BIOMEDICAL CHROMATOGRAPHY
·
2023
·Vol. 37
·期 4
·e5589
·
IF 1.8
Chenchen Liu,Huiling Chen,Yida Zhang,Meng Li,Qiyao Jiang,Zhendong Wang,Liangwen Yu,Qi Wang,Huafeng Pan,Yue Zhuo
Li-Zhong-Xiao-Pi granules (LZXP) are effective for treating gastric precancerous lesions (GPL) in traditional Chinese medicine. However, the active compounds of LZXP and their potential therapeutic mechanism in GPL remained unclarified. The purpose of this study is to investigate the chemical composition and potential targets of LZXP. Based on the accurate masses, ion fragments, and literature data, a total of 128 compounds were identified in the LZXP sample using ultra-performance liquid chromatography and quadrupole time-of-flight mass spectrometry (UPLC–Q-TOF–MS) in both positive and negative ion modes, and 28 of these compounds were exactly determined by comparison with authentic reference standards. Meanwhile, 11 typical components were quantified via UPLC during a 24 min period. The linearity, accuracy, stability and recovery of the method were all proven. Through the network pharmacological analysis, six chemicals (quercetin, 4′-hydroxywogonin, sinensetin, 5, 7, 8, 3′, 4′-pentamethoxyflavanone, 8-gingerdione and quercetin) were identified as the active ingredients, and five LZXP targets (AKT1, CYP1B1, PTGS2, MMP9 and EGFR) were found to be the crucial molecules in the treatment of GPL. This study provides a systematic and applicable method for the rapid screening and identification of the chemical constituents from LZXP, and an effective understanding the mechanism of LZXP in the treatment of GPL.
研究领域:
中药学
·
药理学
·
分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF PHYSICS AND CHEMISTRY OF SOLIDS
·
2021
·
IF 3.995
Jun Liu,Meng Sun,Meng-Jie Chang,Wen-Na Cui,Cong-Miao Zhang,Fu-Rong Ni,Jing Zhang,Si-Meng Fan,Hui-Ling Du
s We present a simple methodology to construct novel Co-Pi decorated TiO 2 /Bi 4 Ti 3 O 12 nanorod (TiO 2 /BTO@Co-Pi NR) arrays as photoanode for enhanced water splitting. By using successive ionic layer adsorption and reaction (SILAR) method, controllable amounts of BiOI nanoplates were uniformly immobilized on the hydrothermal grown TiO 2 NR arrays on Fluorine-doped tin oxide (FTO) substrate. TiO 2 /BTO NR heterojunction was conveniently obtained by partial conversion of TiO 2 to high crystallized Bi 4 Ti 3 O 12 through a solid-state reaction with BiOI nanoplates at high temperature. Afterwards, Co-Pi nanoparticles were deposited on TiO 2 /BTO by photoelectrical deposition to generate TiO 2 /BTO@Co-Pi composites. Photoelectrochemical (PEC) measurements have demonstrated that the prepared TiO 2 /BTO photoanode exhibits extremely enhanced performance than pristine TiO 2 for PEC water splitting thanks to the increased visible light absorption and photogenerated charge separation efficiency. Moreover, both the photocurrent density and incident photo-to-current conversion efficiency (IPCE) were further improved after the decoration of Co-Pi. This work provides a feasible and low-cost strategy to establish TiO 2 /Bi 4 Ti 3 O 12 based photoelectrode, therefore, is suitable for practical applications.
