Analytical Methods
·
2017
·Vol. 9
·期 5
·835-840
·
IF 1.9
Zhongling Gao,Lei Wang,Lun Wang,Hongqi Chen
Long wavelength luminescent NaYF4:Yb,Er/NaGdF4 core–shell upconversion nanoparticles that were synthesized and modified with poly(acrylic acid) (PAA) were used to detect sulfide ions. The NaYF4:Yb,Er/NaGdF4 core–shell upconversion nanoparticles were synthesized to give an emission peak in the red-light region. When the carboxyl-functionalized NaYF4:Yb,Er/NaGdF4 core–shell upconversion nanoparticles and cupric ions (Cu2+) were mixed, the luminescence was quenched because of coordination between the carboxyl of PAA and Cu2+. However, when sulfide ions were added into the system, due to the competitive binding between S2− and Cu2+, the luminescence of the NaYF4:Yb,Er/NaGdF4 core–shell upconversion nanoparticles was recovered. Based on the recovery of the luminescence intensity, a turn-on system for the detection of sulfide ions was designed. Under optimal conditions, the linear range for the detection of sulfide ions ranged from 2.63 × 10−2 to 2.25 × 102 μM (R = 0.99) with a limit of detection for sulfide ions as low as 2.20 × 10−2 μM. The method was successfully applied to sulfide ion sensing in different environments.
研究领域:
纳米技术
·
分析化学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
APPLIED CATALYSIS A-GENERAL
·
2022
·
IF 5.723
Yitong Lin,Taiyu Jin,Yu Liu,Jianhe Tang,Ying Tian,Xueke Liu,Liang Chen,Dawei Fang,Jun Wang
A coated Z-scheme NaGdF 4 :Nd 3+ ,Yb 3+ ,Tm 3+ @CdS-Pd@NiO photocatalyst with core-shell structure is prepared by hydrothermal and coprecipitation methods. NaGdF 4 :Nd 3+ ,Yb 3+ ,Tm 3+ as excellent up-conversion luminescent material can convert infrared light into visible light, broadening the light response range of CdS. Pd nanorods act as conductive channels and co-catalysts, leading to successful construction of titled photocatalyst, increasing contact area between two monomer photocatalysts, promoting transfer of photo-generated electrons. It also provides a large oxidation surface for organic pollutant degradation. The performance of prepared photocatalyst is assessed by Congo red degradation and hydrogen production . The emission spectrum and energy conversion mechanism of NaGdF 4 :Nd 3+ ,Yb 3+ ,Tm 3+ are investigated. The photocatalyst with 3:1 NaGdF 4 :Nd 3+ ,Yb 3+ ,Tm 3+ @CdS-Pd and NiO mass ratio has a preeminent activity. Congo red degradation ratio and hydrogen production amount reach 92.48% and 653.06 µmol/g, respectively, under simulated sunlight irradiation for 180 min. The possible mechanism of organic pollutant degradation with synchronous hydrogen production caused by titled photocatalyst is proposed.
研究领域:
材料科学
·
环境科学
·
光学
✓ 已验证
DOI
高影响因子
Small Methods
·
2022
·Vol. 6
·期 3
·2101145
·
IF 15.367
Zhilin Jiang,Bin Xia,Feng Ren,Bolin Bao,Wei Xing,Tao He,Zhen Li
Revealing the anatomical structures, functions, and distribution of vasculature via contrast agent (CA) enhanced magnetic resonance imaging (MRI) is crucial for precise medical diagnosis and therapy. The clinically used MRI CAs strongly rely on Gd-chelates, which exhibit low T 1 relaxivities and high risks of nephrogenic systemic fibrosis (NSF) for patients with renal dysfunction. It is extremely important to develop high-performance and safe CAs for MRI. Herein, it is reported that ultra-small NaGdF 4 nanoparticles (UGNs) can serve as an excellent safe MRI CA via surface engineering with rationally designed novel hydrophilic block co-polymer (BP n ). By optimizing the polymer molecular weights, the polymer-functionalized UGNs (i.e., UGNs-BP 14 ) are obtained to exhibit remarkably higher relaxivity (11.8 m m –1 s –1 at 3.0 T) than Gd-DTPA (3.6 m m –1 s –1 ) due to their ultracompact and abundant hydrophilic surface coating. The high performance of UGNs-BP 14 enables us to sensitively visualize microvasculature with a small diameter of ≈0.17 mm for up to 2 h, which is the thinnest blood vessel and the longest time window for low field (1.0 T) MR angiography ever reported, and cannot be achieved by using the clinically used Gd-DTPA under the same conditions. More importantly, renal clearable UGNs-BP 14 show lower risks of inducing NSF in comparison with Gd-DTPA due to their negligible release of Gd 3+ ions after modification with the novel hydrophilic block copolymer. The study presents a novel avenue for boosting imaging-performance and systemic biosafety of UGNs as a robust MRI CA with great potential in precise diagnosis of vasculature-related diseases.
