MINERALS ENGINEERING
·
2022
·
IF 5.479
Huizhen Xiao,Guifang Wang,Guangchuan Liang,Jinliang Zhu,Jun Qiu,Chenhui Ding,Sridhar Komarneni
The mining and processing of lead-zinc ores produce many lead-zinc ore tailings, which can cause harm by releasing toxic metal ions to the environment. Therefore, the leaching characteristics, acid generation capacity, and fractions of released heavy metals from two Pb-Zn tailings, one from Guangxi designated as F and another from Inner Mongolia designated as YD, have been investigated in this work. Here, sodium diethyl dithiocarbamate functionalized montmorillonite (DDTC-Mt) was synthesized to remediate both F and YD tailings. It was found that YD tailings have a stronger acid generation potential than F tailings, and both of them could be further oxidized and release acid. Moreover, YD showed a certain buffering capacity to acid rain due to its higher calcite content, while the leaching amounts of heavy metals from F was larger than YD resulting from the former’s higher weathering degree. DDTC-Mt resulted in a superior stabilization performance to Zn, Mn and Pb from both tailings with optimal stabilization ratios, which are all above 94%. The remediating effect of DDTC-Mt on F was better than that of YD, which could be ascribed to the fact that F contained lower amount of carbonate minerals because of a higher degree of weathering in the latter. The leaching amounts and stabilization ratios of the four elements increased with increasing time and dose of DDTC-Mt, however, temperature and pH showed little or no effect. Mineralogical analysis showed minerals in F and YD before and after leaching were mainly quartz, while the contents of sphalerite and pyrite in F-DDTC-Mt and YD-DDTC-Mt decreased although they were more than those in F and YD without DDTC-Mt after leaching for 72 h. DDTC-Mt could inhibit the release of heavy metals to a certain extent by covering the surface of tailings via complexation and precipitation. Furthermore, DDTC-Mt coating can prevent the oxidation of tailings.
研究领域:
环境科学
·
矿物加工
·
土壤化学
✓ 已验证
产品关联
DOI
高影响因子
International Journal of Nanomedicine
·
2023
·
IF 8
Qi Lou,Lu Pan,Shengjin Xiang,Yueting Li,Jiahui Jin,Jingyang Tan,Baoshan Huang,Kaihui Nan,Sen Lin
Introduction Benzalkonium chloride (BAC) is widely employed as a preservative in eye drops, which will cause the death of corneal epithelial cells due to ROS production, DNA strand breakage, and mitochondrial dysfunction, resulting in dry eye disease (DED)-like changes in ocular surface tissues. In this study, Melatonin (MT) liposomes (TAT-MT-LIPs) designed by loading MT into TAT-modified liposomes have been developed, characterized, and used for inhibiting BAC-induced DED (BAC-DED).Methods The TAT was chemically grafted onto the Mal-PEG2000-DSPE by Michael’s addition between the sulfhydryl group in TAT and the maleimide group in Mal-PEG2000-DSPE. TAT-MT-LIPs were prepared using film dispersion followed by the extrusion method and topically treated in rats once a day. BAC-DED was induced in rats by topical administration with 0.2% BAC twice daily. Defects, edema, and inflammation of the corneas, as well as IOP, were examined. Histologic analyses of corneas were performed to assess the change of mitochondrial DNA oxidation and NLRP3/Caspase-1/GSDMD signaling transduction.Results After topical administration, TAT-MT-LIPs significantly alleviated DED-clinical symptoms of experimental animals by inhibiting tissue inflammation and preventing the loss of the corneal epithelium and conjunctival goblet cells. Our data suggested continuous ocular surface exposure of BAC-induced NLRP3/Caspase-1/GSDMD mediated corneal epithelium pyroptosis, which was not reported before. BAC caused substantial mt-DNA oxidation, which promoted the transduction of NLRP3/Caspase-1/GSDMD and consequent corneal epithelium pyroptosis. TAT-MT-LIPs could efficiently suppress the BAC-induced corneal epithelium pyroptosis and inflammation by inhibiting mt-DNA oxidation and the subsequent signal transmission.Conclusion NLRP3/Caspase-1/GSDMD mediated corneal epithelium pyroptosis is involved in the development of BAC-DED. The present study provided new insights into the adverse effects of BAC, which can serve as a new target for protecting corneal epithelium when applying BAC as a preservative in eye drops. The developed TAT-MT-LIPs can efficiently inhibit BAC-DED and give great potential to be developed as a new DED treatment.