研究领域:
材料科学
·
光电化学
·
纳米技术
·
太阳能转换
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2019
·
IF 4.084
Yue Sun,Simeng Shao,Yanfeng Wang,Wenjuan Lu,Pingping Zhang,Qingqiang Yao
For the first time, g-C 3 N 4 @α-Fe 2 O 3 /Co-Pi heterojunctional hollow spheres were successfully fabricated via thermal condensation method followed by solvothermal and photo-deposition treatment, which showed excellent photocatalytical property. Except for the Z-scheme charge transfer between α-Fe 2 O 3 and g-C 3 N 4 , the Co-Pi could further reduce the combination of photogenerated electrons and holes as a hole storage agent, resulting in remarkably enhanced visible-light photocatalytic water splitting activity with the H 2 production rate of 450 μmol h −1 g −1 , which is 15.7 times higher than that of g-C 3 N 4 . Moreover, the photocatalytic activity of the prepared ternary hollow photocatalysts showed almost no significant weakness after five cycles, which indicated their good performance stability. The as-prepared g-C 3 N 4 @α-Fe 2 O 3 /Co-Pi also possessed good activity for overall water splitting with the hydrogen production rate reaching 9.8 μmol h −1 g −1 . This synthesized g-C 3 N 4 @α-Fe 2 O 3 /Co-Pi composite is expected to be a promising candidate for water splitting.
研究领域:
材料科学
·
光催化
·
能源材料
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
FIBERS AND POLYMERS
·
2025
·
IF 2.3
Xu Jing,Liu Jingxiao,Shi Fei,Xiao Jianbin,Pei Wen,Yu Chen
Developing fibers with integrated photothermal conversion and thermal storage functions provides a promising approach for personal thermal management. However, conventional phase change materials (PCMs) are limited by poor solar absorption and leakage issues, reducing their efficiency. Herein, a novel porous polyimide/Cs x WO 3 /GO composite aerogel fiber (PCGAF) was fabricated by freeze-spinning technology, using polyimide as the skeleton and incorporating Cs x WO 3 and graphene oxide (GO) as photothermal absorbers. Moreover, a PCGAF/PEG composite with enhanced phase change thermal storage capacity was obtained by vacuum-impregnating polyethylene glycol (PEG), as a phase change material, into the framework of PCGAF. The as-prepared aerogel fibers exhibit superior radiative heating, outstanding thermal stability, and excellent thermal management properties. The addition of an appropriate amount of GO improves the solar absorption efficiency of the composite aerogel fibers and provides a thermally conductive backbone, facilitating the rapid thermal response of PCGAF/PEG. The optimized PCGAF-1/PEG exhibited high PEG loading (91.5%) and high enthalpy (117.8 J/g). The dynamic thermal properties of the PCGAF/PEG can effectively regulate body temperature fluctuations, making them highly promising for next-generation smart textiles in personal thermal management.
研究领域:
材料科学
·
纳米技术
·
能量转换
·
纺织工程
·
热管理
✓ 已验证
产品关联
DOI
高影响因子
PROGRESS IN ORGANIC COATINGS
·
2023
·
IF 6.6
Yuhang Han,Yingyi Ma,Junming Zhang,Shun Yao,Kaizheng Xu
It is important to reduce dielectric constant while maintaining or improving water resistance and mechanical properties for the practical use of porous low-dielectric materials. Herein, a composite film in which GO and fluorinated PI (FPI) contained porous structure located on the surface of flat PI film was prepared by the simple breath figure method. The incorporation of GO/surfactant can break the design contradiction between low dielectric constant and high mechanical strength for porous structure, thereby realizing the synchronous promotion of dielectric and mechanical properties. Moreover, the water absorption of composite film was decreased significantly due to the synergy of fluorine atoms, porous structure and GO/surfactant, guarantee its high robustness to humid stress. The dielectric, water resistance and mechanical properties of the composite film could be regulated through varying the casting humidity and GO/surfactant content. A low dielectric constant of 2.3, water absorption of 0.6 % and high tensile strength of 122 MPa, with 31.11 % and 75.88 % of decrease and 26.99 % of increase compared to flat PI film was exhibited with the GO/surfactant loading of only 0.5 wt%. The dielectric constant of composite film is still below 2.5 after moisture treatment. These excellent properties facilitate the application of GO/PI composite film in microelectronics.