研究领域:
医学影像学
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纳米医学
·
分子生物学
✓ 已验证
DOI
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2011
·Vol. 21
·期 23
·4470-4477
·
IF 8.508
Meng He,Peng Huang,Chunlei Zhang,Hengyao Hu,Chenchen Bao,Guo Gao,Rong He,Daxiang Cui
A novel OA/ionic liquid two-phase system combining the merits of thermal decomposition method, the IL-based strategy, and the two-phase approach is introduced to synthesize high-quality lanthanide-doped NaGdF 4 upconversion nanocrystals with different crystal-phases in OA-phase and IL-phase through a one-step controllable reaction. Oil-dispersible cubic-phase NaGdF 4 :Yb, Er (Ho, Tm) nanocrystals with ultra-small size (∼5 nm) and monodispersity are obtained in the OA phase of the two-phase system via an IL-based reaction. More importantly, water-soluble hexagonal-phase NaGdF 4 :Yb, Er nanocrystals are obtained in the same system simply by adopting an extremely facile method to complete the dual phase-transition (crystal-phase transition and OA-phase to IL-phase transition) simultaneously. The synthesized lanthanide-doped NaGdF 4 upconversion nanocrystals are effective for dual-mode UCL imaging and CT imaging in vivo.
研究领域:
材料科学
·
生物医学工程
·
纳米医学
✓ 已验证
DOI
高影响因子
JOURNAL OF FLUORINE CHEMISTRY
·
2017
·
IF 2.101
Songxia Yu,Zhiqiang Wang,Ruijun Cao,Lingjie Meng
In this paper, we have developed a series of rare earth fluoride nanocrystals (NCs) that can be used for multimodal imaging applications. Three highly monodisperse and water dispersible NaGdF 4 :Yb,Ln@NaGdF 4 (Ln = Er, Tm, Ho) upconversion luminescence (UCL) NCs with an average size of 75 nm were prepared using a facile and efficient microwave–assisted solvothermal reaction in ethylene glycol (EG). The morphology, crystal structures, size distributions and zeta potentials of the resulting NCs were fully characterized by transmission electron microscopy (TEM), X–ray diffraction (XRD) and Nano–ZS90 Zetasizer. The obtained NaGdF 4 :Yb,Ln@NaGdF 4 (Ln = Er, Tm, Ho) NCs could emit bright blue, green and red luminescence in water upon laser excitation at 980 nm. Furthermore, these core–shell NCs exhibited low cytotoxicity for HeLa and C9H2 cells, separately. Moreover, these NCs also displayed excellent Hounsfield units (HU) values in X–ray computed tomography (CT) imaging and high relaxivity parameters (r 1 ) in magnetic resonance (MR) imaging in vitro . Thus, these small, water–dispersible and biocompatible NCs show excellent potential as contrast agents for UCL/CT/MR multimodal imaging and other biomedical applications.
研究领域:
材料科学
·
生物医学工程
·
影像医学
✓ 已验证
DOI
高影响因子
Chemistry-An Asian Journal
·
2022
·Vol. 17
·期 14
·e202200161
·
IF 4.839
Bo Ling,Yaguang Wang,Ruo Mi,Di Wang,Hongqi Chen,Xiaohu Li,Ye Zhang,Lun Wang
Graphical NaGdF 4 ,Yb,Er@NaGdF 4 ,Yb,Tm@NaYF 4 core@shell@shell three-layer structure of upconversion nanoparticles coated with Fe−TCPP metal-organic frameworks nanocomposite was designed and constructed for multimodal imaging and synergetic chemodynamic therapy/photodynamic therapy of tumors. Here, NaGdF 4 ,Yb,Er@NaGdF 4 ,Yb,Tm@NaYF 4 core@shell@shell three-layer structure of upconversion nanoparticles (UCNPs) coated with Fe−Tetrakis (4-carboxyphenyl) porphine (TCPP) metal-organic frameworks (Fe-MOFs) nanocomposite (UCNPs@MOFs) was designed and constructed for multimodal imaging and synergetic chemodynamic therapy (CDT)/photodynamic therapy (PDT) of tumors. The UCNPs@MOFs were successfully applied for tumor cells imaging in vitro and in vivo in near-infrared (NIR) region. The doped Gd was used as contrast agent for the magnetic resonance imaging (MRI) of mouse tumors. The luminescence in the UV-vis region was absorbed by the Fe-MOFs to produce singlet oxygen ( 1 O 2 ) for PDT. The Fe 3+ doped in the MOFs can catalyze H 2 O 2 to produce oxygen and hydroxyl radical (⋅OH). Hydroxyl radical is used in CDT and cooperates with the 1 O 2 of PDT. Based on the CDT/PDT synergistic effects, the UCNPs@MOFs nanocomposite had obviously enhanced tumor inhibitory efficiency in vivo. These results described that the asprared UCNPs@MOFs nanocomposite have great potential in the effective multimodal imaging and treatment of tumors.
