulative release percentage of ORI: ORI@MOF-5 > ORI@Br–MOF-5 > ORI@H3C–MOF-5 > ORI@H2N–MOF-5 > CH2CH–MOF-5 > ORI@ HO–MOF-5. In particular, the release behaviour of ORI@MOFs is described through a new model. The different drug delivery performance of MOFs may be due to the complex interactions between MOFs and ORI. In addition, the introduction of single substituents does not change the biocompatibility of MOFs. MTT in vitro experiments prove that this series of MOFs has low cytotoxicity. This study shows that the incorporation of single substituents can effectively adjust the drug delivery behaviour of MOFs, which is conducive to realization of personalized drug delivery modes. The introduction of active groups can also facilitate post-synthesis modification to achieve coupling of targeting groups. MOFs incorporated with single substituents perform favorably in terms of use as biomedical drug delivery alternative carriers in effective drug payload and flexible drug release.
研究领域:
材料科学
·
药学
·
生物医学工程
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产品关联
DOI
PubMed
高影响因子
Advanced Sustainable Systems
·
2024
·
IF 6.5
Jiawei Zhou,Ming Liu,Shiyang Bai,Jihong Sun,Jia Wei,Ju Wang
The MOF-5@clinoptilolite (MOF@CP) composites are successfully synthesized using polyvinylpyrrolidone (PVP) for adsorption separation of CO 2 /CH 4 , CO 2 /N 2 , and CH 4 /N 2 . The effects of the PVP amounts on the dispersity of MOF-5 on CP random lamellas of the MOF@CPs are evaluated via various characterizations. Meanwhile, their single-component gas adsorption isotherms, breakthrough experiments, and cycling test are measured. The results elucidate that the used PVP amount has a significant influence on the particle size and the uniformity of MOF-5 dispersed on CP random lamellas. The MOF-5-loaded amount in MOF@CP is estimated to be up to 42.52 wt.%. Especially, the surface fractal evolutions indicated the surfaces of MOF@CP became from rough to smooth with the increase of PVP. The CO 2 /CH 4 , CO 2 /N 2 , and CH 4 /N 2 selectivity factors of MOF@CP are higher than that of CP, displaying a better separation performance. Their cycling test revealed that MOF@CPs could be used repetitively, highlighting efficiency for CO 2 and CH 4 separation. Meanwhile, the MOF-5@CP stability under moisture is preliminarily investigated, showing higher moisture resistance stability than MOF-5. Additionally, the grand canonical Monte Carlo simulations demonstrated the adsorption separation mechanism of the prepared MOF@CPs.
研究领域:
材料科学
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环境科学
✓ 已验证
DOI
高影响因子
DALTON TRANSACTIONS
·
2016
·Vol. 46
·期 1
·193-199
·
IF 4.177
Dongdong Xu,Fangfang Zhang,Yanzhou Sun,Zhihua Yang,Binghua Lei,Lili Liu,Shilie Pan
A new rare-earth borate LiRb2LaB2O6 (LB-1) has been synthesized using a high-temperature solution method. Interestingly, it shares its topological structure with the famous porous material MOF-5, which is formed from Zn4O(BDC)3 (BDC = 1,4-benzenedicarboxylate). The nodes [OZn4] and organic linkers [BDC] of MOF-5 are carefully substituted with La3+ rare-earth cations and the inorganic linkers [BO3] and [LiO4], respectively, in order to construct a pure inorganic open framework. LB-1 exhibits good thermal and water stability. Moreover, it possesses a short cut-off edge (<190 nm) and moderate birefringence (exp. 0.040@589.5 nm, cal. 0.038@589.5 nm). Further insights into the cut-off edge were given by first-principles calculations. The factors that influence the birefringence of LB-1 were discussed in view of the spatial arrangement of the [BO3] anionic groups.
