PHOTOCHEMISTRY AND PHOTOBIOLOGY
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2014
·Vol. 90
·期 5
·1144-1149
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IF 2.684
Zhi Li,Li-Li Pan,Fei-Long Zhang,Xia-Li Zhu,Yang Liu,Zhen-Zhong Zhang
This report explores some properties of 80–200 nm nanoparticles containing 5-aminolevulinic acid (ALA) and fullerene (C60) for photodynamic therapy (PDT). Compared with ALA, the nanoparticles yielded more protoporphyrin IX (PpIX) formation in cells and tissues and to a significant improvement in antitumor efficacy in tumor-bearing mice. Maximum levels of PpIX were obtained 4 h after administration and selective PpIX formation in tumor was observed. These nanoparticles appear to be a useful vehicle for drug delivery purposes. In this study, a procedure for preparing fullerene nanoparticles containing ALA was developed. The product alone exhibited no detectable toxicity in the dark and was superior to ALA alone in promoting PpIX biosynthesis and PDT efficacy both in culture and in a murine tumor model. These results suggest that this procedure could be the basis for an improved PDT protocol for cancer control.
研究领域:
药学
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纳米技术
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肿瘤学
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DOI
PubMed
高影响因子
PHOTOCHEMISTRY AND PHOTOBIOLOGY
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2014
·Vol. 90
·期 6
·1462-1466
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IF 2.684
Ying Mei,Bing Yan
A special multifunctional ionic liquid compound (1-methyl-3-(2-(thiocarboxyoxy)-ethyl)-2H-imidazole-1,3-diium bromide (SHIL)) is used as the chemical bridge to link lanthanide beta-diketonates and polymer resin, which are designated as Ln(L) 4 -SHIL-WR/MR (Ln = Eu, Tb, Sm; L = thenoyltrifluoroacetonate (TTA), acetylacetonate (AA), dibenzoylmethane (DBM); WR = Wang resin, MR = Merrifield resin). Among SHIL and polymer resin are assembled to form covalently bonded system through condensation reaction. Then tetrakis lanthanide beta-diketonates are linked to SHIL through ion-exchange reaction. Physical characterization and especially the photoluminescent performance of the multicomponent hybrids are studied. The hybrid materials possess good stability and excellent luminescent property. The results provide useful path to obtain luminescent hybrids for further practical application.
研究领域:
材料科学
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化学
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DOI
PubMed
高影响因子
PHOTOCHEMISTRY AND PHOTOBIOLOGY
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2018
·Vol. 94
·期 4
·650-658
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IF 2.214
Rong Liu,Yonggang Zhang
Photoelectrocatalytic (PEC) system greatly improves the migration of photoexcited charges, retards the fast recombination of electron-hole and increases the lifetime of photogenerated holes. In this article, we constructed a novel PEC system to degrade berberine chloride form (BCF). XRD patterns indicated aging time was an important condition for the crystal type of TiO 2, and the best proportion of anatase/rutile was 80/20. The band gap energy of the TiO 2 was 3.01 eV. We demonstrated that a synergistic effect existed between photocatalysis (PC) and electrocatalysis (EC). Besides, we discussed the influence of pH, current density, the amount of catalyst and initial BCF concentration on the degradation of BCF. Electron spin resonance (ESR) through spin trap 5, 5-dimethyl-1-pyrroline-N-oxide (DMPO) and the scavenging experiments suggested that the reactive oxygen species (ROS) were superoxide radicals ( ), hydroxyl radicals (·OH) and sulfate radical ( ) in PEC system. Furthermore, we compared the two pathway of formation DMPO-SO 4 adducts and found that was the most major oxidized species in degrading BCF. We proposed a plausible reaction mechanism. Intriguingly, even under lower current and weaker light conditions, the PEC process maintained its effectiveness, demonstrating the feasibility of the PEC approach.