研究领域:
生物医学工程
·
纳米医学
·
肿瘤学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
OPTICAL MATERIALS
·
2019
·
IF 2.687
Huazhen Liao,Song Ye,Yanling Shi,Deping Wang
Small size optical-magnetic bifunctional upconversion nanoparticles (UCNPs) that can be effectively triggered by 808 nm exhibit distinct advantages of improved tissue penetrating depth, minimized overheating effect, possible for multimodal imaging and high clearance rate, which therefore are considered as desirable candidates for bioapplications. In this research, the 808 nm triggered sub-20 nm β-NaYF 4 :Yb 3+ /Er 3+ @NaGdF 4 :Yb 3+ /Nd 3+ @NaGdF 4 active-core@active-shell@inert-shell structured UCNPs with optical and magnetic bifunctional properties were developed by seed-mediated growth method with NaOA as sodium source instead of the generally used NaOH. Through optimizing Nd 3+ doping concentration and outermost NaGdF 4 inert-shell thickness, the optical-magnetic bifunctional core-shell-shell structured UCNPs exhibited strong UC emission intensity and improved magnetic property . Furthermore, the core-shell-shell NPs were validated to be no cytotoxicity by cell viability assessment. Therefore, this research may open a general avenue for the synthesis of small size multifunctional UCNPs for practical bioapplications without overheating.
研究领域:
纳米材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
Small
·
2015
·Vol. 11
·期 30
·3676-3685
·
IF 8.368
Fuyao Liu,Xiuxia He,Junping Zhang,Huimao Zhang,Zhenxin Wang
Hydrophobic ultrasmall nanoparticles synthesized in nonpolar solvents exhibit great potential in biomedical applications. However, a major challenge when applying these nanomaterials in biomedical research is the lack of a versatile strategy to render them water dispersible while preserving the hydrodynamic diameter (HD) to be less than 8 nm for efficient renal clearance. To address this problem, tryptone is employed as the novel ligand to fabricate a simple, versatile, and inexpensive strategy for transferring hydrophobic NaGdF 4 nanodots (3 nm in diameter) from organic phase into aqueous phase without any complicated organic synthesis. The paramagnetic properties of NaGdF 4 nanodots are well retained after the phase transfer process. In particular, the tryptone–NaGdF 4 nanodots have ultrasmall HD (ca., 7.5 nm), which greatly improves their tumor accumulation and facilitates renal clearance within 24 h postinjection. The as-prepared tryptone–NaGdF 4 nanodots can also be further functionalized with other molecules for extensively biomedical and bioanalytical applications. Furthermore, the proposed strategy can easily be extended to transfer other types of inorganic nanoparticles from hydrophobic to hydrophilic for facilitating biomedical applications.
研究领域:
材料科学
·
生物医学工程
·
纳米医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Advanced Optical Materials
·
2026
·
IF 7.2
Yingjun Li,Dawei Sun,Haixin Liu,Hongxian Wei,Shasha Wang,Gejihu De
Lanthanide (Ln 3+ )-doped upconversion luminescent materials (UCLMs) have tremendous potential for applications in solar cells, optical sensors, and various other fields. However, their low luminescent efficiency and thermal stability remain key challenges that hinder their practical applications. Here, we introduce an innovative method for enhancing the upconversion luminescent efficiency of Er 3+ -activated UCLMs by constructing high-entropy fluoride hosts based on the β -NaGdF 4 framework—NaMF 4 (M = Na, Yb, Gd, Ca, La, Lu, or Y). The β -NaGdF 4 structure is preserved despite the decrease in the Gd 3+ concentration with an increase in the number of principal elements. High-entropy engineering introduces severe lattice distortion, which enhances the doping tolerance of the host for Er 3+ ions and significantly modifies the local crystal field around them. These changes result in enhanced emission intensity and a higher quantum yield. Optimum upconversion luminescence is observed for the high-entropy six-element composition at room temperature; the emission intensity and quantum yield are 2.5 times those of NaGdF 4 :20%Yb/2%Er. In addition, Er 3+ -activated high-entropy fluorides exhibit better thermal stability than NaGdF 4 :20%Yb/2%Er. These results demonstrate that high-entropy engineering is a promising approach for improving the luminescent performance of Ln 3+ -doped UCLMs.
