Materials
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2020
·Vol. 13
·期 17
·3735
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IF 3.057
Yihu Wang,Xiaofeng Cao,Ming Ma,Weipeng Lu,Bing Zhang,Yanchuan Guo
A new gelatin methacrylamine (GelMA)-poly (ethylene glycol) diacrylate (PEGDA)-nano hydroxyapatite (nHA) composite hydrogel scaffold was developed using UV photo-crosslinking technology. The Ca2+from nHA can form a [HO]Ca2+[OH] bridging structure with the hydroxyl group in GelMA, thereby enhancing the stability. Compared with GelMA-PEGDA hydrogel, the addition of nHA can control the mechanical properties of the composite hydrogel and reduce the degradation rate. In vitro cell culture showed that osteoblast can adhere and proliferate on the surface of the hydrogel, indicating that the GelMA-PEGDA-nHA hydrogel had good cell viability and biocompatibility. Furthermore, GelMA-PEGDA-nHA has excellent injectability and rapid prototyping properties and is a promising 3D printed bone repair scaffold material.Keywords:hydrogel;GelMA;nHA;photo-crosslinking
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APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING
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2026
·Vol. 132
·期 4
·342
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IF 3
Yang Qianpeng,Yuan Xin,Huang Yumin,Luo Qizhao,Wang Jing,Lan Weiyun,Jiang Haifeng
The growing pressure on global energy and freshwater resources necessitates continuous innovation in resource management technologies to ensure long-term sustainability. Solar energy, as a widely accessible and renewable resource, is of strategic importance for sustainable development. This has driven advancements in photothermal membrane distillation (PMD), which integrates interfacial solar conversion with phase-change separation. However, under prolonged exposure to hypersaline feed solutions, solute accumulation at the thermal interface of hydrophobic membranes often leads to crystalline deposition within micropores. This results in irreversible membrane fouling and a severe decline in permeate flux stability. Aimed at resolving this issue, a highly salt-resistant PTFE/PEGDA/graphene hydrogel composite membrane was developed. In this design, a PEGDA hydrogel forms a hydrophilic cross-linked polymer network that reduces membrane surface adhesion to salt crystals. The incorporation of graphene further inhibits crystal adhesion on the inner pore walls and mitigates excessive local concentration, thereby enhancing resistance to salt crystallization. The water production performance of this composite membrane was evaluated under varying light intensities. In low-concentration brine, water production increased by nearly 35%. The enhancement was even more pronounced at higher salinities, with a production increase of nearly 74%, the water production rate reached 2.08 kg·m −2 ·h −1 . The membrane distillation system maintained strong salt resistance over 3 h of operation, and the desalination rate of the produced water exceeded 99.9%. These results demonstrate that the PTFE/PEGDA/graphene hydrogel composite membrane significantly improves membrane surface resistance to salt crystallization, thereby greatly enhancing system stability and efficiency in high-salinity environments.
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SEPARATION AND PURIFICATION TECHNOLOGY
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2025
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IF 9
Xiaolong Tian,Guoyang Chen,Han Wang,Jian Cui,Ailin Gao,Yehai Yan
Janus membranes exhibit notable benefits in enhancing the anti-fouling ability during membrane distillation (MD). However, the bonding stability between the hydrophilic layer and the hydrophobic matrix is a worrying concern. In this work, we developed an interfacial free radical polymerization (IFRP) method by segregating photoinitiator and polyethylene glycol diacrylate (PEGDA) monomers into the oil and water phases, respectively. This approach facilitated a crosslinking reaction initiated at the oil–water interface, leading to the formation of a discontinuous or continuous hydrogel-like coating on one side of the PVDF membrane within a 30-second light-induced reaction. The PEGDA gel filled the membrane pores rather than growing outward along its surface, thus creating a “physical interlocking” effect and significantly enhancing their bonding stability. Anti-fouling and anti-wetting experiments were conducted under harsh conditions, including hypersaline solution of 20 wt%, high oil-content saline emulsion and humic acid/CaCl 2 mixed brine. Results demonstrated stable water vapor flux and salt rejection. By increasing the molecular weight of PEGDA monomers, a dense gel layer can be conveniently obtained, which can withstand high-concentration surfactant. This proposed IFRP method offers strong customizability, enabling the efficient production of either porous or dense hydrophilic layers to adapt to various salt solutions.