研究领域:
眼科
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药学
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细胞生物学
·
炎症
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CELL
·
2018
·
IF 31.398
Qian Zhang,Xueying Wu,Peng Chen,Limeng Liu,Nan Xin,Ye Tian,Andrew Dillin
Summary The mitochondrial unfolded protein response (UPR mt ) can be triggered in a cell-non-autonomous fashion across multiple tissues in response to mitochondrial dysfunction. The ability to communicate information about the presence of mitochondrial stress enables a global response that can ultimately better protect an organism from local mitochondrial challenges. We find that animals use retromer-dependent Wnt signaling to propagate mitochondrial stress signals from the nervous system to peripheral tissues. Specifically, the polyQ40-triggered activation of mitochondrial stress or reduction of cco-1 (complex IV subunit) in neurons of C. elegans results in the Wnt-dependent induction of cell-non-autonomous UPR mt in peripheral cells. Loss-of-function mutations of retromer complex components that are responsible for recycling the Wnt secretion-factor/MIG-14 prevent Wnt secretion and thereby suppress cell-non-autonomous UPR mt . Neuronal expression of the Wnt ligand/EGL-20 is sufficient to induce cell-non-autonomous UPR mt in a retromer complex-, Wnt signaling-, and serotonin-dependent manner, clearly implicating Wnt signaling as a strong candidate for the “mitokine” signal.
研究领域:
分子生物学
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细胞生物学
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遗传学
·
神经科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Nano
·
2025
·
IF 16
Chuang Shen,Feng Huang,Yuxiang Wang,Yi Dai,Jianwei Chen,Yi Chen,Zhusheng Huang,Ying Zhang,Lixing Weng,Zhimin Luo,Yiqiao Hu,Lianhui Wang
Gynecologic malignancies are prone to metastasis and recurrence due to the low efficacy and sensitivity of current clinical treatments. Here, we construct ultrasmall Sb@Au nanodots (Sb@Au NDs) as a metallothionein 2A (MT 2A)-silencing nanoagonist for effective photothermal immunotherapy of gynecologic malignancies. Sb@Au NDs show high photothermal conversion efficiency of 56.8% under a 1270 nm laser and exceptional capability for downregulating MT 2A overexpressed in gynecologic malignancies. Synergizing mild photothermal therapy (PTT) with targeting downregulation of MT 2A based on Sb@Au NDs offers a robust therapeutic effect, significantly activating adaptive immune response and inhibiting the metastasis of gynecologic malignancies. RNA sequencing results of SKOV-3 cells elucidate that MT 2A downregulation by Sb@Au NDs impedes the transcription of zinc finger protein genes, thereby triggering the TGF-β signaling pathway, which blocks the cell cycle and activates the MAPK/c-fos apoptotic pathway to sensitize the treatment of gynecologic malignancies. Mild PTT synergizing with MT 2A downregulation by Sb@Au NDs can promote the secretion of β-defensin to increase the infiltration of CD4+ and CD8+ T cells and potentiate T-cell-mediated adaptive immune response. Our work provides an MT 2A-silencing nanoagonist for highly effective combination therapy and metastasis inhibition of gynecologic malignancies.