研究领域:
环境科学
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化学
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DOI
PubMed
高影响因子
PHOTOCHEMISTRY AND PHOTOBIOLOGY
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2017
·Vol. 93
·期 5
·1154-1164
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IF 2.121
Fengjun Zhang,Shuang Zou,Tianye Wang,Yuxi Shi,Peng Liu
CeO 2 /Bi 2 WO 6 heterostructured microsphere with excellent and stable photocatalytic activity for degradation tetracyclines was successfully synthesized via a facile solvothermal route. The photocatalytic experiments indicated that CeO 2 /Bi 2 WO 6 heterostructured microspheres exhibited enhanced photocatalytic activity compared to pure Bi 2 WO 6 in both the degradation of tetracycline hydrochloride (TCH) and rhodamine B (RhB) under visible-light irradiation. The 1CeO 2 /2Bi 2 WO 6 exhibited the best photocatalytic activity for degradation of TCH, reaching 91% after 60 min reaction. The results suggested that the particular morphological conformation of the microspheres resulted in smaller size and more uniform morphology so as to increase the specific surface area. Meanwhile, the heterojunction was formed by coupling CeO 2 and Bi 2 WO 6 in the as-prepared microspheres, so that the separation efficiency of photogenerated electrons and holes was dramatically improved and the lifetimes of charge carriers were prolonged. Hence, introduction of CeO 2 could significantly enhance the photocatalytic activity of CeO 2 /Bi 2 WO 6 heterostructured microspheres and facilitate the degradation of TCH. This work provided not only a principle method to synthesize CeO 2 /Bi 2 WO 6 with the excellent photocatalytic performance for actual produce, but also a excellent property of the photocatalyst for potential application in photocatalytic treatment of tetracyclines wastewater from pharmaceutical factory.
研究领域:
环境科学
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材料科学
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光催化技术
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DOI
PubMed
高影响因子
PHOTOCHEMISTRY AND PHOTOBIOLOGY
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2022
·Vol. 98
·期 2
·371-377
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IF 3.521
Xiaokan Yu,Weisheng Zhu,Wenao Ouyang,Xiaojia Zhang,Hao Qiu,Zhijun Zhang,Bengang Xing
Fluorescent probes based on fluorescence resonance energy transfer (FRET) are highly promising for diverse bioapplications. The key to constructing FRET probes is to confine the donor and acceptor within a sufficiently close distance. However, the commonly used covalent linkage often requires elaborate design and complex organic synthesis, and sometimes causes changes in the fluorescence properties of the donor and acceptor. Inspired by the binding between small molecules and protein in nature, herein, we propose a protein-mediated strategy to fabricate FRET probe. In such protein-mediated FRET (P-FRET) probe, protein acts as a carrier to simultaneously confine donor and acceptor in its cavity. As a proof of concept, we use bovine serum albumin (BSA) as a model protein, coumarin derivative as a donor and hydroxyl radical (·OH)-responsive dye fluorescein as an acceptor. Through a series of investigations, including binding parameters, fluorescence properties and detection performance, we prove that the construction of P-FRET probe is simple and feasible and the detection is sensitive. Our P-FRET strategy will provide new insights for the design of FRET probes.
研究领域:
生物化学
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分析化学
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医学检测
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DOI
PubMed
高影响因子
PHOTOCHEMISTRY AND PHOTOBIOLOGY
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2021
·Vol. 98
·期 2
·404-411
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IF 3.421
Na Tong,Zhonglei Xia,Tianzhu Xie,Xu Liu,Jinni Shen,Zizhong Zhang,Xuxu Wang
Mutual transformations of various nitrogen compounds and their reaction mechanisms have been a subject of great concern to the chemical, ecological and environmental communities. In the paper, the reactions of NO 3 - ion with small organic acids such as formic acid (HCOOH), acetic acid (CH 3 COOH) and lactic acid (C 3 H 6 O 3 ) under ultraviolet illumination were investigated systematically. It was found that NO 3 - ion is easily reduced into NO 2 - and NO x and then further into N 2 and NH 3 (in the form of NH 4 + ) in the process. The carboxyl anion radicals and hydrogen formed by photodecomposition of formic acid are responsible for the rapid photoreduction reaction of nitrate. The initial pH and the nitrate concentration considerably affect the product distribution and nitrate conversion. Based on a preliminary simulation study, we speculated that the photoinduced reaction may effectively proceed in oceans, lakes and rivers because of ever-increasing nitrate and organic emissions. This research is helpful to understand nitrogen cycle mechanism and develop water environmental control technologies.