研究领域:
无机化学
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材料科学
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晶体工程
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光学材料
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固体化学
✓ 已验证
DOI
高影响因子
FUEL
·
2024
·
IF 6.7
Yang Sun,Fan Yang,Siyuan Sun,Yankun Sun,Hongchen Liu,Chunhui Yu,Junpu An,Xi Li,Yongfeng Li
The preparation of highly active and stable Pd-based catalysts for direct alcohol fuel cells (DAFC) is hampered by inefficient utilization of the active sites, susceptibility to CO poisoning, poor stability, and relatively slow reaction kinetics. Herein, the stability and anti-toxicity of the catalysts (Pd/ZnO/MDC) are tuned by loading Pd nanoparticles on the carbon-coated ZnO support, achieving efficient electrocatalysis for methanol and ethanol oxidation reaction (MOR and EOR). TEM result shows the ZnO is covered by the carbon layer formed outside of MOF-5 derived porous carbon, which can prevent it from dissolving under harsh conditions. The mass activities of the well-tuned catalyst Pd/ZnO/MDC (8 0 0) for MOR and EOR are 931.83 mA/mg and 1838.30 mA/mg, respectively. It is due to the improved electron transport efficiency between the Pd and ZnO, and the enhanced stability by carbon layer outside the ZnO. It is also found that the onset potential and the peak potential of Pd/ZnO/MDC (8 0 0) (−0.813 V, −0.228 V) in CO stripping experiment in MOR are more negative than Pd/MDC (8 0 0) (−0.261 V, −0.215 V). This result indicates that the existence of ZnO helps to provide surface hydroxyl group, which promotes the oxidation of the intermediates. This work indicates provides a feasible idea for DAFC catalyst design and construction.
研究领域:
材料科学
·
电化学
✓ 已验证
产品关联
DOI
高影响因子
ANALYTICAL CHEMISTRY
·
2020
·
IF 6.785
Dexin Du,Jiangnan Shu,Mingquan Guo,Mohammad A. Haghighatbin,Di Yang,Zhiping Bian,Hua Cui
Recently, nanoluminophores with the potential-resolved multicolor electrochemiluminescence (PRMCECL) property have emerged and shown promising applications in sensitive, selective, and accurate bioassays, bioimaging, and multicolor emitting devices. However, only limited PRMCECL nanoluminophores and their applications in ratiometric biosensors eliminating proportional errors have been reported. Herein, a novel PRMCECL nanoluminophore was synthesized by encapsulating CdS quantum dots (CdSQDs) into MOF-5 (CdSQDs@MOF-5). Using K2S2O8 as a coreactant, two electrochemiluminescence (ECL) peaks, ECL-1 centered at 685 nm and ECL-2 centered at 475 nm, were observed at −1.4 and −1.8 V, respectively. Related ECL mechanisms have been proposed. Based on the potential-resolved ECL signals, a label-free differential ECL immunosensor for the determination of cardiac troponin I (cTnI) was established by assembly of poly(diallyldimethylammonium chloride), CdSQDs@MOF-5, and cTnI antibody-functionalized silver nanoparticles on the surface of the fluorine-doped tin oxide electrode subsequently. In the presence of cTnI, cTnI was captured by the sensing interface, leading to an increase in ECL-1 and ECL-2 intensity. cTnI could be determined in the range of 0.01–1000 pg/mL with a detection limit of 5.01 fg/mL using the intensity difference between ECL-1 and ECL-2. This work provides a new family member of PRMCECL nanoluminophores. The proposed label-free differential ECL immunosensor provides a new strategy based on potential-resolved ECL signals, which could effectively eliminate the additive error and show better sensitivity, selectivity, and accuracy for the detection of cTnI than the single-signal strategy and ratiometric strategy.
研究领域:
电化学
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纳米技术
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生物传感器
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心脏病学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2021
·
IF 13.273
Xiaohai Yan,Yuning Zhao,Gengan Du,Qi Guo,Hong Chen,Qian He,Qiannan Zhao,Huanfeng Ye,Jianlong Wang,Yahong Yuan,Tianli Yue
Tools to detect low molecular weight mycotoxin patulin (PAT) are urgently needed because of its harm to human health. Here, we report a simple, effective, and sensitive fluorescent aptasensor based on sulfur quantum dots encapsulated in MOF-5-NH 2 ( [email protected] 2 ) and self-cycling catalyzed hairpin assembly (scCHA) for the detection of PAT in apple juice. The [email protected] 2 synthesized by a “bottle-around-ship” solvothermal method works as a fluorescent probe and offers enhanced fluorescence intensity and good water-solubility versus MOF-5-NH 2 due to the encapsulation of water-soluble SQDs . Meanwhile, the scCHA designed by the two DNA hairpins is initiated after the formation of PAT/aptamer, which further recycles PAT to effectively capture multiple fluorescence probes ( [email protected] 2 ) and amplify the detection signal. Attributed to the synergistic effect between the strong fluorescence intensity of [email protected] 2 and the efficient PAT utilization of scCHA, the fluorescent aptasensor exhibits high sensitivity with detection limits as low as 0.753 pg/mL. The system has satisfactory specificity, anti-interference, and reproducibility (RSDs of intra-assay and inter-assay were 3.24% and 8.60%, respectively). The recoveries in apple juice were between 89.03% and 107.67%, which were with good consistency versus high-performance liquid chromatography (HPLC). These data collectively show that the developed fluorescent aptasensor has a good practical application value.