研究领域:
纳米医学
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癌症生物学
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免疫治疗
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分子生物学
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材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
APPLIED CLAY SCIENCE
·
2015
·
IF 2.467
Honghai Wu,Hanrui Xie,Guangping He,Yufeng Guan,Yanlin Zhang
Tetracycline frequently needs to be detected in the environment; therefore, iron-intercalated montmorillonite (Fe-Mt) was evaluated as a model adsorbent to evaluate tetracycline adsorption behavior . The Fe-Mt sample derived from Na + -montmorillonite (Mt) by the introduction of iron-(hydr)oxides was fully characterized using the techniques of XRD , FTIR , TEM, and SEM as well as N 2 -adsorption/desorption methods. The delaminated structure of Fe-Mt could cause remarkable increases in both the surface area and pore volume. Fe-Mt also showed remarkably distinct behavior from Mt for TC adsorption. The TC adsorption by Fe-Mt was found to be highly influenced by the pH as well as the types and concentrations of background electrolytes. The positive effect of anions on the TC adsorption by Fe-Mt at acidic pH values follows the following adsorption maximum order: PO 4 3 − > SO 4 2 − » NO 3 − > Cl − > ClO 4 − . The solution pH affects the TC adsorption, and the adsorption maximum occurs at a pH around 5.0. The Langmuir and Freundlich equations were shown to fit well to the TC adsorption isotherms on Fe-Mt, and the former equation was a better fit. These adsorption-related performances could be ascribed to Fe-Mt having formed characteristic bulk/surface/pore structures. The multiple potential coexisting efficient mechanisms or pathways responsible for the TC adsorption by Fe-Mt were finally proposed and discussed in comparison with Mt and ferrihydrite .
研究领域:
环境科学
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化学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
Nutrients
·
2024
·Vol. 16
·期 10
·1468
·
IF 4.8
Yan Zhang,Hong Huang,Chuanlin Luo,Xinfeng Zhang,Yanjing Chen,Fenfang Yue,Bingqing Xie,Tingtao Chen,Changwei Zou
Cadmium (Cd) is recognized as being linked to several liver diseases. Currently, due to the limited spectrum of drugs available for the treatment of Cd intoxication, developing and designing antidotes with superior detoxification capacity and revealing their underlying mechanisms remains a major challenge. Therefore, we developed the first next-generation probioticE. coli 1917-pSK18a-MT that delivers metallothionein (MT) to overcome Cd-induced liver injury in C57BL/6 mice by utilizing bacterial surface display technology. The results demonstrate thatE. coli 1917-pSK18a-MT could efficiently express MT without altering the growth and probiotic properties of the strain. Moreover, we found thatE. coli 1917-pSK18a-MT ameliorated Cd contamination-induced hepatic steatosis, inflammatory cell infiltration, and liver fibrosis by decreasing the expression of aminotransferases along with inflammatory factors. Activation of the Nrf2-Keap1 signaling pathway also further illustrated the hepatoprotective effects of the engineered bacteria. Finally, we showed thatE. coli 1917-pSK18a-MT improved the colonic barrier function impaired by Cd induction and ameliorated intestinal flora dysbiosis in Cd-poisoned mice by increasing the relative abundance of the Verrucomicrobiota. These data revealed that the combination ofE. coli 1917and MT both alleviated Cd-induced liver injury to a greater extent and restored the integrity of colonic epithelial tissues and bacterial dysbiosis.
研究领域:
生物工程
·
毒理学
·
微生物学
✓ 已验证
DOI
高影响因子
JOURNAL OF MATERIALS IN CIVIL ENGINEERING
·
2019
·Vol. 31
·期 10
·04019237
·
IF 1.984
Yongshan Tan,Hongfa Yu,Wanli Bi,Nan Wang,Na Zhang
A new type of material, magnesium oxysulfate cement (MOSC), has attracted widespread attention as an environmentally friendly and low-energy inorganic green cementitious material due to its outstanding performance. In this study, electrochemical impedance spectroscopy (EIS) and in situ X-ray diffraction (XRD) were used to characterize the hydration behavior and process of MOSC. EIS was also used to investigate the effect of fly ash (FA) on the hydration behavior of MOSC. Mercury intrusion porosimetry (MIP), backscattered scanning electron microscopy (BSE), and scanning electron microscopy (SEM) were used to study the evolution of the pore structure and micromorphology of MOSC incorporated with FA. The results show that the resistance values (?1) in the equivalent circuit for MOSC increase with increasing curing time. The incorporation of FA can affect the resistance values for each element in the equivalent circuit. In the early stages of hydration (1 day and 2 days), high-volume FA can reduce the degree of hydration of MOSC paste. At the later stages of hydration, the resistance values (?1) increase with increasing FA content. The MIP, BSE, and SEM results also show that the porosity of MOSC decreases with increasing FA content; the incorporation of FA can significantly improve the morphology of MOSC, resulting in a denser microstructure. This study shows that the electrochemical impedance spectroscopy is a powerful technique to investigate the hydration behavior and process of MOSC, and the results also indicate that FA is a good mineral admixture used as a partial substitute for MOSC cementitious materials.