研究领域:
环境科学
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化学
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PubMed
高影响因子
PHOTOCHEMISTRY AND PHOTOBIOLOGY
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2022
·Vol. 99
·期 1
·68-77
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IF 3.521
Xianhu Wei,Qihui Gu,Ying Feng,Youxiong Zhang,Ying Li,Shuhong Zhang,Jumei Zhang,Shi Wu,Xiaojuan Yang,Qinghua Ye,Yu Ding,Juan Wang,Moutong Chen,Qingping Wu
A new, simple-to-synthesize and sensitive turn-on fluorogenic substrate ( CFMU-Glu ) for β-glucosidase activity was developed. This probe was based on a 7-hydroxycoumarin derivative ( CFMU ) that could emit green fluorescence and had the low p K a value of 5.61 ± 0.01. CFMU-Glu could be used for sensitive monitoring of the almond βGLU and Enterococcus faecalis ( E. faecalis ) at the optimal pHs of 6.50 and 7.00, respectively. Moreover, a new sensitive and selective fluorogenic broth (PBF-B) for E. faecalis , utilizing CFMU-Glu and polymyxin B, was also developed. Polymyxin B was discovered to can significantly improve the detection selectivity and signal intensity. The proposed 4-four method using PBF-B and a microcentrifuge tube could provide fluorogenic detection limits of 5.01 × 10 4 and 1.0 × 10 5 CFU mL −1 by fluorescence microplate reader and naked eye, respectively; it could also provide a turn-on chromogenic detection limit of 1.0 × 10 6 CFU mL −1 by naked eye. The proposed method could detect 8 CFU mL −1 of E. faecalis in drinking water, Liangcha (herbal tea) and milk samples within 10 h, without pre-enrichment.
研究领域:
微生物学
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分析化学
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食品科学
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DOI
PubMed
高影响因子
PHOTOCHEMISTRY AND PHOTOBIOLOGY
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2023
·Vol. 99
·期 5
·1310-1317
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IF 3.3
Xiaoyi Dai,Zhong Li,Xusheng Shao
Carbendazim (MBC) is a high-efficient and broad-spectrum fungicide, but excessive residues caused by its improper use have caused health toxicity and environmental pollution. It is an irresistible trend to find green, safe, accurate and controllable release technology of MBC. To achieve the purpose of safe and efficient use of MBC, photolabile protecting group was used to realize the controllable release. This study aimed to covalently link MBC and 6-nitropiperonyl alcohol (NP) to synthesize photocaged molecule NP-MBC. The photodegradation test showed that NP-MBC could effectively release MBC under ultraviolet light. The antifungal activity of NP-MBC showed significant difference against Rhizoctonia solani , Sclerotinia sclerotiorum and Fusarium graminearum before and after irradiation, and the effects on mycelial morphology are different. The hyphae morphology of R. solani and F. graminearum changed significantly, and mycelia were severely damaged. The hyphae surface of former was swollen and broken, and the latter was collapsed and shriveled after NP-MBC light treatment. NP-MBC could realize the light-controlled release of MBC, and the antifungal activity before and after irradiation was significantly different, which provides an effective way to release MBC.
研究领域:
植物保护
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环境科学
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DOI
PubMed
高影响因子
PHOTOCHEMISTRY AND PHOTOBIOLOGY
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2022
·
IF 3.521
Ziwei Chen,Xueli Wang,Menghui Jia,Xiaoxiao He,Haifeng Pan,Jinquan Chen
5-Azacytosine (5-AC) is one of the best interesting noncanonical nucleobases due to its functionalization and structural imitation of natural bases. 5-AC can be used as the scaffold of two important chemotherapeutic medicines, 5-azacytidine and 2′-deoxy-5-azacytidine. Furthermore, increased sensitivity to UV leads to the photochemical effects of 5-AC also attracted attention. Yet, no study has been reported to explore the effect of glycosyl groups on the photophysical and photochemical properties of 5-AC, which can help to reveal the photostability of related actual clinic drugs. In this study, the excited-state dynamics of 5-azacytidine and 2′-deoxy-5-azacytidine are studied by femtosecond transient absorption and quantum-chemical calculations while revisiting that of 5-AC with a wider probe spectral range. It is shown that glycosyl substitution on the N1 position leads to ultrafast excited-state relaxation within several picoseconds in both nucleosides, which is distinct compared with the 17 ps lifetime seen in 5-AC. It is proposed that these changes are due to altering the energy level of the dark nπ* state. Moreover, our results suggest that it should be cautioned to simply replace sugar groups with methyl groups when doing a theoretical calculation study on nucleobases and their derivatives.