研究领域:
分析化学
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纳米技术
·
食品安全
✓ 已验证
产品关联
DOI
高影响因子
MICROCHIMICA ACTA
·
2017
·Vol. 184
·期 4
·1029-1036
·
IF 4.58
Zhou Qingxiang,Lei Man,Li Jing,Liu Yongli,Zhao Kuifu,Zhao Danchen
Metal organic frameworks of type MOF-5 exhibit good adsorption capacity for many organic compounds. The authors have used nanoscale silica-coated zerovalent iron and MOF-5 to prepare, by co-precipitation, a novel magnetic nanomaterial of type Fe@MOF-5. Its morphology and structure were characterized by transmission electron microscopy and X-ray diffraction. The nanomaterial is shown to be well suited for magnetic solid phase extraction for five kinds of N- and S-containing polycyclic aromatic hydrocarbons prior to quantitation by HPLC. The limits of detection are in the 25 to 33 ng⋅L −1 concentration range. Four real water samples were used to validate the method, and the recoveries of spiked samples with concentrations of 5 and 10 ppb were found to be in the range between 92.6 and 97.3% ( n = 3). The Fe@MOF-5 sorbent obviously has excellent adsorption capability for such compounds, can be fairly easily synthesized, displays sensitivity, simplicity, ease of operation, and can be prepared at low costs. In our perception, it has a large potential in terms of monitoring such environmental pollutants.
A metal organic framework of type Fe@MOF-5 is found to exhibit good adsorption capacity for N- and S-containing polycyclic aromatic hydrocarbons. A sensitive magnetic solid phase extraction method with Fe@MOF-5 was developed for the determination of N- and S-containing polycyclic aromatic hydrocarbons from the water samples.
研究领域:
环境科学
·
分析化学
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
·
2014
·Vol. 30
·期 3
·356-361
·
IF 1.119
Han Pengfei,Yuan Changfu,Xu Junyi,Liu Jin
We reported a dripping solvothermal method for synthesizing metal-organic framework-5(MOF-5). It started from separately dissolving Zn(NO 3 ) 2 and terephthalic acid(H 2 BDC) in dimethyl formamide(DMF), and then dripping one solution into the other. Results of SEM, XRD and laser particle size distribution show that regular cubic-shaped and micro-crystallite powder of MOF-5 can be obtained. The d
0.5 (volume-median-diameter) values are 4.32 μm for particles prepared by dripping Zn(NO 3 ) 2 into H 2 BDC(ZH) and 9.32 μm for those prepared by dripping H 2 BDC into Zn(NO 3 ) 2 (HZ), much smaller than 22.7 μm that of particles prepared by the traditional adding water solvothermal method(L). The standard deviations of the particle size distributions fitted by the GaussAmp model are 2.49, 4.38 and 15.4 respectively for ZH, HZ and L, further revealing narrower size distributions of particles prepared by the dripping method. In addition, the Langmuir specific surface areas are 923 m 2 /g for ZH and 868 m 2 /g for HZ. The TGA results present mass losses of 4.18% and 3.62% at 105 °C, 17.19% and 14.78% at 245 °C, 39.04% and 34.85% at 600 °C separately for ZH and HZ, which correspond to the removal of H 2 O, DMF and the decomposition of MOF-5. This indicates that MOF-5 has a strong adsorption ability for small molecules. Besides, the mass loss of 48.39%(ZH) and 41.02%(HZ) between 400 °C and 600 °C are less than the theoretical value of 57.81% for MOF-5 decomposition to ZnO, suggesting that an impure phase with an extra amount of ZnO may exist in the cavities of MOF-5.
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产品关联
DOI
高影响因子
Journal of Chemistry
·
2021
·
IF 2.506
Renjie Zhou,Gui Chen,Yuejun Ouyang,Hairui Ni,Nonglin Zhou,Bailin Xiang
Using MOF-5 as a template, the porous carbon (MDPC-600) possessing high specific surface area was obtained after carbonization and acid washing. After MDPC-600 was loaded with Cu ions, the catalyst Cu/MDPC-600 was acquired by heat treatment under nitrogen atmosphere. The catalyst was characterized by X-ray powder diffraction (XRD), N2 physical adsorption (BET), field emission electron microscope (SEM), energy spectrum, and transmission electron microscope (TEM). The results show that the Cu/MDPC-600 catalyst prepared by using MOF-5 as the template has a very high specific surface area, and Cu is uniformly supported on the carrier. The catalytic hydrogen peroxide oxidation reaction of phenol hydroxylation was investigated and exhibits better catalytic activity and stability in the phenol hydroxylation reaction. The catalytic effect was best when the reaction temperature was 80°C, the reaction time was 2 h, and the amount of catalyst was 0.05 g. The conversion rate of phenol was 47.6%; the yield and selectivity of catechol were 37.8% and 79.4%, respectively. The activity of the catalyst changes little after three cycles of use.