研究领域:
材料科学
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环境工程
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化学工程
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2024
·
IF 4.9
Shenghao Yang,Zhongrui Wang,Yuwen Meng,Xu Wang
Biphasic hydrogels are one of the most important biomaterials in tissue engineering due to their ability to mimic the properties of extracellular matrix. However, the lack of quantitative researches on biphasic hydrogel systems hinder the precise construction of the necessary living conditions for different cells. This fundamental study focuses on a biphasic emulsion hydrogel system consisting of polyethylene glycol diacrylate (PEGDA) and gelatin methacryloyl (GelMA), emphasizing the importance of microstructure in determining the physicochemical properties of biphasic hydrogels. Our approach utilizes a water-in-water (W/W) emulsion system, which is easy to operate and requires no purification steps. By constructing the phase diagram of PEGDA/GelMA biphasic emulsions, we demonstrate that adjusting the volume fractions of the two components results in distinct microstructures, including droplet-based and bicontinuous forms. The composition of biphasic hydrogel significantly influences its mechanical properties, swelling behavior, and biodegradability. Furthermore, the excellent biocompatibility of PEGDA/GelMA biphasic hydrogel system was demonstrated. This study conducts a more in-depth and quantitative study of the PEGDA/GelMA biphasic system. making it a versatile platform for creating precisely biomimetic environments suitable for cell encapsulation and tissue regeneration applications.
研究领域:
组织工程学
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生物材料科学
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Polymers
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2019
·Vol. 11
·期 12
·2102
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IF 3.164
Jianwei Liang,Xiaoning Zhang,Zhenyu Chen,Shan Li,Chi Yan
In this work, poly(ethylene glycol) diacrylate (PEGDA) molecules were grafted to silk fibroin (SF) molecules via a thiol–ene click reaction under 405 nm UV illumination for the fabrication of a PEGDA/SF composite hydrogel. The composite hydrogels could be prepared in a short and controllable gelation time without the use of a photoinitiator. Features relevant to the drug delivery of the PEGDA/SF hydrogels were assessed, and the hydrogels were characterized by various techniques. The results showed that the prepared PEGDA/SF hydrogels demonstrated a good sustained-release performance with limited swelling behavior. It was found that a prior cooling step can improve the compressive strength of the hydrogels effectively. Additionally, the MTT assay indicated the prepared PEGDA/SF hydrogel is non-cytotoxic. Subcutaneous implantation of the PEGDA/SF hydrogel in Kunming mice did not induce an obvious inflammation, which revealed that the prepared PEGDA/SF hydrogel possessed good biocompatibility. Furthermore, the mechanism of the gelation process was discussed.Keywords:silk fibroin;PEGDA;thiol–ene click reaction;gelation;drug delivery
研究领域:
材料科学
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生物材料
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药物递送系统
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生物医学工程
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ACS Applied Materials & Interfaces
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2014
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IF 5.9
Yunlong Wang,Buchang Zhang,Lin Zhu,Yanjie Li,Fangzhi Huang,Shikuo Li,Yuhua Shen,Anjian Xie
In this study, a novel composite hydrogel that contains spinach extract (SE), gold nanorods (AuNRs), and poly(ethylene glycol) double acrylates (PEGDA) is prepared through a one-step in situ photopolymerization under noninvasive 660 nm laser irradiation for localized antitumor activity. SE plays a role as a photoinitiator for initiating the formation of the PEGDA hydrogel and as an excellent photosensitizer for generating cytotoxic singlet oxygen (1O2) with oxygen to kill tumor cells. AuNRs can be used as a photoabsorbing agent to generate heat from optical energy. Moreover, the introduction of AuNRs is conducive to the formation of the hydrogel and accelerates the rate of 1O2 generation. The composite hydrogel shell, which has good biocompatibility on tumor cells, can prevent the photosensitizer from migrating to normal tissue and maintains a high concentration on lesions, thereby enhancing the curative effect. The combination of NIR light-triggered mild photothermal heating of AuNRs, the photodynamic treatment using SE, and localized gelation by photopolymerization exhibits a synergistic effect for the destruction of cancer cells.
