APPLIED SURFACE SCIENCE
·
2022
·
IF 7.392
Ruxia Song,Shihong Zhang,Yi He,Bo Liu,Hongjie Li,Zhifei Zhang,Yahui He
In this study, a novel Ni-Cu/OH-BN(h)-PA-Zn-DCD composite coatings with excellent wear resistance and corrosion resistance was developed, which may be used in the field of seawater corrosion. By the self-assembling of phytic acid, Zn 2+ and dicyandiamide to grow PA-Zn-DCD structure onto the surface of hydroxylated BN(h) nanosheets, obtained a hybrid denoted as OH-BN(h)-PA-Zn-DCD, which was doped into Ni-Cu coating by pulse electrodeposition. The results show that OH-BN(h) and OH-BN(h)-PA-Zn-DCD hybrids affect the surface morphology, roughness, microcrystals size and thickness of the composite coatings. Simultaneously, compared with NC coating and NC/HB-1.5 coating, NC/BP-1.5 coating has the highest microhardness (559.26 Hv), the lowest friction coefficient (0.172), and the best corrosion resistance (i corr is 3.551 × 10 −8 A·cm −2 , R ct is 1.098 × 10 6 Ω·cm 2 ). In addition, the EIS results of the immersed specimens showed that the NC/BP-1.5 composite coating still has good protective ability after soaking for 15 days in simulated seawater medium (R ct is 7.434 × 10 6 Ω·cm 2 ).
研究领域:
材料科学
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表面工程
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腐蚀科学
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DOI
高影响因子
Scientific Reports
·
2017
·Vol. 7
·期 1
·1-13
·
IF 4.259
Chen Xubo,Zhao Xueyan,Lan Fazhang,Zhou Tao,Cai Hua,Sun Haiying,Kong Weijia,Kong Wen
Studies have reported attenuation of insulin resistance (IR) by improving phosphorylation of the insulin signalling pathway. However, the upstream molecular signalling pathway is still elusive. In this study, Western blot was used to evaluate the phosphorylation level of the insulin signalling pathway and the AMPK pathway. 2-NBDG was used to evaluate glucose uptake. Ca 2+ imaging was used to assess change of intracellular Ca 2+ concentration. We found that NaHS enhanced the intracellular Ca 2+ concentration and glucose uptake and activated the insulin signalling cascade in a palmitic acid (PA)-induced IR model in C2C12 cells. Furthermore, activation of the IRS1/PI3K/AKT pathway and glucose uptake were decreased when AMPK or CaMKKβ was inhibited. Our study also showed that the mitochondrial electron transport chain, ATP production, and intramitochondrial cAMP declined in the IR model but that this effect was reversed by NaHS, an effect that may be mediated by the Ca 2+ /CaMKK2/AMPK and PI3K/AKT pathways. Our data indicate that H 2 S improves activation of the insulin signalling cascade and glucose uptake via activation of the Ca 2+ /CaMKK2/AMPK pathway and mitochondrial metabolism in C2C12 cells. Furthermore, NaHS protects mitochondrial function and maintains normal ATP production by activating the cAMP system and the Ca 2+ /CaMKK2/AMPK and PI3K/ATK pathways.
研究领域:
分子生物学
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细胞代谢
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内分泌学
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糖尿病研究
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PubMed
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
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2017
·Vol. 135
·期 13
·46052
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IF 1.86
Cong Jia,Xiao Zhang,Yufeng Li,Yanghui Jiang,Min Zhang,Panfang Lu,Hongkun Chen
A novel controlled release fertilizer was developed using interpenetrating polymer network (IPN) as the coating material. The IPN was successfully sprayed on the surface of the urea particles to form IPN-coated fertilizers (IPNCU) for controlled nitrogen release. The IPN was synthesized by bio-based polyamide (PA) from d -glucaric acid and epoxy (EP) through network interpenetrating. The chemical structure and microscopic morphology characteristics of IPN were examined by Fourier transform infrared spectroscopy, 1 H-nuclear magnetic resonance, and scanning electron microscopy. The property of IPN with the different PA/EP mass ratios were investigated and compared with that of EP-coated fertilizers (EPCU). The nutrient release behaviors of IPNCU in water and soil were detected. The results showed that the IPNCU with 5% PA content increased the nitrogen release longevity by 41 days, raised the water contact angle of surface by 23.9°, and then significantly slowed the nitrogen release rate of the IPNCU. The nutrient release mechanism of IPNCU was discussed in detail. This work indicated that the environment-friendly IPN with superior controlled release properties could be especially useful in horticultural and agricultural applications. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018 , 135 , 46052.