研究领域:
生物化学
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药物化学
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光化学
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PubMed
高影响因子
PHOTOCHEMISTRY AND PHOTOBIOLOGY
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2023
·
IF 3.3
Jialan Zhang,Yufeng Chen,Shaojin Wang,Yingbao Liu,Li Li,Mengxiang Gao
Light, magnetic field, and methylation affected the growth and secondary metabolism of fungi. The regulation effect of the three factors on the growth and Monascus pigments (MPs) synthesis of Monascus purpureus was investigated in this study. 5-azacytidine (5-AzaC), DNA methylation inhibitor, was used to treat M. purpureus (wild-type, WT). Twenty micromolar 5-AzaC significantly promoted the growth, development, and MPs yield. Moreover, 250 lux red light and red light coupled magnetic field (RLCMF) significantly promoted the biomass. For WT, red light, and RLCMF significantly promoted MPs yield. But compared with red light treatment, only 0.2 mT RLCMF promoted the alcohol-soluble MPs yield. For histone H3K4 methyltransferase complex subunit Ash2 gene knockout strain (Δ Ash2 ), only 0.2 mT RLCMF significantly promoted water-soluble MPs yield. Yet red light, 1.0 and 0.2 mT RLCMF significantly promoted alcohol-soluble MPs yield. This indicated that methylation affected the MPs biosynthesis. Red light and weaker MF had a synergistic effect on the growth and MPs synthesis of Δ Ash2 . This result was further confirmed by the expression of related genes. Therefore, histone H3K4 methyltransferase was involved in the regulation of the growth, development, and MPs synthesis of M. purpureus by the RLCMF.
研究领域:
微生物学
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表观遗传学
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DOI
PubMed
高影响因子
PHOTOCHEMISTRY AND PHOTOBIOLOGY
·
2023
·
IF 3.3
Peng Shu,Ling Jiang,Menggeng Li,Yi Li,Zhengqiang Yuan,Li Lin,Ju Wen,Haji Akber Aisa,Zhiyun Du
Over the past decades, increasing evidences have demonstrated that five retinoids, including retinol (ROL), retinol acetate (RAc), retinol propionate (RP), retinol palmitate (RPalm), and hydroxypinacolone retinoate (HPR), can be potential therapeutic agents for skin photoaging. However, therapeutic efficacies and biosafety have never been compared to these compounds. This study aimed to determine the optimal retinoid type(s) for anti-photoaging therapy both in vitro and in vivo. Our data demonstrated that four retinoids (RPalm, RP, HPR and ROL) but not RAc were effective for anti-photoaging treatment at 5 μg/mL in vitro, with action mechanisms associated with antioxidative, anti-inflammatory and anti-skin ECM degradation activities. Notably, both RPalm and RP appeared superior to HPR and ROL for those activities. Importantly, both RPalm and RP were shown to be optimal for anti-photoaging therapy when topically applied at 5 mg/kg in a UVB-induced mice model of photoaging, which is consistent with their high anti-photoaging activities in vitro. Additionally, topical application of these five retinoids showed satisfactory biosafety without causing significant apoptosis in animal organs, although RP application led to a slight decline in animal body weights. Collectively, these data have laid a good foundation for the next development of the clinical application of these retinoids for skin healthcare.
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PubMed
高影响因子
PHOTOCHEMISTRY AND PHOTOBIOLOGY
·
2023
·
IF 3.3
Xing Liu,Longxin Hu,Yujie Zhang,Hua Lai,Gang Peng,Junhua Li,Rongying Zeng,Zhengji Yi
In the present work, carbon nitride quantum dots (CNQDs)-modified cobalt phosphate (CoPi) composites CNQDs/CoPi- x ( x = 1, 2, 3) were prepared at room temperature and characterized by FTIR, XRD, UV–Vis DRS, EIS, SEM, TEM/HR-TEM, XPS, and N 2 gas adsorption. The morphologies and surface areas of CNQDs/CoPi- x have no remarkable change after modification of CNQDs, compared with pure CoPi. The obtained CNQDs/CoPi- x shows enhanced activity and stability of photocatalytic H 2 evolution compared to pure CoPi using Eosin Y (EY) as a sensitizer and triethanolamine as an electron donor. The CNQDs/CoPi-2 possesses the highest hydrogen evolution rate, 234.5 μmol h −1 g −1 , upon visible light, which outshines that of CoPi by 2.4 times. It was believed that the enhanced photocatalytic performances of the CNQDs/CoPi-2 could result from the boosted electron transfer from radical EY ·− to CNQDs/CoPi-2 by the employment of CNQDs; in addition, the visible-light activity of CNQDs contributes to hydrogen evolution. The mechanism of photocatalytic hydrogen production was discussed. This study may contribute toward the development of production of “green hydrogen” using solar.
研究领域:
材料科学
·
能源化学
·
环境科学
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DOI
PubMed
高影响因子
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