研究领域:
材料科学
·
电气工程
·
化学工程
✓ 已验证
DOI
高影响因子
ELECTROCHIMICA ACTA
·
2025
·
IF 5.6
Saijin Wang,Huiting Mao,Meng Wang,Ximing Cui,Ye Li,Yuxin Cao,Jiazheng Jin,Shi Zhou,Jinlian Li,Guogang Shan
Abnormal purine metabolism can result in oxidative stress and endothelial dysfunction, heightening the risks for conditions such as gout and cardiovascular disorders, which may subsequently trigger various physiological dysfunctions. Thus, the rapid and sensitive detection of metabolic abnormalities in purines is crucial for the early diagnosis and prevention of related diseases. Zebrafish has emerged as a popular model organism in metabolic, genetic, and toxicological studies due to its high genetic similarity to humans and the transparency of its embryos, facilitating observation. In this study, we developed a novel electrochemical sensor based on m OMe-Ir-PI/MWCNTs@PDA/GCE to detect purine molecules sensitively. Using this method, we analyzed the electrochemical behavior of zebrafish embryos, correlating the electrochemical signals with X/G and HX/A. Investigating purine metabolism in zebrafish embryos across different developmental stages, we found that from the cleavage stage to the somite formation stage, the activity of degrading enzymes increased, leading to enhanced purine oxidative degradation and the activation of metabolic pathways. This resulted in a decline in purine content, observed as decreasing electrochemical signals. Conversely, from the somite formation stage to hatching, cell differentiation, tissue formation, and organ development accelerated, leading to an increase in purines involved in energy metabolism and biosynthesis, which was reflected in rising electrochemical signals. This study represents the first application of electrochemical methods for detecting purine metabolism in zebrafish embryos throughout various developmental stages, thus providing insights into the role of purine metabolism in early life development.
研究领域:
生物化学
·
分析化学
·
发育生物学
·
电化学
·
分子生物学
·
毒理学
·
遗传学
✓ 已验证
产品关联
DOI
高影响因子
Journal of Environmental Chemical Engineering
·
2025
·
IF 7.2
Siqi Fang,Zhengang Bu,Yuanlin Zhan,Wenzhuo He,Yibin Huang,Jianhua Li
The indiscriminate of tetracycline (TC) has led to significant environmental and health concerns, particularly the proliferation of antibiotic resistance. This study presents a visible-light photocatalytic composite membrane with a Z-scheme heterojunction to improve TC removal efficiency and address the challenge of catalyst powder recovery in practical applications. Firstly, the PI/NH 2 -UiO-66 (PNs) composite photocatalyst was synthesized via a one-step thermal solvent method. Subsequently, the PVDF/MXene/PI/NH 2 -UiO-66 (PMPNs) composite fiber membrane was successfully fabricated by stably loading the PNs and MXene onto PVDF fiber membranes through electrospinning. Under visible light irradiation, the removal efficiency of TC by the PMPN1.5 composite fiber membrane could reach 86.07% through the combined effects of filtration, adsorption, and photocatalysis. Even after three cycles, the recovery rate of the PMPN1.5 membrane could still reach 86.16%. The enhanced photocatalytic performance was due to the Z-scheme heterojunction between PI and NH 2 -UiO-66. This heterojunction structure enhanced the redox capability of the photocatalyst. Additionally, the incorporation of MXene facilitated effectively charged carrier transfer at the heterojunction interface, prolonging the electron-hole separation time and further improving the photocatalytic capability. This study successfully integrates photocatalytic technology with membrane separation to develop a visible light-responsive composite fiber membrane with considerable potential for treating antibiotic-contaminated wastewater. The developed membrane not only mitigates fouling but is also easily recyclable, minimizing the risk of secondary pollution.