研究领域:
材料科学
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纳米技术
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生物医学工程
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癌症研究
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MACROMOLECULAR MATERIALS AND ENGINEERING
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2018
·Vol. 303
·期 12
·1800233
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IF 2.69
Ya Gao,Mengmeng Hou,Ruihao Yang,Lei Zhang,Zhigang Xu,Yuejun Kang,Peng Xue
Polymeric microneedles have attracted increasing interest for transdermal drug delivery owing to the unique advantages of minimal invasiveness, biocompatibility, biodegradability, and efficient drug-loading capacity. However, drug release from polymeric microneedles lacks controllability during transdermal administration. Herein, a poly(ethylene glycol) diacrylate/polyvinylpyrrolidone (PEGDA/PVP) microneedle patch with tailorable matrix constitutions is designed and fabricated using a two-step ultraviolet (UV) light-induced polymerization method. Scanning electron microscopic characterization reveals a non-uniform interior matrix of microneedles, resulting from the aggregation of PVP in the polymerized PEGDA matrix induced by UV irradiation. The fabricated microneedles are found to show sufficient mechanical strength for skin penetration and they can be removed intact after application. The controllable release property of rhodamine B (RhB)-loaded PEGDA/PVP microneedles is demonstrated in vitro by tuning the fraction of PVP content. The typical characteristics including initial burst and subsequent sustained release are attributed to the rapid dissolution of PVP and prolonged swelling of PEGDA, respectively. In addition, the microneedle insertion site can be completely recovered within 1 h on a porcine skin, indicating the minimally invasive feature of microneedle-mediated therapeutic delivery. This scalable microneedle platform may serve as a convenient and effective drug carrier for transdermal delivery of various pharmaceuticals under precise control.
研究领域:
药物递送
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材料科学
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生物医学工程
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NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT
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2025
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IF 1.4
Long-fei An,Ling-hua Zheng,Yan-hong Chen,Ming-shuo Tang,Yan-shi Zhang,Liang-wen Chen,Yun-long Wang,Rui Cheng,Jie Yang,Lei Yang
The precise determination of 2D dose distribution at high doses and convenient dose measurement methods are ongoing challenges in the study of beam diagnosis on large-scale scientific devices. The current work offers an impressive solution by integrating PEGDA photonic crystal films with HSB (Hue, Saturation, Brightness) image processing technology. Under irradiation by a proton beam with a low energy of 182.5 keV, the dose dependence of the radiochromic properties of PEGDA films was confirmed in the experiment. Low-energy protons can alter the microstructure of PEGDA films during energy deposition, reducing the characteristic distance and decreasing the diffraction center wavelength. Under irradiation by proton beams with high doses from 1 MGy to 17.6 MGy (on average), the PEGDA films exhibited a significant blue shift in color phase, with a clear linear relationship between wavelength and absorbed dose. This study offers a straightforward and effective real-time dose feedback analysis method compared to traditional radiochromic readout systems. This approach, which is based on visual observation and digital image analysis, could provide a precise assessment of dose distribution through intuitive image interpretation. In summary, this work introduces a direct and effective dosimeter along with a simple and rapid method for dose readout, offering valuable validation for beam diagnosis.
研究领域:
辐射生物学
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医学物理
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Materials Science & Engineering C-Materials for Biological Applications
·
2017
·
IF 4.164
Le Pan,Yanjie Li,Lin Zhu,Buchang Zhang,Yuhua Shen,Anjian Xie
In this study, the poly (ethylene glycol) double acrylates (PEGDA) was first initiated by Spinacia oleracea L. extract (SOLE) to in situ form a polymer hydrogel shell on Hela cells with near infra-red irradiation. The SOLE was also a natural photosensitizer for photodynamic therapy of tumor. The use of SOLE is simple, eco-friendly, low cost, and convenient. More importantly, the PEGDA/SOLE composite hydrogel shell on Hela cells not merely prevents SOLE from diffusing to normal tissue for reducing the side effects, but also keeps high SOLE concentration on tumor cell for improving the antitumor effect. Such a hydrogel system has good biocompatibility and exhibits high therapeutic efficacy. This study extended the application of the SOLE/PEGDA gel in photodynamic therapy.