研究领域:
聚合物科学
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农业化学
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环境科学
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高影响因子
Journal of Pharmaceutical Analysis
·
2025
·
IF 8.9
Yuexiang CHANG,Hao TIAN,Jia-Huan QU,Jiaming YUAN,Rongkai GU,TingTing ZHANG,Jincai WANG,Zhengjin JIANG
The N -terminal domain of influenza viral polymerase (PA N ), a highly conserved region with critical catalytic function related to viral RNA replication and transcription, is considered as a very promising anti-influenza drug target. There is an urgent need for highly efficient and rapid screening methods to identify potential PA N inhibitors (PA N Is) from complex matrices. In this work, a novel high-throughput screening (HTS) platform was established by coupling high performance liquid chromatography and high-resolution mass spectrometry (HPLC-HRMS) with a fluorescence resonance energy transfer (FRET)-based endonuclease activity assay through an at-line nanofractionation system (ANF). The proposed screening platform could rapidly identify potential PA N Is from plant extracts with good sensitivity (baloxavir at the half maximal inhibitory concentration (IC 50 ) could be detected) and reliability ( Z ’ factor of 0.77). This platform was then successfully applied to the screening of potential inhibitors against PA N /PA N I38T from an aqueous extract of Artemisiae Argyi and 17 potential PA N Is were identified. Among them, three compounds (cynarine, isochlorogenic acid B and isochlorogenic acid C) showed comparable inhibitory activity against PA N and even better activity against PA N I38T compared to baloxavir. This study not only established a novel high-throughput ANF-based PA N Is screening platform, but also proved the feasibility to discover PA N Is from complex TCMs, which has a great potential in future anti-influenza drug discovery.
研究领域:
病毒学
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药物筛选
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植物药理学
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生物分析技术
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DOI
PubMed
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
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2025
·
IF 11.3
Xianyu Kang,Xiangfang Liu,Qingchun Ge
Conventional polyamide nanofiltration (NF) membranes (PA-M 0 ) exhibit poor As(III) removal efficiency primarily due to the neutral molecular form (H 3 AsO 3 ) of As(III) under typical conditions. Although alkaline environments can convert As(III) into an anionic species to enhance separation, most NF membranes lack chemical stability at high pH. Herein, we develop a series of alkali-resistant NF membranes (PA-M T , T = 1–24 h, representing the reaction time) through H₂SO₄/EtOH-induced physical swelling and chemical reconstruction of PA-M 0 , enabling efficient As(III) removal in alkaline media. The optimized membrane, PA-M 6 h , improves As(III) rejection substantially from 19.9 % to 90.2 % as feed pH increases from 7 to 10, while maintaining a high water flux of 17.7 LMH/bar, This performance considerably surpasses that of PA-M 0 and previously reported NF systems (typically 10 – 60 % rejection). Furthermore, PA-M 6 h exhibits exceptional antifouling properties, sustaining 91.5 % As(III) rejection and a stable flux of 13.7 LMH/bar over extended cycles in the presence of humic acid foulants — more than doubling the removal efficiency of PA-M 0 (5.9 LMH/bar). This study advances molecular-scale interfacial engineering in membrane design, promoting the development of environmentally sustainable separation technologies and providing a scalable solution for arsenic-safe water purification.
研究领域:
环境科学
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材料科学
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DOI
PubMed
高影响因子
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
·
2026
·
IF 3.1
Meichen Liu,Yalin Yu,Yifei Jing,Yingxia Guo,Chuya Wang,Hongyu Xue,Hong Liu,Lei Yin,Meiyun Shi
While polyethylene glycol (PEG) is an extensively utilized pharmaceutical polymer with established biocompatibility and regulatory acceptance, the in vivo pharmacokinetics of its bifunctional derivatives, such as α,ω-dipropionic acid polyethylene glycol (PA-PEG-PA), remain largely unexplored. This study presents the development and validation of a highly sensitive and selective UPLC-MS/MS method for the accurate quantification of PA-PEG 12 -PA in various biological matrices, utilizing a straightforward protein precipitation protocol. After intravenous administration in rats (10 mg/kg), PA-PEG 12 -PA demonstrated rapid clearance (t 1/2 = 3.99 ± 1.06 h). Tissue distribution analysis revealed a pronounced affinity for renal accumulation, with kidney concentrations (16473 ± 881 ng/g at 2 h) substantially surpassing those in the liver and lungs, followed by rapid depletion within 24 h. Excretion studies indicated renal clearance as the dominant pathway, with 55.93 % of the administered dose recovered unchanged in urine over 72 h, while fecal excretion was minimal (1.76 %). This work provides the first comprehensive pharmacokinetic and biodistribution profile of PA-PEG 12 -PA, underscoring its renal-driven clearance and tissue disposition. The findings offer crucial insights for the rational design of PEGylated drug delivery systems, and the robust UPLC-MS/MS assay established herein serves as a valuable tool for characterizing polymeric excipients in biological environments.