✓ 已验证
DOI
高影响因子
CRYSTENGCOMM
·
2020
·Vol. 22
·期 38
·6330-6338
·
IF 3.117
Chunyan Cheng,Yueshan Xu,Gejihu De,Jianxun Wang,Wei Wu,Yuexing Tian,Shasha Wang
Rare-earth doped upconversion nanoparticles (UCNPs) have attracted wide-ranging interest due to their potential applications in bioimaging and biolabeling, where a high emission intensity and small particle size are needed. However, common synthesis processes can be somewhat complex or require additional reactants, and the use of small-size NPs is limited by their weak luminescence intensity. In this work, uniform, monodisperse ∼5 nm β-NaGdF4:20% Yb/2% Er NPs were synthesized via a simple one-pot synthesis method in the high boiling-point solvents 1-octadecene (ODE) and oleic acid (OA) using a single dose of NaF at an ultralow NaF concentration of NaF/RE = 4. The effects of NaF/RE, the reaction temperature, and the reaction time on the size and phase of the particles were investigated. High-quality β-NaGdF4:20% Yb/2% Er@β-NaGdF4:20% Yb/10% Nd core–shell NPs with a size of ∼13 nm, enhanced UC luminescence, long UC lifetimes (τ) for green (τ ≈ 150 μs) and red (τ ≈ 105 μs) emission under 980 and 808 nm excitation, revealed via lifetime imaging, and obvious emission in the near-infrared (NIR) II region were synthesized. The synthesized core–shell NPs may result in a decrease in the overheating effect and allow for a deep penetration depth when further used for bioimaging applications. This work could inspire the synthesis of other high-quality RE-doped UCNPs via adding a single dose of a small amount of NaF and could lay the foundation for the use of Gd-based UCNPs in biomedical applications.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
DOI
高影响因子
RSC Advances
·
2016
·Vol. 6
·期 85
·81542-81551
·
IF 3.289
Shuwen Zhao,Wei Liu,Xianya Xue,Yushi Yang,Zhiyong Zhao,Youfa Wang,Bin Zhou
In this work, a new strategy to enhance upconversion emission has been realized for the first time, based on β-NaGdF4:Yb3+, Er3+ nanocrystals (UCNC) using tridoping with magnesium (Mg2+) ions. X-ray diffraction (XRD) and inductively coupled plasma–atomic emission spectroscopy data indicated successful incorporation of the Mg2+ ions in β-NaGdF4:Yb3+, Er3+. The effect of the Mg2+ tridopant on the crystal structure, upconversion luminescence, and paramagnetization in β-NaGdF4:Yb3+, Er3+ was investigated in detail. The red, green and violet emission intensities were clearly enhanced and the maximum emission intensities were enhanced by about 9, 6, and 7 times, respectively, by tridoping with 13.5 mol% Mg2+ ions. The possible mechanism for enhancing upconversion emission was determined by the alteration of inter-ionic distance and the distortion of crystal structure based on the XRD data. The paramagnetic property can be modulated by the introduction of Mg2+ ions and the core–shell structure, and this can be ascribed to the change in the gadolinium molar percentage. Additionally, a synergistic effect on emission intensity enhancement was observed in a Mg2+-doped core–shell structure. At last, an improved ligand exchange method has been designed to render oleic acid-stabilized 13.5 mol% Mg2+-doped UCNCs dispersible in water and their three day cytotoxicity was assayed using stem cells. It is expected that this material could be applied in biomedical nanoprobes, bioseparation, magnetic resonance imaging, and so on.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
BIOMATERIALS
·
2014
·
IF 8.312
Liangjun Zhou,Xiaopeng Zheng,Zhanjun Gu,Wenyan Yin,Xiao Zhang,Longfei Ruan,Yanbo Yang,Zhongbo Hu,Yuliang Zhao
We developed a facile strategy to obtain a new kind of mesoporous core-shell structured up-conversion nanoparticles (mUCNPs), composed of a NaYbF 4 :2%Er core and a mesoporous NaGdF 4 shell. This mesoporous shell not only enhanced the up-conversion luminescence but also endowed many other functionalities of the nanoparticles such as drug delivery and bio-imaging capabilities. Moreover, after being conjugated with polyethylenimine (PEI) and folic acid (FA), core-shell mUCNPs exhibited good water dispersibility , enhanced drug delivery efficiency, and remarkable targeting ability to cancer cells. To certify the folate receptors (FR)-mediated targeted drug delivery , cell viability assay, cell up-conversion luminescence imaging and flow cytometry analysis were carried out. Furthermore, apart from the application for targeted drug delivery, the as-prepared core-shell mUCNPs could also be employed as the contrast agents for X-ray computed tomography (CT) and magnetic resonance (MR) imaging, because of the strong X-ray attenuation ability of Yb and high longitudinal molar relaxivity ( r 1 ) of Gd in the nanoparticles, providing the potential for simultaneously bio-imaging and cancer-targeting therapy.
研究领域:
生物医学工程
·
纳米医学
·
分子影像学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）