研究领域:
环境科学
·
材料工程
·
光催化
·
纳米技术
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
COMPOSITES COMMUNICATIONS
·
2025
·
IF 7.7
Azim Abdullaev,Fujian Liu,Kun Peng,Yujie You,Kehan Qu,MD Zahidul Islam,Yinsong Si,Yaqin Fu
The development of advanced dielectric materials is integral to improving the performance of high-frequency telecommunication devices. Developing composite membranes that effectively balance superior dielectric properties, high thermal stability, mechanical strength, and other key characteristics for practical applications remains a significant challenge. This study presents the fabrication of a nanocomposite membrane, combining polyimide (PI) and polytetrafluoroethylene (PTFE) within a PI matrix, designed for dielectric applications. The PI/PTFE@PI nanocomposite membranes were fabricated through electrospinning and dip-coating techniques. These membranes exhibited dielectric constants between 1.64 and 1.99 at 10 GHz, accompanied by a low dielectric loss, ranging from 0.001 to 0.009. Dielectric breakdown strengths varied between 108.38 and 169.44 kV/mm. Mechanical properties included a tensile strength of 26.81 MPa and a Young's modulus of 858 MPa. Thermal stability tests showed a maximum thermal degradation temperature ( T max ) of 659 °C and a 5% weight loss temperature ( T d5% ) of 450 °C for pure PI composite membranes. The PI/PTFE@PI-40% composite membrane demonstrated a water contact angle of 110.8° and a water absorption rate of 0.5%, indicating its suitability as a potential dielectric material for telecommunication applications.
研究领域:
材料科学
·
电子工程
✓ 已验证
产品关联
DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2024
·
IF 8.1
Chen-Yan Hu,Zi-Yi Dong,Zheng-Yu Dong,Yi-Hui Wu,Sheng-Jie Ji,Li-Li Hu,Xin-Yu Yang,Hao Liu,Bin Xu
The present study investigated the mechanism of manganese ion (Mn(II))-activated periodate (PI) for rapid removal of sulfadiazine (SDZ). The Mn(II)/PI system showed excellent SDZ degradation results with 99.8 % degradation efficiency within 2 min at pH = 5.5. Mechanism study reveals that the degradation of SDZ in the Mn(II)/PI system takes place mainly through an electron transfer process. Mn(II) can be oxidized by PI to formed the in-situ MnO 2 , followed by the generation of MnO 2 -PI complex. Electrochemical methods have confirmed that the generated MnO 2 -PI complex significantly contributes to the degradation of pollutants. MnO 2 -PI mediates the transfer of electrons from SDZ to PI surface through surface vacancies, thereby achieving efficient degradation of pollutants. p -methoxyphenyl sulfone (PMSO) is used as a probe compound, and almost 90 % of PMSO is converted into PMSO 2 in the Mn(II)/PI/SDZ system, manifesting that excessive PI may oxidize active Mn(IV) to Mn(V). And the generated Mn(V) also contributes to the SDZ degradation. The SDZ degradation pathway is proposed and the transformation of iodine species is detected. The final iodine species in the system are iodate. The chloride culture experiment has confirmed that the production of organic iodine is very low, indicating no significant health risks. This study reveals mechanism of periodate-based process, providing theoretical and technical implementation guidelines of periodate in water treatment.