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DOI
PubMed
高影响因子
JOURNAL OF CHROMATOGRAPHY A
·
2020
·
IF 4.049
Bo Tang,Xin Zhang,Lina Geng,Liquan Sun,Aiqin Luo
Chiral metal-organic cages (MOCs) are a new type of porous materials with unique molecular recognition ability, which have received research attention as a chiral stationary phase (CSP) for gas chromatography (GC). Herein, we report the detailed investigation of a chiral MOC ([Cu 12 (L PA ) 12 (H 2 O) 12 ], PA = L-phenylalanine, MOC-PA) as a novel stationary phase for GC separations. The MOC-PA capillary column exhibited a high-resolution performance for a wide range of analytes, including n-alkanes, n-alcohols, esters, aromatic compounds and the Grob mixture, positional isomers and racemates. In particular, MOC-PA coated column displayed good resolution and performance for amino acid derivatives. Moreover, the MOC-PA column showed excellent separation repeatability and reproducibility. The relative standard deviation (RSD) values for the retention times were in the range of 0.16-0.30% for run to run ( n = 3), 0.31-0.77% for day-to-day ( n = 3), and 3.6-4.7% for column-to-column ( n = 3), respectively. The experimental results showed that MOC-PA had great potential as a GC stationary phase.
研究领域:
分析化学
·
材料科学
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DOI
PubMed
高影响因子
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
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2025
·
IF 3.5
Zhengjiao Gao,Dingtao Tang,Bingfeng He,Jiajie Quan,Zhengke Zhang,Yueming Jiang,Bao Yang,Jiali Yang
BACKGROUND Prenylated flavonoids are widely distributed in plants, including fruits and vegetables in the Moraceae and Fabaceae families. These chemicals are potential functional food ingredients owing to their attractive biological activities. However, natural prenylated flavonoids are rare, which limits their application. RESULTS Here, we reported the prenylation of apigenin and genistein catalyzed by DMATS1, a dimethylallyl- l -tryptophan synthase from Fusarium fujikuroi . High-performance liquid chromatography–tandem mass spectrometry and nuclear magnetic resonance identified their structure as 6- C -prenylapigenin (6-PA) and 6- C -prenylgenistein (6-PG), respectively. Cell-based assay suggested that both 6-PA and 6-PG induced the proliferation of THP-1 cells under low concentrations and were safe in doses less than 50 μmol L −1 . 6-PA and 6-PG exhibited significant anti-inflammatory activity in lipopolysaccharide-stimulated THP-1 cells, and inhibited the production of nitric oxide as well as downregulating the transcriptional levels of pro-inflammatory cytokines, including tumor necrosis factor-α, interleukin-8, and interleukin-1β. CONCLUSION The findings suggested that DMATS1 could catalyze the 6- C prenylation of apigenin and genistein, and the generated 6-PA and 6-PG exhibited anti-inflammatory activity, aiding in the recognition of 6-PA and 6-PG as nutraceuticals. © 2025 Society of Chemical Industry.
CAS / MDL:
研究领域:
植物化学
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药理学
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生物合成
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DOI
PubMed
高影响因子
Polymer Chemistry
·
2013
·Vol. 4
·期 22
·5597-5602
·
IF 5.231
Zengchao Tang,Xiaoli Liu,Yafei Luan,Wei Liu,Zhaoqiang Wu,Dan Li,Hong Chen
A new strategy to regulate the attachment of plasminogen and its activator, t-PA, to a polyurethane surface is reported. The method is based on the one-step graft copolymerization of a lysine-containing methacrylic monomer and hydroxyethyl methacrylate (HEMA). The copolymer-modified PU surfaces showed high capacity for plasminogen and t-PA binding. The release of pre-adsorbed t-PA from the lysine-containing PU surfaces in contact with plasma was also investigated. It was shown that the interactions of plasminogen and t-PA on this type of surface can be controlled simply by changing the monomer feed ratio, and thus the relative quantities of HEMA and lysine in the grafts. This approach may be useful for the development of fibrinolytic, blood-contacting materials and, more generally, for controlling protein-surface interactions for biocompatibility.
