Benign prostatic hyperplasia (BPH) is a prevalent urological disease affecting elders. Currently, the prostatic artery embolization (PAE) is considered as a minimally invasive and safe technique to treat BPH. However, various drug-loaded embolic agents have not been thoroughly investigated in BPH therapy. In this study, finasteride/poly(3-hydroxybutyrate-3-hydroxyvalerate)@polyvinyl alcohol/chitosan (FNS/PHBV@PVA/CS) reservoir-type microspheres were prepared via the solid-in-water-in-oil (S/W/O) emulsion crosslinking method with the aim to reduce the burst effect and control localized drug delivery. The structure and properties of the drug and resultant microspheres were characterized via field emission scanning electron microscopy (FESEM), Fourier-transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), and thermogravimetric analysis (TGA). The results showed that the drug-loaded hybrid microspheres were well-dispersed and spherical with a mean diameter of 238.1 ± 27.3 μm. All samples exhibited excellent thermal stability. The FNS/PHBV microspheres were successfully encapsulated inside the PVA/CS polymeric matrix, which effectively suppressed the burst effect and prolonged the drug release up to 51 days. In vitro biocompatibility assessment indicated that the microspheres possessed excellent cytocompatibility and hemocompatibility. Furthermore, in vivo studies performed in the rabbit ear embolization model showed the formation of progressive ischemic necrosis after treatment for various periods. Histopathological studies revealed that the microspheres completely occluded the blood vessels with minimal foreign body response and formed the fibrotic area at the periphery of embolized arteries. Furthermore, the auricular vascular endothelial cells showed acute ultrastructural changes, associated with the ischemic necrosis induced by the embolization procedures. All these findings suggest that the FNS/PHBV@PVA/CS hybrid microspheres could be used as a promising drug delivery system for potential applications in BPH therapy.
PAC@PHZ-II exhibits a distinct color change for different pH values and ammonia. • Bilayer film's low water vapor transmission rate aids food preservation. • PAC@PHZ-II strongly inhibited S. aureus , E. coli , and L. monocytogenes . • PAC@PHZ-II effectively indicate fresh pork and spoiled pork. A PAC@PHZ-II bilayer film composed of polyvinyl alcohol/carboxymethyl konjac glucomannan/alizarin as the sensor layer and poly(3-hydroxybutyrate- co -3-hydroxyvaleric acid)/nano-ZnO as the antibacterial layer was developed using electrospinning technology for meat preservation and freshness perception. Structure analyses revealed that there are interactions between the sensor layer and antibacterial layer. The bilayer film has a lowest water vapor transmission rate of 26.03 ± 0.21 g·m −2 ·h −1 , and the tensile strength and elongation at break are approximately 150% and 290% higher than those of single-layer films, respectively. The bilayer film is sensitive to pH and ammonia, exhibiting visible color changes from yellow to purple. Antibacterial test indicated the dual functional film had strong antibacterial activity against Staphylococcus aureus , Escherichia coli and Listeria monocytogenes . Pork packaged with the film exhibits a 3 days shelf-life extension, and the color changed when meat freshness decreases, suggesting a potential use in preserving and monitoring pork freshness. Download: Download high-res image (236KB) Download: Download full-size image
Zhuoyu Lu,Nuoyan Ou,Lanying Lin,Kun Liu,Xiaolu Wu,Chuanshuang Hu,Jiangtao Xu,Yonghui Zhou,Mizi Fan
Novel development of high-loading bamboo flour/PHBV biocomposites. • Synergistic treatment of bamboo flour via delignification and impregnation of coupling agents. • Surface roughness and chemical interactions benefitted interfacial adhesion. • Enhanced interfacial bonding contributed to mechanical and thermal property improvement. This paper presents a novel development of bamboo flour/poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) biocomposites with a particular focus on addressing the interfacial bonding through a synergistic treatment. The synergistic strategy involves the delignification of bamboo flour followed by impregnation of PHBV-based coupling agents synthesised in this work, including maleic anhydride (MA)-grafted PHBV (MA- g -PHBV), acrylic acid (AA) grafted-PHBV (AA- g -PHBV) and itaconic anhydride (IA) grafted-PHBV (IA- g -PHBV). Chemical structural analyses of bamboo flour suggested the removal of lignin and the possible interactions between surface hydroxyl groups and the introduced anhydride/carboxyl groups after the synergistic treatment. Microstructure analysis suggested the treated bamboo flour with increased surface roughness had better interfacial adhesion with PHBV matrix in the composites, which was further confirmed by their lower loss factor. The tensile strength and flexural strength of MA- g -PHBV modified delignified bamboo flour/PHBV composite were increased by 333.3% and 250.4% respectively, compared to those of the untreated counterpart. The improved interfacial bonding also resulted in the shift of composite failure mechanism from fibre pull-out to fibre breakage. The work provides a feasible and effective modification approach of lignocellulosic fibres for enhancing fibre-matrix interfacial bonding in biobased and biodegradable composites.
危险品化学品经营许可证（带存储）