研究领域:
生物材料学
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肿瘤学
·
光动力治疗
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BMC BIOTECHNOLOGY
·
2026
·
IF 4.8
Bei Gao,Jie Yao,Yijie Wang,Chen Chen,Zhen Chai,Wanting Wan,Shiyang Wu,Zhongbo Liu,Rui Zou
Background Matrix stiffness is a key feature of the mechanical microenvironment. Periodontal tissue is a multicomponent structure composed of cementum, periodontal ligament, and alveolar bone, and is essential for the physiological reconstruction and stress of teeth. Simulating the stiffness of periodontal tissue with a biomimetic extracellular matrix is of great significance for regulating cell behavior and tissue repair. In this study, the application of GelMA-PEGDA hybrid hydrogels with different matrix stiffnesses for periodontal bone regeneration was explored. Results In this work, a GelMA‒PEGDA hybrid hydrogel ink was prepared, and the proportion of PEGDA significantly increased the matrix stiffness of the hybrid hydrogel, which had good biocompatibility. In addition, matrix stiffness promoted the osteogenic differentiation and mineralization capacity of periodontal ligament stem cells on the surface of the gels. A high-precision hydrogel scaffold was obtained by introducing a photoinhibitor. The porosity and biocompatibility of the scaffold were good. Conclusions This 3D-printed hydrogel provides a promising strategy for periodontal bone tissue regeneration.
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SENSORS AND ACTUATORS A-PHYSICAL
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2025
·
IF 4.9
Linghan Shen,Kai Luo,Luming Li,Mingyong Zhou
Flexible conductive films have been increasingly demanded for wearable devices that are widely applied. However, existing fabrication methods are limited by uneven particle distribution, complex processes, and material selectivity. Herein, a particle manipulation method based on surface acoustic wave (SAW) technology was proposed to align spherical silver (Ag) particles and fabricate a flexible conductive film with a linear arrangement structure. The process for fabricating conductive films was optimized by investigating the influence of the dielectrophoresis (DEP) effect, along with the effects of chamber height and solution solid content, on the alignment of Ag particles. Besides, the conductivity of the films and their applications in flexible sensing including wrist bending, finger short-term and continuous pressing actions were explored. Results showed that the acoustic radiation force dominates the aggregation of spherical-like Ag particles into periodic stripe patterns along the acoustic pressure node lines at locations distal to the substrate. Ag particles at the potential nodes are dominated by the dielectrophoretic force, leading to the formation of chain-like structures, which can be eliminated by utilizing the electric field shielding layer. The optimized film has a high conductivity of 4774 S/m and exhibits stable resistance characteristics during flexible deformation. The resistance change can be attributed to the changes in particle spacing, the breakage and recovery of conductive paths caused by deformation. The current work provides a new scheme for the fabrication of conductive films with high process controllability in the field of flexible sensing.
研究领域:
材料科学
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柔性电子学
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声学工程
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传感器与执行器
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JOURNAL OF MEMBRANE SCIENCE
·
2023
·
IF 9.5
Sihui Li,Keming Zhang,Chenlu Liu,Xiaoting Feng,Peijin Wang,Shaofei Wang
Polymeric membranes containing polyethylene oxide (PEO) groups are promising CO 2 separation materials, but suffer from the trade-off between separation performance and mechanical strength . To overcome this challenge, we combine the merits of semi-interpenetrating polymer network and nanohybrid to maintain a high PEO loading and robust membrane structure. The membranes were prepared by introducing in-situ formed PEO networks with silica nodes into Pebax1657 to produce a semi-interpenetrating network structure. The introduced network and in situ formed silica nanoparticles reduce the chain packing efficiency of Pebax matrix to enhance the CO 2 diffusivity , while the increased PEO content enhances CO 2 solubility. Under feed gas pressure of 25 bar, nanohybrid membranes containing 40 wt% polymer network display excellent gas separation performance with CO 2 permeability of 272.8 Barrer and CO 2 /N 2 selectivity of 79.6 under mixed gas separation tests, surpassing 2008 Robeson upper bound. Moreover, the hybrid membranes showed high mechanical strength, the Young's modulus increases by 1.95 times. This strategy provides a simple route for the design of nanohybrid membranes with high separation performance as well as excellent durability.
研究领域:
材料科学
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环境工程
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