研究领域:
材料科学
·
催化化学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
·
2016
·
IF 2.357
Caina Jiao,Yanen Wang,Menghua Li,Qiuhua Wu,Chun Wang,Zhi Wang
In this paper, a magnetic nanoporous carbon (Fe 3 O 4 /NPC) was successfully synthesized by using MOF-5 as carbon precursor and Fe salt as magnetic precursor. The texture properties of the as-synthesized nanocomposite were characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), vibration sample magnetometer (VSM), and N 2 adsorption–desorption isotherms. The Fe 3 O 4 /NPC had a high surface area with strong magnetic strength. Its adsorption behavior was tested by its adsorption capacity for the removal of methylene blue from aqueous solution. The results demonstrated that the Fe 3 O 4 /NPC had a high adsorption capacity, rapid adsorption rate, and easy magnetic separabilty. Moreover, the adsorbent could be easily regenerated by washing it with ethanol. The Fe 3 O 4 /NPC can be used as a good alternative for the effective removal of organic dyes from wastewater.
研究领域:
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
MATERIALS CHEMISTRY AND PHYSICS
·
2023
·
IF 4.6
Wei He,Yucheng Liu,Zhi Huang,Wenwen Tu,Rui Liu,Mingyan Chen
A novel superhydrophilic and underwater superoleophobic material (MOF-5/PDA/SSM) with high flux, outstanding oil/water separation performance and durability was prepared. The stainless steel mesh (SSM) was modified by MOF-5 crystals and PDA. The introduction of MOF-5 can improve the hydrophilicity of SSM and achieve high water flux at the same time. PDA is a substance with strong adhesion which can be used as an effective bonding intermediate. The preparation strategy includes the self-polymerization of dopamine and the deposition of cubic clusters on SSM via hydrothermal reaction . The MOF-5 particles on the mesh are cubic hexahedral crystal with a uniform size diameter, which can trap water in the rough microstructure, forming a strong hydration barrier layer or composite water-solid interface on its surface, hindering the penetration of oil. The super-hydrophilicity and underwater superoleophobicity of the modified meshes were introduced by pre-wetting surface. The FTIR, XRD , XPS and SEM characterizations demonstrated that the successfully growth of MOF-5 and a rough structure was obtained on the mesh. The special wetting and the robustness of the fabricated mesh led to the outstanding separation efficiency (up to 99.5%), excellent recyclability (about 20 cycles) and high water flux (53.9 k L m −2 h −1 ). The mesh also showed remarked water flux and various oil/water mixtures separation performance. Particularly, the successfully prepared materials were found to be significant stable under various physical and chemical extremes environments, including maintain UWOCA>150 under acid/alkali media, marvelous performance after 120 min of continuous separation and high anti-oil intrusion pressure. The combination of metal organic framework and stainless steel mesh may provide a candidate application to effective oil-water separation.
研究领域:
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2014
·
IF 3.84
Xiangyu Wan,Hongjie Song,Di Zhao,Lichun Zhang,Yi Lv
In the present work, Y-doped metal-organic framework-5 (MOF-5) was synthesized by a simple solvothermal method and characterized by X-ray diffraction, scanning electron microscope , energy dispersive X-ray spectroscopy and nitrogen adsorption–desorption measurements, and firstly used as gas sensor materials based on cataluminescence (CTL). When isobutanol passed through the surface of the material, CTL emission was observed. The luminescence characteristics and optimal parameters were investigated in detail. Under the optimized conditions, the present gas sensor exhibited a linear range of 6.4–80.1 mg L −1 toward isobutanol and with a limit of detection of 3.7 mg L −1 . The designed CTL sensor based on Y-doped MOF-5 shows no or weak sensing performance for foreign common volatile organic compounds. Moreover, compared with pure MOF-5, Y-doped MOF-5 exhibited a better CTL response to isobutanol under the same conditions. This work exploits a new application domain of metal-organic frameworks (MOFs).
研究领域:
材料科学
·
化学传感
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）