研究领域:
材料科学
·
硅酸盐工程
·
建筑材料
·
无机非金属材料
·
绿色建材
✓ 已验证
DOI
高影响因子
JOURNAL OF MATERIALS IN CIVIL ENGINEERING
·
2023
·Vol. 35
·期 5
·04023068
·
IF 3.2
Junyan Wang,Xin Yu,Gongying Ding,Jingjing Si,Mingzhen Zhang,Ziqi Jiang
Cold-mixed epoxy asphalt (CEA) is an emerging energy-saving and environment-friendly material for steel bridge decks, overload roads, and airfield pavement. Occasionally, CEA suffers from impact with high strain rates, which will be extremely detrimental to the pavement’s safety and stability. Since little research deals with this dynamic mechanical behavior, this study aims to clarify the dynamic mechanical performance of CEA mixtures (CEAM) under high strain rates. First, this study evaluated the quasi-static strength evolution by Marshall stability tests. The Marshall stability of CEAM more than quadrupled within the first 20 h and 1.6 times up again when exposed at 60°C, while its flow value showed the opposite trend. Then, the dynamic mechanical behavior under different high strain rates and temperatures was investigated by split Hopkinson pressure bar tests. Results showed that the peak strain rate (146–316 s−1) was 1.7–2.0 times greater than the average strain rate (84–162 s−1). The strain–stress curves became steep as the temperature and the pressure ascended. Under the same test conditions, the peak stress and the peak dynamic modulus of CEAM were 1.7 times larger than that of cement concrete. CEAM absorbed more energy below 25°C than 60°C. All the CEAM had binder failure, and the crushed specimens had aggregates broken. The constitutive model of CEAM was established based on the statistical damage theory and the modified Weibull distribution function. Besides, multiparametric regression analysis proved a demarcation point during the impact.
研究领域:
土木工程
·
路面材料
·
动态力学
·
复合材料
·
交通基础设施
✓ 已验证
DOI
高影响因子
JOURNAL OF MATERIALS IN CIVIL ENGINEERING
·
2019
·Vol. 31
·期 6
·04019073
·
IF 1.984
Xiuzhi Zhang,Xiaohan Du,Xiaoyan Zhao,Zonghui Zhou,Xin Cheng
Durability is a major concern with concrete structures. The ion transport properties of concrete cover can greatly influence the durability of concrete structures since most of the deterioration starts from the surface. The study described here focused on improvement of the durability of conventional concrete (CC) by covering it with nanosilica-modified mortar cover (NMMC). NMMC was designed according to the Dinger-Funk particle-packing model. The results revealed that mortar with low porosity and high strength could be produced by utilizing this particle-packing model, and that the durability of CC could be greatly improved when it was covered with NMMC: the chloride diffusion coefficient decreased by 95.12% and the Coulomb electric flux decreased by 97.02%. The NMMC also increased the freeze-thaw resistance of CC: the mass loss of CC+NMMC was only 1.72% after 300 rapid freeze-thaw cycles. Further, NMMC can significantly improve the carbonation resistance of CC. Almost no carbonation was observed after CC+NMMC was put into a chamber for carbonation for 28 days. The NMMC and CC had comparable drying shrinkage. Through fluidity adjustment and roughing of the NMMC surface, the bonding strength between NMMC and CC reached 5.4 MPa. Scanning electron micrography (SEM) showed a compact bonding between NMMC and CC.