研究领域:
生物材料学
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医学工程
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DOI
高影响因子
JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY
·
2012
·Vol. 50
·期 10
·2053-2067
·
IF 3.919
Yan-Ling Luo,Wei Yu,Feng Xu,Li-Li Zhang
A novel double brush-shaped copolymer with amphiphilic polyacrylate- b -poly(ethylene glycol)- b -poly acrylate copolymer (PA- b -PEG- b -PA) as a backbone and thermosensitive poly( N -isopropylacrylamide) (PNIPAM) long side chains at both ends of the PEG was synthesized via an atom transfer radical polymerization (ATRP) route, and the structure was confirmed by FTIR, 1 H NMR, and SEC. The thermosensitive self-assembly behavior was examined via UV-vis, TEM, DLS, and surface tension measurements, etc. The self-assembled micelles, with low critical solution temperatures (LCST) of 34–38 ° C, form irregular fusiform and/or spherical morphologies with single, double, and petaling cores in aqueous solution at room temperature, while above the LCST the micelles took on more regular and smooth spherical shapes with diameter ranges from 45 to 100 nm. The micelle exhibits high stabilities even in simulated physiological media, with low critical micellization concentration (CMC) up to 5.50, 4.89, and 5.05 mg L −1 in aqueous solution, pH 1.4 and 7.4 PBS solutions, respectively. The TEM and DLS determination reveled that the copolymer micelle had broad size distribution below its LCST while it produces narrow and homogeneous size above the LCST. The cytotoxicity was investigated by MTT assays to elucidate the application potential of the as-prepared block polymer brushes as drug controlled release vehicles. © 2012 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2012
研究领域:
高分子化学
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材料科学
·
药物递送
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DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2026
·
IF 9.1
Rouwen Shen,Yu Li,Sufen Jiang,Aimei Zhu,Qinglin Liu,Qiugen Zhang
Constructing polyamide (PA) separation layers from rigid, three-dimensionally twisted aromatic diamine monomers is a promising route toward high-permeance organic solvent nanofiltration (OSN) membranes. However, the poor water solubility of such monomers limits their application in conventional aqueous interfacial polymerization (IP). Herein, water/DMF cosolvent assisted interfacial polymerization strategy was adopted to address this bottleneck. The poorly water-soluble 2,2-bis(4-aminophenyl) hexafluoropropane (BAHFP) monomer can solve in water/DMF co-solvent and get controlled monomer diffusion and IP kinetics to form an ultra-thin, defect-free polyamide active layer. The introduction of DMF enhances the solubility of BAHFP with three-dimensional twisted configuration. A minor quantity of 50 wt% N , N -dimethylformamide (DMF) was introduced into the water as a cosolvent, facilitating the formation of a continuous polyamide (PA) layer with a thickness of 85.7 ± 3.5 nm on the surface of the composite membrane. Additionally, the membrane prepared at the optimal DMF concentration of 60% exhibited the continuous and complete PA film and a methanol permeability of 28.3 ± 0.4 L m −2 h −1 bar −1 and 98.7 ± 0.3% rejection of RB for 30 h. The smoother top surface significantly improves the membrane's anti-fouling properties. This work offers an effective way for the fabrication of high permeance BAHFP-PA membrane through IP process.
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高影响因子
DESALINATION
·
2019
·
IF 6.035
Yuan Gao,Kunmei Su,Xiaotian Wang,Maliang Zhang,Zhenhuan Li,Kang Jia
A novel layer consisting of nano graphene oxide (NGO) sheets was created with disordered arrangement and dual-channel structures on modified Polyphenylene sulfide (PPS) support surface. Polyamide (PA) and Piperazine (PIP) were used to cross-link and fasten the NGO layer, constructing water molecule transport channels. Meanwhile, the interlayer spacing of NGO and transport capacity of polyamide permeation channels could be changed by adjusting PIP content, thereby a large number of small-sized vacancy were formed as water molecular transport channels and played a role in intercepting small molecules and metal salts. Physicochemical structure and application performance of the composite membranes were analyzed using various testing methods, showing that the introduction of polyamide greatly increased water flux and metal salts rejection rate. In particular, M-3 membrane with the best performance was achieved with salt rejections of 48.24%, 92.14%, 92.93% and 91.23% for NaCl, CuSO 4 , ZnSO 4 and AlCl 3 , and a water flux of 40.80 LMH at 0.6 MPa.
研究领域:
材料科学
·
环境工程
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）