研究领域:
环境科学
·
化学工程
·
水处理
✓ 已验证
产品关联
DOI
高影响因子
APPLIED SURFACE SCIENCE
·
2025
·
IF 6.9
Pengyu Li,Xiaohua Feng,Xiangkui Liao,Shihan Sheng,Axin Huang,Yi Liu,Hua Li
Developing efficient microwave-absorbing coatings via thermal spraying is usually hindered by the thermal demagnetization and oxidation of fillers. Herein, a low-temperature flame spraying strategy is proposed to fabricate Nd-doped BaFe 12 O 19 /nano-carbon spheres (CS)/polyimide (PI) coatings. By systematically controlling the feed rate of the starting feedstock, we precisely modulate filler dispersion and coating microstructure evolution, thereby inducing significant transitions in the dominant microwave attenuation mechanisms. At high feed rates, limited CS addition promotes localized surface plasmon resonance (LSPR) and metallization effects within the surface-dense layer, while excessive CS loading induces an overconnected network and prominent skin effect, impairing microwave absorption (MA) in both cases. Conversely, under low feed rates, favorable thermodynamic and kinetic conditions enable the formation of PI-encapsulated spherical filler structures in the surface region. This unique structure effectively suppresses LSPR and the skin effect, enhances polarization losses, prevents excessive conductivity rise (mitigating impedance mismatch), and thus optimizes over MA. Consequently, the high-feed-rate coating delivers a minimum reflection loss ( RL min ) of−39.1 dB and an effective absorption bandwidth ( EAB ) of 3.7 GHz at a thickness of 4.3 mm. In contrast, the coating with PI-encapsulated spherical filler structures achieves a better RL min of −52.3 dB and a wider EAB of 6.1 GHz at 2.1 mm. Furthermore, the coatings demonstrate outstanding adhesion, achieving Class 0 in the cross-cut testing. Scratch testing demonstrates excellent cohesion and interfacial robustness without catastrophic delamination. The results would give critical mechanistic insight into establishing scalable technical route for engineering flame-sprayed microwave absorbers with simultaneously enhanced structure-function integration and long-lasting mechanical performance.
研究领域:
材料科学
·
微波吸波材料
·
热喷涂技术
·
电磁功能涂层
✓ 已验证
产品关联
DOI
高影响因子
PROGRESS IN ORGANIC COATINGS
·
2026
·
IF 7.9
Pengyu Li,Xiaohua Feng,Mingsheng Wang,Xiangkui Liao,Yi Liu,Hua Li
This work proposes a generalizable structural strategy for designing microwave-absorbing coatings that are both thickness-tolerant and disturbance-resistant. Here, we develop a coating based on a porous PI wall-encapsulated filler structure, in which the unique pore-wall interfaces markedly smooth the thickness evolution of impedance matching and attenuation, enabling effective Ku -band absorption over a 2.5–3.1 mm thickness window. An appropriate composition ratio combined with PI-encapsulated porous structure collectively achieves thickness-insensitive strong absorption performance. To evaluate its anti-interference capability, short-term surface oxidative etching tests were performed. The results show that, even after surface erosion, the internal wall-encapsulated network preserves stable Ku -band absorption and radar-cross-section reduction, maintaining the thickness-insensitive characteristics.
✓ 已验证
产品关联
DOI
高影响因子
Materials Science & Engineering C-Materials for Biological Applications
·
2017
·
IF 4.164
Xiaolong Tang,Shuping Zhou,Xinrong Tao,Jian Wang,Fangyu Wang,Yong Liang
Delivery of taxane-based chemotherapeutics including Docetaxel (DTX) by conventional polymeric micelles still suffers from insufficient stability and rapid premature release during the circulation, which limits their targeting and anticancer efficiency. To conquer these challenges, we developed a novel DTX-loaded Pi-Pi stacking-stabilized dendritic polymeric micelle for targeted therapy of liver cancer. This dendritic polymeric micelle, referred to DPM-DTX-cRGD, was self-assembled from DTX and biodegradable dendritic block copolymers Poly(amidoamine)-poly(γ-benzyl- l -Glutamate)- b -polyethylene glycol-cRGD (PAM-PBLG- b -PEG-cRGD). DPM-DTX-cRGD held robust stability due to its covalent dendritic structure and would load abundant DTX with excellent retention via Pi-Pi stacking between DTX and the aromatic groups of the PBLG segments. The cellular uptake studies demonstrated that the cRGD-conjugated dendritic polymeric micelle (DPM) exhibited much higher cellular uptake in human liver cancer HepG2 cells than non-targeted DPM. The MTT assay also confirmed that DPM-DTX-cRGD caused much greater cytotoxicity than non-targeted DPM-DTX and a clinically available DTX formulation (Taxotere®). Therefore, this DPM-DTX-cRGD provides a novel attractive approach for targeted therapy of liver cancer.
研究领域:
药学
·
肿瘤学
·
生物材料学
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）