研究领域:
土木工程
·
建筑材料
·
混凝土技术
·
建筑中的纳米材料
✓ 已验证
DOI
高影响因子
JOURNAL OF MATERIALS IN CIVIL ENGINEERING
·
2019
·Vol. 31
·期 5
·04019041
·
IF 1.984
Kuangyi Hu,Zhenping Sun,Haijing Yang
Effects of polycarboxylate superplasticizers (PCEs) with different functional units on the flowability, hydration heat, and hydration products of cement paste were investigated. Two kinds of functional units, the sulfo unit and the amide unit, were mentioned, and four series of PCEs with different monomers were synthesized. It was proved that different functional units had varying influence on fluidity, induction period, heat flow peak, and the amount of hydration products of cement paste. Moreover, a modified model for explaining cement paste hydration with PCEs was propounded to describe the aforementioned effects.
研究领域:
建筑材料
·
水泥化学
·
混凝土用聚合物添加剂
✓ 已验证
DOI
高影响因子
JOURNAL OF MATERIALS IN CIVIL ENGINEERING
·
2019
·Vol. 31
·期 11
·04019279
·
IF 1.984
Zhi Cheng,Xiaobo Pei,Hua Hou,Tao Han,Lan Liu,Huiqi Wang,Yunshan Han
This work provides a systematic analysis of the expansive and load-deformation behaviors in circular steel tube stub columns (CSTCs) of self-compacting concrete (SCC) blended with ground circulating fluidized bed (CFB) bottom ashes (BAs). A series of SCCs with different expansive properties was fabricated by adding CFB-BAs. As the dosage of CFB-BAs increased, the time-dependent circumferential and axial strains increased. The expansive and load-deformation behaviors of cured SCCs filling the CSTCs were evaluated. Time-dependent expansive strain (TDES) measurements revealed that the expansive behavior in both the circumferential and axial directions had the same variation trend. The circumferential TDES values were much larger than the axial values. The axial load-displacement relations indicated that the specimen with 30% CFB-BAs had a 34% higher ultimate load, and it had a 54% higher ultimate load when 1.5% sodium sulfate was added to the specimen. The prestress had a significant impact on the ultimate capacity of concrete-filled steel tubes (CFTs). However, the ultimate capacity still was determined by the compressive strength of the core concrete, and it was not directly proportional to the initial prestress. The specimen with a 4-mm wall thickness and 30% CFB-BAs gained the most ultimate stress, indicating that the wall thicknesses of steel tubes had a distinct influence on the load-deformation behavior.
研究领域:
土木工程
·
建筑材料
·
结构工程
✓ 已验证
DOI
高影响因子
JOURNAL OF MATERIALS IN CIVIL ENGINEERING
·
2019
·Vol. 31
·期 8
·04019139
·
IF 1.984
K. Wei,B. Ma,S. Y. Duan
This study aimed to evaluate the potential use of polyurethane solid–solid phase change material (PUSSPCM) as polymer modifier in asphalt binder. PUSSPCMs were synthesized via the two-step condensation reaction of 4,4′–diphenylmethane diisocyanate, polyethylene glycol, and 4,4′-methylenebis(2-chloroaniline). The synthesized PUSSPCMs possessed suitable transition temperature in the range of 10.9°C to 46.8°C and high latent heat enthalpy in the range of 71.68 to 73.87 J/g. The synthesized PUSSPCMs possessed good thermal stability even at 320°C. Furthermore, varying amounts of PUSSPCM modifiers were added to a neat asphalt binder. The viscosity of all the modified bitumen samples was lower than 2,000 cP. The addition of the PUSSPCMs did not greatly affect the penetration, softening point, and storage stability of modified asphalt. However, excessive content of PUSSPCMs adversely affected the ductility of modified asphalt. The temperature change rate of the PUSSPCM modified asphalt decreased with increasing PUSSPCM content. When the content of PUSSPCMs reached 7% by weight, the maximum temperature difference of neat bitumen specimen and modified bitumen specimen reached about 9.0°C in the laboratory.
研究领域:
材料科学
·
土木工程
·
热能存储
·
聚合物改性
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）